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신재호,Sung-Jin Park,Hyun-Jin Cho,Geumhee Gwak,Byung-Noe Bae,Ki Whan Kim,Hong-Yong Kim2,Kyeongmee Park,Sehwan Han 한국유방암학회 2009 Journal of breast cancer Vol.12 No.1
Purpose: Human epidermal growth factor receptor-2 (HER-2)/neu amplification affects the cell proliferation through the modulation of multiple G1 cell cycle regulators in breast tumor cells. We performed this study to investigate whether retinoblastoma protein (pRB) and p27Kip1 were differently expressed according to the HER2 amplification status in human breast cancer. Methods: HER2 amplification was assayed by fluorescence in situ hybridization and the expression of cell cycle regulators were assayed by immunohistochemistry on 153 consecutive invasive breast cancers. The proliferative activity of breast cancer was analyzed according to the HER2 amplification and cell cycle protein expression status. Results: HER2 amplification was observed in 39 (25.5%) of 153 breast cancers. In the HER2 amplified breast cancers, the pRB expression was significantly increased (p=0.011) whereas there was no significant relationship between HER2 amplification and p27Kip1 expression. There was an inverse correlation between pRB expression and Ki-67 labeling index in the HER2 amplified breast cancers (p=0.036). In contrast, Ki67 labeling index was significantly decreased as p27Kip1 expression increased in HER2 non-amplified breast cancers (p=0.028). In HER2 non-amplified breast cancers, we could not observe any association between the pRB expression and Ki67 labeling index. Conclusion: The proliferation of the breast cancers was associated with pRB expression in HER2 amplified tumors whereas it was associated with p27Kip1 expression in HER2 non-amplified tumors. The results of the current study indicate that the cell proliferative activity of the breast cancer is under different growth signal pathways according to HER2 amplification status.
Kim Geumhee,Lee Jiho,양효주,이윤영,Yang Yoonyong,Choi Sungho,Hur Moonsuk,Lee Byounghee,조경숙 한국미생물·생명공학회 2022 한국미생물·생명공학회지 Vol.50 No.4
본 연구에서는 토양, 담수 및 염수 퇴적물, 슬러지 등 8종의 접종원을 이용하여 배양인자(기질종류, 염농도, 배양온도)에 따른 바이오수소 생산 잠재능을 평가하고 최적조건을도출하고자 하였다. 각 접종원 별 바이오수소 생산속도는 배양온도와 접종원 종류에 의해 유의한 영향을 받았다. 반면기질종류와 염농도는 바이오수소 생산속도에 대체로 유의한영향을 끼치지 않았다. 고온(50°)보다 중온(37℃)의 배양 온도가 수소 생산에 더 적합하였으며, 8종의 접종원 중에서 중에서는 혐기소화슬러지의 수소 생산능이 가장 우수하였다. 혐기소화슬러지의 최대 수소 생산속도는 중온(37℃)과 고온(50℃)에서 각각 2,729.0 및 1,384.7 ml-H2·l-1·d-1였다.
Geumhee Gwak,Hae Kyung Lee,Hee-Jung Kim,Si Youn Lee,박용래,Jong Won Lee,Seung Gi Kim,Ho Huh,신혁재,김제룡,안진석,Ju Hyuk Son,Il Gyun Lee,박우찬,김성용,Sehwan Han,이은숙 한국유방암학회 2012 Journal of breast cancer Vol.15 No.2
This survey was performed to analyze the usability of the third edition of the Korean breast cancer clinical practice guidelines (KBCCPG) in clinical practice. We made a questionnaire composed of 18 general and 82 specific questions regarding benign breast disease (B; 1 question); non-invasive disease (N; 12 questions); early-stage disease (E; 26 questions); advanced disease (A; 24 questions); and metastatic (M) breast cancer-related problems (19 questions). A total of 100 questionnaires, with a link to an online survey, were delivered via e-mail to over 700 members of the Korean Breast Cancer Society (KBCS), and associated academy members, over 20 days between 26th February and 16th May 2010. Out of 270 respondents who read the e-mail,96 answered the questionnaire. Participants included 87 surgical oncologists, 5 radiation oncologists, 2 oncoplastic surgeons, 1 pathologist, and 1 medical oncologist. The third KBCCPG were perceived as differing from the second guidelines in terms of the level of clinical evidence required before choosing a recommendation. For the progress of the KBCCPG, the guideline committee should try to reinforce all courses of guideline development with several elements including data from clinical trials of Korean breast cancer patients, securing a multidisciplinary approach, developing consistent and reasonable processes for each step of the revision of the guidelines, induction of liberal scientific and ethical discussion about all issues with all KBCS members. The cost-effectiveness of healthcare and the logical development of the KBCCPG would also be ensured. Timely updates of the clinical guidelines for breast cancer treatment are essential to facilitate optimal decision-making in daily practice, and to ensure adequate patient feedback.
