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Synthesis and Properties of Ultra-fine (Ti, M1, M2)(CN)-Ni Cermets
Kang Young-Jae,Kang Shin-Hoo 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
TiC-and Ti(C,N)-based cermets are excellent in semi-and final finishing of work piece during cutting operations. Typical microstructure of the cermets is a core/rim structure. The undissolved Ti(C,N) cores contribute to their high hardness while the rim phases, (Ti,M1,M2)(C,N)-type solid solutions, play great roles in enhancing the toughness. In this paper, various ultrafine pre-mixed MeC-Ni powders were synthesized and the powders were sintered or hot pressed after mixing in order to control the size and volume fractions of core and rim phases in the system. This paper will present the factors determining the microstructure along with mechanical properties.
Hepatoprotective Effect of Aged Black Garlic Extract in Rodents
Shin, Jung Hyu,Lee, Chang Woo,Oh, Soo Jin,Yun, Jieun,Kang, Moo Rim,Han, Sang-Bae,Park, Heungsik,Jung, Jae Chul,Chung, Yoon Hoo,Kang, Jong Soon Korean Society of ToxicologyKorea Environmental Mu 2014 Toxicological Research Vol.30 No.1
In this study, we investigated the hepatoprotective effects of aged black garlic (ABG) in rodent models of liver injury. ABG inhibited carbon tetrachloride-induced elevation of aspartate transaminase (AST) and alanine transaminase (ALT), which are markers of hepatocellular damage, in SD rats. D-galactosamine-induced hepatocellular damage was also suppressed by ABG treatment. However, ABG does not affect the elevation of alkaline phosphatase (ALP), a marker of hepatobilliary damage, in rats treated with carbon tetrachloride or D-galactosamine. We also examined the effect of ABG on high-fat diet (HFD)-induced fatty liver and subsequent liver damage. ABG had no significant effect on body weight increase and plasma lipid profile in HFD-fed mice. However, HFD-induced increase in AST and ALT, but not ALP, was significantly suppressed by ABG treatment. These results demonstrate that ABG has hepatoprotective effects and suggest that ABG supplementation might be a good adjuvant therapy for the management of liver injury.
Rifampin 의존성 항체가 증명된 Rifampin에 의한 범발성 혈관내 응고증, 급성 간신부전 용혈성 빈혈 동시 발생 1예
신동호,김인순,박성수,강경원,박찬현,이동후,이숭환,안명주,이웅수,김연수,이영열,김태화,김덕언 대한내과학회 1997 대한내과학회지 Vol.53 No.3S
저자들은 6년전 RFP을 복용했던 과거력이 있는 환자에서 RFP 재투여시 환자가 임의로 불규칙하게 복용한 후 범발성 혈관내 응고증, 급성 간신부전, 용혈성 빈혈 등 심각한 다발성 장기 손상이 모두 나타나고, 특히 RFP 의존성 항체가 증명되었던 예를 치험하였기에 문헌고찰과 함께 보고하는 바이다. We descirbe the case of a patient who developed DIC, acute liver failure, hemolytic anemia, acute renal failure, and thrombocytopenia while receiving etambutol and isoniazid plus rifampin, and in whom readministation of rifampin for pulmonary tuberculosis after an interruption of 6 years resulted in these adverse reactions. Two hour after ingestion of the third dose he felt ill, suffered from severe back pain, nausea, vomiting, fever and chills. On admission a few hours later he was jaundiced and was almost anuric. Laboratory tests at presentation showed DIC, acute liver failure, hemolytic anemia, acute renal failure, and thrombocytopenia. Subsequently, rifampin was withdrawn and transfusion instituted, this resulting in a complete resolution of the DIC, acute liver failure, hemolytic anemia, and thrombocytopenia whereas hemodialysis was required for recovery of the renal failure. Rifampin-dependent antibodies were detected in the antiglobulin phase with broad spectrum anti-human globulin, mono-specific anti-gamma chain, and anti-complement antisera. Rifampin-dependent antibodies were demonstrated by drug-induced immune complex test. To our knowledge this represents the first report of simultaneous occurence of DIC, acute liver failure, hemolytic anemia, acute renal failure, and thrombocytopenia due to rifampin.
