치주염의 원인균 및 정상상주균간의 길항기전 규명 및 치주치료에의 응용

손성희,정종평,김각균,김강주 대한구강생물학회 1991 International Journal of Oral Biology Vol.15 No.1

It has been reported that microbial distribution and colonization in oral cavity have a relation to antagonism, synergism or symbiosis among microorganisms and bacterial antagonism have a relation to bacteriocin, hydrogen peroxide and bacterial metabolic end-products. The purpose of this study is to investigate on the in vivo and in vitro ecological interrelation and to detect the growth inhibition subatance and to clarify the antagonistic mechanism of the periodontopathic bacteria. In vivo ecological interrelation was studied by bacterial isolation & identification and in vitro ecological was studied by stab culture method. Bacteriocin-like substance was examined, purified, electrophoresed, and stained with silver stain. After the producer microorganism was cultured in various conditions, the pH & bacterial end-products of it was examined and the susceptibility of indicator bacteria by pH was measured. The presence of plasmid DNA was investigated by hot-boiling method. In in vivo ecologic interrelationship, Actinobacillus actinomycetemcomitans(Aa) was not isolated, black-pig-mented Bacteroides was less in the presence of Actinomyces species than in the absence of it in refractory periodontitis. In in vitro ecologic interlationship, S. mutans showed strong growth inhibitory activity against Porphyromonas gingivalis and Aa strains and more strong growth inhibitory activity against Aa Korean isolates than S. sanguis. After bacteriocin-like substance was examined, purified, electrophoresed, and stained with silver stain, a band was appeared whose molecular weight was 36 kd, pH and the production rate of lactic acid was varied according to the presence and absence of oxygen and glucose. These results suggested that there exists in vivo and in vitro growth inhibition among oral microorganisms and growth inhibition was affected by bacteriocin-like substance, pH and bacterial end-products of producer strains and sensitivity of indicator strains. Animal study is needed by using strains of growth inhibition and growth inhibitory substance.

性別 및 年齡에 따른 體格과 體力의 特性과 變化에 關한 縱斷的 硏究Ⅱ : Emphasised on College Men of Department of Physical Education 體育專功 大學生을 中心으로

金尙國,姜東洹,張周鎬,金昇一,徐再均,金耕知,孫斗玉,鮮于攝,崔榮烈,尹宇相,金亨燉,方永鎭,朴英震,柳在忠 慶熙大學校 體育科學大學 1989 體育科學論叢 Vol.- No.2

The purpose of this study was to compare the characteristics, change in physique and physical function of college students majoring physical education and Taekwondo (454 males and 64 females of age groups ranging from 18 to 26). The results are as following: 1. The male group of 23yrs old in physical education showed highest values in 7 items(Weight, Chest Girth, Fore Arm Girth, Thigh Girth, Calf Girth, Scapular Skinfold Thickness and Suprailiac Skinfold Thickness). 2. In the Physical function, the male group of 18yrs old showed highest values in Power, Flexibility, and then 21yrs old at Back Strength, Vital Capacity, and 23yrs old at Grip Strength, and 25yrs old at Blood Pressure, respectively. 3. In the physique, the male group of 22yrs old showed highest values in Weight, Chest Girth, Thigh Girth, Calf Girth, and then 24yrs old Upper Arm Girth, Fore Arm Girth, and 19yrs old at Height, Upper Limb Length, respectively. 4. In Physical Function, the 22yrs old showed highest values in Back Strength, Vital Capacity, and then 23yrs old at Side Step, Trunk Extension, but 18yrs old showed lower Values in Grip Strength, Side Step, Vital Capacity and Blood Pressure. 5. The female group of 22yrs old showed highest values in 8 items(Height, Sitting Height, Waist Girth, Upper Limb Length, Lower Limb Length, Skinfold Thickness), and then 18yrs old at 5 items (Weight, Upper Arm Girth, Fore Arm Girth, Thigh Girth, Calf Girth), respectively. 6. In the physical function, the 22yrs old showed highest Values in Grip strength, Back Strength, Power, 5 Minute Run, and 18yrs old at flexibility, Harvard Step Test, respectively. 7. In the change of the physique for two years(1988-1989) in the male group, majoring Physical education the 22yrs old showed increase in 4 items, and the 20yrs old in 3 items, but 18yrs old showed decrease in 3 items. 8. In the change of the physical function for two years in the male group, the 20yrs old showed increase in 4 items, and the 21, 25, 26yrs old in 3 items, but the 19yrs old showed decrease in 6 items, and 18, 22 yrs old in 5 items, respectively. 9. The change of the physique for two years in all female group, of 18, 19, 20, 21yrs old showed increase in 11 items except Skinfold Thickness. 10. In the change of physical function for two years in female group, the 18yrs old showed increase in 3 items, and then 20yrs old in 5 items, but 19, 22yrs old decreased 12 items, respectively. 11. The highest significant difference in physique between male and female was found in weight(mean Value 17.5%), and the lowest difference was found Thigh Girth, Calf Girth(1,3%), Upper Limb Length, Lower Limb Length(2.5%). 12. The Highest difference in physical function was Strength (mean Value 40%), Vital Capacity (33%), Power(22%), but Lower Trunk Flexion, Foot Balance(3.4%). 13. In the difference of Physique and physical function between physical education major and taekwondo major, the physical education showed higher values in skinfold Thickines (mean Value 16.5%), Weight, Waist Girth(4.7%) and Strength(33%), Endurance(5.6%), but subjects majoring Taekwondo showed higher values in Flexibility and Foot Balance. 14. In all male groups, Waist Girth, Scapular Skinfold Thickness, Back Strength, Sargent Jump, Trunk Extension and Diastolic Blood Pressure were showed a significantly related at 0.001 level.

