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Jun Seop Yun,Hyeeun Song,Nam Hee Kim,So Young Cha,Kyu Ho Hwang,Jae Eun Lee,Cheol-Hee Jeong,Sang Hyun Song,Seonghun Kim,조은애산드라,김현실,육종인 한국분자세포생물학회 2022 Molecules and cells Vol.45 No.12
A structural protein of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), nucleocapsid (N) protein is phosphorylated by glycogen synthase kinase (GSK)-3 on the serine/arginine (SR) rich motif located in disordered regions. Although phosphorylation by GSK-3β constitutes a critical event for viral replication, the molecular mechanism underlying N phosphorylation is not well understood. In this study, we found the putative alpha-helix L/FxxxL/AxxRL motif known as the GSK-3 interacting domain (GID), found in many endogenous GSK-3β binding proteins, such as Axins, FRATs, WWOX, and GSKIP. Indeed, N interacts with GSK-3β similarly to Axin, and Leu to Glu substitution of the GID abolished the interaction, with loss of N phosphorylation. The N phosphorylation is also required for its structural loading in a virus-like particle (VLP). Compared to other coronaviruses, N of Sarbecovirus lineage including bat RaTG13 harbors a CDK1-primed phosphorylation site and Gly-rich linker for enhanced phosphorylation by GSK-3β. Furthermore, we found that the S202R mutant found in Delta and R203K/G204R mutant found in the Omicron variant allow increased abundance and hyper-phosphorylation of N. Our observations suggest that GID and mutations for increased phosphorylation in N may have contributed to the evolution of variants.
( Han Jun Bae ),( Ji Hyun Son ),( Yun Kyeong Cho ),( Hyoung Seob Park ),( Hyuck Jun Yoon ),( Hyung Seop Kim ),( Chang Wook Nam ),( Seung Ho Hur ),( Yun Nyun Kim ),( Kwon Bae Kim ) 대한내과학회 2011 대한내과학회 추계학술발표논문집 Vol.2011 No.1
Background: Anemia was known as a powerful and independent predictor of major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS). The development of anemia during hospitalization for acute myocardial infarction was frequent and was associated with an increased long-term mortality. It has been reported that a decline of hemoglobin concentration during intensive care unit stay in ACS patients without bleeding events was powerful predictor of clinical ischemic events. However there were limited datas available if the decreased hemoglobin level is related to major adverse cardiac events (MACE) after percutaneous coronary intervention (PCI) in ACS patients. Methods: We retrospectively enrolled 211 patients from March 2003 through October 2009. The inclusion criteria was patients diagnosed stable angina or ACS and underwent PCI. Patients were free of blood cell transfusion or bleeding events after PCI. All patients had been checked hemoglobin level 1 day and 2 days after PCI. The 1-year incidences of MACE, including death, myocardial infarction (MI), target vessel revascularization (TVR) and stent thrombosis (ST) were evaluated in all patients included. Statistical analysis was performed using SPSS 18.0. The association between hemoglobin changes and MACE was analyzed with ANOVA. Results: Participated patients were composed of 167 males and mean age was 60.31±10.72. Number of patients diagnosed stable angina were 63, unstable angina were 53, non-ST segment elevation myocardial infarction were 47, and ST segment elevation MI were 42. Initial hemoglobin level was 12.0 to 17.7 g/dL (mean value 13.64±1.19). Hemoglobin change was from -4.1 to +1.8 g/dL 24 hours after PCI and from -4.0 to +1.8 g/dL 48 hours after PCI. Hemoglobin change on 1day after PCI had no significant relation with mortality, subsequent MI, TVR, and ST (p=NS). And hemoglobin on 2day after PCI also had no relation with mortality, subsequent MI, TVR, ST (p=NS). Conclusions: In patients underwent PCI, hemoglobin change day 1 and day 2 after PCI was not related to MACE in stable angina and ACS patients. Therefore routine hemoglobin follow-up after PCI is not needed if patient has low risk of bleeding.
