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성인 천식 환자에서 체질량지수와 기도과민성 및 폐기능의 연관성
최정은 ( Jung Eun Choi ),신태림 ( Tae Rim Shin ),박상면 ( Sang Myeon Park ),김주희 ( Joo Hee Kim ),신성호 ( Sung Ho Shin ),이현영 ( Hyun Young Lee ),장주아 ( Juah Jang ),이훈구 ( Hun Gu Lee ),김철홍 ( Cheol Hong Kim ),현인규 ( In 대한천식알레르기학회 2014 Allergy Asthma & Respiratory Disease Vol.2 No.1
Purpose: Obesity is commonly regarded as a risk factor for asthma development, poor asthma control, and poor response to asthma therapy. However, its relationships are not always consistent. Gender difference has been reported to influence asthma severity and asthma control. We investigated the contribution of obesity to airway hyperresponsiveness (AHR) and lung function before and after treatment in adult asthmatics. Methods: The medical records of a total of 323 adult asthmatics were analyzed retrospectively. Asthma was diagnosed based on the positive result of methacholine bronchial provocation test (PC20≤25 mg/mL) or bronchodilator test (≥12% and 200-mL improvement in forced expiratory volume in 1 second after inhalation of a bronchodilator). Follow-up spirometry was performed in 113 patients after at least 3 months of asthma treatment with controller medication. Percent change between spirometry before and after treatment was defined as {[(value after treatment.value before treatment)/value before treatment]×100}. Body mass index (BMI, weight [kg]/height [m2]) was categorized into underweight (<18.5), normal weight (18.5.24.9), overweight (25.0.29.9), and obese (>30) according to the world health organization classification. Results: BMI did not show any significant correlation with PC20 value of methacholine provocation test and each lung function parameter before and after treatment. When we divided the study subjects according to gender and age, BMI was negatively correlated with PC20 value only in female adult asthmatics under 65 years old (r=.0.024, P=0.036). Conclusion: Obesity is positively correlated with the intensity of AHR in female adult asthmatics. Gender seems to differentially contribute to the relationship between BMI and AHR. (Allergy Asthma Respir Dis 2014;2:16-22)
불멸화된 일차 간세포를 이용한 C형 간염바이러스의 in vitro 배양
최정은 ( Jung Eun Choi ),허원희 ( Won Hee Hur ),신주엽 ( Ju Yeop Shin ),박련숙 ( Lian Shu Piao ),윤승규 ( Seung Kew Yoon ) 대한소화기학회 2008 대한소화기학회지 Vol.52 No.3
Background/Aims: It is essential to develop an in vitro culture model of primary hepatocytes for the study of hepatocellular function and the pathogenesis of hepatitis C virus (HCV) infection. In this study, we have established the immortalized primary human hepatocyte (IPHH) and performed in vitro culture of HCV derived from human patient. Methods: Primary human hepatocytes were isolated from surgically resected liver tissue and then were immortalized by transfection with the SV40 large T antigen. The characterization of the IPHH during culture was analyzed by immunocytochemistry, RT-PCR, Western blot, ELISA, and soft agar assay. Next, sera and/or liver tissue homogenates from surgically resected liver tissues of patients with HCV infection were inoculated for the culture of HCV in IPHH. After HCV RNA extraction from IPHH and culture media, positive or negative stranded HCV RNA was examined by specific nest RT-PCR. Results: IPHH expressed liver-associated proteins but did not express alpha-fetoprotein. Also IPHH showed ammonia removal activity. With regard to its malignant potential, colony formation in soft agar assay was not observed. Next, positive and negative stranded HCV RNAs in IPHH infected with patient`s sera plus liver tissue homogenates were clearly detected whereas those in IPHH infected with only patient`s sera were not detected. Conclusions: These results demonstrated the phenotypic characteristics of IPHH and the feasibility in vitro culture system of HCV infected human samples. This system might be useful for study of pathogenesis of HCV infection or hepatocyte-based applications. (Korean J Gastroenterol 2008;52:150-160)
부 · 모의 양육행동과 유아의 외현화 문제행동의 관계에서 정서조절능력의 매개효과
최정은(Jung Eun Choi),이소연(SoYean Lee) 한국아동학회 2017 아동학회지 Vol.38 No.1
Objective: The purpose of this study was to investigate the mediating effects of emotional regulation abilities on the relationship between parenting behavior and preschoolers’ externalizing behavior problems. Methods: A survey was conducted with the parents of 166 preschoolers; the children were attending seven different daycare centers in Seoul. Results: The results were as follows: First, emotional regulation abilities fully mediated the relationship between fathers’ rejection-restriction parenting behavior and externalizing behavior problems. Second, emotional regulation abilities fully mediated the relationship between mothers’ warmth-acceptance, rejection-restriction, and permissive-neglectful parenting behavior and externalizing behavior problems. Third, after controlling for fathers’ parenting behavior, emotional regulation abilities fully mediated the relationship between mothers’ parenting behavior and externalizing behavior problems. Conclusion: Both parenting behavior and emotional regulation abilities should be considered when attempting to understand the development of preschoolers’ externalizing behavior problems. In particular, the results from this study stress the important role of emotional regulation abilities in decreasing externalizing behavior problems and buffering against the influence of negative parenting behavior.
