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      • KCI등재

        Early childhood eating behaviors associated with risk of overweight and its socio-ecological determinants in Korean preschool children

        Kim Yeri,Kim Jiye,Lee Bomi,Jung Seungyoun,Chung Seo-Jin,Kim Hyekyeong,Shin Nana,Kim Yuri 한국영양학회 2023 Nutrition Research and Practice Vol.17 No.4

        BACKGROUND/OBJECTIVES: This study aimed to identif y preschool children’s eating behaviors associated with early childhood obesity and its multi-level, socio-ecological determinants. SUBJECTS/METHODS: In a cross-sectional study of 364 mothers of preschool children aged 3–5 years, these children’s healthy eating behaviors were assessed using a validated preschool nutrition quotient (NQ-P) questionnaire. The children’s over weight or obesity statuses were determined based on body mass index percentiles from the 2017 Korean National Growth Chart. The associations between the NQ-P score and risk of over weight or obesity were examined using multivariable logistic regression. The associations of individual, maternal, physical, and media environmental factors with the NQ-P score were also examined using multivariable linear regression. RESULTS: Preschool children with greater NQ-P scores were at a significantly lower risk of over weight or obesity (P < 0.01). The NQ-P score had a significantly positive association with maternal body mass index and an inverse association with household income (all P < 0.05). Maternal parenting and feeding practices exhibited associations with the NQ-P score. Positive associations were obser ved with “warm,” “structured,” and “autonomy-supportive” parenting as well as monitoring feeding practices (all P < 0.05). In addition, the NQ-P score had a significantly positive association with the childcare center’s anti-obesogenic environment, such as the provision of nutritional and physical-activity support and vicinity of the built food environment to the home, including access to good-quality food, fruits and vegetables, and low-fat foods (all P < 0.05). Regarding media environments, the NQ-P score demonstrated more significant associations with viewing and eating and/or cooking content displayed on online video platforms (all P < 0.05) than with that on television. CONCLUSIONS: Our findings confirm the significance of healthy eating behaviors in early- childhood-obesity prevention and underscore the importance of multilevel maternal, physical, and media environmental inter ventions that effectively guide eating behaviors in preschool children.

      • KCI등재

        Risk Factors for Coronavirus Disease 2019 (COVID-19)-Associated Pulmonary Aspergillosis in Critically Ill Patients: A Nationwide, Multicenter, Retrospective Cohort Study

        Kim Si-Ho,Hong Jin Yeong,Bae Seongman,Lee Hojin,Wi Yu Mi,Ko Jae-Hoon,Kim Bomi,Joo Eun-Jeong,Seok Hyeri,Shi Hye Jin,Yoo Jeong Rae,Hyun Miri,Kim Hyun ah,Jang Sukbin,Mun Seok Jun,Kim Jungok,Kim Min-Chul 대한의학회 2022 Journal of Korean medical science Vol.37 No.18

        Background: Coronavirus disease 2019 (COVID-19) is often accompanied by secondary infections, such as invasive aspergillosis. In this study, risk factors for developing COVID-19- associated pulmonary aspergillosis (CAPA) and their clinical outcomes were evaluated. Methods: This multicenter retrospective cohort study included critically ill COVID-19 patients from July 2020 through March 2021. Critically ill patients were defined as patients requiring high-flow respiratory support or mechanical ventilation. CAPA was defined based on the 2020 European Confederation of Medical Mycology and the International Society for Human and Animal Mycology consensus criteria. Factors associated with CAPA were analyzed, and their clinical outcomes were adjusted by a propensity score-matched model. Results: Among 187 eligible patients, 17 (9.1%) developed CAPA, which is equal to 33.10 per 10,000 patient-days. Sixteen patients received voriconazole-based antifungal treatment. In addition, 82.4% and 53.5% of patients with CAPA and without CAPA, respectively, received early high-dose corticosteroids (P = 0.022). In multivariable analysis, initial 10-day cumulative steroid dose > 60 mg of dexamethasone or dexamethasone equivalent dose) (adjusted odds ratio [OR], 3.77; 95% confidence interval [CI], 1.03–13.79) and chronic pulmonary disease (adjusted OR, 4.20; 95% CI, 1.26–14.02) were independently associated with CAPA. Tendencies of higher 90- day overall mortality (54.3% vs. 35.2%, P = 0.346) and lower respiratory support-free rate were observed in patients with CAPA (76.3% vs. 54.9%, P = 0.089). Conclusion: Our study showed that the dose of corticosteroid use might be a risk factor for CAPA development and the possibility of CAPA contributing to adverse outcomes in critically ill COVID-19 patients.