( Yun Kyeong Cho ),( Seung Ho Hur ),( Nam Hee Park ),( Sang Woong Choi ),( Ji Hyun Sohn ),( Hyun Ok Cho ),( Hyoung Seob Park ),( Hyuck Jun Yoon ),( Hyung Seop Kim ),( Chang Wook Nam ),( Yoon Nyun Kim 대한내과학회 2014 The Korean Journal of Internal Medicine Vol.29 No.1
Background/Aims: While drug-eluting stents (DESs) have shown favorable out-comes in ST-segment elevation myocardial infarction (STEMI) compared to bare metal stents (BMSs), there are concerns about the risk of stent thrombosis (ST) with DESs. Because intravascular ultrasound (IVUS) guidance may help optimize stent placement and improve outcomes in percutaneous coronary intervention (PCI) patients, we evaluated the impact of IVUS-guided BMS versus DES implan-tation on long-term outcomes in primary PCI. Methods: In all, 239 STEMI patients received DES (n = 172) or BMS (n = 67) under IVUS guidance in primary PCI. The 3-year incidence of major adverse cardiac events (MACEs) including death, myocardial infarction (MI), target vessel revas-cularization (TVR), and ST was evaluated. Results: There was no difference in all cause mortality or MI. However, the in-cidence of TVR was 23.9% with BMS versus 9.3% with DES (p = 0.005). Thus, the number of MACEs was significantly lower with DES (11.0% vs. 29.9%; p = 0.001). The incidence of definite or probable ST was not different (1.5% vs. 2.3%; p = 1.0). IVUS-guided DES implantation (hazard ratio [HR], 0.25; 95% confidence interval [CI], 0.08 to 0.78; p = 0.017), stent length (HR, 1.03; 95% CI, 1.00 to 1.06; p = 0.046), and multivessel disease (HR, 3.01; 95% CI, 1.11 to 8.15; p = 0.030) were independent predictors of MACE. Conclusions: In patients treated with primary PCI under IVUS guidance, the use of DES reduced the incidence of 3-year TVR versus BMS. However, all cause mor-tality and MI were similar between the groups. The incidence of ST was low in both groups.
Laparoscopic vs Transumbilical Single-Port Laparoscopic Appendectomy
Jun Ho Park,Kee Hoon Hyun,Chan Heun Park,Su Yun Choi,Won Hyuk Choi,Doo Jin Kim,Samuel Lee,Joo Seop Kim 대한외과학회 2010 Annals of Surgical Treatment and Research(ASRT) Vol.78 No.4
Purpose: Conventional three-port laparoscopic appendectomy (LA) is more commonly performed than transumbilical single port laparoscopic appendectomy (TUSPLA). In this report, we performed a prospective randomized study comparing the outcomes of LA and TUSPLA. Methods: Between April 14, 2009 and June 10, 2009, 40 patients who required laparoscopic appendectomies were randomly selected to receive either a TUSPLA or a LA. None of these patients had perforation or abscess. Twenty of the patients received a LA and the other 20 received a TUSPLA. The clinical outcomes and visual analog pain scores (VAS) were compared between the groups. Results: The TUSPLA procedures were performed successfully in every indicated patient. Clinical outcomes were similar in both study groups. The TUSPLA group showed a significantly higher VAS score 24 hours postoperatively than the LA group. Conclusion: Compared with LA, TUSPLA was technically feasible and safe in patients with non-complicated appendicitis. However, the patients in the TUSPLA group reported more postoperative pain than those in the LA group.
Design of a Multi-Threaded Image Signal Processor with a Multi-Bank Cache Memory
Yun-Seop Hwang,Jun-Mo Jeong 보안공학연구지원센터 2016 International Journal of Software Engineering and Vol.10 No.9
This paper proposes a multi-thread architecture-based Image Signal Processor (ISP). As the required image quality is gradually increasing in today’s society and the image processing algorithms are becoming more diversified, the burden of calculations in the main processor such as CPU is growing bigger. To solve these problems, an ISP was designed in order to reduce the burden on the main processor by applying the multi-thread architecture and applying various image processing algorithms, allowing a high performance processing. The proposed ISP has a multi-bank cache memory that can perform the multi-thread data and instructions with a hit-save-FIFO and latency hiding unit. The proposed ISP was verified with Virtex-7 FPGA and showed about 2.4 times higher processing speed compared to the conventional DSP.
Jun-Seop Park,장혜옥,Eun-Jong Choi,Dong-Soo Jeong,Hak-Jin Yang,Kyoung-Phil Kim,Kuk-Kyung Son,Hyun-Wook Lee,Min-Jung Kang,Sang-Min Kim,정인교,배문경,Il Yun 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.10
The aim of this study was to provide a basis for examining the molecular mechanism for the pharmacological action of ethanol. Energy transfer between the surface fluorescent probe 1-anilinonaphthalene-8-sulfonic acid and hydrophobic fluorescent probe 1,3-di(1-pyrenyl)propane was used to examine the effect of both dimyristoylphosphatidylethanol (DMPEt) and ethanol on the thickness (D) of the synaptosomal plasma membrane vesicles (SPMV) isolated from the bovine cerebral cortex. The thickness (D) of the intact SPMV was 1.044 ± 0.008 (arbitrary units, n=5) at 37oC (pH 7.4). Both DMPEt and ethanol decreased the thickness of the SPMV lipid bilayer in a dose-dependent manner with a significant decrease in thickness observed at 5 μM and 25 mM, respectively. It was assumed that both ethanol and DMPEt cause interdigitation in the SPMV lipid bilayers. The effects of ethanol on the neuronal membranes were attributed to its direct and indirect actions. The indirect action of ethanol refers to the action of phosphatidylethanol, which is an ethanol abnormal metabolite, on the neuronal membranes. The decrease in membrane thickness by both DMPEt and ethanol might be responsible for some, but not all of its anesthetic actions.