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A Study on Fire Spread between Office Room and Atrium in the Atrium Building
Lee,Su-Kyung,Kim,Jong-Hoon,Ko,Han-Mog 한국화재소방학회 1997 한국화재소방학회 학술대회 논문집 Vol.1997 No.-
We could analyse the fire behavior using the developed software for fire safety assessment in a large space such as atrium. But Korean building law hasn't admitted the result of fire risk assessment in atrium. In the legislation fire resistant wall or shutter must be required between atrium and office rooms, That has obstructed development of building design and fire protection technique in Korea. From this point of view, we made scenarios of fire spread between atrium and office rooms, and then computed fire spread and fire phenomena using FASTLite and Breakl. In this study, we can decide that fire compartmentalization between atrium and office rooms doesn't require in Atrium building if the material and fire protection system were reliable. Consequently, Korean Fire Protection Regulations have to consider in direction of increasing freedom of building.
The inhibitory effect of honokiol, a natural plant product, on vestibular schwannoma cells.
Lee, Jong Dae,Lee, Jae Yong,Baek, Byoung Joon,Lee, Byung Don,Koh, Yoon Woo,Lee, Won-Sang,Lee, Yu-Jin,Kwon, Byoung-Mog Triological Foundation [etc.] 2012 The Laryngoscope Vol.122 No.1
<P>As the molecular biology of vestibular schwannoma (VS) is better understood, new means of targeting the pathways involved for intervention in schwannoma cells are being developed. Honokiol, a bioactive constituent of Magnolia officinalis, has attracted attention due to its diverse biological effects. This study was conducted to determine the inhibitory effect of honokiol on schwannoma cell proliferation.</P>
Lee, Kiho,Kwon, Byoung-Mog,Kim, Kangjeon,Ryu, Jekyung,Oh, Soo Jin,Lee, Kye Sook,Kwon, Mu-Gil,Park, Song-Kyu,Kang, Jong Soon,Lee, Chang Woo,Kim, Hwan Mook Taylor Francis 2009 Xenobiotica Vol.39 No.3
<P>The pharmacokinetics and metabolism of 2'-benzoyloxycinnamaldehyde (BCA) was characterized in male Sprague-Dawley rats as part of the preclinical evaluations for developing this compound as an antitumour agent. BCA was not detected in the plasma following either intravenous or oral dose, whereas its putative metabolites 2'-hydroxycinnamaldehyde (HCA) and o-coumaric acid were present at considerable levels. In separate pharmacokinetics studies, HCA exhibited a high systemic clearance and a large volume of distribution, whereas both pharmacokinetic parameters were much lower for o-coumaric acid. The terminal half-life of both metabolites was approximately 2 h. BCA was converted rapidly to HCA in rat serum, liver microsomes and cytosol in vitro; HCA was subsequently converted to o-coumaric acid in a quantitative manner only in the liver cytosol. In addition, the formation of o-coumaric acid was inhibited significantly by menadione, a specific inhibitor for aldehyde oxidase. Taken collectively, the results suggest that the rapid systemic clearance of HCA is likely due mainly to hepatic clearance occurring from aldehyde oxidase-catalysed biotransformation to o- coumaric acid. In conclusion, the present work demonstrates that the anticancer drug candidate BCA is highly likely to work as its active metabolite HCA in the body.</P>
The clinical impact of family history of cancer in female never-smoker lung adenocarcinoma
Lee, Youngjoo,Jeon, Jae Hyun,Goh, Sung-Ho,Roh, Hanseong,Yun, Ji-Young,Kwon, Nak-Jung,Choi, Jin Ho,Yang, Hee Chul,Kim, Moon Soo,Lee, Jong Mog,Lee, Geon Kook,Han, Ji-Youn Elsevier 2019 Lung cancer Vol.136 No.-