Geumhee Gwak,Kyeongmee Park,Eunah Shin,Sehwan Han,Ji-Young Kim,Hong-Yong Kim,김영덕,Hong Ju Kim,김기환,배병노,Keun Ho Yang,Hyun-Jin Cho,Sung-Jin Park 한국유방암학회 2011 Journal of breast cancer Vol.14 No.3
Purpose: Our study aimed to evaluate the feasibility of adjuvant cyclophosphamide/vinorelbine/5-fluorourail (CVF) chemotherapy as an alternative to cyclophosphamide/methotrexate/5-fluorouracil (CMF) chemotherapy for treating early breast cancer. Methods: One hundred and forty-nine patients were randomly assigned to CMF or CVF adjuvant chemotherapy for treating their early stage breast cancer between September 2000 and December 2007. The disease-free survival (DFS), the overall survival (OS), and the toxicity profiles of both groups were compared. Results: Sixty-seven patients underwent CMF chemotherapy whereas 82 patients underwent CVF chemotherapy. The DFS and OS were 88 months (95% confidence interval [CI], 76-101 months) and 94 months (95% CI, 83-104 months), respectively for the CMF group, and 97 months (95% CI, 93-101 months), and 101 months (95% CI, 98-104 months), respectively for the CVF group. However, those survival gains of the CVF group were not statistically significant (p-value=0.069 for the DFS and 0.99 for the OS). The CVF group showed a favorable toxicity profile in terms of the grade 3/4 hematologic toxicities as compared to that of the CMF group. Conclusion: Clinical outcome of CVF chemotherapy was comparable to CMF with a favorable toxicity profiles. However, it is difficult to conclude the feasibility of CVF regimen because of small number of studied patients.
Jaeyoon Kim,Yujin Lee,Taeyong Yoo,Jungbin Kim,Jonghee Hyun,Inseok Park,Hyunjin Cho,Keunho Yang,Byungno Bae,Kihwan Kim,Kyeongmee Park,Geumhee Gwak 한국유방암학회 2019 Journal of Breast Disease Vol.7 No.1
Purpose: We aimed to investigate organ-specific recurrence or the metastatic pattern of breast cancer according to biological subtypes and clinical characteristics. Methods: We retrospectively analyzed the medical records of 168 patients with recurrent breast cancer who were diagnosed between January 1, 2000 and April 30, 2017. Four biological subtypes were classified according to estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki-67 expression: luminal A, luminal B, HER2-enriched, and triple negative breast cancer (TNBC). To analyze recurrence patterns according to biological subtypes, we accessed clinical variables including age at diagnosis, TNM stage, type of surgery in the breast and axilla, histologic grade, nuclear grade, lymphatic, vascular, and neural invasion, Ki-67 expression and recurrence to distant organs. Results: The biological subtypes of recurrent breast cancer comprised the following luminal A (n=33, 19.6%), luminal B (n=95, 56.5%), HER2 enriched (n=19, 11.3%), and TNBC (n=21, 12.5%). Luminal A (7.7%) and B (6.5%) subtypes were associated with the increased rate of local recurrence compared to HER2-enriched (2.4%) and TNBC subtypes (1.8%) (p=0.005). The bone (53.6%) was the most common metastatic organ, followed by the lung (34.5%), liver (29.8%), brain (17.9%), and other visceral organ (7.7%). Bone metastasis was commonly observed in individuals with luminal B (63.2%), HER2-enriched (57.9%), and luminal A (42.4%) subtypes (p=0.005). Most liver metastases occur in individuals with luminal B (40.0%) and HER2-enriched subtypes (31.6%) (p=0.002). Conclusion: Luminal B subtype was commonly observed in individuals with recurrent breast cancer, and the bone is the most common target organ for breast cancer metastasis, followed by the lungs and liver.
