햄릿 : Scourge and Minister

서길수 한국현대영어영문학회 2002 현대영어영문학 Vol.46 No.3

In any Shakespeare's play we can see the action which triggers the complications of the plot. In his early tragedies, Shakespeare dealt with vice which represented the inevitable evil force in the world. In particular, the problem of evil, as his greatest concern, is represented through various shapes in his plays. The problem of evil, associated with Machiavelli, is addressed in Hamlet. Not only is Claudius a traitor, he has also married Hamlet's mother, a marriage Hamlet regards as incestuous. Claudius is Shakespeare's imaginative projection of the new species of man, with a new order of conscienceless unconscionable greed and self-seeking. Hamlet thus focuses on the evil that results from a lust for power and lustful instincts in life. Hamlet's weakness may be that he 'thinks too much' and cannot make up his mind. His sensitivity and noble qualities lead to his downfall. Not until the final moments of the play does he finally kill Claudius. He can simultaneously accomplish his own deepest purpose. Even if Hamlet was written during Shakespeare's age, its characters are still valid during our time.

Naloxone의 Polyphosphazene 이식제제에 관한 연구

서성연,박주애,김길수 梨花女子大學校 藥學硏究所 1998 藥學硏究論文集 Vol.- No.7

For the effective administration of naloxone. we attempted to investigate the naloxone sustained-release implants. Using the biodegradable polymer, poly〔(diethyl glutamate)-co-(ethyl glycinate)phosphazenes〕(PGGP). the implantable devices containing naloxone hydrochloride(NLX·HCI) and naloxone base(NLX) were prepared. The release rates of NLX and NLX·HCI were compared. Influences of NLX contents on release rates were examined. For pharmacokinetic studies, NLX and NLX·HCI loaded devices were implanted subcutaneously in rabbits and then the plasma concentrations of NLX were determined by HPLC(ECD). NLX-containing devices were implanted with various doses and pharmacokinetic parameters according to dose were calculated. The relative bioavailabilities were evaluated and compared. Incorporation of NLX in the polymer leaded to a slow release. There were no differences of release rates based on drug contents. In pharmacokinetic parameters determined in 216 hours. NLX loaded devices resulted in enhanced bioavailbility with the higher AUC(p<0.01) than NLX·HCI loaded devices and MRT was significantly (p<0.05) increased. This result demonstrates that NLX is more suitable for sustained release devices than NLX·HCI. Therefore it is anticipated that the effective concentrations of naloxone could be maintained for longer periods and bioavailabilities could be improved by naloxone sustained-release implants. with varying drug base/hydrochloride.

5-Fluorouracil과 그 유도체를 함유하는 Solid Lipid Nanoparticles 제조와 평가

서혜선,최명신,한규원,박소민,김길수 이화여자대학교 약학연구소 2005 藥學硏究論文集 Vol.- No.16

Solid lipid nanoparticles(SLNs) are particulate systems for parenteral drug administration and have good biocompatibility and stability. SLNs were prepared with lauric acid, as the lipid core. Tween 20 and tween 80 were used as surfactant. 5-fluorouracil and 1-benzoyl-5-fluorouracil were used as model drugs. Drug-loaded SLNs were prepared by the hot homogenization technique in order to evaluate the physical stability, entrapment efficiency of drugs as well as release profile. The particle size of SLNs was 40~600 nm. By increasing speed, the mean particle size of SLfs was decreased. And entrapment efficiency in the case of using 1-Benzoyl-5-fluorouracil was higher than using 5-Fluorouracil. The higher surfactant concentration, the faster release rate at the range of 1.5~2.5%.

『비운의 쥬드』에 나타난 사회적 불평등

서길수 현대영미어문학회 2001 현대영미어문학 Vol.19 No.2

In Jude the Obscure Hardy, as in his earlier novels, deals with the social injustice This novel provides the reader with an insight into the social institution and the social convention. Jude is linked by Hardy to the grandest and the humblest aspects of human life. Jude sets his heart on leaving his obscure village for the university city of Christminster. He is on his way to Christminster, putting into effect his dream of being a scholar. But Jude, a mere labourer, is rejected as a student by the colleges. Hardy stresses that Jude's disillusionment is not a private burden but part of an inevitable process. As the sociological fiction, Jude the Obscure reveals social tradition in marriage. Jude's marriage to Arabella are ruined by his physical impulse. Sue's marriage to Phillotson are ruined by her intellectual emphasis. Jude and Sue live together against the social tradition of legal marriage. But Jude and Sue are alienated, because they live in an unconventional way against social convention. Jude's common-law marriage to Sue is his ideal drive. Jude and Sue become the spokesmen for countless inarticulate men and women. Hardy believes that a better world can be built on the foundation of the spontaneity of man. Jude the Obscure, Hardy's last novel, reveals his effort to cope with social tradition, social pressure and social stability.

