송화분이 고지방 식이 섭취 흰쥐의 혈청과 간장에 미치는 영향

이영주,박무희,황성원,배만종,한준표 대구효성가톨릭대학교 식품과학연구소 1994 식품과학지 Vol.6 No.-

6주간 고지방식이를 섭취한 흰쥐에 있어 송화분과 탈지 송화분이 혈청과 간장에서의 지방 축적과 대사에 미치는 효과를 관찰하였다. 혈청에서의 total lipid, total cholesterol 농도는 고지방 식이군에 비해서 탈지 송화분과 송화분 투여군이 유의적으로 감소하였다. 혈청에서의 triglyceride 농도는 탈지 송화분과 송화분 투여군이 고지방 식이군과 비교했을 때 뚜렷한 감소를 보였으며, 이는 정상군과 비슷한 농도를 나타내었다. 혈당농도는 송화분, 탈지 송화분 투여군에서 유의성 있게 감소하였다. 간장을 조직학적으로 관찰한 결과, 고지방식이로 인한 조직의 지방 침착은 송화분 투여군에서 다소 억제함을 보였다. 이상의 결과를 미루어 볼 때 송화분은 동맥경화증 및 순환기계 질환의 예방과 치료에 효과적일 것으로 사료된다. Effect of pine pollen and defatted pine pollen on lipid accumulation and metabolism in serum and liver were investigated with rats fed high fat-supplemented diets for 6 weeks. Concentrations of total lipid and total cholesterol in serum significantly decreased in the experimental groups(treated with pine pollen and defatted pine pollen) compared with the control group. Concentration of triglyceride in serum was remarkably lower than that of control group. This was similar to that of normal group. Concentration of glucose in serum was significantly lower in the experimental group. It was observed from photographs of hepatic tissue in rats that pine pollen inhibits the lipid accumulation induced by high fat diets.

음이온 리빙중합에 의한 방향족 아민 양말단변성 폴리부타디엔의 합성

전준표,이범재,박상호 忠南大學校 産業技術硏究所 2002 산업기술연구논문집 Vol.17 No.2

Functionalization reaction of poly(butadienyl)lithium with 4,4'-bis(dimethylamino)-benzophenone, 4,4'-bis(diethylamino)benzophenone, 1,1'-bis[(4-dimethylamino)phenyl]ethylene, and 1,1'-bis[(4-diethylamino)phenyl]ethylene in n-heptane provide the corresponding ω-amine chain-end funstionalized polymers in 90∼95% yields. α-Functionalized polybutadienes were prepared by the polymerization using amine functional initiator, which was obtained by the stoichiometric reaction of sec-butyllithium and 1,1'-bis[(4-dimethylamino)phenyl]ethylene, or 1,1'-bis[(4-diethylamino)phenyl]ethylene. Utilizing these two reaction technologies, well-known α,ω-difunctionalized polybutadienes could be synthesized by the polymerization using amine functional initiator followed by chain-end functionalization.

도시 노숙자의 주요 정신장애에 관한 역학 연구

안준호,홍진표,유제춘,박종익,이철,한오수 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.2

외환위기 이후 대도시를 중심으로 노숙자들이 급증하여 이들이 심각한 사회문제로 등장하였다. 외국의 연구에 의하면 노숙자 중 상당수가 만성 정신질환을 앓고 있으며, 정신질환이 노숙의 원인 및 예후와 밀접한 관련이 있다고 한다. 그러나 국내에서는 아직 노숙자의 정신장애의 유병률에 관하여 알려진 바 없으므로 이에 대하여 조사하였다. 방법: 1998년 말부터 1999년 초까지 부산지역의 쉼터 두 곳에 거주하는 노숙자 216명을 대상으로 인구학적 자료에 대한 설문조사를 한 뒤 Structured Clinical Interview for DSM-Ⅳ(SCID)을 이용하여 Axis Ⅰ의 주요 정신장애를 진단하였다. 이들의 정신장애의 평생유병률 및 현재유병률을 국내 일반인구 및 외국 노숙자의 정신장애의 유병률과 비교하였다. 결과: DSM-Ⅳ Axis Ⅰ의 정신장애 중 기분장애, 정신병적 장애, 물질사용장애에 대한 진단 평가 결과 상기 정신장애의 전체 평생유병률은 60.1%, 현재유병률은 35.7%이었다. 그 중 주요우울장애의 평생유병률 이 22.5%로서 외국의 노숙자에 대한 역학연구 결과와 비교해 볼 때 높은 수준이었고 알코올 사용 장애의 평생유병률은 47.4%이었다. 정신병적 장애의 평생유병률은 3.8%이었고, 그 중에서도 정신분열병의 평생유병률은 1.9%이어서 외국의 노숙자에 대한 연구결과보다 낮은 편이었다. 결론: 국내 노숙자에서 기분장애와 물질사용장애가 주된 정신장애였으며 정신분열병 등 정신병적 장애의 유병률은 외국에 비해 낮은편이었다. 이러한 정신장애를 가지고 있는 노숙자에 대하여 접근하고 치료하기 위한 대책이 마련되어야 할 것이다. Objective:As homeless people increased in urban areas after the economic crisis in Korea, they became a serious social problem. Foreign research showed that many homeless people had chronic mental illnesses which were closely related with the cause and prognosis of homelessness. But very little was known about the prevalence of mental disorders in Korean homeless people. This study tried to capture the overall picture of mental disorders in homeless people. Method:The study subjects were 216 homeless people who stayed at two Pusan shelters between late 1998 and early 1999. Questionnaires on sociodemographic data were administered to the subjects, and then diagnoses of major DSM-IV Axis I mental disorders were made using Structured Clinical Interview for DSM-IV Axis I Disorders(SCID). The lifetime and current prevalence of mental disorders in this study were compared to those from other studies in Korean general population and in foreign homeless people. Results:The lifetime prevalence of major DSM-IV mental disorders(mood disorders, psy-chotic disorders, and substance use disorders) of 216 homeless people was 60.1%, and current prevalence was 35.7%. The lifetime prevalence of major depressive disorders was 22.5% which was higher than that of foreign studies. The lifetime prevalence of alcohol use disorder was 47. 4%. The lifetime prevalence of psychotic disorders was 3.8%, and among them the lifetime prevalence of schizophrenia was 1.9% which was lower than that of foreign studies. Conclusions: In Korean homeless people, mood disorders and substance use disorders were the main mental disorders and psychotic disorders such as schizophrenia were less than in foreign homeless people. The plans to approach and treat homeless people with mental disorders should be made.

