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Polymorphisms of the Reg1α Gene and Early Onset Type 2 Diabetes in the Korean Population
구보경,조영민,Kuchan Kimm,이종영,오범석,박병래,정현섭,신형두,고경수,박상규,이홍규,박경수 대한당뇨병학회 2010 Diabetes and Metabolism Journal Vol.34 No.4
Background: The Reg gene has been reported to be expressed in regenerating islets and Reg1 protein to be up-regulated at an early stage of diabetes in mice. As human Reg1α is homologous with murine Reg1, we investigated whether common variants in Reg1α are associated with type 2 diabetes in the Korean population. Methods: We sequenced the Reg1α gene to identify common polymorphisms using 24 Korean DNA samples. Of 11 polymorphisms found, five common ones (g.-385T>C [rs10165462], g.-36T>G [rs25689789], g.209G>T [rs2070707], g.1385C>G [novel],and g.2199G>A [novel]) were genotyped in 752 type 2 diabetic patients and 642 non-diabetic subjects. Results: No polymorphism was associated with the risk of type 2 diabetes. However, g.-385C and g.2199A lowered the risk of early-onset type 2 diabetes, defined as a diagnosis in subjects whose age at diagnosis was 25 years or more but less than 40 years (odds ratio [OR], 0.721 [0.535 to 0.971] and 0.731 [0.546 to 0.977] for g.-385C and g.2199A, respectively) and g.1385G increased the risk of early-onset diabetes (OR, 1.398 [1.055 to 1.854]). Although adjusting for errors in multiple hypotheses-testing showed no statistically significant association between the three individual polymorphisms and early-onset diabetes, the haplotype H1, composed of g.-385C, g.1385C, and g.2199A, was associated with a reduced risk of early-onset diabetes (OR, 0.590 [0.396 to 0.877], P = 0.009). Conclusion: Polymorphisms in the Reg1α were not found to be associated with overall susceptibility to type 2 diabetes, though some showed modest associations with early-onset type 2 diabetes in the Korean population.
Polymorphisms of the <i>Reg</i> 1α Gene and Early Onset Type 2 Diabetes in the Korean Population
Koo, Bo Kyung,Cho, Young Min,Kimm, Kuchan,Lee, Jong-Young,Oh, Bermseok,Park, Byung Lae,Cheong, Hyun Sub,Shin, Hyoung Doo,Ko, Kyung Soo,Park, Sang Gyu,Lee, Hong Kyu,Park, Kyong Soo Korean Diabetes Association 2010 Korean diabetes journal Vol.34 No.4
<P><B>Background</B></P><P>The <I>Reg</I> gene has been reported to be expressed in regenerating islets and Reg1 protein to be up-regulated at an early stage of diabetes in mice. As human <I>Reg</I>1α is homologous with murine <I>Reg</I>1, we investigated whether common variants in <I>Reg</I>1α are associated with type 2 diabetes in the Korean population.</P><P><B>Methods</B></P><P>We sequenced the <I>Reg</I>1α gene to identify common polymorphisms using 24 Korean DNA samples. Of 11 polymorphisms found, five common ones (g.-385T>C [rs10165462], g.-36T>G [rs25689789], g.209G>T [rs2070707], g.1385C>G [novel], and g.2199G>A [novel]) were genotyped in 752 type 2 diabetic patients and 642 non-diabetic subjects.</P><P><B>Results</B></P><P>No polymorphism was associated with the risk of type 2 diabetes. However, g.-385C and g.2199A lowered the risk of early-onset type 2 diabetes, defined as a diagnosis in subjects whose age at diagnosis was 25 years or more but less than 40 years (odds ratio [OR], 0.721 [0.535 to 0.971] and 0.731 [0.546 to 0.977] for g.-385C and g.2199A, respectively) and g.1385G increased the risk of early-onset diabetes (OR, 1.398 [1.055 to 1.854]). Although adjusting for errors in multiple hypotheses-testing showed no statistically significant association between the three individual polymorphisms and early-onset diabetes, the haplotype <I>H1</I>, composed of g.-385C, g.1385C, and g.2199A, was associated with a reduced risk of early-onset diabetes (OR, 0.590 [0.396 to 0.877], <I>P</I> = 0.009).</P><P><B>Conclusion</B></P><P>Polymorphisms in the <I>Reg</I>1α were not found to be associated with overall susceptibility to type 2 diabetes, though some showed modest associations with early-onset type 2 diabetes in the Korean population.</P>
