각형강관을 이용한 스틸콘크리트 단위벽체의 축내력에 관한 실험적 연구

김곤묵,홍석일,이대현,김호수 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2(구조계)

The steel house, one of new construction methods, has been mainly adapted to a lot of housing and developed in construction skill. But the disadvantage of steel house system is that the system is limited to small housing because it is composed of light gauge steel. Therefore, in order to solve it, this study presents the new system which is made of a carbon steel square for general structural purpose. The framed wall system which is presented in this study is composed of the steel stud members by using the carbon steel square and is reinforced by the horizontal members called runner. So, this system has more sufficient strength and axial load capacity than the steel house wall system. Besides, this system gives us the improved effects of the adiabatic and sound insulation by filling up the autoclaved lightweight concrete. Accordingly, this study evaluates on the axial capacity of unit wall of the system through the experimental study according to the experimental variable and analysis on the structural performance of the framed wall system using carbon steel square.

Euryhelmis squamula (Digenea: Heterophyidae) Recovered from Korean Raccoon Dog, Nyctereutes procyonoides koreensis, in Korea

Hyeon Cheol Kim,Eui Ju Hong,Si Yun Ryu,Jinho Park,Jeong Gon Cho,Do Hyeon Yu,Joon Seok Chae,Kyoung Seong Choi,Bae Keun Park 대한기생충학열대의학회 2021 The Korean Journal of Parasitology Vol.59 No.3

급성 골수성 백혈병의 관해유도제가 동종 조혈모세포 이식후에 미치는 영향

김희제,이종욱,김기원,박수정,서정곤,민창기,엄현석,홍영선,최일봉,민우성,신완식,김춘추,김원일,김동집 대한조혈모세포이식학회 1998 대한조혈모세포이식학회지 Vol.3 No.2