송화분을 이용한 간기능 증진제 개발 연구

하은주,이해경,한준표 대구효성가톨릭대학교 1993 연구논문집 Vol.47 No.1

To investigate the effect of the pine pollen on serum and liver of rat pretreated with carbon tetrachloride. Rats were first administrated CCl₄and then treated orally with the water-washed pine pollen as indicated in the book of "Imperial courtcookery" The results are summarized as follows ; GPT activity of rat administrated the pine pollen was lower than that of rat treated with CCl₄to induce a chronic liver injury and was similar to that of nontreatment group. Totla cholesterol in serum of pine pollen administrated rat decreased significantly compared with that of the CCl₄-treated group. There was a noticeable improvement in the activity of the live protein synthesis of pine polllen-administrated rat, compared with that of CCl₄-treated group. Body weight of non-treated group are increased but that of CCl₄-treated and pine pollen-treated group were retarded according to time.

길경 Saponin 이 고지방식이를 한 흰쥐의 혈청, 간장 및 분변 지질 함량에 미치는 영향

박무희,이영주,황성원,한준표,배만종 대구효성가톨릭대학교 식품과학연구소 1994 식품과학지 Vol.6 No.-

6주간 고지방식이를 섭취한 흰주에 있어서 길경 saponin이 지방 축적 억제와 대사에 미치는 영향을 검토하고자 혈청과 간장 및 분변 중 지방 성분을 생화학적으로 분석하여 다음과 같은 결과를 얻었다. 1. 혈청 및 간장중의 총지질, 총콜레스테롤 및 중성지방 함량은 길경 saponin군이 대조군에 비하여 유의한 감소를 보였다. 2. 분변 중 총지질 및 총콜레스테롤 함량은 대조군과 비교할 때 길경 saponin군이 다소 배설이 증가되었으나, 유의성은 인정되지 않았다. This study was conducted to investigate the effect of Platycodi radix saponin(PRS) on the reduction of lipid status in rats fed on high fat diet for 6 weeks after which lipid contents were measured in serum, liver and feces. The results obtained from this study are as follows; That the levels of total lipid, total cholesterol and triglyceride in serum and liver were significantly lower in the PRS group as compared with the control group. The contents of total lipid and total cholesterol excreted in the feces were tended to be slightly increase in PRS group compared to the control group, which were not significant.

대량 우측 흉막 삼출로 발현한 알코올성 만성 췌장염 1예

이상인,조승현,박효진,강진경,한기준,정재복,이세준,정준표,문병수,서원태,이관식,송시영 대한소화기내시경학회 2001 Clinical Endoscopy Vol.22 No.2

사염화탄소로 급성 간손상이 유발된 흰쥐에서 혈청 및 간조직의 Transforming Growth Factor-β1의 변화와 비타민 E의 효과

이상인,이정일,이관식,김현숙,전재윤,한광협,문영명,박영년,이세준,정준표 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.2

