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Augmentation by Hypercholesterolemia of Amyloid β Peptide-Induced Learning and Memory Deficit
Yun-Bae Kim,Dongsun Park,Jiyoung Oh,Tae Kyun Kim,Young Jin Cho,Sun Hee Lee,Dae-Kwon Bae,Yun-Hui Yang,Goeun Yang,Seock-Yeon Hwang 충북대학교 동물의학연구소 2009 Journal of Biomedical and Translational Research Vol.10 No.2
The present study was carried out to establish an animal model, displaying long-term learning and memory dysfunction, since single intracerebroventricular (icv) injection of amyloid β peptide (Aβ) causes a short-term memory impairment. Male ICR mice were fed a high-cholesterol diet (HCD) containing 3% cholesterol, 1% corn oil and 0.5% cholic acid, and 1 week later, icv injected with Aβ<sub>1-42</sub> (5 μg/head). Learning/ memory function was assessed via passive avoidance performances 1 day and 2, 4, and 6 weeks after Aβ<sub>1-42</sub> injection, in addition to blood biochemical analyses for lipid profiles and hepatic function. Total cholesterol, lowdensity lipoproteins and hepatic dysfunction parameters markedly increased, while high-density lipoproteins were reduced following HCD feeding. Whereas single injection of Aβ induced temporary memory loss 1 day after administration, exhibiting full recovery after 2 weeks, Aβ treatment in combination with HCD feeding lasted the learning/memory impairment up to 6 weeks. Therefore, it is suggested that hypercholesterolemia augments Aβ-induced memory loss, and that Aβ injection plus HCD feeding could be a long-term memorydeficit model suitable for long-term treatment with drugs or stem cells.
Jiyoung Yun,김경곤,MeeJoo Kang,Hyunsoo Kim,김선회,장진영,김영수 한국생물공학회 2013 Biotechnology and Bioprocess Engineering Vol.18 No.5
Pancreatic ductal adenocarcinoma (PDAC) is the fourth most frequent cause of cancer mortality in the United States. Because CA 19-9 increases not only in PDAC, but also in benign conditions, there is urgent need for an additional PDAC biomarker. Isotope tags for relative and absolute quantification (iTRAQ) were performed using 6 pairs of PDAC and normal tissues from the same patients, to obtain preliminary PDAC-specific proteins; and verification was performed by multiple reactions monitoring (MRM), using 30 PDAC and 20 normal serum, targeting high-abundant serum proteins without any pre-preparation. As a result, 17 candidate proteins from tissue iTRAQ were verified as potential markers (AUC values > 0.7). Multivariate analysis (MA) demonstrated that a 6-marker panel,consisting of alpha-1 antitrypsin, haptoglobin beta chain,hemopexin, transferrin, zinc alpha-2 glycoprotein, and apolipoprotein A4 from the MRM result, had comparable discriminatory power versus CA 19-9. Our study demonstrated that a combination of iTRAQ on PDAC tissue and verification MRM-MA on individual serum was an efficient method for the development of PDAC multimarkers.
Yun, Jiyoung,Jeong, Hyung Hwa,Cho, Jonghan,Kim, Eun Key,Eom, Jin Sup,Han, Hyun Ho Korean Society of Plastic and Reconstructive Surge 2018 Archives of Plastic Surgery Vol.45 No.3
Background Slim patients or those with large breasts may be ineligible for breast reconstruction with an abdominal flap, as the volume of the flap may be insufficient. This study aimed to establish that abdominal tissue-based breast reconstruction can be well suited for Korean patients, despite their thin body habitus. Methods A total of 252 patients who underwent postmastectomy breast reconstruction with an abdominal flap from October 2006 to May 2013 were retrospectively reviewed. The patients' age and body mass index were analyzed, and a correlation analysis was performed between the weight of the mastectomy specimen and that of the initial abdominal flap. Results The average weights of the mastectomy specimen and initial abdominal flap were 451.03 g and 644.95 g, respectively. The ratio of the weight of the mastectomy specimen to that of the initial flap was $0.71{\pm}0.23$. There was a strong positive linear relationship between the weight of the mastectomy specimen and that of the initial flap (Pearson correlation coefficient, 0.728). Thirty nulliparous patients had a final-to-initial flap weight ratio of $0.66{\pm}0.11$. The 25 patients who underwent a contralateral procedure had a ratio of $0.96{\pm}0.30$. The adjusted ratio of the final flap weight to the initial flap weight was $0.66{\pm}0.12$. Conclusions Breast weight had a strong positive relationship with abdominal flap weight in Koreans. Abdominal flaps provided sufficient soft tissue for breast reconstruction in most Korean patients, including nulliparous patients. However, when the mastectomy weight is estimated to be >700 g, a contralateral reduction procedure may be considered.