연구배경: 급성 골수성 백혈병 환자에서 관해유도 치료제로 관해유도후 동종 조혈모세포이식을 시행한 경우에 관해유도제의 종류가 이식후 장기 무병생존율에 미치는 영향들을 분석하고자 하였다. 방법: 가톨릭 조혈모세포 이식센타에서 1984년 6월부터 1997년 9월까지 급성 골수성 백혈병으로 처음으로 진단받고 세가지(TAD, TIA, TIB) 주된 관해유도요법에 따라 치료받은 환자들 중에서 골수검사 결과 및 임상적으로 완전 관해상태에서 동종 조혈모세포이식을 시행받은 56명의 이식성적을 분석하였다. 전체 56명의 대상환자들중 TAD(A군) 치료가 12명, TIA(B군) 치료가 12명이었고 TIB(C군) 치료가 32명이었다. 완전관해 유도를 위해서 처음 7일간의 항암제 투여후 7일째 골수 검사를 시행하여 필요한 경우 본 센타의 기준에 따라 3일간의 부가적 강화화학요법제 치료를 시행하였다. 최대 10일간의 1차 치료에 실패한 경우에는 혈액학적 소견이 회복된수 재차 본 센타의 치료지침에 따른 다양한 2차 관해유도요법을 시행하였으며 관해상태에서 후속 공고요법은 본 센타의 표준치료계획에 따라 0~3회까지 다양하게 시행되었다. 동종 조혈모세포이식 전처치요법으로는 통상의 'TBI+ Cyclophosphamide'와 'Busulfan+Cyclophosphamide'를 사용하였으며 무병 생존율에 미치는 영향인자들을 통계분석하였다. 결 과: 1. 관해 유도요법으로 3×10만으로 완전 관해상태에 이르러 이식한 경우가 21명(37.5%)이었고 C군에서는 5명이 3×10 요법으로도 관해유도에 실패하여 2차 관해유도요법이 필요하였던 경우였다. 각군간에 FAB 형분포, 이식전 공고요법의 횟수, 관해후 이식까지의 기간등은 차이가 없었다. 2. 전체 56명 환자를 이식후 중앙값 26개월(3~123)동안 추적 관찰한 결과 2년간 무병생존율은 A, B, 그리고 C군에서 각각 75%, 67,1%, 그리고 66.7%였다. 세군간에 생존율의 통계적 의의는 없었다(p= 0.8168). B군과 C군과의 비교에서도 통계학적으로는 의의있는 결과는 발견되지 않았다(p=0.5368). A, B, 그리고 C군에서 무병 생존기간의 중앙값은 각각 84.3개월(6~123), 39.3개월(3~53), 그리고 18개월(6~43) 이었다. 3. A, B, C군별로 급성 이식편대 숙주반응 발생 빈도는 0~1도가 각각 10명, 8명, 30명이었고 2도 이상은 각각 2명, 4명, 3명이었다. 2도 이상의 급성 이식편대 숙주반응 발생률은 15.7%(9/57)였다. 만성 이식편대 숙주반응 발생 빈도는 국한성이 A군 3명, C군 2명이었으며 평가 가능한 대상 환자중 국한성 만성 이식편대 숙주반응은 25%(14/56)였고, 범발성은 10.7%(6/56)의 빈도를 보였다. 사망 원인을 보면 A군에서는 재발 2명, 범발성만성 이식편대 숙주반응 1명, B군은 범발성 만성 이식편대 숙주반응 2명, 3도 급성 이식편대 숙주반응 1명, CMV 폐렴 1명, 재발 1명이었고 C군은 3도 급성 이식편대 숙주반응 1명, 범발성 만성 이식편대 숙주반응 2명, 재발 4명이 있었다. 각 군간의 재발률 비교에서는 통계적인 의의는 없었다. 4. 전체 56명에 대한 무병 생존율에 영향을 미치는 인자를 분석한 결과 남녀 성차이, 나이, FAB아형, 급, 만성 이식편대 숙주반응 발생유무, 공고요법의 횟수, 완전관해 유도후 이식까지 소요된 시간, 관해유도치료시 3×7만으로 완전관해에 이른 군(n=21)과 3×10후(n=30), 그리고 2차 관해유도요법후 완전관해에 도달한 군(n=5)간의 이식후 무병 생존율차이 등은 모두 통계학적인 의의가 없었으나 2도 이상의 급성 이식편대 숙주반응 발생시(p=0.0012)와 이식전처치요법에 따른 영향에 대한 단변량분석 결과 (p=0.0292)만이 통계학적인 의의가 있는 인자들로 나타났다. 그러나 다변량 분석 결과 의의있는 인자는 발견할 수 없었다. 결론: 저자들은 처음 치료받는 급성 골수성 백혈병 환자들에서 세가지 종류의 초기 관해유도요법으로 완전관해를 이루고 이후 계획된 동종 조혈모세포이식을 시행한 경우들을 대상으로 이식 이후의 각군의 무병생존율 및 재발률을 분석하였으나 통계적으로 유의한 결과를 보이지 않았다. 따라서 일차관해시의 관해유도제의 종류와 이식후 장기생존율과의 의의 있는 상관관계는 없다고 생각된다. Background: To evaluate the outcome after allogeneic stem cell transplantation (allo-SCT) according to the remission induction chemotherapy, we analysed results of the three types of induction chemotherapy including Ara-C+daunorubicin(group A), Ara-C+idarubicin(group B), and BHAC+idarubicin(group C) for patients with acute myelogenous leukemia(AML) in first remission. Methods: Fifty-six AML patients were enrolled between June 1984 and September 1997. The median age was 33 years(range, 15 to 45). The remission induction therapy consisted of daunorubicin(D1-D3)+Ara-C(D1-D7) in group A(n=12), idarubicin(D1-D3)+Ara-C(D1-D7) in group B(n=12), idarubicin(D1-D3)+BHAC(D1-D7) in group C(n=32) and the augmentation were added based upon the results of bone marrow study on seventh-day(D7) of induction chemotherapy by residual leukemic blast percent. Conditioning regimens for SCT included total body irradiation(TBI) + cyclophosphamide(n=53) or busulfan+cyclophosphamide(n=3). Graft- versus-host-disease prophylaxis consisted of cyclosporine and short-term methotrexate. Results: Five cases of AML in group C were needed more than one course of induction chemotherapy for achieving complete remission(CR). 56 patients were performed allo-SCT and we compared disease-free survival(DFS) in each group. Probability of DFS at 2 years in group A, B and C showed 75%, 67.1% and 66.7%, respectively with median follow-up of 23 months (3-123)(p=0.8168). Probability of relapse and incidence of acute or chronic GVHD were not statistically significant between three groups. The causes of death after SCT in each group were as following: two relapses and one extensive chronic GVHD in group A, two extensive chronic GVHD, one grade III acute GVHD, one relapse, and one CMV pneumonia in group B, and one grade III acute GVHD, two extensive chronic GVHD, and four relpases in group C. The worst prognostic factor influencing DFS after allo-SCT was the presence of more than grade II acute GVHD in univariate analysis(p=0.0012). Conclusion: Although there was different follow-up period in these three groups, these data indicate that type of induction chemotherapy does not affect the outcome after allo-SCT for patients with AML in first CR.