<P><B>Abstract</B></P> <P><B>Objectives</B></P> <P>Accumulating evidence reveals the association between the risk of never-smoker lung cancer and family history of cancer. However, the clinicogenomic effect of family history of cancer in never-smoker lung cancer remains unknown.</P> <P><B>Material and methods</B></P> <P>We screened 3,241 lung cancer patients who (a) underwent curative resection at National Cancer Center (Goyang, Korea) between 2001–2014, and (b) completed a pre-designed interview about family/smoking history at the time of diagnosis and identified 604 female never smoker lung adenocarcinoma. A positive family history of cancer [categorized as pulmonary cancer (FH-PC) or non-pulmonary cancer (FH-NPC)] was defined as a self-reported history of cancer in first-degree relatives. Survival data were followed up until January 2017. Multiplexed targeted next-generation sequencing was performed for genetic profiling.</P> <P><B>Results</B></P> <P>Of 604 patients, 29.1% (n = 176) had a FH, including 132 (21.9%) with FH-NPC and 44 (7.3%) with FH-PC. Patients with the FH-NPC had a higher proportion of young patients (≤45 years) than those without the FH-NPC (FH-NPC, FH-PC, and no FH; 13.6%, 2.3%, and 8.2%, respectively; <I>P</I> = 0.032). Patients with the FH-NPC had an increased risk of recurrence (hazard ratio [HR]: 1.90; 95% confidence interval [CI]: 1.40–2.56; <I>P<</I>0.001) and death (HR: 1.67; 95% CI: 1.18–2.37; <I>P=</I>0.004). In contrast, the FH-PC had no prognostic effect on recurrence (HR: 1.23; 95% CI: 0.71–2.15; <I>P = 0.456</I>) and death (HR: 0.93; 95% CI: 0.45–1.91; <I>P=</I>0.838). Among three driver oncogene alterations, <I>EGFR</I> mutation was significantly associated with the FH-PC (53.8%, 84.1%, and 65.8%, respectively; <I>P</I> = 0.016), <I>ALK</I>/<I>ROS1</I>/<I>RET</I> fusions was significantly associated with the FH-NPC (13.7%, 0.0%, and 5.0%, respectively; <I>P</I> = 0.004), but <I>KRAS</I> mutation was not associated with any type of the FH (13.8% vs. 6.0% vs. 7.8%, respectively; <I>P</I> = 0.288).</P> <P><B>Conclusion</B></P> <P>The type of family history of cancer was associated with distinct clinocogenomic subtypes and prognosis of never-smoker lung adenocarcinoma.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Family history of cancer is related to distinct subtypes of never smoker lung cancer. </LI> <LI> <I>ALK/ROS1/RET</I> fusions are enriched in patients with family history of nonlung cancer. </LI> <LI> <I>EGFR</I> mutations are enriched in patients with family history of lung cancer. </LI> <LI> Family history of nonlung cancer is associated with poor prognosis after operation. </LI> </UL> </P>
Lee,Won-Chang,Lee,Sang-Mog,Lee,Tae-Jong,Lee,Joong-Bok 건국대학교 동물자원연구센터 1999 動物資源硏究誌 Vol.20 No.-
國內에서 牛型結核 發生의 豫防管理를 위하여 實施되고 있는 튜버클린 檢索과 陽性反應된 젖소를 殺處分하는 方法에 대하여 그 成果를 推移(retrospective study) 하고자 試圖하고, 1965年부터 1997年度 사이의 農林部刊行 統計資料를 收集 醫學統計學的 分析을 한 結果, 젖소의 튜버클린 陽性反應에 의한 牛型結核의 罹患率 每10萬頭當 最低 14.9頭부터 最高 669.3頭에 이르고 있었다. 1973年度부터 HCSM과 PPD 튜버클린 檢索을 竝行한 결과 그 效果가 있어 1990年度까지는 陽性反應率이 순조럽게 減少?형勢를 보였으나, 1997年度부터는 다시 多少 增加되는 傾向을 보이고 있었다. 以上의 結果로 미루어 보아 現在 進行되고 있는 젖소에 대한 튜버클린 檢索과 陽性反應된 젖소의 殺處分法은 酪農先進國의 境遇에서와 같이 繼續進行되어야 할 것으로 본다. This study was aimed at making a retrospective observation of the morbidity rate of bovine tuberculosis with tuberculin reactors through the effects on the expanded program of test and slaughter for eradication and management among dairy cattle in Korea, from 1965 to 1997. The morbidity rate of tuberculin reactors during the period varied from 14.9 to 669.3 per 100,000 dairy population, however, those tended to decreased from 1975 to 1990, but the rate of reactor were trended to increased after 1991. In conclusion, expanded program of test and slaughter reduced the incidence cases and morbidity rates of bovine tuberculosis with tuberculin reactor available for management of dairy cattle in Korea, when the tuberculin of HCSM and PPD together used after 1973. Finally, it is our hope that these information could be use for reference in further study of the field of veterinary public health and preventive medicine.