서울형혁신교육지구 사업의 협력적 거버넌스 분석 - 도봉구, 마포구, 은평구 사례를 중심으로 -
최정은 ( Choi Jung Eun ),김혜원 ( Kim Hye Won ) 한국자치행정학회 2019 한국자치행정학보 Vol.33 No.4
서울형혁신교육지구는 학교와 지역사회가 연계하여 ‘아이들의 올바른 성장’을 추구하는 자치교육공동체를 구축하기 위한 사업이다. 서울형혁신교육지구 사업의 핵심은 민(지역사회, 학부모, 학생)과 관(서울시, 자치구, 교육지원청), 학(학교, 교사)의 협력적 거버넌스를 통한 참여와 협력이다. 본 연구에서는 Ansell & Gash(2007)의 협력적 거버넌스 모형을 이론적 분석틀로 활용하여 도봉구와 마포구, 은평구에서 민관학 세 주체 간에 나타나는 협력 과정을 분석하였다. 사례분석 결과, 기초자치단체의 초기 조건, 촉진적 리더십, 제도 설계, 협력 과정에 따라 거버넌스 구조가 다르게 형성되며, 이는 각 자치구별 협력의 차이에 영향을 미치는 것으로 나타났다. 본 연구는 민관학 거버넌스에서 각 주체의 실질적인 협력을 제고하기 위해 필요한 정책적 시사점을 제시하였다. The Innovative Education District in Seoul is a project to build a self-governing educational community in which schools and communities connect with each other in pursuit of 'the right growth of children.' The core of the Seoul Innovation Education District project is participation and cooperation through collaborative governance of citizens (local communities, students and their parents), government (Seoul Metropolitan City, autonomous district, and Seoul District office of Education), and schools (schools, teachers). This research used the collaborative governance model of Ansell & Gash (2007) as a theoretical framework to analyze the cooperative process between the three actors in Dobong-gu, Mapo-gu and Eunpyeong-gu. According to the result of case study, the governance structure is formed differently depending on the initial conditions of each autonomous district, the leadership, the institutional design, and the cooperative process. This study suggests the policy implications to enhance the practical cooperation of each policy actors in public-private governance.
사상자탕과 가미사상자탕의 항염증 및 항산화 효과 비교 연구
최정은 ( Jung Eun Choi ),박보경 ( Bo Kyung Park ),진미림 ( Mi Rim Jin ) 대전대학교 한의학연구소 2015 혜화의학회지 Vol.23 No.2
Objectives : The anti-inflammatory and antioxidant effects of water extracts of Sasangja-tang(SSJ) and Gami-sasangja-tang(GSJ) were investigated. The effects of SSJ and GSJ were compared. Methods : We performed cell viability assay in HaCaT cells and RAW 264.7 cells using 3- (4,5-dimethylthiazol-2-yl)-2, 5 diphenyltetrazolium bromide(MTT) assay. We measured chemokines( regulated on activation normal T-cell expression and secreted ; RANTES/CCL5, interferon-inducible protein; IP-10/CXCL10, macrophage-derived chemokine; MDC/CCL22) in HaCat cells, also we measured cytokines (tumor necrosis factor-α; TNF-α, interleukin-6; IL-6) and nitric oxide(NO) production in RAW 264.7 cells using enzyme-linked immunosorbent assay(ELISA) and NO assay. Western blot assay was used to evaluate the expression for inducible nitric oxide synthase(iNOS) in RAW 264.7 cells. Results : SSJ and GSJ did not affect the cell viability at the concentrations treated (0-800 μg/ml). As a result of SSJ and GSJ treatment in HaCat cells stimulated by TNF-α(10 ng/ml) and interferon(IFN)-γ(10 ng/ml), the production of RANTES and IP-10 was inhibited significantly. However there was no significant difference in the secretion of MDC. And in RAW 264. 7 cells stimulated by lipopolysaccharide(LPS, 1 μg/ml), SSJ and GSJ treatment significantly inhibited the secretion of TNF-α and IL-6 and the production of NO. The expression of iNOS was also decresed by SSJ and GSJ treatment in RAW 264. 7 cells. Compared with SSJ, GSJ was superior to SSJ in inhibition of RANTES, IP-10, TNF-α, IL-6 and NO production at the concentration of 200 μg/ml. Conclusion : Both SSJ and GSJ have anti-inflammatory and antioxidant effects. And GSJ has better effects than SSJ.
최정은(Choi, Jung Eun),김미선(Kim, Mee Sun),송진란(Song, Jin Ran) 기본간호학회 2017 기본간호학회지 Vol.24 No.3
Purpose: The aim of this study was to synthesize the best available evidence for active warming interventions during cesarean section. Methods: A database search was done for randomized controlled trials utilizing active warming interventions. Maternal temperature, shivering and neonatal temperature were evaluated as outcome variables. Data were analyzed using Cochrane Review Manager software Version 5.3. Results: Thirteen studies including 1306 patients were reviewed. The degree of lowering of maternal temperature decreased in the warmed fluids (MD 0.51; p=.004) and warming mattress interventions (MD 0.22; p<.001) compared with control groups. Incidence of shivering was also lower in the active warming group (OR 0.55; p=.003). There was no statistically significant difference in maternal temperature with a forced air warming intervention (MD 0.64; p=.15) or in neonatal temperature (MD 0.12; p=.26). Conclusion: Findings show that with warmed fluids and warming mattresses applied during cesarean sections maternal temperature decline was reduced and also the incidence of shivering declined, but no significant effect was observed for forced air warming interventions. These findings provide a basis for developing a warming guideline for women having a cesarean section and will help to improve the quality of care for cesarean section patients.