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Jih-Jong Lee,Han-You Lin,Chun-An Chen,Chen-Si Lin,Lih-Chiann Wang 대한수의학회 2019 Journal of Veterinary Science Vol.20 No.1
Canine MDR1 gene mutations produce translated P-glycoprotein, an active drug efflux transporter, resulting in dysfunction or over-expression. The 4-base deletion at exon 4 of MDR1 at nucleotide position 230 (nt230[del4]) in exon 4 makes P-glycoprotein lose function, leading to drug accumulation and toxicity. The G allele of the c.-6-180T>G variation in intron 1 of MDR1 (single nucleotide polymorphism [SNP] 180) causes P-glycoprotein over-expression, making epileptic dogs resistant to phenobarbital treatment. Both of these mutations are reported to be common in collies. This study develops a more efficient method to detect these two mutations simultaneously, and clarifies the genotype association with the side effects of chemotherapy. Genotype distribution in Taiwan was also investigated. An oligonucleotide microarray was successfully developed for the detection of both genotypes and was applied to clinical samples. No 4-base deletion mutant allele was detected in dogs in Taiwan. However, the G allele variation of SNP 180 was spread across all dog breeds, not only in collies. The chemotherapy adverse effect percentages of the SNP 180 T/T, T/G, and G/G genotypes were 16.7%, 6.3%, and 0%, respectively. This study describes an efficient way for MDR1 gene mutation detection, clarifying genotype distribution, and the association with chemotherapy.
( Jih Ye Kim ),( Jae Yong Park ),( Seung Wook Hong ),( Joo Young Lee ),( Jin Woo Kang ),( Jaeyoung Chun ),( Jong Pil Im ),( Joo Sung Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Metronidazole is a widely used antibiotic for the treatment of anaerobic-related infections. The use of metronidazole may cause various manifestations of neurotoxicity including peripheral neuropathy, ataxia, seizure, and encephalopathy. Metronidazole- induced encephalopathy (MIEP) is a rare but potentially reversible disease. In most cases, MIEP occurred after long-term use of metronidazole at high cumulative dose. However, the exact mechanism of MIEP remains unclear and the difference in the neurotoxic effects between oral and intravenous (IV) routes of metronidazole administration has not been determined yet. We report the case of a Crohn`s disease (CD) patient who experienced encephalopathy immediately after IV administration of a single-dose of metronidazole followed long-term exposure to orally administered metronidazole. The 64-year-old man who had undergone right hemicolectomy and small bowel segmental resection for intractable CD presented with sudden onset of altered mental status, aphasia and muscle weakness after IV administration of metronidazole. He had taken metronidazole 250mg orally 3 times a day since 13 years ago. After 8 years of treatment, he stopped taking metronidazole orally because of peripheral neuropathy as a side effect of the drug although he received IV metronidazole on an intermittent schedule for the treatment of acute exacerbations of CD. Six months ago, he restarted oral metronidazole for the treatment of active CD and the cumulative dose of metronidazole was 111.75g. The brain MRI scan showed high intensity signals in bilateral medial thalamus, midbrain and tegmentum of pons on T2-weighted images. After 7 days of thiamine replacement therapy with discontinuation of metronidazole, he showed an improvement in the level of consciousness and the abnormal fi ndings of the brain MRI scans resolved partially. However, the typical clinical signs of frontal lobe dysfunctions including executive dysfunction and abulia remained 2 months after the onset of encephalopathy.