      • SCOPUSSCIEKCI등재

        Hard- and soft-tissue profiles of the midface region in patients with skeletal Class III malocclusion using cone-beam computed tomography multiplanarreconstructed image analysis

        Bomi Kim,Hyung-Chul Lee,Seong-Hun Kim,Yongil Kim,Woosung Son,Seong Sik Kim 대한치과교정학회 2018 대한치과교정학회지 Vol.46 No.3

        Objective: This study examined cone-beam computed tomography (CBCT)-derived multiplanar-reconstructed (MPR) cross-sections to clarify the salient characteristics of patients with skeletal class III malocclusion with midface deficiency (MD). Methods: The horizontal and sagittal plane intersection points were identified for middle-third facial analysis in 40 patients in the MD or normal (N) groups. MPR images acquired parallel to each horizontal plane were used for length and angular measurements. Results: A comparison of the MD and N groups revealed significant differences in the zygoma prominence among female patients. The convex zygomatic area in the N group was larger than that in the MD group, and the inferior part of the midface in the N group was smaller than that in the MD group for both male and female patients. A significant difference was observed in the concave middle maxillary area among male patients. Conclusions: This study was conducted to demonstrate the difference between MD and normal face through MPR images derived from CBCT. Male patients in the MD group had a more flattened face than did those in the N group. Female patients in the MD group showed a concave-shaped lower section of the zygoma, which tended to have more severe MD. These findings indicate that orthognathic surgery to improve skeletal discrepancy requires different approaches in male and female patients.

      • KCI등재후보

        Unmodifiable Clinicopathological Risk Factors of Shoulder Tip or Subcostal Pain after Laparoscopic Appendectomy

        Bomi Kim,Jungbin Kim,박인석,Hyunjin Cho,Geumhee Gwak,Keun Ho Yang,Byung-Noe Bae,Kihwan Kim 대한내시경복강경외과학회 2020 Journal of Minimally Invasive Surgery Vol.23 No.1

        Purpose: Appendectomy, which comprises most benign intra-abdominal surgeries, is currently assisted by laparoscopy in most cases. However, many patients complain of postoperative shoulder or subcostal pain after laparoscopic surgery. In some cases, the pain lasts even several weeks after surgery. This study aimed to analyze unmodifiable clinicopathological factors of patients who underwent laparoscopic appendectomy and to minimize preoperative and postoperative discomfort. Methods: Patients admitted for laparoscopic appendectomy for acute appendicitis with an American Society of Anesthesiology (ASA) grades I and II, and ages 12–70 years were enrolled in the study. Postoperative shoulder or subcostal pain was assessed using the visual analogue scale (VAS) for pain and analyzed with the clinicopathological factors of the patients, including age, sex, weight, height, body mass index (BMI), and abdominal circumference (AC) difference. Results: Of the 124 patients, 40 complained of postoperative shoulder or subcostal pain with a VAS score of ≥4. The risk of the postoperative shoulder or subcostal pain increased in women (p = 0.001). From a univariate analysis, the risk of postoperative shoulder or subcostal pain increased with lower height, weight and BMI (p = 0.002, p = 0.001, p = 0.012) and with greater AC difference (p = 0.012). However, a multivariate analysis showed that lower weight was the only risk factor of postoperative pain (p = 0.005). Conclusions: The risk of postoperative shoulder or subcostal pain after laparoscopic appendectomy was significantly increased with lower weight.