『아테네의 타이먼』에 나타난 주변인물들의 역할

서길수 신영어영문학회 2000 신영어영문학 Vol.16 No.-

The basic point to grasp about the main characters in a play is that they embody the division between simple ideas and passions that disturb an ideal of a harmonious society. All the central characters are pulled in two ways: They are attracted by an idea of reasonable behaviour. However, they often find themselves acting disorderly and irrationally. Therefore there is constant tension between order and disorder in the play. In this pattern, the minor characters play an important dramatic function. They often serve to draw attention to the gap between an orderly world and an disorderly world, in the play. Timon, a rich and noble Athenian of gracious nature, having ruined himself by his prodigal liberality to friends and flatters, turns to his rich friends for assistance in his difficulties, and is denied it and deserted by all who had previously frequented him. But his servants and steward still love Timon. The faithful Flavius follows his master, as Kent followed Lear. Flavius is not a complex human being, but is an emblematic figure who embodies loyalty. He has a confident nature and is clearly aligned on the side of virtue. Apemantus warned Timon about his excessive indulgence just as Flavius warned him about his false friends. His insults and remarks offer a strong critique of both the gullible Timon and the false Athenians. The minor characters including Flavius are very important to this play, for they contrast with Timon’s false friends, and emphasize humanity which is one of this play’s main themes. Even though humanity has been destroyed, Shakespeare emphasizes humanity, the ultimate human quality, through the sympathetic minor characters in Timon of Athens.

매체 풍요도 이론의 가정에 대한 재검토 : 매체 풍요도는 매체에 내재된 속성인가 Is Media Richness an Inherent Property of Media

서길수 연세대학교 경영연구소 1997 연세경영연구 Vol.34 No.4

통신 매체와 과업의 성과에 관한 이론 중 대표적인 이론은 매체 풍요도 이론이다. 이 이론에 따르면 풍요도는 매체에 따라 달라지며, 과업에서 요구되는 풍요도와 매체의 풍요도가 일치할 때 과업의 성과가 극대화된다는 것이다. 이 이론의 높은 액면 설명력에도 불구하고, 많은 후속 실증 연구에서 매체 풍요도 이론은 지지받지 못하였다. 따라서, 이러한 결과를 설명하기 위하며 다양한 대안이 제시되었는데, 그 중 하나가 사회 정보처리 이론이다. 매체 풍요도 이론에서는 매체 풍요도를 매체에 내재되어 있는 변치 않는 속성이라고 보는 반면, 사회 정보처리 이론에서는 이를 사회적 환경에 따라 변하는 것으로 보고 있다. 본 연구는 이 두 이론의 상반된 주장을 검토하기 위하여, 주어진 과업에 따라 사용자가 매체의 풍요도를 달리 인식하는지를 살펴보는 실험실 실험을 실시하였다. 실험 결과에 따르면, 피험자는 과업에 따라 매체 풍요도의 수준을 달치 인식하였으나, 매체에 따른 풍요도의 상대적인 순서에 있어서는 차이를 보이지 않았다.

강원지역의 자원관리를 위한 지리정보시스템 개발

서백수,임길재,정영준,송화선,류창희,민경원,서희정 강원대학교 석재복합신소재제품연구센터 1997 석재연 논문집 Vol.2 No.-

강원도는 오랫동안 금속, 비금속, 석재 및 석탄과 같은 지하자원들을 공급하는 국내 주요생산지로 알려져 왔으나, 장기적인 채광과 비 계획적인 생산으로 인하여 매장량이 고갈되고 있으며, 대외적으로 생산 경쟁력 마저 잃어가고 있다. 이러한 문제점에 대한 해결방안의 일환으로 본 연구에서는 강원도내에 산재되어 있는 지하자원의 분포, 자원 생산시설 및 생산량, 경제성, 자원개발, 환경문제 등 자원관리에 필요한 제반사항을 수행할 수 있는 강원지역 자원 종합관리 GIS 시스템을 개발하였다. 이 시스템의 개발은 방대한 양의 정보 조사 및 저장, 오랜 개발기간, 많은 소요인력 및 개발 비용이 요구되기 때문에 본 연구에서는 조기에 자원관리 GIS 시스템을 개발하여 이와 관련된 생산 및 연구 분야에 조기에 적용할 수 있도록, 일차년도에는 현재 석재복합 신소재제품 연구센터의 집중적 연구대상 지역인 태백지역에 대한 탄광지역을 중심으로 자원 종합관리 GIS 시스템을 개발하였다. The Kangwon province has been well-known to be one of major underground resource producing districts which are mainly supplying metals, non-metals, stones, and coals. However, due to the long-term mining and unplanned production, the natural resource reserves have been rapidly drained and oversea production competition has been losing. In this study, we has developed a GIS system for regional resource management in the Kangwon province, which can operate, maintain, and manage the distribution of underground resources, resource production facilities, production and economic development, and environmental issues. The development of this system requires the collection, analysis, evaluation, and storage for a huge amount of research data, and in addition, the long period of time, the big research man power, and big development cost. Accordingly, to shorten the development period of time and to early apply itself to production, this stage of study has been intensively developed a regional resource GIS system for managing the mines scattered in the Tabak province, which is one of hottest RRC's research areas.

