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피부사상균 이외의 진균이 배양된 손발톱진균증의 KONCPA 소견
강봉선,박현정,이준영,조백기 대한의진균학회 2008 대한의진균학회지 Vol.13 No.1
Background: When Candida species and molds (non-dermatophytic filamentous fungi) are cultured from the onychomycotic nail samples, it is sometimes difficult to consider whether they are the causative fungi or not. Although repeated culture is the most effective method to solve the problem, it is time-consuming and not cost-effective. But KONCPA (KOH + Nail clipping + PAS stain) is an inexpensive, quick, sensitive and very useful supportive test for considering whether the cultured non-dermatophytic fungi are real causative fungi or not. Objectives: This study was aimed to know whether KONCPA test would increase the diagnostic sensitivity of onychomycosis and whether KONCPA findings would be of help to diagnose the accurate causative fungi in case where the Candida species and molds were cultured. Methods: Nail samples were obtained from 213 patients with onychomycosis for fungus culture and KONCPA test. And the KONCPA findings were reviewd for the onychomycotic nail samples where the non-dermatophytic fugi such as Candida species and molds were cultured. Results: The results of this study were summarized as follows: 1. From 93 onychomycotic nail samples, dermatophytes were cultured in 24 (11.3%), Candida spp. in 36 (16.9%), and molds in 33 samples (15.5%). 2. Of the 36 samples where the Candida spp. were cultured, 24 (66.7%) showed findings of dermatophytes, 2 (5.6%) of Candida spp. and remaining 10 (27.7%) samples were inadequate for diagnosis. 3. Of 33 samples where the molds were cultured, 30 (90.9%) showed findings of dermatophytes, 1 (3.0%) of molds and remaining 2 (6.1%) samples were inadequate for diagnosis. Conclusions: Among 93 onychomycotic nail samples where the non-dermatopytic fungi were cultured, only 3 samples were compatible with KONCPA findings. Therefore, in cases where Candida spp. and molds were cultured and the KONCPA findings were not compatible with the cultured fungi, the cultured fungi should not be considered as the definite causative fungi until other material evidence was obtained. Background: When Candida species and molds (non-dermatophytic filamentous fungi) are cultured from the onychomycotic nail samples, it is sometimes difficult to consider whether they are the causative fungi or not. Although repeated culture is the most effective method to solve the problem, it is time-consuming and not cost-effective. But KONCPA (KOH + Nail clipping + PAS stain) is an inexpensive, quick, sensitive and very useful supportive test for considering whether the cultured non-dermatophytic fungi are real causative fungi or not. Objectives: This study was aimed to know whether KONCPA test would increase the diagnostic sensitivity of onychomycosis and whether KONCPA findings would be of help to diagnose the accurate causative fungi in case where the Candida species and molds were cultured. Methods: Nail samples were obtained from 213 patients with onychomycosis for fungus culture and KONCPA test. And the KONCPA findings were reviewd for the onychomycotic nail samples where the non-dermatophytic fugi such as Candida species and molds were cultured. Results: The results of this study were summarized as follows: 1. From 93 onychomycotic nail samples, dermatophytes were cultured in 24 (11.3%), Candida spp. in 36 (16.9%), and molds in 33 samples (15.5%). 2. Of the 36 samples where the Candida spp. were cultured, 24 (66.7%) showed findings of dermatophytes, 2 (5.6%) of Candida spp. and remaining 10 (27.7%) samples were inadequate for diagnosis. 3. Of 33 samples where the molds were cultured, 30 (90.9%) showed findings of dermatophytes, 1 (3.0%) of molds and remaining 2 (6.1%) samples were inadequate for diagnosis. Conclusions: Among 93 onychomycotic nail samples where the non-dermatopytic fungi were cultured, only 3 samples were compatible with KONCPA findings. Therefore, in cases where Candida spp. and molds were cultured and the KONCPA findings were not compatible with the cultured fungi, the cultured fungi should not be considered as the definite causative fungi until other material evidence was obtained.
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Heat shock protein 70 alters the endosome-lysosomallocalization of huntingtin
강봉선,안진영,김민기,김현정,강라미,임헌창,박경숙,이재선,서정선,차중익,김승업,박유정,김만호 생화학분자생물학회 2007 Experimental and molecular medicine Vol.39 No.1
Huntingtons disease is caused by CAG trinucleotide expansions in the gene encoding huntingtin. N- terminal fragments of huntingtin with polyglu-tamine produce aggregates in the endosome-ly-sosomal system, where proteolytic fragments of huntingtin is generated. Heat shock protein 70 (HSP70) prevents the formation of protein aggre-gates, but the effect of HSP70 on the huntingtin in the endosome-lysosomal system is unknown. This study was to determine whether HSP70 alters the distribution of huntingtin in endosome-lysosomal system. HSP70 expressing stable cells (NIH/3T3 or cerebral hybrid cell line A1) were generated, and mutant [(CAG)100] huntingtin was transiently over-expressed. Analysis of subcellular distribution by immnuocytochemistry or proteolysis cleavage by Western blotting was performed. 18 CAG repeat wild type [WT; (CAG)18] huntingtin was used as a control. Cells with huntingtin showed paterns of endosome- lysosomal accumulation, from a dispersed vacuole (DV) type into a coalescent perinuclear vacuole (PV) type over time. In WT huntingtin, HSP70 increased the cells with the PV types that enhanced the proteolytic cleavage of huntingtin. However, HSP70 reduced cells of the DV and PV types expressing mutant ess proteolysis than that of control. In addition, intranuclear inclusions were formed only in mutant cells, which was no t affected by HSP70. These results suggest that HSP70 alters the distribution of huntingtin in the endosome- lysosomal system, and that this contributes to huntingtin proteolysis.
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강봉선,이만홍,이후경,이호영,김경희,노경선 中央醫學社 1987 中央醫學 Vol.52 No.12
This study was done for the purpose of identifying symptoms with discriminating power in the diagnosis of childhood depression by DSM-III criteria. The data were obtained from 155 primary school age children and their parents through interviews with the depres-sion section of the Diagnostic Interview Schedule for Children (DISC) and the Diagnostic Interview Schedule for Parents (DISP), which were developed by A. