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Lim, Joo Weon,Song, Ji Yeon,Seo, Jeong Yeon,Kim, Hyeyoung,Kim, Kyung Hwan Wiley (Blackwell Publishing) 2009 Annals of the New York Academy of Sciences Vol.1171 No.1
<P>Previously we showed that oxidative stress induces apoptosis of pancreatic acinar cells with nuclear loss of DNA repair proteins. Oxidative stress has an important role in the pathogenesis of pancreatitis. Pancreatitis-associated protein 1 (PAP-1) is a protein secreted upon induction of acute pancreatitis. In this study, we investigated the role of PAP-1 on oxidative stress-induced cell death of pancreatic acinar AR42J cells. AR42J cells were transfected with or without full-length sense cDNA of PAP-1 (PAP-1 S cDNA) or antisense cDNA of PAP-1 (PAP-1 AS cDNA) and received oxidative stress caused by glucose oxidase acting on beta-D-glucose, glucose/glucose oxidase. PAP-1 mRNA expression and cell viability were determined. As a result, oxidative stress induced PAP-1 mRNA expression in AR42J cells in a time-dependent manner. Cell viability decreased with the concentration of glucose oxides delivered to the cells that had received glucose. Oxidative stress-induced PAP-1 expression was augmented in the cells transfected with PAP-1 S cDNA compared with wild-type cells or cells transfected with control vector pcDNA. PAP-1 induction by oxidative stress decreased in the cells transfected with PAP-1 AS cDNA. Cell death caused by oxidative stress was inhibited in the cells transfected with PAP-1 S cDNA, but it increased in the cells transfected with PAP-1 AS cDNA. These results indicate that PAP-1 may be a defensive gene for oxidative stress-induced cell death of pancreatic acinar cells.</P>
문맥압항진증에 의한 식도정맥류와 울혈성 위병변에서 Inducible Nitric Oxide Synthase mRNA 발현양상
임창영,송일한,노임환,진영주,김정원,최정 대한소화기학회 1998 대한소화기학회지 Vol.32 No.2
Background/Aims: Chronic portal hypertension is associated with hyperdynamic splanchnic circulation, leading to collateralization of portal system and bleeding of gastrointestinal tracts. Nitric oxide (NO) induced by NO synthase (NOS) is endothelium-derived relaxing factor. Constitutive NOS (cNOS) is normally present in vascular endothelia and produces NO in response to physiologic stimuli. On the other hand, inducible NOS (iNOS) induces NO in response to bacterial endotoxins and cytokines. In addition, the endotoxemia is frequently observed in portal hypertension. Thus, to clarify the role of NO in development of esophageal varix and congestive gastropathy in patients with portal hypertension by measuring the expression of iNOS mRNA, we carried out this study. Methods: We compared the expression of iNOS mRNA in esophageal variceal and congestive gastric mucosa of 16 patients with portal hypertension with that in distal esophageal and gastric mucosa of 10 normal controls. The expression of iNOS mRNA was measured using reverse transcription-polymerase chain reaction (RT-PCR) in biopsied esophageal variceal and congestive gastric mucosa after endoscopic variceal ligation. Results: There was no expression of iNOS mRNA in distal esophageal and gastric mucosa of normal controls. In the 16 patients with portal hypertension, the expression of iNOS mRNA of esophageal variceal and congestive gastric mucosa was observed in 9 (56.3%) and 8 (50%) patients, respectively. Additionally, in all cases except one, iNOS gene was concurrently expressed in both variceal and congestive gastric mucosa. There was no difference in biochemical data and endoscopic finding between the patients with or without iNOS mRNA expression. Conclusions: The iNOS mRNA was activated in some patients with portal hypertension. Thus, we suggest that NO induced by iNOS may be associated with hyperdynamic circulation and development of collaterals in these patients.
