Evaluation of the Efficacy and Safety of DA-9601 versus Its New Formulation, DA-5204, in Patients with Gastritis: Phase III, Randomized, Double-Blind, Non-Inferiority Study

Choi, Yoon Jin,Lee, Dong Ho,Choi, Myung-Gyu,Lee, Sung Joon,Kim, Sung Kook,Song, Geun Am,Rhee, Poong-Lyul,Jung, Hwoon-Yong,Kang, Dae-Hwan,Lee, Yong Chan,Lee, Si Hyung,Choi, Suck Chei,Shim, Ki-Nam,Seol, KOREAN ACADEMY OF MEDICAL SCIENCE 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.11

<P>This study compared the efficacy of DA-9601 (Dong-A ST Co., Seoul, Korea) and its new formulation, DA-5204 (Dong-A ST Co.), for treating erosive gastritis. This phase III, randomized, multicenter, double-blind, non-inferiority trial randomly assigned 434 patients with endoscopically proven gastric mucosal erosions into two groups: DA-9601 3 times daily or DA-5,204 twice daily for 2 weeks. The final analysis included 421 patients (DA-5204, 209; DA-9601, 212). The primary endpoint (rate of effective gastric erosion healing) and secondary endpoints (cure rate of endoscopic erosion and gastrointestinal [GI] symptom relief) were assessed using endoscopy after the treatment. Drug-related adverse events (AEs), including GI symptoms, were also compared. At week 2, gastric healing rates with DA-5204 and DA-9601 were 42.1% (88/209) and 42.5% (90/212), respectively. The difference between the groups was −0.4% (95% confidence interval, −9.8% to 9.1%), which was above the non-inferiority margin of −14%. The cure rate of gastric erosion in both groups was 37.3%. The improvement rates of GI symptoms with DA-5204 and DA-9601 were 40.4% and 40.8%, respectively. There were no statistically significant differences between the two groups in both secondary endpoints. AEs were reported in 18 (8.4%) patients in the DA-5204 group and 19 (8.8%) in the DA-9601 group. Rates of AE were not different between the two groups. No serious AE or adverse drug reaction (ADR) occurred. These results demonstrate the non-inferiority of DA-5204 compared to DA-9601. DA-5204 is as effective as DA-9601 in the treatment of erosive gastritis. Registered randomized clinical trial at ClinicalTrials.gov (NCT02282670)</P>

鼻毛의 白毛發生에 의한 年齡推定

김진국,홍석찬,진정언,박의우,김동욱 大韓法醫學會 1999 대한법의학회지 Vol.23 No.1

The gray vibrissae of Korean males(n= 189) between 15 and 75 years old and females(n=111) between 15 and 74 years old whop visited the department of otorhinolaryngology, Konkuk university Chungju hospital during 1996 to 1998, were counted for the purpose of estimating approximate age range in individuals of unknown age. The lowest age appearing gray hairs in both sexes was 15-year-old. The Pearson's correlation coefficient in both sexes was 0.490 (p<0.01). The age appearing gray vibrissae in females was slightly earlier than that of males, however, the differences between right and left sides of nasal cavity were insignificant. This method of counting gray vibrissae would be useful to estimate age range in personal identification together with other methods available until now.

라인케 부종의 수술 전후 음성분석

김동영,성원진,황찬호,이상준,고태용,전상준,김광현,성명훈 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.9

Spheroid 조합자극치료 적용이 신체구성에 미치는 영향

홍성찬,김영빈,정동혁,박병근,김유성,이성진 원광대학교 체력과학연구소 2008 體力科學硏究 Vol.30 No.1

The present study aims to explore the effects of applying spheroid-combined stimulating therapy on body composition. For this aim. 20 persons were selected as subjects and 10 of them each were assigned to the experimental group and control group, respectively. The experimental group was applied a 12-week combined stimulating therapy and changes in physical constitution of the members were measured before application and 4, 8 and 12 weeks after application. From the study, following conclusions could be drawn: First, body weights of the experimental group decreased from 59.9kgs before application of the spheroid-combined stimulating therapy to 57.2kgs 12 weeks after application, no significant but 4.51% change. Second, body fats of the experimental group changed from 18.8kgs before application to 16.4kgs 12 weeks after application, no significant but 12.77% reduction. Third, % fats of the experimental group decreased from 31.2% before application to 28.6% 12 weeks after application, no significant change but 8.33% reduction. Fourth, body mass index(BMI) of the experimental group decreased from 23.23 kg/㎡ before application of the therapy to 21.43kg/㎡ after application, no significant but 8.03% reduction. As seen above, the 12-week application of the spheroid-combined stimulating therapy produced no significant changes in physical constitution as physical exercise did, but improved physical constitution by reducing certain amount of boy weight, body fat, % fat and BMI. In order to detect more positive and significant changes in physical constitutions, continued studies and clinical experiments should be performed to more diverse subjects using technically reinforced equipment for spheroid-combined stimulating therapy.