      • SCOPUSSCIEKCI등재

        Hard- and soft-tissue profiles of the midface region in patients with skeletal Class III malocclusion using cone-beam computed tomography multiplanarreconstructed image analysis

        Bomi Kim,Hyung-Chul Lee,Seong-Hun Kim,Yongil Kim,Woosung Son,Seong Sik Kim 대한치과교정학회 2018 대한치과교정학회지 Vol.48 No.3

        Objective: This study examined cone-beam computed tomography (CBCT)-derived multiplanar-reconstructed (MPR) cross-sections to clarify the salient characteristics of patients with skeletal class III malocclusion with midface deficiency (MD). Methods: The horizontal and sagittal plane intersection points were identified for middle-third facial analysis in 40 patients in the MD or normal (N) groups. MPR images acquired parallel to each horizontal plane were used for length and angular measurements. Results: A comparison of the MD and N groups revealed significant differences in the zygoma prominence among female patients. The convex zygomatic area in the N group was larger than that in the MD group, and the inferior part of the midface in the N group was smaller than that in the MD group for both male and female patients. A significant difference was observed in the concave middle maxillary area among male patients. Conclusions: This study was conducted to demonstrate the difference between MD and normal face through MPR images derived from CBCT. Male patients in the MD group had a more flattened face than did those in the N group. Female patients in the MD group showed a concave-shaped lower section of the zygoma, which tended to have more severe MD. These findings indicate that orthognathic surgery to improve skeletal discrepancy requires different approaches in male and female patients.

      • KCI등재후보

        Organizing an in-class hackathon to correct PDF-to-text conversion errors of Genomics & Informatics 1.0

        Kim, Sunho,Kim, Royoung,Nam, Hee-Jo,Kim, Ryeo-Gyeong,Ko, Enjin,Kim, Han-Su,Shin, Jihye,Cho, Daeun,Jin, Yurhee,Bae, Soyeon,Jo, Ye Won,Jeong, San Ah,Kim, Yena,Ahn, Seoyeon,Jang, Bomi,Seong, Jiheyon,Lee, Korea Genome Organization 2020 Genomics & informatics Vol.18 No.3

        This paper describes a community effort to improve earlier versions of the full-text corpus of Genomics & Informatics by semi-automatically detecting and correcting PDF-to-text conversion errors and optical character recognition errors during the first hackathon of Genomics & Informatics Annotation Hackathon (GIAH) event. Extracting text from multi-column biomedical documents such as Genomics & Informatics is known to be notoriously difficult. The hackathon was piloted as part of a coding competition of the ELTEC College of Engineering at Ewha Womans University in order to enable researchers and students to create or annotate their own versions of the Genomics & Informatics corpus, to gain and create knowledge about corpus linguistics, and simultaneously to acquire tangible and transferable skills. The proposed projects during the hackathon harness an internal database containing different versions of the corpus and annotations.

      • SCISCIESCOPUS

        Inactivation of Norovirus by Lemongrass Essential Oil Using a Norovirus Surrogate System

        Kim, Ye Won,You, Hyun Ju,Lee, Soyoung,Kim, Bomi,Kim, Do Kyung,Choi, Joo-Bong,Kim, Ji-Ah,Lee, Hee Jung,Joo, In Sun,Lee, Jeong Su,Kang, Dong Hyun,Lee, Giljae,Ko, Gwang Pyo,Lee, Sung-Joon ational Association for Food Protection 2017 Journal of food protection Vol.80 No.8

