서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

관상동맥 시술 도중 발생한 좌주간부 관상동맥 박리에 대한 스텐트 삽입 치료의 단장기 임상 결과 : acute and long-term results

이세환,이승환,홍명기,김영학,이철환,한기훈,송종민,강덕현,송재관,김재중,박성욱,박승정 대한내과학회 2004 대한내과학회지 Vol.66 No.6

목적 : 심도자 사용 시술과 관련된 좌주간부 관상동맥박리에 대한 적절한 치료는 아직 확실히 정립되지 않은 상태이다. 이에 본 연구는 좌주간부 관상동맥 박리에 대한 스텐트 삽입술의 단장기 임상결과를 후향적으로 분석하였다. 방법 : 좌주간부 관상동맥 박리에 대한 치료로 즉각적인 스텐트 삽입술을 시행하는 것이 안전하고 효과적인 방법임을 가설하였고, 이러한 즉각적인 스텐트 삽입을 시행한 10명의 환자를 대상으로 단장기적 임상경과를 의무기록 고찰과 전화 면담을 통해서 평가하였다. 결과 : 전체 환자 모두 처음부터 좌주간부 관상동맥에 유의한 협착을 가진 환자는 없었으며, 8명의 환자는 심도자의 조작으로 인한 박리가 발생한 경우였고(진단적 혈관 조영술 중에 3명, 유도 도자 조작 중에 5명), 나머지 2명은 다른 병변에 스텐트 삽입시술을 하는 중에 박리가 발생하였다. 이 10명의 환자에서 모두 즉각적인 스텐트 삽입술이 시행되었고, 4명의 환자에서 시술 도중 혈압 저하로 Intra-aortic Ballon Pump (IABP)를 장착하였다. 모든 환자에서 성공적으로 스텐트가 삽입되었고, 병원내 사망은 1명도 없었다. 6개월 추적 관상동맥 조영술은 8명의 환자에서 시행되었다. 혈관 조영상의 재협착(직경 협착 50% 이상)은 8명 모두에게서 관찰되지 않았으며, 퇴원 후 평균 31±25개월의 추적관찰 결과 주요 심장사건은 1건도 발생하지 않았다. 결론 : 비록 대상 환자가 적은 연구였지만 좌주간부 관상동맥 박리에 대한 스텐트 삽입술은 기술적으로 안전하고 빠르게 시행 할 수 있으며, 훌륭한 단장기적인 치료 효과를 보여준다. Background : The optimal treatment of patients with left main coronary artery (LMCA) dissection during catheter-based procedure remains uncertain. We retrospectively analyzed the acute and long-term results of bail-out stenting for LMCA dissection. Methods : In cases with significant LMCA dissection occurring during catheter-based procedure, prompt stent implantation may be safe and associated with favorable clinical outcome. We evaluated the acute and long-term results of bail-out stenting for LMCA dissection occurring during catheter-bases procedure in 1- patients. Results : Initially, there was significant stenosis of LMCA segment in these patients. Catheter-induced dissection occurred in 8 patients (during diagnostic angiography in 3 patients and guiding catheter manipulation in 5 patients). Two patients suffered dissection in the setting of stent deployment in other vessels. Therefore, bail-out stenting LMCA dissection was performed in a total of 10 patients. In 4 patients, hypotension developed and intra-aortic balloon pump was placed during procedure. Stents were successfully deployed in all patients. There was no in-hospital mortality. Six-month angiographic follow-up was performed in 8 patients. Angiographic restenosis(diameter stenosis 50%) was not observed in all patients at follow-up study. During a mean follow-up of 31±25 months after hospital discharge, there was no major adverse cardiac event (death, myocardial infarction, and target lesion revascularization). Conclusion : Bail-out LMCA stenting is technically feasible, and showed good acute and long-term results in a small series of patients.

엉겅퀴(Cirsium japonicum var. ussuriense KITAMURA)의 조직배양에 의한 식물체의 재분화

강호종,박상현,박기관,김재환 진주산업대학교 1993 論文集 Vol.32 No.-

To examine proper part and medium in in-vitro culture shoot formation of in-vitro Crisium japonicum var. ussurinese KITAMURA, the test was carried out. The results are as follow: The wsa good in differentiation of the plant on the medium was good in MS+BA 10.0+Ki 10.0㎎/ℓ. In the results of formation and roots formation, proper medium was MS+Ki 0.1/ℓ. The case of MS+Ki 0.1㎎/ℓ was much no of shoots, ratio of roots, no of roots, also was good on growth.