강신삼,이길홍,이근후,장동산 중앙대학교 의과대학 의과학연구소 1990 中央醫大誌 Vol.15 No.3
In this study, the author has attempted to set up guideline of prevention and early therapeutic intervention of psychiatrically illed female workers by analyzing the effect of psychosocial role conflicts originated from home and occupation on the mental disorders. Among psychiatric inpatients, the employed females were selected as study group, while the unemployed females and employed males were selected as control groups. The author had tried to extract sociopsychiatric variables of female employment. The sampling was performed through the three stage clustered random sampling method and questionnaires were finally applied to a total of 303 psychiatric inpatients including 124 men and 179 women at march, 1988. The major findings were as follows; 1. The employed female patients showed higher rates of working at professional, technical or administrative part, and more frequently having western religion and graduating college. 2. The employed female patients showed higher rates of divorce, and specifically the rates of divorce were higher in person of engage in upper class occupation such as professional or administrative manager. 3. It showed higher rates that the employed female patients showed the compulsive, passive-aggressive or dependent personality traits, and tended to dissatisfy in their sexual life. 4. The employed female patients showed higher life change scores and had many difficulties in their occupational adjustment, but they showed lower rates of doing serious maladaptive behaviors such as working off several jobs or loss of work than employed males patients. 5. The father of the employed female patients showed higher rates of working at non-professional part and having lower educational level. And the employed female patients were more perceived that the economical level of their family was relatively poor. 6. Among the familial psychological variables, the mother's rearing attitude was more closely related with female employment. Particularly, in employed female patients, adultcentered and punish oriented maternal care were prominent. 7. The employed female patients showed relatively lower rates of friction in spouse-parent relations or in spouse-children relations, and lower rates of children's dissatisfaction at home than unemployed female patients. In conclusion, the employed female patients had many psychiatric problems in their home environment, developmental process, and personality development. And they tended to suffer from various psychosocial stressor-s originated from role conflicts in their job and home environment after employment. Therefore, it is necessary that we must concrete the counter-plan for relieving from psychosocial stresses and have psychiatric consideration for unconscious motivation of employment, for promoting mental health of employed female workers.
만성 간염 , 간경변 및 간세포암 조직에서의 암유전자 발현 동태
신동호,박성수,강경원,이동후,유병무,이중달,노임환,권기운 대한소화기학회 1992 대한소화기학회지 Vol.24 No.3
Liver cell replication is known to invlove a sequential activation of proto-oneogenes including c-myc and e-Ha-ras. These positive regulations of proliferative signal are thought to be counter- balanced by growth-constraining tumor suppressor genes. During the genesis of liver cell carcinoma both the qualitative and the quantitative changes in growth promoting proto-oncogenes were elucidated in animal models. And also mutational inactivation bf suppressor genes such as p53 liberates the cell from the negative regulation, resulting in deregulated growth. Since there is strong corrleation between persistence of hepatitis B virus infection and the development of hepatocellular carcinoma, we attempted to investigate the dynamic changes of proto-oncogenes and tumor suppressor gene in HBV DNA positive lliver tissues among 8 chronic persistent hepatitis, 9 chronic active hepatitis, 12 liver cirrhosis, and 13 hepatocellular carcinomas, employing in situ hybridization and immunohistochemistry. Comparing to chronie hepatitis and liver cirrhosis, c-myc overexpression was heterogeneously distributed in hepatocellular carcinoma, Intensity of c-Ha-ras expressions was strong in hepatocellular carcinomas, liver cirrhosis, chranic active hepatitis, and chronic persistent hepatitis in orders. Whereas wild type of p53 was immunohistochemically detectable in all of the cases investigated, mutant gene deleted 9 amino acids adjacent to carboxyl terminal revealed in 37.5% of chronic persistent hepatitis, 33.3% of chronic active hepatitis or liver cirrhosis, and 46.2% of hepatocelluar carcinomas, respectively. In conclusion, these data support that enhanced expressian of positive growth promoting proto-oncogenes is related with regeneration of the liver and progression of tumor cell growth. And the various mutant genes of tumor suppressor might be emerged during the persistent replication of hepatocytes in HBV DNA positive chronic liver diseases, in cooperation with proto-oncogenes, eventually resulting in development of hepatocellular carcinoma. This means, in turn, that HBV-related chronic liver diseases retained a malignant potential.
홍장후,신현진,김운겸,강경묵 서울産業大學校 1999 논문집 Vol.49 No.2
PVA/Algin blend films were prepared by solution blending method for the purpose of useful biodegradable polymer. Characteristics properties of blend films such as DSC, Elongation, Tensile strength and Morphological changes by SEM were determined. Tensile strength and Elongation were rapidly reduced as increasing the blend ratio of Algin. Blend films were found that phase separation was occured as more than 25wt% increasing the blend ratio of Algin. Blend films were observed to be less partially compatibility than 10wt% increasing the blend ratio of Algin by DSC, mechanical properties and SEM Also, Blend films at the laboratory soil test(Pot Test) were completely degraded in months with four kinds of soils by microganisms.