Incidence of cervical, endometrial, and ovarian cancer in Korea, 1999-2010
Lim, Myong Cheol,Moon, Eun-Kyeong,Shin, Aesun,Jung, Kyu-Won,Won, Young-Joo,Seo, Sang Soo,Kang, Sokbom,Kim, Jae-Weon,Kim, Joo-Young,Park, Sang-Yoon Asian Society of Gynecologic Oncology; Korean Soci 2013 Journal of Gynecologic Oncology Vol.24 No.4
<P><B>Objective</B></P><P>To investigate the recent incidence of and trends in cervical, endometrial, and ovarian cancer in Korean females.</P><P><B>Methods</B></P><P>Data from the Korea Central Cancer Registry between 1999 and 2010 were analyzed. Age-standardized rates (ASRs) and annual percent changes (APCs) were calculated.</P><P><B>Results</B></P><P>The absolute incidence rates of the three major gynecologic cancers increased: 6,394 in 1999 to 7,454 in 2010. The ASR for gynecologic cancer was 23.7 per 100,000 in 1999 and decreased to 21.0 in 2010 (APC, -1.1%; 95% confidence interval [CI], -1.53 to -0.70) due to a definitive decrease in the incidence of cervical cancer (APC, -4.3%). Endometrial cancer has been definitively increasing (APC, 6.9% during 1999-2010), especially in females <30 years old (APC, 11.2%) and in females ≥80 years old (APC, 9.5%). The incidence of ovarian cancer is increasing gradually (APC, 1.5%).</P><P><B>Conclusion</B></P><P>ASRs and APC for gynecologic cancers overall are decreasing due to the decrease in the incidence of cervical cancer. However, the incidence of endometrial and ovarian cancer has been increasing.</P>
The Effect of $H^+$ on Reduction of $[Co(NH_3)_4(C_2O_4)]^+$ with $[Fe(H_2O)_6]^{2+}$
Lim, Joo-Sang,Lee, Jae-Weon,Kang, Seung-Gu,Park, Byung-Kak Korean Chemical Society 1990 Bulletin of the Korean Chemical Society Vol.11 No.4
Kinetic studies were carried out for the redox reaction of $[Co(NH_3)_4(C_2O_4)]^+$ with aqueous $[Fe(H_2O)_6]^{2+}$ solution in the present of $H^+$ by UV/VIS-spectrophotometric method. It was found that the order of $H^+$ for the reaction is first one in the higher $H^+$ concentration range of $1.67×10^{-1} M{\sim}1.00 M,$ while second order in the lower range of $6.30×10^{-2} M{\sim}1.67{\times}10^{-1} M.$ Reaction order of the substrates was found to be first order with respect to each of them. Accordingly overall reactions are third or fourth order. The results of calculation for the Extended Huckel Molecular Orbital theory contribute to estimate the preferred intermediates, bridging form of binuclear complex. On the basis of these results, we propose that this redox reaction proceed via inner-sphere reaction mechanism.
Synthesis of Isopropyldichlorosilane by Direct Process
Weon Cheol Lim,Joo Hyun Cho,Joon Soo Han,유복렬 대한화학회 2007 Bulletin of the Korean Chemical Society Vol.28 No.10
Direct reaction of elemental silicon with a gaseous mixture of isopropyl chloride (1) and hydrogen chloride in the presence of copper catalyst using a stirred bed reactor equipped with a spiral band agitator gave isopropyldichlorosilane having a Si-H bond (2a) as a major product and isopropyltrichlorosilane (2b) along with chlorosilanes, trichlorosilane and tetrachlorosilane. A process for production of 2a was maximized using the 1:0.5 mole ratio of 1 to HCl and smaller size of elemental silicon at a reaction temperature of 220 C. When a reaction was carried out by feeding a gaseous mixture of 1 [12.9 g/h (0.164 mol/h)] and HCl [2.98 g/h (0.082 mol/h)] to a contact mixture of elemental silicon (360 g) and copper (40 g) under the optimum condition for 45 h, 2a among volatile products kept up about 82 mol % until 35 h and then slowly decreased down 68 mol % in 45 h reaction. Finally 2a was obtained in 38% isolated yield (based on 1 used) with an 85% consumption of elemental silicon in a 45 h reaction. In addition to 2a, 2b was obtained as minor product along with chlorosilanes, trichlorosilane, and tetrachlorosilane. The decomposition of 1 was suppressed and the production of 2a improved by adding HCl to 1.