Expression Profiles of Retinoblastoma Protein and p27Kip1 According to HER2 Amplification Status in Primary Breast Cancer

신재호,Sung-Jin Park,Hyun-Jin Cho,Geumhee Gwak,Byung-Noe Bae,Ki Whan Kim,Hong-Yong Kim2,Kyeongmee Park,Sehwan Han 한국유방암학회 2009 Journal of breast cancer Vol.12 No.1

Purpose: Human epidermal growth factor receptor-2 (HER-2)/neu amplification affects the cell proliferation through the modulation of multiple G1 cell cycle regulators in breast tumor cells. We performed this study to investigate whether retinoblastoma protein (pRB) and p27Kip1 were differently expressed according to the HER2 amplification status in human breast cancer. Methods: HER2 amplification was assayed by fluorescence in situ hybridization and the expression of cell cycle regulators were assayed by immunohistochemistry on 153 consecutive invasive breast cancers. The proliferative activity of breast cancer was analyzed according to the HER2 amplification and cell cycle protein expression status. Results: HER2 amplification was observed in 39 (25.5%) of 153 breast cancers. In the HER2 amplified breast cancers, the pRB expression was significantly increased (p=0.011) whereas there was no significant relationship between HER2 amplification and p27Kip1 expression. There was an inverse correlation between pRB expression and Ki-67 labeling index in the HER2 amplified breast cancers (p=0.036). In contrast, Ki67 labeling index was significantly decreased as p27Kip1 expression increased in HER2 non-amplified breast cancers (p=0.028). In HER2 non-amplified breast cancers, we could not observe any association between the pRB expression and Ki67 labeling index. Conclusion: The proliferation of the breast cancers was associated with pRB expression in HER2 amplified tumors whereas it was associated with p27Kip1 expression in HER2 non-amplified tumors. The results of the current study indicate that the cell proliferative activity of the breast cancer is under different growth signal pathways according to HER2 amplification status.

정보화사업 타당성분석제도의 개선방향 모색 : 공공분야 타당성분석제도들의 비교를 중심으로

김기환 한국정보사회진흥원 2005 정보화정책 Vol.12 No.1

2003년부터 우리나라 공공정보화사업에 대한 타당성분석이 사전평가의 일환으로 시범적으로 실시되기 시작하여 2005년부터 제도화단계를 거쳐 본격적으로 이루어질 전망이다. 대규모 공공사업의 추진여부를 판단하는 사전 검토작업으로서의 타당성분석은 사업의 효과적인 추진 및 정부재정의 효율적 운용이라는 측면에서 매우 중요하다. 정부사업에 대한 타당성분석 결과가 객관성과 신뢰성을 확보하고 정부예산과정에 적극적으로 반영되기 위해서는 타당성분석을 위한 방법론에 대한 심도 있는 연구가 필요하다. 이 글은 현재 우리나라 공공부문에서 시행중인 사전분석(또는 평가)제도들을 종합하여 비교해보고 이를 통해 올해부터 시행될 정보화부문 타당성분석제도의 효과적인 개선방안을 제시해보고자 한다. 현행의 대표적인 공공부문 타당성분석제도는 국가연구개발사업에 대한 사전조정제도, 지방투자사업에 대한 사전타당성조사제도, SOC사업에 대한 예비타당성조사제도 등이 있다. 이들은 분석의 대상이 되는 사업의 특성은 약간씩 다르지만 공공사업이라는 공통점을 갖고 있으며, 대상사업의 선정기준, 분석의 지표 및 측정항목, 분석의 방법, 결과의 활용방안 등 비교가능한 요소들을 적지 않게 포함하고 있다. 이들 요소들에 대한 체계적인 비교검토는 특정부문에 대한 타당성분석제도를 바람직한 방향으로 운영하기 위한 지침을 제시하는 데에 도움을 줄 것이라 기대한다.

하악과두 전위로 인한 두부방사선계측의 변화에 관한 연구

김상철,국윤아,유기환 대한치과교정학회 1991 대한치과교정학회지 Vol.21 No.3

To determine the difference in cephalometric measurements between centric relation and centric occlusion, 60 patient-20 patients for each malocclusion group-were examined with the cephalograms in centric relation and in centric occlusion. The results are as follows: 1.There are differences in cephalometric measurements with the mandible in the two different position, and some measurements are statistically significant. 2.No clinically useful prediction may be made from cephalometric radiographs concerning the amount of mandibular deflection from centric relation to centric occlusion. 3.If, the large differences in the cephalometric measurements with the mandible in the two different position, the analysis with the cephalogram in centric occlusion is needed to be compensated with the other clinical approach.

