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춘계학술대회 : 포스터발표 ; 간세포암종에서 Telomerase 활성도, hTERTmRNA 발현 및 Telomere 길이 상호관계와 예후에 미치는 영향
박영년,오봉경,김혜령,최진섭,김경식,박찬일 대한간학회 2005 Clinical and Molecular Hepatology(대한간학회지) Vol.11 No.3(S)
Purpose: Telomerase reactivation is crucial for cellular transformation by stabilizing telomere length. This study investigated the relationship of hTERT mRNA, a key component of telomerase, telomerase activity and telomere length to their clinical implic
간의 전이성암의 세침흡인 세포학적 소견 - 110예에 대한 연구 -
박영년,홍순원,이광길,Park, Young-Nyun,Hong, Soon-Won,Lee, Kwang-Gil 대한세포병리학회 1991 대한세포병리학회지 Vol.2 No.2
Metastatic tumors occur more frequently in the liver than in any other organ. Guided percutaneous fine-needle aspiration (FNA) of the liver is often recommended for confirmative diagnosis of the metastatic lesion, because of its simplicity, high yield, and reasonable safety. The authors studied retrospectively cytologic findings of 110 cases of metastatic tumors to the liver. The frequent primary sites were the stomach (23 cases), pancreas(19 cases), gallbladder(12 cases), and periampullary lesions(6 cases). Most of the metastases were carcinoma (106 cases). There were only 4 cases of sarcoma. The characteristic cytologic findings of FNA of meatastatic tumors were dirty background, abrupt change between hepatocytes and malignant cells, and desmoplasia. Some tumors displayed rather distinctive cytologic appearance that suggests primary sites. For example, the colonic adenocarcinoma showed tall columnar cells with a palisading arrangement, adenocarcinoma of gallbaldder showed focal squamous differentiation in some cases, and metastatic renal cell carcinoma and neuroblastoma showed also distinctive cytologic findings. Because the cytologic features of metastatic tumor are very similar to those of primary tumor, correct cytologic typing may be helpful in pursuit of an occult primary site of metastatic liver lesions, reducing extensive diagnostic investigation in poor prognostic patients.