Association of Interleukin-18 Gene Polymorphisms with Hepatitis B Virus Clearance
Cheong, Jae Youn,Cho, Sung Won,Oh, Bermseok,Kimm, Kuchan,Lee, Kee Myung,Shin, Sung Jae,Lee, Jung A.,Park, Byung Lae,Cheong, Hyun Sub,Shin, Hyoung Doo,Cho, Bo Young,Kim, Jin Hong Springer-Verlag 2010 Digestive diseases and sciences Vol.55 No.4
Identification of a Novel PGE₂ Regulatyed Gene in SNU1 Gastric Cancer Cell
Nam,Myeong-Jin,Park,Min-Seon,Kim,Hong-Tae,Kimm,Kuchan,Min,Byung-Re The Korea Science and Technology Center 2000 BMB Reports Vol.33 No.2
Prostaglandin E₂(PGE₂) plays an important role in the regulation of various gastric functions, and the growth-inhibitory activities on tumor cells are studied in vitro and in vivo. Although the mechanisms have attracted many researchers in the past decade, the molecular mechanisms of cell cycle arrest, or induction of apoptosis by PGE₂, is unclear. We investigated the effects of PGE₂on the growth of the human gastric carcinoma cell line SNU1 and genes that are regulated by PGE₂and isolated them using differential display RT-PCR (DD RT-PCR). FACS analysis suggested that SNU1 cells were arrested at the G1 phase by PGE₂treatment. This growth inhibitory effect was in a time-and dose-dependent manner. Treatment of SNU1 cells with 10 ㎍/ml PGE₂, followed by DD RT-PCR analysis, revealed differently expressed bands patterns from the control. Among the differently expressed clones, we found an unidentified cDNA clone (HGP-27) overexpressed in PGE₂-treated cells. The full-length cDNA of HGP-27 was isolated using RACE, which consisted of a 30-nt 5’-noncoding region, a 891-nt ORF encoding the 296 amino acid protein, and a 738-nt 3’-noncoding region including a poly(a) signal. This gene was localized on the short arm of chromosome number 11. Using the MotifFinder program, a myb-DNA binding repeat signature was detected on the ORF region. The COOH-terminal half was shown to have similarity with the NH₃-terminal domain of thioredoxin (Trx). This relation between HGP-27 and Trx implied a potential role for HGP-27 in modulating the DNA binding function of a transcription factor, myb.
Koh, Jung-Min,Oh, Bermseok,Lee, Jong-Young,Lee, Jong-Keuk,Kimm, Kuchan,Park, Byung Lae,Shin, Hyoung Doo,Lee, Il-Kwon,Kim, Hyeoung-Joon,Hong, Jung-Min,Kim, Tae-Ho,Kim, Ghi Su,Kim, Shin-Yoon,Park, Eui K Wiley (John WileySons) 2007 Journal of bone and mineral research Vol.22 No.11
<P>The genetic effects of FLT3 polymorphisms on BMD and fracture risk in postmenopausal women were studied. We found that FLT3+13348C>T polymorphism and haplotype 2 were significantly associated with low BMD and high risk of fracture. Introduction: FMS-related tyrosine kinase 3 (FLT3) has been shown to play a critical role in the development of myelolymphoid progenitors and in the development of osteoclasts, but any possible genetic effect of FLT3 on bone metabolism has not been studied. Materials and Methods: To study a possible genetic effect of FLT3, we directly sequenced the FLT3 gene in 24 Korean individuals and identified 23 sequence variants. Seven polymorphisms were selected and genotyped in Korean postmenopausal women (n = 946). Results: We found that FLT3+13348C>T was associated with low BMD at the lumbar spine (p = 0.04) and femoral neck (p = 0.04). Haplotype analysis revealed that FLT3-ht2 (TTCTT) containing the rare allele in the +13348 position also showed significant association with low BMD in the lumbar spine (p = 0.04) and femoral neck (p = 0.05). Consistent with these results, the FLT3+13348C>T polymorphism and FLT3-ht2 were also significantly associated with high risk of fracture in the vertebrae (OR = 1.44-1.58; p = 0.03-0.04 and OR = 1.45-1.59; p = 0.02-0.03, respectively) and in any sites (OR = 1.34-1.81; p = 0.02-0.03 and OR = 1.34-1.81; p = 0.02-0.03, respectively). Conclusions: These results suggest that FLT3 polymorphisms play a role in determination of BMD and subsequent fractures in postmenopausal women.</P>