청소년에서 폭력에의 노출과 관련된 정신의학적 증상

김동기,이호분,민성길,송동호,육기환,전여숙 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.2

서울 시내 중학생 1345명을 대상으로 폭력에 노출되는 정도와 이와 연관된 정신의학적 증상을 알아보고자 하였다. 이를 위해 자기보고식 설문지를 사용하였는데. 설문지의 내용은 사회인구학적 자료와 집. 학교, 동네에서 폭력을 당하거나 목격했는지를 묻는 문항과 폭력에 의한 정신의학적 증상의 정도를 묻는 TSC(trauma symptom checklist)로 구성되었으며, 그 결과는 다음과 같다. 1) 전체 학생 중 45%가 폭력에 노출된 경험이 있었으며. 남자가 여자보다 많았다 (p<0.025). 집에서 구타 당한 경험은 여학생이 22.8%로 남학생보다 유의하게 높았다 (p<0.001). 학교. 동네에서 구타당한 경험은 남학생이 각각 22.1%. 10.1%로서 여학생보다 유의하게 높았다. 2) TSC를 요인 분석한 결과 불안-우울, PTSD, 해리, 분노 증상으로 나뉘었다. TSC는 폭력 경험 변인들과 상관 관계를 나타냈다. 다중 회귀분석을 실시한 결과 TSC와 연관된 폭력 노출 변인은 일생 동안의 폭력 노출(R²=0.18). 최근의 성폭력 경험(R²=7.12). 최근 집에서의 폭력 경험(R²=0.08), 최근 학교에서의 폭력 경험(R²=0.08), 최근 집에서의 폭력 목격(R²=0.07). 모든 종류의 폭력 노출(R²=0.29)로 나타났다. 3) TSC와 유의하게 연관된 사회인구학적 변인은 여성, 물질 남용의 가족력이 있는 경우, 술이나 담배 약물 남용을 하는 청소년인 것으로 나타났다. 따라서 청소년 폭력에의 희생자에 대한 정신의학적 개입에는 이러한 위험인자에 대한 고려가 필요하리라고 본다. In this research, we examined the frequency of exposure to violence in the home, school and neighborhood among middle school students as well as its related psychiatric symptoms. A total of 1,345 students from 5 middle schools in Seoul participated in this study : 670 were male,675 were female. We administered self-reported questionaires including discriptions of exposure to violence and a trauma symptom checklist(TSC)(Singer 1995). 1) The total frequency of exposure to any type of violence was 45% in our sample. The frequency of girls' being hit in home was 22.8%, which was significantly higher than it was for boys(p<0.001). The frequency of boys' exposure to violence in school and in the neighbor-hood was 22.1% and 10.1% respectively, which was higher than it was for girls(p <0.005). 2) In factor analysis of TSC, 4 factors were identified. TSC including depression-anxity, PTSD, dissociation and anger was correlated with violence exposure variables. Multiple regression analysis revealed that TSC is related with violence victimization in life(R2=0.18), sexual assault(R2= 0.12), recent victimization in the home(R2= 0.08), recent witness to violencein the home(R2=0.07), recent victimization in school(R2=0.08) and all violence exposures(R2=0.29). 3) Among the demographic variables, sex, parental alcohol problem and student alcohol-smoking-drug problems influenced the TSC(p <0.005). TSC could be result of witness to violence as well as violence victimization. And the risk factors for violence-related psychiatric symptoms were mainly seen in females, who have parents with alcohol problems or who themselves have alcohol-smoking-substance problems. So intervention programs for violence victims should be focused on the these high risk group.

구르기 學習에서 映像媒體를 利用한 KP 附與效果의 實驗的 硏究

김영환,김기연 仁荷大學校 스포츠科學硏究所 1995 論文集 Vol.7 No.-

The purpose of this study is to find out on the allowance effect of KP (Knowledge) by VTR in motor learning in first grade of middle school students. The sample students were 60 female selected randomly from "K" middle girl school in Inchoen City. The whole group was dwvied into 3 sub-groups. Two of them were used for experimental purpose, and the third one was the controlled group. The program implemented are as follows: Whole group was given 3 class. The controlled group progressed repear training, the experimental group-I was given KP by VTR of normal speed, and another group was given KP by VTR of slow speed. To estimate it, the effect of motor learning, the effect of transferance of motor learning, and the effect on retetion of motor learning were tested. COANOVA is used to know the difference among the 3 groups in 3 items. 1. In the effect on learning of correct foreward rolling, the experimental grup-Ⅱ was given KP by VTR of slow speed (17f/sec) showed the highest score. 2. In the effect on learning of correct back rolling, the experimental group-I was given KP by VTR of normal speed (24f/sec) showed the highest score. 3. In the effect on transferance of rolling learning, the experimental group-Ⅱ was given KP by VTR of slow speed (17/sec) showed the highest score. 4. No significant mean difference among three groups is found in the another items (the effect on ;earning of fast foreward rolling, and the effect on retention in case of all).

뇌혈관질환(CVD)환자에서의 Ca-Hopantenate(Hopate^(�))의 임상사용 경험

김기환 최신의학사 1988 最新醫學 Vol.31 No.1

瞬間熱處理에 依한 담배 組織構造 變化의 顯微鏡 觀察

金基煥,金厚澤 건국대학교 1982 論文集 Vol.14 No.1

The structure of tobacco leaf tissues was observed by light microscope. It was compared the surface morphology short term thermal (S. T. T.) treatment samples with control. It was observed change of the morphology or anatomy of midrib and lamina from each pact of tobacco leaf. These results obtained are summarized as follows; 1.Elastic enlargement power of midrib tissues by moistening and S. T. T. treatment was larger than lamina tissues of tobacco leaf. 2.Increase ratio of elastic enlargement by moisture absorption and S.T.T treatment was measured to be about 20 and 8.4 times for sponge tissues of lamina and parenchyma tissues of midrib but it was very low for the xylem of midrib and upper epidermis of lamina. 3.Increase ratio of filling power by S.T.T. treatment was obtained to be about 28% and 92% for shredded lamina and midrib, respectively.