공원녹지의 합리적 조성과 개선방안에 관한 연구 : 서울 특별시를 중심으로 A case study of Seoul

김동찬,박율진 경희대학교 부설 식량자원개발연구소 1993 硏究論文集 Vol.14 No.-

In order to present the basic data on the rational prep-plan and the fundamental conception with regards to the city park of Seoul, the improvement plan and fundamental conceptions are herewith presented after examining the present stats and problems of Seoul city's park. 1. For the state of park greens as of the end of 1992, Seoul has 1,348 parks covering 150.4 square kilometers which is equivalent to 13.71 square meters per person who inhabits in the city. 2. For the problems to be solved on the park green, laying the park sites disproportionately to the outskirts, the excessive numbers of non-furnished parks, the shortage of special faculties and so forth are listed. 3. As for the improvement plan regarding the park greens' problems, the fractionalizing of city park classification, the suppression of usage change of natural green spaces, the revision of regulations regarding the securing of city park facilities and sites in the park related regulations, the new installation of management post and park greens, the training and disposition of special manpowers, the activation of local resident participation in the administrative organization of park greens, the preparation of various space facilities, the execution of civil consignment of management, the expansion of park to new city center etc in the park preparation and operations are listed.

공원녹지관리 운영실태 및 의식구조에 관한 연구 : 인사관리측면을 중심으로

박율진,김동찬 경희대학교 지역문제연구부 1996 지역개발연구 Vol.3 No.-

This study is based on the investigation of the actual conditions of management and the comparative analysis of related actions of parks and green spaces in local autonomous entities (six cities). For conducting this research, questionnaires were used. The research findings are summarized as follows and they could be used for improving the quality of management systems of urban parks and green spaces. Meanwhile, this study's findings are in brief as following; in case of employment and promotion, research the new member of forest section during 3 years(1992-1994) in order to Seoul 57 persons(38.4%), Busan 45 and KwangJu 4 persons(2.7%). DaeGu and DaeJeon's employment had equalbalance according to the local. Also, application had an unbalance of the personnel structure about position balance so that's why so many low position worker engagement. In case of educational training and consideration of professional, member's professional improvement required re-education and have to re-set up the curriculum that all self government groups depend on office of forestry except Seoul city. In case of consciousness tendency analysis, member's working desire requirement(4.60), professional worker for the park and green administration requirement(4.60) were showed so high. Efficiency of position management(2.39), Structure discrepancy of personnel management system(2.45), functional worker shortage of parks and green space(2.40) and etc. were showed low. In evaluative model analysis, for the efficiency of managing system, member's work desire, proper educational training, discrepancy of personnel management system discrepancy, professional worker required for the park and green space, working circumstance, personnel evaluation according to task achievement via educational training course relatively.

중년 여성의 운동참여 종목간 신체구성 및 생활습관의 비교

김기진,안동찬,박주식,홍창배 啓明大學校 生活科學硏究所 2005 科學論集 Vol.31 No.-

This study was performed the comparison of body composition and lifestyle following to participating exercise events in middle-aged women. Subjects were divided to five groups by participating exercise events as non-exercise, swimming, running, aerobic dance, weight training. Abdominal circumferences showed a higher values in aerobic dance group and non-exercise group, and thigh circumference showed the highest values in aerobic dance group among groups. But skinfold thickness showed no significant differences among groups. Non-exercise group showed the lowest values of muscular volume amng groups. Lifestyle including general habits, recognition of obesity, and participating of regular exercise showed the difference between exercise and non-eercise groups. A most subjects could not satisfied the individual healthy status and body style, but have been interesting in obesity and healthful life. Although they have been performing a various exercise program for the prevention of obesity, they could not maintain the optimal body composition. Main reasons of these negative problems were suggested the irregular diet habit and negative lifestyle.