        <B>ABSTRACT</B><P>This study investigated the effect of lemongrass essential oil (LGEO) on the infectivity and viral replication of norovirus. Murine norovirus 1 (MNV-1), a surrogate of human norovirus, was preincubated with LGEO and then used to infect RAW 264.7 cells in a plaque reduction assay. LGEO exhibited a significant reduction in MNV-1 plaque formation in both time- and dose-dependent manners. The quantification of viral genome by quantitative real-time PCR showed similar results in line with those of the plaque reduction assay. It was revealed that citral, a single compound in LGEO, showed dramatic reduction in MNV-1 infectivity (−73.09% when using a treatment of 0.02%, v/v). The inhibitory activity of LGEO on viral replication was further investigated in HG23 cells that harbored a human norovirus replicon. LGEO treatment significantly reduced viral replication in HG23 cells, which suggests that LGEO may have dual inhibitory activities that inactivate viral coat proteins required for viral infection and suppress norovirus genome replication in host cells. In animal experiments, oral administration of murine norovirus preincubated with LGEO significantly suppressed virus infectivity in vivo. Collectively, these results suggest that LGEO, in particular the LGEO component citral, inactivates the norovirus and its subsequent replication in host cells. Thus, LGEO shows promise as a method of inhibiting norovirus within the food industry.</P>

      • Microfluidic fabrication of photo-responsive hydrogel capsules

        Kim, Bomi,Soo Lee, Hye,Kim, Jaeyun,Kim, Shin-Hyun The Royal Society of Chemistry 2013 Chemical communications Vol.49 No.18

        <P>We report thermo- and photo-responsive hydrogel capsules, providing controlled encapsulation and triggered release of water-soluble encapsulants. Monodisperse O/W/O (oil-in-water-in-oil) double-emulsion drops are produced in a capillary microfluidic device as templates, which transform into hydrogel capsules upon polymerization of thermo-sensitive monomers in the water phase containing gold nanorods.</P> <P>Graphic Abstract</P><P>Microcapsules, whose membrane is composed of thermo-sensitive hydrogels and gold nanorods, enable the remote and reversible control of membrane permeability. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3cc37719a'> </P>

      • SCIESCOPUSKCI등재

        Combined Skin Moisturization of Liposomal Serine Incorporated in Hydrogels Prepared with Carbopol ETD 2020, Rhesperse RM 100 and Hyaluronic Acid

        Kim, Hyeongmin,Ro, Jieun,Barua, Sonia,Hwang, Deuk Sun,Na, Seon-Jeong,Lee, Ho Sung,Jeong, Ji Hoon,Woo, Seulki,Kim, Hyewon,Hong, Bomi,Yun, Gyiae,Kim, Joong-Hark,Yoon, Young-Ho,Park, Myung-Gyu,Kim, Jia,S The Korean Society of Pharmacology 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.6

        We investigated the combined moisturizing effect of liposomal serine and a cosmeceutical base selected in this study. Serine is a major amino acid consisting of natural moisturizing factors and keratin, and the hydroxyl group of serine can actively interact with water molecules. Therefore, we hypothesized that serine efficiently delivered to the stratum corneum (SC) of the skin would enhance the moisturizing capability of the skin. We prepared four different cosmeceutical bases (hydrogel, oil-in-water (O/W) essence, O/W cream, and water-in-oil (W/O) cream); their moisturizing abilities were then assessed using a $Corneometer^{(R)}$. The hydrogel was selected as the optimum base for skin moisturization based on the area under the moisture content change-time curves (AUMCC) values used as a parameter for the water hold capacity of the skin. Liposomal serine prepared by a reverse-phase evaporation method was then incorporated in the hydrogel. The liposomal serine-incorporated hydrogel (serine level=1%) showed an approximately 1.62~1.77 times greater moisturizing effect on the skin than those of hydrogel, hydrogel with serine (1%), and hydrogel with blank liposome. However, the AUMCC values were not dependent on the level of serine in liposomal serine-loaded hydrogels. Together, the delivery of serine to the SC of the skin is a promising strategy for moisturizing the skin. This study is expected to be an important step in developing highly effective moisturizing cosmeceutical products.

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