최근 12년간 피부과를 방문한 조갑백선 환자의 치료 결과 분석을 통한 실제 임상에서 항진균제의 효과 및 환자의 순응도 조사
이지민 ( Jih Min Lee ),신동훈 ( Dong Hoon Shin ),최종수 ( Jong Soo Choi ),김기홍 ( Ki Hong Kim ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.5
Background: We have little information about long-term treatment results of tinea unguium based on the treatment methods and oral antifungal agents used in dermatology. Objective : The purpose of this study was to assess the confirmed effectiveness and side effects of antifungal agents and to investigate the ratio of patients who completely finished the course of treatment in the practical area, not in the experimental studies. Methods : The medical records of 684 patients diagnosed with tinea unguium from January 1985 to December 1996 in Yeungnam l.Jniversity Hospital were analysed for the results. Results : The number of patients who were diagnosed with tinea unguium during this period was 684. In this study, we segregafed the patients whose outcome could be confirmed and calculated the percentage of completely treated and improved cases according to the antifungal agents used (griseofulvin-7.0%, ketoconazole-8.2%, itraconazole-9.0%, terbinafine-13.7%). We also calculated the percentage of patients who had completely finished the course of treatment (griseofulvin-6.8%, ketoconazole-7.4%, itraconazole-32.S%, terbinafine-31.8%). Among the patients whose results were unknown, more than half of patients(51.7%) had discontinued treatment within 3 weeks. The frequency of side effects of griseofulvin was 5.27a, ketoconazole 11.1%, itraconazole 6.7%, and terbinafine 6.1%. Conclusion : The treatment results of tinea unguium in clinical fields are different from results of previously reported studies. The percentages of completely treated and improved cases and those of patients who had completely finished the course of treatment are much lower than the results of previous experimental studies. Jt may be due to low compliance of patients and the long-term treatment course required. To increase the patients compliance and improve the results of treatment, we should explain to the patients about the disease course and duration of the treatment. (Korean J Dermatol 1998;36(5) . 772-779)
Moonhyun Lee,Jong-Woo Kim,Jih-Sheng Lai 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
This paper presents small-signal modeling of three-level boost (TLB) converter for active front-end power-factor-correction in medium-voltage (MV) solid state transformer (SST). The analysis has been conducted for continuous conduction mode (CCM) in two different voltage modes of TLB to derive system dynamics and to confirm that transfer functions in the voltage modes are identical to one another. Based on the derived models, this paper introduces MV-SST system design guidelines including controller and input filter, considering limited selection width of off-the-shelf high-voltage-rating capacitors and nontrivial source impedances. Digital feedback controller and input filters are designed based on the derivations and implemented to a 4-module-stacked SST system prototype of which TLB plays a role of active front-end PFC. In order to verify the effectiveness of small-signal analysis and system design, experimental verifications of the prototype have been conducted for single phase 3.8-kVrms input voltage to 400-V dc bus voltage conversion and 15-kW full load condition in the existence of 65-mH source impedance.
Elevated plasma YKL-40 level is found in the dogs with cancer and is related to poor prognosis
Kai-Chung Cheng,Jih-Jong Lee,Shang-Lin Wang,Chun-Yu Lin,Ching-Tien Tseng,Chen-Si Lin,Albert Taiching Liao 대한수의학회 2019 Journal of Veterinary Science Vol.20 No.5
YKL-40, a secreted glycoprotein, may serve as an autoantigen, which mediates multipleinflammatory diseases and cancers. A high YKL-40 serum level is correlated with metastasisand poor survival in a variety of human cancers. However, the role of YKL-40 in dogs is stillunder evaluation. Herein, we examined the associations between plasma YKL-40 level andYKL-40 autoantibody (YAA) titers with malignancy and prognosis in canine cancer. Plasmalevels of YKL-40 in healthy dogs (n = 20) and in dogs (n = 82) with cancer were evaluatedusing enzyme-linked immunosorbent assay. Our results indicated that plasma YKL-40 levelswere significantly higher (p < 0.01) in dogs with cancer than in healthy dogs. A significantdecrease in the YAA titers was detected in the dogs with cancer when compared with thoseof the healthy dogs (p < 0.05), although the change was not correlated with the YKL-40levels. Among the dogs with cancer, plasma YKL-40 levels in the dogs that later relapsed orhad metastasis were significantly higher than in the dogs with no signs of relapse (p < 0.01)or metastasis (p <0.05). The relapse and metastasis rates were significantly higher in thehigh YKL-40 group (> 180 pg/mL) than in the low YKL-40 group (< 180 pg/mL). The resultsimply that plasma YKL-40 levels might have the potential to be developed as a marker ofmalignancy progression and prognosis in canine cancers.
Wen-Ting Ting,Ru-Wen Chang,Chih-Hsien Wang,Yih-Sharng Chen,Jih-Jong Lee 대한수의학회 2020 Journal of Veterinary Science Vol.21 No.1
Currently, the optimal resuscitation fluid remains debatable. Therefore, in the present study, we designed a trometamol-balanced solution (TBS) for use as a resuscitation fluid for hemorrhagic shock. Hemorrhagic shock was induced in 18 male Wistar-Kyoto rats, which were assigned to normal saline (NS), Ringer's solution (RS), and TBS groups. During the hemorrhagic state, their hemodynamic parameters were recorded using an Abbott i-STAT analyzer with the CG4+ cartridge (for pH, pressure of carbon dioxide, pressure of oxygen, total carbon dioxide, bicarbonate, base excess, oxygen saturation, and lactate), the CG6+ cartridge (for sodium, potassium, chloride, blood glucose, blood urea nitrogen, hematocrit, and hemoglobin), and enzyme-linked immunosorbent assay kits (calcium, magnesium, creatinine, aspartate aminotransferase, alanine aminotransferase, bilirubin, and albumin). Similar trends were found for the parameters of biochemistries, electrolytes, and blood gas, and they revealed no significant changes after blood withdrawal-induced hemorrhagic shock. However, the TBS group showed more effective ability to correct metabolic acidosis than the NS and RS groups. TBS was a feasible and safe resuscitation solution in this study and may be an alternative to NS and RS for resuscitation in hemorrhagic shock patients without liver damage.