한국인 연령에 따른 Actinobacillus actinomycetemcomitans의 발현빈도 및 항체 역가에 관한 연구

정종평,김강주,이상철,손성희 대한구강생물학회 1988 International Journal of Oral Biology Vol.12 No.2

In order to investigate on the frequency and antibody levels to Actinobacillus actinomycetemcomitans from Korean population, normal group were divided into 5 category by the related age : 3-6 years, 7-12 years, 13-20 years, 21-35 years and over 36 years, and also disease group were divided into the diagnostic condition : Localized juvenile periodontitis, post-localized juvenile periodontitis, rapidly progressive periodontitis, adult periodontitis. Each group was composed of 10 to 20 patients and plque sampling was also performed on the mesial pocket of mandibular lst molar with 3 paper points on anaerobic condition. Isolation and identification were done by using a selective medium(tryptic soy agar supplemented with 10% serum, 75ug of Bacitracin and 5ug of Vancomycin per ml) in 10% CO_2 incubator for 3 days with routine Gram staining, biochemical test and colony morphology. Serum antibody levels were also performed with isolated A. actinomycetemcomitans SNUDC 10-1 by using modified ELISA technique. The frequency of A. actinomycetemcomitans in normal healthy group was within 10% and no detection was revealed in 7 years group. Otherwise, the frequency of localized juvenile, rapidly progressive, adult perioduntitis and adult periodontitis associated with diabetes mellitus were 75%, 68%, 42%, and 25%, respectively. Serum IgG antibody levels to A.a SNUDC 10-1 in umbrical cord blood was similar to 3-6 years or 13-20 years group, and 3-6 months group were shown only trace amount of antibody levels. The antibody levels of 1 year and 7-12 years group were revealed 2/4-1/3 levels of 3-6 years group and this levels were gradually increased from 7-12 years group until over 36 years group. However, the antibody levels of localized juvenile, post-localized juvenile and rapidly progressive periodontitis were significantly higher than that of healthy group and no significant differences of the level were recognized between each disease group.

뇌기저동맥 첨단부 폐쇄증후군 후 지연성 올리브 비대에 동반된 눈떨림

김영진,정주리,강성원,한선정,이성익,손일홍,양현덕 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.2

눈입천장떨림(Oculopalatal tremor)은 치아핵, 적핵 및 올리브핵을 연결하는 신경로(dentatorubro-olivary pathway, Guillain-Mollaret triangle)의 손상 이후에 발생하는 비대성올리브핵 변성(hypertrophic inferior olivary degeneration)에 의한 지연성(delayed) 합병증이다. 다리 뇌출혈(pontine hemorrhage) 또는 뇌줄기경색(brainstem infarction)후 아래 올리브핵비대(inferior olivary hypertrophy)가 발생한 환자에서 입천장떨림(palatal tremor) 없이 눈떨림이 보고된 경우가 있으나, 뇌바닥동맥끝증후군(top of the basilar syndrome) 후 아래올리브핵비대가 발생한 환자에서 눈떨림이 보인 경우는 드물다. 뇌바닥동맥끝증후군 후에 아래올리브핵비대가 발생한 환자에서 지연성 수평 눈떨림 보고하고자 한다. 이것은 양측 소뇌다리의 손상 때문에 눈떨림의 수직 성분이 동반되지 않은 수평눈떨림을 보인 것으로 유추할 수 있다. Oculopalatal tremor(OPT) is a delayed complication of hypertrophic inferior olivary degeneration after the lesion in the dentato-rubro-olivary pathway, the Guillain-Mollaret triangle. Some cases of ocular tremor without palatal tremor associated with inferior olivary hypertrophy after pontine hemorrhage or brainstem infarction have been reported, but ocular tremor with inferior olivary hypertrophy after top of the basilar syndrome has rarely been described. We describe a patient showing delayed-onset horizontal ocular tremor with inferior olivary hypertrophy after top of the basilar syndrome. It can be postulated that the vertical component of ocular tremor could have not developed because of the lesions in bilateral cerebral peduncles.

