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만성 신부전 환자에서 관찰된 십이지장의 가성 흑피증 1 예
김태년,박진호,강승호,정문관,이현우,장병익,남혜주 대한내과학회 1993 대한내과학회지 Vol.45 No.4
Pseudomelanosis duodeni is a rare condition that has been only recently recognized. Dark pigment accumulates in macrophages located in the lamina propria of the duodenal mucosa. Diffuse small discreted brownishblack pigmentation at duodenal bulb was noted during gastroduodenoscopy by chance, in a 50 year old male patient with chronic renal failure, who had been treated antihypertensive drugs for 15 years and regular hemodialysis for 6 years. With the electron microscope, blackish electron dense granules were found within the cytoplasm of the macrophage located in the lamina propria and with the study of histochemistry (stained with Prussian-Blue, Masson-Fontana method) the pigment contained iron and other unknown material. The source of the pigment or the mechanism of pigment formation is unclear and has yet to be clarified.
Body size phenotypes and low muscle mass: the Korean sarcopenic obesity study (KSOS).
Kim, Tae Nyun,Park, Man Sik,Yang, Sae Jeong,Yoo, Hye Jin,Kang, Hyun Joo,Song, Wook,Seo, Ji A,Kim, Sin Gon,Kim, Nan Hee,Baik, Sei Hyun,Choi, Dong Seop,Choi, Kyung Mook Issued for the Endocrine Society by the Williams W 2013 The Journal of clinical endocrinology & metabolism Vol.98 No.2
<P>Unique subsets of body size phenotypes seem to be more prone or more resistant to the development of obesity-associated metabolic disorders, although the underlying mechanism is not yet clearly understood.</P>
Kim, Tae Nyun,Park, Man Sik,Yang, Sae Jeong,Yoo, Hye Jin,Kang, Hyun Joo,Song, Wook,Seo, Ji A.,Kim, Sin Gon,Kim, Nan Hee,Baik, Sei Hyun,Choi, Dong Seop,Choi, Kyung Mook American Diabetes Association 2010 Diabetes care Vol.33 No.7
<P><B>OBJECTIVE</B></P><P>We examined prevalence of sarcopenia in Korean patients with type 2 diabetes and compared body compositional parameters between subjects with and without type 2 diabetes.</P><P><B>RESEARCH DESIGN AND METHODS</B></P><P>The Korean Sarcopenic Obesity Study (KSOS) included 810 subjects (414 patients with diabetes and 396 control subjects) who were examined using dual-energy X-ray absorptiometry. Prevalence of sarcopenia was defined using the skeletal muscle index (SMI).</P><P><B>RESULTS</B></P><P>Prevalence in patients with diabetes and in the control group was 15.7 and 6.9%, respectively. In both men and women, SMI values were significantly decreased in patients with diabetes compared with subjects without diabetes. Furthermore, multiple logistic regression analysis showed that type 2 diabetes was independently associated with sarcopenia.</P><P><B>CONCLUSIONS</B></P><P>Type 2 diabetes was associated with increased risk of sarcopenia. These characteristics may contribute to physical disability and metabolic disorders in older adults with diabetes.</P>
Kim, Tae Nyun,Park, Man Sik,Lim, Kang Il,Yang, Sae Jeong,Yoo, Hye Jin,Kang, Hyun Joo,Song, Wook,Seo, Ji A.,Kim, Sin Gon,Kim, Nan Hee,Baik, Sei Hyun,Choi, Dong Seop,Choi, Kyung Mook Elsevier 2011 Diabetes research and clinical practice Vol.93 No.2
<P><B>Abstract</B></P> <P><B>Aims</B></P> <P>Sarcopenia measured as appendicular skeletal muscle mass (ASM), and central obesity measured as visceral fat area (VFA) may act synergistically to influence metabolic syndrome and atherosclerosis. However, several previous studies reported that metabolic risk is higher in non-sarcopenic obesity groups than in sarcopenic obesity groups because of the close relationship between muscle mass and body fat. We investigated the association of the ASM to VFA ratio, which we have termed the muscle-to-fat ratio (MFR), with metabolic syndrome and arterial stiffness.</P> <P><B>Methods</B></P> <P>This study was performed in 526 apparently healthy adults enrolled in the Korean Sarcopenic Obesity Study, an ongoing prospective observational cohort study. ASM was evaluated with dual energy X-ray absorptiometry and VFA with computed tomography. Arterial stiffness was measured using brachial-ankle pulse wave velocity (baPWV).</P> <P><B>Results</B></P> <P>MFR was significantly associated with waist circumference, blood pressure, lipid profiles, glucose and baPWV. By multiple logistic regression analysis, the odds ratio for metabolic syndrome was 5.43 (lowest versus highest tertile of MFR, 95% confidence interval, 2.56–13.34). Multiple stepwise regression analysis showed that MFR was an independent determinant of baPWV (<I>R</I> <SUP>2</SUP> =0.57).</P> <P><B>Conclusions</B></P> <P>MFR, a new index of sarcopenic obesity, showed an independent negative association with metabolic syndrome and arterial stiffness.</P>
Coupled Motion Simulation of the Mobile Harbor and Anti-Rolling Devices in Waves
Hyeon-Kyu Yoon,Joo-Nyun Kang,Jae-Moon Lew,Seok-Joon Moon,Tae-Young Chung 한국항해항만학회 2010 한국항해항만학회지 Vol.34 No.4
The Mobile Harbor(MH) is a new transportation platform that can load and unload containers to and from very large container ships in the sea. This loading and unloading by crane can be performed with only very small movements of the MH in waves because MH is operated outside of the harbor. For this reason, an anti-rolling tank(ART) and an active mass driving system(AMD) were designed to reduce MH’s roll motion, especially at the natural frequency of MH. In the conceptual design stage, it is difficult to confirm the design result of theses anti-rolling devices without modeling and simulation tools. Therefore, the coupled MH and anti-rolling devices’ dynamic equations in waves were derived and a simulation program that can analyze the roll reduction performance in various conditions, such as sea state, wave direction, and so on, was developed. The coupled equations are constructed as an eight degrees of freedom (DOF) motion that consists of MH’s six DOF dynamics and the ART's and AMD’s control variables. In order to conveniently include the ART’s and AMD’s control dynamics in the time domain, MH’s radiated wave force was described by an impulse response function derived by the damping coefficient obtained in the frequency domain, and wave exciting forces such as Froude-Krylov force and diffraction force and nonlinear buoyancy were calculated at every simulation time interval. Finally, the roll reduction performances of the designed anti-rolling devices were successfully assessed in the various loading and wave conditions by using a developed simulation program.