Proteome analysis of rice blast fungus (Magnaporthe grisea) proteins during appressorium formation

Kim, Sun-Tae,Yu, Seok,Kim, Sang-Gon,Kim, Han-Ju,Kang, Sun-Young,Hwang, Du-Hyeon,Jang, Yu-Sin,Kang, Kyu-Young Plant molecular biology and biotechnology research 2004 Plant molecular biology and biotechnology research Vol.2004 No.-

We used two-dimensional gel electrophoresis (2-DE) to identify the proteins that are induced in the rice blast fungus Magnaporthe grisea during appressorium formation. Proteins were extracted from conidia that had germinated on hydrophilic glass plates or from germinated and appressoria-forming conidia on leaf wax-coated hydrophobic glass plates after 4, 8, and 12 h of incubation. Differentially expressed protein spots during appressorium formation were confirmed from gels after 2-DE analysis where proteins had been labeled with ^(35)S methionine and stained with silver. Internal amino acid sequencing identified five proteins among several proteins induced during appressorium formation. Two denoted as M. grisea proteasome homolgues (MgP1 and MgP5) were 20S proteasome α subunits. The remaining three were scytalone dehydratase (SCD), and serine carboxypeptidase Y (CPY). None of the five have been reported previously in the rice blast fungus apart from SCD. We further investigated the role the α subunit of 20S proteasome plays in appressorium formation. We confirmed by Western blot analysis that MgP5 is highly expressed during appressorium formation and found that it is also markedly induced by nitrogen- and carbon-starvation, in particular by the former. These observations suggest that the 20S proteasome may be involved in remobilizing storage proteins, which then help to build the appressorium. Thus, fungal proteome analysis may provide important clues about developmental changes such as the generation of the appressorium.

Proteomic analysis of pathogen-responsive proteins from rice leaves induced by rice blast fungus, Magnaporthe grisea

Kim, Sun-Tae,Kim, Sang-Gon,Hwang, Du-Hyeon,Kang, Sun-Young,Kim, Han-Ju,Lee, Byung-Hyun,Lee, Jeung-Joo,Kang, Kyu-Young Plant molecular biology and biotechnology research 2004 Plant molecular biology and biotechnology research Vol.2004 No.-

Proteomic approaches using two-dimensional gel electrophoresis (2-DE) were adopted to identify proteins from rice leaf that are differentially expressed in response to the rice blast fungus, Magnaporthe grisea. Microscopic observation of inoculated leaf with M. grisea revealed that callose deposition and hypersensitive response was clearly visible in incompatible interactions but excessive invading hypha with branches were evident in compatible interactions. Proteins were extracted from leaves 24, 48, and 72 hours after rice blast fungus inoculation. Eight proteins resolved on the 2-DE gels were induced or increased in the Inoculated leaf. Matrix-assisted laser desorption/ionization-time of flight analysis of these differentially displayed proteins showed them to be two receptor-like protein kinases (RLK), two β-1.3-glucanases (Glu1, Glu2), thaumatin-like protein (TLP), peroxidase (POX 22.3), probenazole-inducible protein (PBZ1), and rice pathogenesis-related 10 (OsPR-10). Of these proteins. RLK, TLP, PBZ, and OsPR-10 proteins were induced more in the incompatible interactions than in compatible ones, A phytohormone, jasmonic acid also induced all eight proteins in leaves. To confirm whether the expression profile is equal to the 2-DE data, seven cDNA clones were used as probes In Northern hybridization experiments using total RNA from leaf tissues inoculated with incompatible and compatible rice blast fungal races. The genes encoding POX22.3, Glu1, Glu2, TLP, OsRLK, PBZ1, and OsPR-10 were activated in inoculated leaves, with TLP, OsRLK, PBZ1, and OsPR-10 being expressed earlier and more in incompatible than in compatible interactions. these results suggest that early and high induction of these genes may provide host plants with leading edges to defend themselves. The localization of two rice PR-10 proteins, PBZ1 and OsPR-10, was further examined by immunohistochemical analysis. PBZ1 accumulated highly in mesophyll cells under the attachment site of the appressorium. In contrast, OsPR-10 expression was mainly localized to vascular tissue.