Jiyoung Yun,Hyung Hwa Jeong,Jonghan Cho,김은기,엄진섭,한현호 대한성형외과학회 2018 Archives of Plastic Surgery Vol.45 No.3
Background Slim patients or those with large breasts may be ineligible for breast reconstruction with an abdominal flap, as the volume of the flap may be insufficient. This study aimed to establish that abdominal tissue–based breast reconstruction can be well suited for Korean patients, despite their thin body habitus. Methods A total of 252 patients who underwent postmastectomy breast reconstruction with an abdominal flap from October 2006 to May 2013 were retrospectively reviewed. The patients’ age and body mass index were analyzed, and a correlation analysis was performed between the weight of the mastectomy specimen and that of the initial abdominal flap. Results The average weights of the mastectomy specimen and initial abdominal flap were 451.03 g and 644.95 g, respectively. The ratio of the weight of the mastectomy specimen to that of the initial flap was 0.71±0.23. There was a strong positive linear relationship between the weight of the mastectomy specimen and that of the initial flap (Pearson correlation coefficient, 0.728). Thirty nulliparous patients had a final-to-initial flap weight ratio of 0.66±0.11. The 25 patients who underwent a contralateral procedure had a ratio of 0.96±0.30. The adjusted ratio of the final flap weight to the initial flap weight was 0.66±0.12. Conclusions Breast weight had a strong positive relationship with abdominal flap weight in Koreans. Abdominal flaps provided sufficient soft tissue for breast reconstruction in most Korean patients, including nulliparous patients. However, when the mastectomy weight is estimated to be >700 g, a contralateral reduction procedure may be considered.
두피에 생긴 광범위한 편평세포암의 수술적 치료로써 유리피판술의 증례
윤지영(Jiyoung Yun),김은기(Eun Key Kim) 대한두개저학회 2013 대한두개저학회지 Vol.8 No.1
Wide excision of extensive sq cc in scalp often requires free flap for adequate coverage. Various flaps can be considered depending on the size of the defect, donor site morbidity, or surgeon preferences etc. Here we report a case of extensive squamous cell carcinoma in scalp initially covered with free LD flap, which eventually required a free VRAM flap with wide skin paddle after severe atrophy of muscle portion probably due to adjuvant radiation. 51 year-old female was diagnosed SCC on three fourths of scalp. After wide excision, LD free flap was performed to cover the defect. After three months later, SCC was reccured on the skull, so artificial bone graft was performed with partial elevation of the previous LD flap. The patient underwent adjuvant radiation and developed a few events of infection afterwards. Infection finally subsided but artificial bone was exposed at thinned LD muscle portion. Finally a free VRAM flap covered the defect. There was no significant complication such as flap necrosis or fat necrosis. The VRAM flap was well maintained throughout the follow-up period. Postoperative radiotherapy could cause severe atrophy of a muscle flap and a thin muscle flap like LD might even develop full thickness defect. In such situation a MC flap with larger skin peddle and small muscle flap such as TRAM or VRAM would be a better option than a MC flap with small skin paddle and thin wide muscle such as LD.