알코올 의존 환자에서의 혈청 성호르몬, 성선자극호르몬, 코티졸 및 프로락틴

서동수,박두병,이길홍 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.3

목 적 : 알코올 의존 환자들에서 흔히 보이는 성기능장애는 신경병적 요인과 사회심리학적 요인을 배제할 수는 없지만 내분비 기능의 이상에 의해 기인하는 것으로 알려져왔다. 이러한 내분비 이상을 밝히는 예비적 단계로써 알코올 의존 환자에서 성호르몬, 성선 자극 호르몬, 코티졸과 프로락틴을 살펴보고자 본 연구를 시행하였다. 방 법 : 알코올 의존을 가진 15명의 환자군에서 금단중과 금주후 21일 후에 시상하부-뇌하수체-성선축 호르몬(테스토스테론, 에스트라디올, 황체화 호르몬, 난포자극 호르몬)을 검사하였으며, 이축에 영향을 미칠 수 있는 코티졸 프로락틴도 포함시켰다. 그리고 12명의 건강 대조군에서 동일한 검사를 시행하여 그 결과를 환자군과 비교하였다. 결 과 : 금단중에 황체화 호르몬, 에스트라디올, 코디졸, 프로락틴은 의미있게 상승되었고 이들 호르몬 중 황체화 호르몬과 프로락틴은 금주후 3주뒤에도 여전히 상승되어있었다. 결 론 : 본 연구 결과 간경화가 없는 만성 알코올 의존 환자들은 정상범위에 테스토스테론 농도를 유지하는 것으로 보여진다. 이에비해 에스트로젠과 프로락틴 농도는 뚜렷하게 상승되는 것으로 보이며 이들 호르몬의 상승이 성기능장애를 포함한 만성 알코올 환자들의 여러 가지 임상증상들과 관련이 있는지에 대한 연구가 추후에 이루어져야될 것으로 생각된다. Objective : Sexual dysfunction has been frequently experienced by male alcoholics. The possible etiologies of the sexual problems in alcoholics has been known to be hormonal rather than neuropathic or psychosocial. The main purpose of our study was, therefore, to examine the different parameters of the hypothalamic-pituitary-gonadal axis(testosterone, estradiol, luteinizing hormone, follicle-stimulating hormone : HPG axis) in chronic alcoholic men. On the other hand, cortisol and prolactin were included because they could influence the HPG axis. Methods : Serum concentrations of testosterone, estradiol, luteinizing hormone, follicle-stimulating hormone, cortisol, and prolactin were measured in 15 male patients with alcohol dependence once during withdrawal and once after 21 days of abstinence. The results were compared with those of 12 healthy male volunteers. Results : During withdrawal, luteinizing hormone, estradiol, cortisol and prolactin levels were significantly enhanced. Estradiol and cortisol concentrations fell significantly during abstinence, whereas luteinizing hormone and prolactin concentrations remained elevated. Conclusions : These results suggest that normal serum concentrations of testosterone were maintained in alcoholic men without hepatic cirrhosis. In contrast to this. estrogen and prolactin concentrations seemed to be markedly enhanced. Whether this increase in estrogen and prolactin concentrations is implicated in difference clinical and psychological symptoms seen in chronic alcoholics remains to be investigated.

대변에서 동시에 분리된 vibrio parahaemolyticus와 Vibrio alginolyticus 1예

김지수,박수연,길영철,이희주,서진태 대한임상미샐물학회 2000 Annals of clinical microbiology Vol.3 No.2

이용자의 참여 동기가 가상공동체 의식 및 충성도에 미치는 영향

배상현,이문봉,서길수,이성철 연세대학교 경영연구소 2001 연세경영연구 Vol.38 No.2

이용자의 참여 동기는 가상공동체의 성공에 매우 중요한 요소이다. 가상공동체에의 참여 동기 중에서, 가상공동체 의식과 충성도에 영향을 주는 '인지적 유용성과 즐거움'이 이 연구에서 분석되었다. 가상공동체에 관심이 있는 사람들은 많지만, 아직까지 가상공동체에 관한 체계적이고 깊이 있는 연구는 진행된 바 없다. 따라서 이 연구에서는 기술수용모형으로부터 참여 동기 요인과 공동체 심리학으로부터 공동체의식 지수를 도입하여 수정하였다. 본 연구의 결과에 따르면, 과업지향 가상공동체에서조차 '인지된 즐거움'이 '유용성'보다도 가상공동체 의식에 더 큰 영향을 미쳤다. 따라서 가상공동체 기획자와 운영자들은 공동체의 성공을 위해 유용성 요인들 뿐만 아니라 재미 요소에 관심을 기울이고, 발전시키는 데 최선을 다해야 할 것이다.