Neuronal Cell Protection Activity of Macrolactin A Produced by Actinomadura sp .

( Hyeon Ho Kim,Won Gon Kim,In Ja Ryoo,Chang Jin Kim,Jae Eun Suk,Kyou Hoon Han,Se Young Hwang,Ick Dong Yoo ) 한국미생물생명공학회 1997 Journal of microbiology and biotechnology Vol.7 No.6

Determination of Clinical Characteristics of Mycobacterium kansasii -Derived Species by Reanalysis of Isolates Formerly Reported as M. kansasii

Kim Young-gon,Lee Hong Yeul,Kwak Nakwon,Park Jae Hyeon,Kim Taek Soo,Kim Man Jin,Lee Jee-Soo,Park Sung-Sup,Yim Jae-Joon,Seong Moon-Woo 대한진단검사의학회 2021 Annals of Laboratory Medicine Vol.41 No.5

Background: Seven genotypic subtypes of Mycobacterium kansasii were recently demonstrated to represent distinct species based on phylogenomic analysis. Mycobacterium kansasii sensu stricto (formerly known as subtype 1) is most frequently associated with human diseases; only a few studies have compared the diverse clinical characteristics of M. kansasii subtypes, including their drug susceptibilities. We determined the actual incidence of infections caused by each subtype of M. kansasii and identified their clinical characteristics. Methods: We subtyped isolates identified as M. kansasii over the last 10 years at a tertiary care hospital. Percent identity score of stored sequencing data was calculated using curated reference sequences of all M. kansasii subtypes. Clinical characteristics were compared between those classified as subtype 1 and other subtypes. Student’s t-test, Wilcoxon rank-sum test, and Fisher’s exact test were used for comparisons. Results: Overall, 21.7% of the isolates were identified as species distinct from M. kansasii. The proportion of patients with subtype 1 M. kansasii infection who received treatment was significantly higher than that of patients with other subtype infections (55.3% vs. 7.7%, P=0.003). Only patients with subtype 1 infection received surgical treatment. Non-subtype 1 M. kansasii isolates showed a higher frequency of resistance to ciprofloxacin and trimethoprim/sulfamethoxazole. Conclusions: Non-subtype 1 M. kansasii isolates should be separately identified in routine clinical laboratory tests for appropriate treatment selection.

The Operating Performance Following Corporate Asset Sales

Kim, Yong-Hyeon(김용현),Kim, Nam-Gon(김남곤) 대한경영학회 2010 大韓經營學會誌 Vol.23 No.3

The Long-Run Performance Following Securities Offerings

Kim, Yong-Hyeon(김용현),Kim, Nam-Gon(김남곤),Park, Young-S(박영석),Park, Seong-Ho(박성호) 대한경영학회 2011 大韓經營學會誌 Vol.24 No.2

Application of fracture mechanical assessment to in-wall shield ribs in ITER vacuum vessel

Kim, Yu-Gyeong,Kim, Hyun-Soo,Park, Chul-Kyu,Kim, Gwang-Ho,Moon, Ho-Kyu,Hong, Kwen-Hee,Chung, Woo-Ho,Lee, Hyeon-Gon,Sa, Jeong-Woo,Choi, Chang-Ho,Sim, Jae-Min,Chang, Yoon-Suk North-Holland 2017 Fusion engineering and design Vol.124 No.-

<P><B>Abstract</B></P> <P>In-wall shield ribs are installed between double walls of vacuum vessel and their role is to hold neutron shielding blocks. Since one of key issues on these structures is to sustain integrity during entire ITER operation without any in-service inspection or maintenance, fracture behavior shall be evaluated in design stage. In the present study, a weight function method was employed for crack initiation assessment. The most critical structure was selected as a representative one and its structural integrity was evaluated. In order to check validity of this method, an extended finite element method was adopted for bounding cases. As a result, not only structural safety but also quite conservatism were observed comparing to those of extended finite element analysis with similar tendency. It means that the weight function method could be a conservatively practical approach for fracture mechanical assessment of in-wall shield ribs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Structural analysis of IWS rib assembly was performed and verified via RCC-MR. </LI> <LI> Systematic crack initiation assessment was conducted by using weight function method. </LI> <LI> Conservatism of the weight function method was verified by detailed X-FEM analyses. </LI> </UL> </P>