Surgical Outcomes of Adrenocortical Carcinoma; 20 Years of Experience in a Single Institution

Min Jhi Kim,Eun Jeong Ban,Soo Jung Jung,Hai Young Son1,Cho Rok Lee,Sang-Wook Kang,Jong Ju Jeong,Kee-Hyun Nam,Woong Youn Chung,Cheong Soo Park 대한갑상선-내분비외과학회 2014 The Koreran journal of Endocrine Surgery Vol.14 No.4

Purpose: Adrenocortical carcinoma (ACC) is a rare malignant tumor. Early detection is difficult and prognosis is poor. We report on 20 years of ACC surgical experience at our institution. Methods: This study included 32 ACC patients who underwent surgical resection at the Department of Surgery of the Yonsei University Health System in South Korea between January 1990 and February 2012. We reviewed these 32 patients and retrospectively analyzed long-term clinical outcomes and prognosis after radical surgery for ACC. Results: The median age of the 32 patients at diagnosis was 42.25 years (range 3∼81 years). There were 16 (50%) female and 16 (50%) male patients. Mean tumor size was 12.36 cm (range 1.8∼20 cm). Twenty-five patients (78.12%) had nonfunctioning tumors while the other seven patients (21.87%) had functioning tumors. Seventeen patients (53.12%) were classified as stage II, two (6.25%) as stage III, and 13 (40.62%) as stage IV. Fourteen patients underwent radical surgical resection, while 14 patients received adjuvant chemotherapy, two received adjuvant radiotherapy, and two received adjuvant chemoradiation. Four patients were lost to follow-up. Among the remaining 28 patients, 15 patients survived. The 5- and 10-year overall survival was 60.6% and 37.8%, respectively (median survival=85±24.3 months). Seventeen patients (53%) experienced disease recurrence. Five- and 10-year recurrence-free survival was 41.5% and 29.7%, respectively (median survival=18±5.5 months). Conclusion: Early stage at diagnosis and surgical resection were the most important prognostic factors associated with prolonged survival. The role of additional therapy remains controversial and new agents should continually be evaluated for efficacy.

Retinoic acid regulates thioredoxin and peroxiredoxin-2 in ischemic-injured cerebral cortex

Ju-Bin Kang,Dong-Ju Park,Murad-Ali Shah,Hyeon-Kyeong Son,Sang-Hyun Park,Phil-Ok Koh 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.1

Molecular design of large-bandgap host materials and their application to blue phosphorescent organic light-emitting diodes

Kang, Ju Sik,Hong, Tae Ryang,Kim, Hyung Jong,Son, Young Hoon,Bin, Jong-Kwan,Lee, Bang Sook,Yang, Joong Hwan,Kim, JinWuk,Cho, Min Ju,Kwon, Jang Hyuk,Choi, Dong Hoon Elsevier 2015 ORGANIC ELECTRONICS Vol.26 No.-

<P><B>Abstract</B></P> <P>New large-bandgap host materials with carbazole and carboline moieties were designed and synthesized for high-performance blue phosphorescent organic light-emitting diodes (PhOLEDs). The two kinds of host materials, 9-(4-(9<I>H</I>-carbazol-9-yl)phenyl)-6-(9<I>H</I>-carbazol-9-yl)-9<I>H</I>-pyrido[2,3-<I>b</I>]indole (<B>pP2CZCB</B>) and 9-(3-(9<I>H</I>-carbazol-9-yl)phenyl)-6-(9<I>H</I>-carbazol-9-yl)-9<I>H</I>-pyrido[2,3-<I>b</I>]indole (<B>mP2CZCB</B>), displayed promisingly high triplet energies of ∼2.92–2.93eV for enhancing the exothermic energy transfer to bis[2-(4,6-difluorophenyl)pyridinato-C<SUP>2</SUP>,<I>N</I>](picolinato)iridium(III) (FIrpic) in PhOLED devices. It was found that the blue PhOLEDs bearing the new host materials and the FIrpic dopant exhibited markedly higher external quantum efficiencies (EQEs) than a device made with 1,3-bis(<I>N</I>-carbazolyl)benzene (mCP) as the host. In particular, the PhOLED device made with 3wt% FIrpic as the dopant and <B>mP2CZCB</B> as the host material displayed a low driving voltage of 4.13V and the high EQE of 25.3% at 1000cdm<SUP>−2</SUP>.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Two new host materials showed high triplet energies over 2.92eV for blue PhOLED. </LI> <LI> Both host materials exhibited bipolar property. </LI> <LI> EQE of mP2CZCB-based PhOLED is measured to be 25.3% at 1000cd/m<SUP>2</SUP>. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Exercise-Induced Vasospastic Angina With Prominent Regional Wall Motion Abnormality