Hyeon-Kyu Yoon,Joo-Nyun Kang 한국항해항만학회 2010 한국항해항만학회지 Vol.34 No.7
Mobile Harbor (MH) is a new transportation platform that can load and unload containers onto and from very large container ships at sea. It could navigate near harbors where several vessels run, or it could navigate through very narrow channels. In the conceptual design phase when the candidate design changes frequently according to the various performance requirements, it is very expensive and time-consuming to carry out model tests using a large model in a large towing tank and a free-running model test in a large maneuvering basin. In this paper, a new Planar Motion Mechanism(PMM) test in a Circulating Water Channel (CWC) was conducted in order to determine the hydrodynamic coefficients of the MH. To do this, PMM devices including three-component load cells and inertia tare device were designed and manufactured, and various tests of the MH such as static drift test, pure sway test, pure yaw test, and drift-and-yaw combined test were carried out. Using those coefficients, course-keeping stability was analyzed. In addition, the PMM tests results carried out for the same KCS (KRISO container ship) were compared with our results in order to confirm the test validity.
Yoon, Hyeon-Kyu,Kang, Joo-Nyun Korean Institute of Navigation and Port Research 2010 한국항해항만학회지 Vol.34 No.7
Mobile Harbor (MH) is a new transportation platform that can load and unload containers onto and from very large container ships at sea. It could navigate near harbors where several vessels run, or it could navigate through very narrow channels. In the conceptual design phase when the candidate design changes frequently according to the various performance requirements, it is very expensive and time-consuming to carry out model tests using a large model in a large towing tank and a free-running model test in a large maneuvering basin. In this paper, a new Planar Motion Mechanism(PMM) test in a Circulating Water Channel (CWC) was conducted in order to determine the hydrodynamic coefficients of the MH. To do this, PMM devices including three-component load cells and inertia tare device were designed and manufactured, and various tests of the MH such as static drift test, pure sway test, pure yaw test, and drift-and-yaw combined test were carried out. Using those coefficients, course-keeping stability was analyzed. In addition, the PMM tests results carried out for the same KCS (KRISO container ship) were compared with our results in order to confirm the test validity.
Coupled Motion Simulation of the Mobile Harbor and Anti-Rolling Devices in Waves
Yoon, Hyeon-Kyu,Kang, Joo-Nyun,Lew, Jae-Moon,Moon, Seok-Joon,Chung, Tae-Young Korean Institute of Navigation and Port Research 2010 한국항해항만학회지 Vol.34 No.4
The Mobile Harbor(MH) is a new transportation platform that can load and unload containers to and from very large container ships in the sea. This loading and unloading by crane can be performed with only very small movements of the MH in waves because MH is operated outside of the harbor. For this reason, an anti-rolling tank(ART) and an active mass driving system(AMD) were designed to reduce MH's roll motion, especially at the natural frequency of MH. In the conceptual design stage, it is difficult to confirm the design result of theses anti-rolling devices without modeling and simulation tools. Therefore, the coupled MH and anti-rolling devices' dynamic equations in waves were derived and a simulation program that can analyze the roll reduction performance in various conditions, such as sea state, wave direction, and so on, was developed. The coupled equations are constructed as an eight degrees of freedom (DOF) motion that consists of MH's six DOF dynamics and the ART's and AMD's control variables. In order to conveniently include the ART's and AMD's control dynamics in the time domain, MH's radiated wave force was described by an impulse response function derived by the damping coefficient obtained in the frequency domain, and wave exciting forces such as Froude-Krylov force and diffraction force and nonlinear buoyancy were calculated at every simulation time interval. Finally, the roll reduction performances of the designed anti-rolling devices were successfully assessed in the various loading and wave conditions by using a developed simulation program.