Synthesis of Isopropyldichlorosilane by Direct Process
Lim, Weon-Cheol,Cho, Joo-Hyun,Han, Joon-Soo,Yoo, Bok-Ryul Korean Chemical Society 2007 Bulletin of the Korean Chemical Society Vol.28 No.10
Direct reaction of elemental silicon with a gaseous mixture of isopropyl chloride (1) and hydrogen chloride in the presence of copper catalyst using a stirred bed reactor equipped with a spiral band agitator gave isopropyldichlorosilane having a Si-H bond (2a) as a major product and isopropyltrichlorosilane (2b) along with chlorosilanes, trichlorosilane and tetrachlorosilane. A process for production of 2a was maximized using the 1:0.5 mole ratio of 1 to HCl and smaller size of elemental silicon at a reaction temperature of 220 °C. When a reaction was carried out by feeding a gaseous mixture of 1 [12.9 g/h (0.164 mol/h)] and HCl [2.98 g/h (0.082 mol/h)] to a contact mixture of elemental silicon (360 g) and copper (40 g) under the optimum condition for 45 h, 2a among volatile products kept up about 82 mol % until 35 h and then slowly decreased down 68 mol % in 45 h reaction. Finally 2a was obtained in 38% isolated yield (based on 1 used) with an 85% consumption of elemental silicon in a 45 h reaction. In addition to 2a, 2b was obtained as minor product along with chlorosilanes, trichlorosilane, and tetrachlorosilane. The decomposition of 1 was suppressed and the production of 2a improved by adding HCl to 1.
Effect of TSHAC on Human Cytochrome P450 Activity, and Transport Mediated by P-Glycoprotein
( Ye Lim Im ),( Yang Weon Kim ),( Im Sook Song ),( Jeong Min Joo ),( Jung Hoon Shin ),( Zhe Xue Wu ),( Hye Suk Lee ),( Ki Hun Park ),( Kwang Hyeon Liu ) 한국미생물 · 생명공학회 2012 Journal of microbiology and biotechnology Vol.22 No.12
TSAHC [4`-(p-toluenesulfonylamido)-4-hydroxychalcone] is a promising antitumorigenic chalcone compound, especially against TM4SF5 (four-transmembrane L6 family member 5)-mediated hepatocarcinoma. We evaluated the potential of TSAHC to inhibit the catalytic activities of nine cytochrome P450 isoforms and of P-glycoprotein (Pgp). The abilities of TSAHC to inhibit phenacetin Odeethylation (CYP1A2), coumarin 6-hydroxylation (CYP2A6), bupropion hydroxylation (CYP2B6), amodiaquine Ndeethylation (CYP2C8), diclofenac 4-hydroxylation (CYP2C9), omeprazole 5-hydroxylation (CYP2C19), dextromethorphan O-demethylation (CYP2D6), chlorzoxazone 6-hydroxylation (CYP2E1), and midazolam 1`-hydroxylation (CYP3A) were tested using human liver microsomes. The P-gp inhibitory effect of TSAHC was assessed by [3H]digoxin accumulation in the LLCPK1-MDR1 cell system. TSAHC strongly inhibited CYP2C8, CYP2C9, and CYP2C19 isoform activities with Ki values of 0.81, 0.076, and 3.45 ?M, respectively. It also enhanced digoxin accumulation in a dose-dependent manner in the LLCPK1-MDR1 cells. These findings indicate that TSAHC has the potential to inhibit CYP2C isoforms and P-gp activities in vitro. TSAHC might be used as a nonspecific inhibitor of CYP2C isoforms based on its negligible inhibitory effect on other P450 isoforms such as CYP1A2, CYP2A6, CYP2B6, CYP2D6, CYP2E1, and CYP3A.