KIM, JINYOUNG,CHOI, CHANGHO,SHIN, KYUNGRIM,YI, HYERYEON,PARK, MINGYU,CHO, NAMHAN,KIMM, KUCHAN,SHIN, CHOL Blackwell Science Pty 2005 Psychiatry and clinical neurosciences Vol.59 No.3
<P>Abstract </P><P>The present study was purposed to identify the prevalence of restless legs syndrome (RLS) and its associated factors in the Korean adult population. Among a total of 9939 participants derived from the Korean Health and Genome Study, 12.1% of subjects (men, 8.5%; women, 15.4%) suffered from RLS. Factors independently related with RLS were older age and frequent fatigue in both men and women.</P>
Comparative Statistic Module (CSM) for Significant Gene Selection
Kim, Young-Jin,Kim, Hyo-Mi,Kim, Sang-Bae,Park, Chan,Kimm, Kuchan,Koh, InSong Korea Genome Organization 2004 Genomics & informatics Vol.2 No.4
Comparative Statistic Module(CSM) provides more reliable list of significant genes to genomics researchers by offering the commonly selected genes and a method of choice by calculating the rank of each statistical test based on the average ranking of common genes across the five statistical methods, i.e. t-test, Kruskal-Wallis (Wilcoxon signed rank) test, SAM, two sample multiple test, and Empirical Bayesian test. This statistical analysis module is implemented in Perl, and R languages.
Prevalence of insomnia and its relationship to menopausal status in middle-aged Korean women
SHIN, CHOL,LEE, SANGYEOL,LEE, TAEWOOK,SHIN, KYUNGRIM,YI, HYERYEON,KIMM, KUCHAN,CHO, NAMHAN Blackwell Science Pty 2005 Psychiatry and clinical neurosciences Vol.59 No.4
<P>Abstract </P><P>Although the prevalence of insomnia and the association of insomnia with menopause have been well reported, not much work has been conducted in population-based research on insomnia and menopause in Korea. The purpose of the present report was to determine overall and different prevalence of insomnia by menopausal status, and the relationship between insomnia and menopause in a population-based sample of middle-aged Korean women. A total of 96.1% of 2497 randomly selected middle-aged Korean women participated. Insomnia was defined as occurring three times a week or more in the previous month. Subjects were categorized into three groups: premenopaues, perimenopause, and postmenopause. The overall prevalence of insomnia in middle-aged Korean women was 14.3%. The most common symptom of insomnia was difficulty maintaining sleep (9.7%), followed by difficulty initiating sleep (7.9%), and early morning awakening (7.5%). Multiple logistic regression analysis revealed that menopause was independently associated with insomnia after adjusting for confounding factors such as age, income, and depression. Perimenopause was significantly associated with a dramatic increase in the risk of insomnia, but there was no significant association for postmenopause. The major finding is that insomnia is significantly associated with the menopausal transition. The prevalence of insomnia increases significantly by the transition from premenopause to perimenopause, but not to postmenopause. A further prospective study is needed to investigate the influence of menopause on insomnia.</P>
한국인 유전체 역학 정보의 효율적 관리를 위한 정보 관리 시스템
양은주(Eun Joo Yang),안윤진(Younjhin Ahn),이지은(Ji Eun Lee),김규찬(Kuchan Kimm) 한국정보과학회 2003 한국정보과학회 학술발표논문집 Vol.30 No.1A
본 논문에서는 경기도 안성과 안산 지역에 설치된 유전체역학센터에서 조사 지역에 거주하는 45세 이상 69세 이차의 성인을 대상으로 고혈압, 당뇨, 골다공증, 천식, 비만 등 총국민의료비용에서 큰 부분을 차지하는 4-5개의 중요 만성질환을 주요 분석 분야로 진행중에 있는 한국인 유전체 역학조사사업으로부터 산출되는 임상검사 및 역학정보를 입력 · 관리하는 시스템에 대해 소개하고 있다. 검진 대상자를 접수하는 접수자 및 정보 관리자는 본 시스템을 통해 검진대상자의 개인식별 정보, 생활습관 정보 등과 같은 설문 정보와 임상 검사 정보를 입력 후 이에 대한 조회, 관리, 집계현황 출력, 데이터 백업 등을 수행할 수 있다.