Bomi Kim,Jungbin Kim,박인석,Hyunjin Cho,Geumhee Gwak,Keun Ho Yang,Byung-Noe Bae,Kihwan Kim 대한내시경복강경외과학회 2020 Journal of Minimally Invasive Surgery Vol.23 No.1
Purpose: Appendectomy, which comprises most benign intra-abdominal surgeries, is currently assisted by laparoscopy in most cases. However, many patients complain of postoperative shoulder or subcostal pain after laparoscopic surgery. In some cases, the pain lasts even several weeks after surgery. This study aimed to analyze unmodifiable clinicopathological factors of patients who underwent laparoscopic appendectomy and to minimize preoperative and postoperative discomfort. Methods: Patients admitted for laparoscopic appendectomy for acute appendicitis with an American Society of Anesthesiology (ASA) grades I and II, and ages 12–70 years were enrolled in the study. Postoperative shoulder or subcostal pain was assessed using the visual analogue scale (VAS) for pain and analyzed with the clinicopathological factors of the patients, including age, sex, weight, height, body mass index (BMI), and abdominal circumference (AC) difference. Results: Of the 124 patients, 40 complained of postoperative shoulder or subcostal pain with a VAS score of ≥4. The risk of the postoperative shoulder or subcostal pain increased in women (p = 0.001). From a univariate analysis, the risk of postoperative shoulder or subcostal pain increased with lower height, weight and BMI (p = 0.002, p = 0.001, p = 0.012) and with greater AC difference (p = 0.012). However, a multivariate analysis showed that lower weight was the only risk factor of postoperative pain (p = 0.005). Conclusions: The risk of postoperative shoulder or subcostal pain after laparoscopic appendectomy was significantly increased with lower weight.
A study on the effect on birth satisfaction in women who gave birth naturally in a midwifery clinics
Kyoungwon Kim,Sunhee Lee,Geumhee Jeong,Hyun Kyoung Kim 한국간호과학회 2021 한국간호과학회 학술대회 Vol.2021 No.10
Aim(s): The purpose of this study was to confirm the birth satisfaction of women who gave birth naturally at midwifery clinics. Method(s): This is a descriptive research study to confirm the birth satisfaction of women who gave birth naturally at midwifery clinics. In this study, a total of 77 respondents in 2019 to 2020 were used using the online survey method for women who gave birth with a gestational period of 37 weeks or more. Using SPSS version 26.0 for Windows, general characteristics were analyzed with frequency and percentage, and birth experience, birth care experience, perceived quality of birth care through mothers" eyes, and birth satisfaction were analyzed with mean and standard deviation. Correlation between parity, family care, personal care, emotional empowerment, information provision, labor pain, perceived safety, birth experience, birth care experience, and birth satisfaction were analyzed by Pearson"s correlation coefficient. The Affecting factor on birth satisfaction was analyzed using regression analysis. Result(s): The average score for birth experience was 84.12 points (±7.73), the average score for birth care experience was 73.08 (±4.08), and the average total score of nursing quality perceived by the mother was 26.26 (±3.41). Birth satisfaction was statistically significant positive correlation with birth experience (r=.79, p<.001), birth nursing experience (r=.68, p<.001), and sense of safety (r=.45, p<.001). On the other hand, birth satisfaction and labor pain (r=-.32, p=.005) showed a statistically significant negative correlation. Factors influencing birth satisfaction were birth experience (b=.65, <.001), birth nursing experience (b=.33, p=.003), family care (b=.19, p=.004), personal care (b=.19, p=.018), perceived safety (b=.19, p=.029), and the explanatory power of the model was 72.5% (F=22.79, p<.001). Conclusion(s): Birth satisfaction is affected by birth experience, birth nursing experience, family care, personal care, and perceived safety.