$quot;Background/Aims: The evaluation of the relationship between oxidative stress induced by acute carbon tetrachloride (CCl4) administration and transforming growth factor-β1 (TGF-β1), and the investigation of temporal patterns of serum alanine aminotransferase (ALT) and TGF-β1 expression which may clarify the pathogenesis of CCl4 induced liver injury and thus the mechanism of liver fibrogenesis. The aim of this study was to investigate TGF-β1 expression in rats with acute CCl4 injury and effect of vitamin E (vit. E) on TGF-β1 expression. Methods: Sixty male Sprague-Dawley rats had a single intraperitoneal injection of CCl4, of which 30 rats had daily intraperitoneal injection of vit. E, starting from 2 days before CCl4 treatment until the time of their sacrifice. The group of rats with CCl4 injection only was designated as group 1 and the group of rats with vit. E combined treatment was designated as group 2. Five rats from each group were sacrificed before and 8, 16, 32, 48, 60 hours after CCl4 injection, heir serum ALT, serum TGF-β1, and hepatic expression of TGF-β1 were examined. Results: The serum ALT levels were highest at 32 hours after CCl4 injection in both groups, serum TGF-β1 levels did not show any statistically significant changes after CCl4 injection in both groups, and TGF-β1 expression in the livers was highest at 32 hours after CCl4 injection in both groups. In the multiple regression analysis of vit. E's effect on serum ALT levels, serum TGF-β1 levels and hepatic TGF-β1 expression, only serum ALT level (p=0.049) and hepatic TGF-β1 expression (p=0.015) showed statistically significant suppression. Conclusion: Oxidative stress seems to play a role in the pathogenesis of hepatic fibrogenesis by increasing TGF-β1 expression in early acute liver damage. and vit. E may be effective in reducing acute liver injury and hepatic fibrogenesis. (Korean J Hepatol 2000;6:147-155)$quot;

Surface characteristics of orthodontic materials and their effects on adhesion of mutans streptococci.

Lee, Seung-Pyo,Lee, Shin-Jae,Lim, Bum-Soon,Ahn, Sug-Joon Angle Orthodontists Research and Education Foundat 2009 The Angle orthodontist Vol.79 No.2

<P>OBJECTIVE: To test the hypothesis that there are no significant differences in the adhesion of mutans streptococci (MS) to various orthodontic materials based on their surface characteristics. MATERIALS AND METHODS: Surface roughness (SR) and surface free energy (SFE) characteristics were investigated for nine different orthodontic materials (four orthodontic adhesives, three bracket raw materials, hydroxyapatite blocks, and bovine incisors) using confocal laser scanning microscopy and sessile drop method. Each material, except the bovine incisors, was incubated with whole saliva or phosphate-buffered saline for 2 hours. Adhesion assays were performed by incubating tritium-labeled MS with each material for 3 or 6 hours. RESULTS: Orthodontic adhesives had higher SFE characteristics and lower SR than bracket materials. Orthodontic adhesives showed a higher MS retaining capacity than bracket materials, and MS adhesion to resin-modified glass ionomer and hydroxyapatite was highest. Extended incubation time increased MS adhesion, while saliva coating did not significantly influence MS adhesion. SFE, specifically its dispersive and polar components, was positively correlated with MS adhesion, irrespective of saliva coating. CONCLUSIONS: The hypothesis is rejected. This study suggests that SFE characteristics play an important role in the initial MS adhesion to orthodontic materials.</P>

Development of Automated Analysis System for Model Plane Engine Using Fuzzy Knowledge Processing

Lee, Joon-Seong,Lee, Shin-Pyo Korean Institute of Intelligent Systems 2002 한국지능시스템학회논문지 Vol.12 No.2

This paper describes a new automated analysis system for model plane engine. An automatic finite element (FE) mesh generation technique, which is based on the fuzzy knowledge processing and computational geometry technique, is incorporated into the system, together with one of commercial FE analysis codes, ANSYS, and one of commercial solid modelers, Designbase, The system allows a geometry model of concern to be automatically converted to different FE models, depending on physical phenomena of plane engine to be analyzed, i.e. deformation analysis, thermal analysis and so on. The FE models are then automatically analyzed by the FE analysis code. Among a whole process of analysis, the definition of a geometry model, the designation of local node patterns, the assignment of material properties and boundary conditions onto the geometry model are only the interactive processes to be done by a user. The interactive operations can be processed in a few minutes. The other processes which are time consuming and labour-intensive in conventional CAE systems are fully automatically performed in a personal computer environment. The proposed analysis system is successfully applied to evaluate a model plane entwine.

A SURVEY ON DOPING AMONG KOREAN ATHLETES

Lee,Kwang-Pyo,Kim,Chang-Jong,Jhoo,Wang-Kee,Han,Sang-Joon,Lee,Chul-Kyu,Park,Chang-Pyung 江原大學校附設體力硏究所 1976 江原大學校附設體育科學硏究所論文集 Vol.- No.1

1974년 10월 대구에서 거행된 대한민국 체전에 참가한 112명의 선수를 대상으로 흥분제 복용여부를 조사하기 위하여 TLC에 의해서 뇨를 분석하였다. 그 결과 5명(4.46%)이 ephedrine을 복용한 것으로 나타났다. 그러나 이들이 경기기록을 인위적으로 향상시키기 위하여 약물을 복용했는지 아니면 의학적인 목적으로 사용했는지는 밝히지 못했다.