스페로이드 조합자극치료 적용 후 만성요통의 통증 감소 효과

홍성찬,김영빈,박병근,김유성,이성진,정동혁 원광대학교 체력과학연구소 2008 體力科學硏究 Vol.30 No.1

The aim of the present study is to evaluate effects of Spheroid 9000NS applied to 10 elderly patients with Chronic Low Back Pain. The effects were measured and analyzed by means of MPQWL, VRS, VAS-I and VAS-U after 4, 8 and 12 weeks, respectively, during the 12-week application of the Spheroid 9000NS. From the findings of the measurement and analysis, following conclusion could be drawn: 1. Significant reductions in MPQWL were confirmed at each period of measurement since the use of Spheroid 9000NS(p<.001). 2. Significant reductions were also revealed in VRS at each period of the measurement(p<.001). 3. Significant reductions were also revealed in VAS-I at each period of the measurement(p<.001). 4. The same reductions were found as well in VAS-U 4, 8 and 12 weeks after the application of the Spheroid 9000NS(p<.001). In sum, it may be concluded from the outcomes that the use of Spheroid 9000NS may help reduce drastically Chronic Low Back Pain, mostly effective to remove them speedily and safely. Patients, rehabilitation therapists and health experts are, therefore, recommended to employ the products as safe and effective means to control pains. Continued researches and experiments should further be conducted to collect more data from the larger population of patients with particular diseases in clinical situation, though.

소요동력 절감을 위한 트랙터용 로타리 커버의 개발

오종진,김기대,이현동,김찬수,김성환,나건영 충남대학교 농업과학연구소 2002 농업과학연구 Vol.29 No.2

본 연구에서는 로타리 경운작업시 흙 부착이 가장 많이 되고 소요동력에 큰 영향을 미치는 로타리 커버 내측에 흙이 부착되는 것을 방지하여 경운 소요동력의 절감에 기여할 수 있는 로타리 커버를 개발하는데 목적이 있으며, 그 구체적인 연구결과는 다음과 같다. 1. 본 연구의 수행을 위하여 트랙터의 로타리 경운소요동력을 측정하고자 트랙터 PTO축과 로타리 동력 입력축을 연결하는 PTO 동력 전달축을 이용하여 로타리 경운 소요동력 측정장치를 설계, 제작하였다. 2. 로타리에 장착한 흙부착 방지장치의 재질로는 스테인리스 스틸, 고무, PE 등을 사용하였다. 흙부착 방지장치 장착 로타리를 이용하여 로타리 경운시험을 통한 경운 소요동력을 측정한 결과 평균 일반 로타리는 52.18ps, 스테인리스 스틸재질 장착 로타리는 52.44ps, 고무재질 장착 로타리는 49.01ps, 그리고 PE재질 장착 로타리는 46.34ps의 소요동력을 나타냈다. 3. 흙부착 방지장치 장착 로타리를 이용하여 로타리 경운시험 후 부착된 흙의 양을 조사한 결과 평균 일반 로타리는 5.6㎏, 스테인리스 스틸재질 장찰 로타리는 5.7㎏, 고무재질 장착 로타리는 3.1㎏, 그리고 PE재질 장착 로타리는 2.7㎏으로 나타났다. 4. 실험결과를 토대로 유의수준 5%의 모평균 차에 의한 검정으로 분석해본 결과 스테인리스 스틸재질의 경우 흙부착 방지효과가 없는 것으로 나타났으며, 고무와 PE재질의 경우에 방지 효과가 있는 것으로 나타났다. 그 중 PE 재질이 소요동력과 흙부착 방지에 각각 11%, 52%의 감소효과가 있어 소요동력 감소 및 흙부착 방지 효과가 탁월한 것으로 나타났다. This study aims at investigating the realities of tractor rotary tilling and paving operations performed by farm families in the central part of the country, measuring the power requirement so as to find the energy-saving factors for tractor rotary tilling, and designing a device to prevent soil adherence to the inside of the rotary cover-this part is the most subject to soil adherence and affects the power requirement. As a result of rotary tilling tests using rotaries equipped with a soil adherence preventer, the power requirement values were measured to be 52.18, 52.44, 49.01 and 46.34 PS for general, stainless steel, rubber and PE rotaries, and as a results of measurement of the quantities of the sod adhered to rotaries after their tilling tests, on the average, the quantities were measured to be 5.6, 5.7, 3.1 and 2.7㎏ for general, stainless steel, rubber and PE rotaries, respectively. The PE rotary cover reduced the power requirement and soil adherence by 11 and 52%, respectively.

BaFBr:Eu²+,Na+ 영상판 제작과 특성

김찬중,김성환,이병화,김완,강희동,김도성,서효진,도시홍 경북대학교 센서기술연구소 2002 센서技術學術大會論文集 Vol.13 No.1