Byeng-Ju Son,Jong-Il Park,Jong-Ho Nam,Chan-Hee Lee,Jang-Won Son,Ung Kim,Jong-Seon Park,Kang-Un Choi 아시아심장혈관영상의학회 2024 Cardiovascular Imaging Asia Vol.8 No.1

In vasospastic angina, exercise typically does not lead to vasoconstriction. We present the case of a patient with an atypical presentation of vasospastic angina, characterized by regional wall motion abnormalities confirmed by exercise stress echocardiography. A 58-year-old female patient presented to the hospital reporting chest pain during both exercise. During the exercise stress echocardiogram, regional wall motion abnormality was confirmed. However, the coronary angiography did not reveal significant lesions. Subsequently, ergonovine test was positive and then exercise induced vasospastic angina was diagnosed. Following medical treatment, the patient’s symptoms showed improvement. This case underscores an uncommon presentation of vasospastic angina in an individual already diagnosed with coronary artery disease, indicating that exercise stress echocardiography could serve as a valuable screening tool for specific types of vasospastic angina.

인지기능 정보 연계를 통한 치매 환자 대상 노인장기요양급여 확대 정책 효과

손강주 ( Kang Ju Son ),이지은 ( Jee Eun Lee ),윤여주 ( Yeoju Yun ),신동교 ( Donggyo Shin ),이준홍 ( Jun Hong Lee ) 한국보건경제정책학회 2021 보건경제와 정책연구 Vol.27 No.4

우리나라는 경증 치매 환자도 장기요양등급을 부여하기 위해 2014년 7월 치매특별등급, 2018년 1월 인지지원등급을 신설하였다. 정책 확대에 따라 경증 치매 환자에서 등급인정률이 높아지는지 계량적으로 확인할 필요가 있다. 이를 위해 국민건강보험 일산병원 인지기능 검사 자료와 공단 청구 및 장기요양 자료를 연계하여 인지기능을 반영한 장기요양 등급인정 데이터를 구축하였다. 그 결과 시간이 흐름에 따라 치매 환자 등급인정률은 높아지는 추세였다. 인지기능 수준이 저하될수록 장기요양 인정점수는 높아지는 편이었지만, 정책 확대에 따른 인정점수는 변함이 없었다. 인지기능 수준과 등급인정 사이에 관련성은 찾기 어려웠다. 그렇지만 정책이 확대될수록 치매 환자에서 등급인정 가능성은 커졌다. 이는 우리나라가 경증 치매 환자 등급인정을 위해 장기요양인정점수 산정방식에 변화를 주기보다 치매 환자일 때 등급인정을 부여하는 정책 방향과 부합하는 결과임을 시사한다. 본 연구는 현재 장기요양 급여 확대 정책이 경증 치매 환자 장기요양 등급인정에 긍정적인 효과를 발휘하고 있음에 대한 근거로 활용 할 수 있다. Republic of Korea(ROK) has implemented dementia limited long-term care(LTC) rate that Rating-V at July 2014, Cognitive assistant Rating at January 2018. It needs to be Quantitatively confirmed that the approval rate of dementia to increase after policy extension. This study combined National Health Insurance Service Ilsan Hospital cognitive function test and National Health Insurance data and Long-term Care Insurance data. the approval rate of dementia has been increasing between 2011~2018. The approval points(AP) for LTC tended to increase as the cognitive function level deceases, but there was no significant change in the AP according to the policy expansion. although there was not quite the correlation between cognitive function level and LTC approval, it was confirmed that the possibility of LTC approval increased as the policy extended. ROK has directed LTC approval to mild dementia rather than changing the LTC AP calculation method. the result of above is consistent with the policy direction. This study can be used as evidence that the current LTC policy is a positive effect on LTC approval for mild dementia.

고령의 고관절 골절 환자의 노인장기요양 서비스 현황 분석

손강주(Kang Ju Son),박상훈(Sang Hoon Park),최희민(Hee Min Choi),윤한국(Han Kook Yoon) 대한정형외과학회 2023 대한정형외과학회지 Vol.58 No.5