IgM, Lambda 형 단일클론 감마병증이 동반된 만성 림프구성 백혈병 1 예
이동철,이정호,이영현,이승석,김정란,양창헌,하경임,이상구,윤형진,김종목,김탁관 대한내과학회 1996 대한내과학회지 Vol.50 No.3
It appears that chronic lymphocytic leukemia (CLL) has a world wide distribution, but the incidence of CLL has known to be low in Korea. Hypogammaglobulinemia is common in chronic lymphocytic leukemia, but monoclonal gammopathy is rare. So we present a case of B-cell chronic lymphocytic leukemia associated with monoclonal gammopathy (IgM, λ type). A 60-year-old male patient visited Dongguk University Hospital due to blood-tinged sputum, cough and dyspnea for 3 to 4 weeks. Physical examination revealed inspiratory rales on the right lower lung field, non-tender 5 finger breaths sized splenomegaly and both inguinal lymphadenopathy. Radiologic study showed a single lung abscess accompanied by acute bacterial pneumonia on the right lower lobe. The peripheral blood smear and bone marrow examination presented many mature appearing small sized lymphocytes. The bone marrow biopsy revealed nodular lymphocyte infiltrates. On the immunohistochemical stain, these cells exhibited anti-CD19 phenotype. The lymph node was largely flooded by small monotonous mature lymphocytes. Serum protein electrophoresis and immunoelectrophoresis showed monoclonal gammopathy(lgkl, λtype, 3.7g/dL). The immunophenotyping study of lymphocytes demonstrated CD19 (+), CD20 (+), HLA-DR (+) but CD5 We concluded that this patient's diagnosis is B-cell chronic lymphocytic leukemia with monoclonal gammopathy.
이병찬 ( Lee Byeong Chan ),이재규 ( Lee Jae Gyu ),이강창 ( Lee Gang Chang ),정종길 ( Jeong Jong Gil ),이건목 ( Lee Geon Mog ),신민교 ( Sin Min Gyo ),송호준 ( Song Ho Jun ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.3
N/A Objectives : It is well known that oxidative stress of reactive oxygen species is involved in neuronal disease. The purpose of this study was to examine the cytotoxicity of glucose oxidase(GO) and protective effect of Ramulus et Uncus Uncariae(REUU) on GO- induced cytotoxicity in the cultured cerebral neurons of mouse. Methods : Neurototoxicity of GO and protective effect of REUU were done by MTT assay, after cerebral neurons were cultured in the media containing 1-40 mU/ml CO for 4 hours. Results : GO decreased cell viability in dose-and time-dependent mannner, and REUU increased cell viability decreased by C d induced cytotoxicity in these cultures. Conclusion : From these results. Go showed neurotoxicity, and REUU is very effective in preventing GO-mediated cytotoxicity in cultured mouse cerebral neurons.