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Gallic acid regulates body weight and glucose homeostasis through AMPK activation.
Doan, Khanh V,Ko, Chang Mann,Kinyua, Ann W,Yang, Dong Joo,Choi, Yun-Hee,Oh, In Young,Nguyen, Nguyen Minh,Ko, Ara,Choi, Jae Won,Jeong, Yangsik,Jung, Min Ho,Cho, Won Gil,Xu, Shanhua,Park, Kyu Sang,Park, The Endocrine Society 2015 Endocrinology Vol.156 No.1
<P>Gallic acid [3,4,5-trihydroxybenzoic acid (GA)], a natural phytochemical, is known to have a variety of cellular functions including beneficial effects on metabolic syndromes. However, the molecular mechanism by which GA exerts its beneficial effects is not known. Here we report that GA plays its role through the activation of AMP-activated protein kinase (AMPK) and by regulating mitochondrial function via the activation of peroxisome proliferator-activated receptor-γ coactivator1α (PGC1α). Sirtuin 1 (Sirt1) knockdown significantly blunted GA's effect on PGC1α activation and downstream genes, suggesting a critical role of the AMPK/Sirt1/PGC1α pathway in GA's action. Moreover, diet-induced obese mice treated with GA showed significantly improved glucose and insulin homeostasis. In addition, the administration of GA protected diet-induced body weight gain without a change in food intake. Biochemical analyses revealed a marked activation of AMPK in the liver, muscle, and interscapular brown adipose tissue of the GA-treated mice. Moreover, uncoupling protein 1 together with other genes related to energy expenditure was significantly elevated in the interscapular brown adipose tissue. Taken together, these results indicate that GA plays its beneficial metabolic roles by activating the AMPK/Sirt1/PGC1α pathway and by changing the interscapular brown adipose tissue genes related to thermogenesis. Our study points out that targeting the activation of the AMPK/Sirt1/PGC1α pathway by GA or its derivatives might be a potential therapeutic intervention for insulin resistance in metabolic diseases.</P>
The First Probable Case of Hereditary Angioedema in Vietnam
Khanh Bui Van,Doan Nguyen Van 대한천식알레르기학회 2012 Allergy, Asthma & Immunology Research Vol.4 No.3
Hereditary angioedema (HAE) is rare disorder due to C1-inhibitor deficiency (C1-INH) that are debilitating and may be life-threatening. HAE is a lack of consensus concerning diagnosis, therapy, and management, particularly in Vietnam. In this case report, we report a 40-year-old male patient with typical clinical symptoms and family history but he showed normal C4 level, and we could not measure C1q and C1-INH level. However, the diagnosis of HAE can be made based on typical clinical symptoms and the favorable prophylactic response to danazol treatment. Based on these findings,we suggest that he has type I HAE, although he showed normal C4 level.
Nguyen Doan Quoc Anh,Tran Hoang Quang Minh,Nguyen Huu,Khanh Nhan 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.5
Recently, high-power light-emitting diodes (LEDs) have attracted great attention on the study and made remarkable progress. In this paper, method for enhancing uniform white light of a multi-chip white light LED by adding silicon dioxides in the phosphor layer is presented. Firstly, theory of study by using Mie theory and Monte Carlo ray-tracing is proposed. And then simulation and experimental results by using package LightTools software are performed. The experimental results and theory have the same direction: 1) the angular color temperature in narrow angles is much higher than that in wider angles for the non-SiO2 case and 2) in significantly reducing CCT deviation of a multi-chip white light LED by adding silicon dioxides in the phosphor layer.
Tran, Khanh Long,Phung, Xuan Son,Kim, Bao Giang,Phan, Thi Hai,Doan, Thi Thu Huyen,Luong, Ngoc Khue,Pham, Thi Quynh Nga,Nguyen, Tuan Lam,Hoang, Van Minh,Le, Thi Thanh Huong Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.no.sup1
Evidence shows that tobacco advertising and promotion activities may increase tobacco consumption and usage, especially in youth. Despite the regulation on prohibiting advertisement of any tobacco product, tobacco advertisement and promotion activities are still common in Vietnam. This article presents current exposure to tobacco advertising and promotion (TAP) among school children aged 13 to 15 years in Vietnam in 2014 and potential influencing factors. Data from the Global Youth Tobacco Survey 2014 in Vietnam covering 3,430 school aged children were used. Both descriptive and analytical statistics were carried out with Stata 13 statistical software. Binary logistic regression was applied to explain the exposure to TAP among youth and examine relationships with individual factors. A significance level of p<0.05 and sampling weights were used in all of the computations. In the past 30 days, 48.6% of the students experienced exposure to at least 1 type of tobacco advertising or promotion. Wearing or otherwise using products related to tobacco was the most exposure TAP type reported by students (22.3%). The internet (22.1), points of sales (19.2) and social events (11.5) were three places that students aged 13-15 frequently were exposed to TAP. Binary logistic results showed that gender (female vs male) (OR = 0.61, 95%CI: 0.52 - 0.71), susceptibility to smoking (OR = 2.12, 95%CI: 1.53 - 2.92), closest friends' smoked (OR = 1.43, 95%CI: 1.2 - 1.7) and parents smoking status (OR = 2.83, 95%CI: 1.6 - 5.01) were significantly associated with TAP exposure among school-aged children. The research findings should contribute to effective implementation of measures for preventing and controlling tobacco use among students aged 13-15 in Viet Nam.
Nguyen Huu Khanh Nhan,Tran Hoang Quang Minh,Nguyen Doan Quoc Anh 보안공학연구지원센터 2016 International Journal of Database Theory and Appli Vol.9 No.4
In this paper, a novel solution and application of the red Y2O3:Eu3+ dopant phosphor for enhancing color rendering index to more 86 for multi-chip white LED lamps (MCW-LEDs), which have correlated color temperature (CCT) of 7700 K, 6600 K, 5600 K, are presented. Then the effect of the concentration of Y2O3:Eu3+ phosphor on the color rendering index (CRI) is simulated, analyzed and demonstrated. After that the lumen output of MCW-LEDs depended on concentration Y2O3:Eu3+ phosphor is discovered. The lumen output has a decrease tendency at large weight range due to the enhancement extinction coefficient, according to Mie-scattering theory. Simulation results provided important conclusions for selecting and developing the phosphor materials in MCW-LEDs manufacturing.
Ann W Kinyua,고창만,Khanh V Doan,양동주,My Khanh Q Huynh,모상현,최윤희,김기우 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
4-hydroxy-3-methoxycinnamic acid (ferulic acid, FA) is known to have numerous beneficial health effects, including anti-obesity and anti-hyperglycemic properties. However, the molecular networks that modulate the beneficial FA-induced metabolic effects have not been well elucidated. In this study, we explored the molecular mechanisms mediating the beneficial metabolic effects of FA. In mice, FA protected against high-fat diet-induced weight gain, reduced food intake and exhibited an overall improved metabolic phenotype. The food intake suppression by FA was accompanied by a specific reduction in hypothalamic orexigenic neuropeptides, including agouti-related protein and neuropeptide Y, with no significant changes in the anorexigenic peptides proopiomelanocortin and cocaine and amphetamine-regulated transcript. FA treatment also inhibited fat accumulation in the liver and white adipose tissue and suppressed the expression of gluconeogenic genes, including phosphoenolpyruvate carboxylase and glucose-6-phosphatase. Furthermore, we show that FA phosphorylated and inactivated the transcription factor FoxO1, which positively regulates the expression of gluconeogenic and orexigenic genes, providing evidence that FA might exert its beneficial metabolic effects through inhibition of FoxO1 function in the periphery and the hypothalamus.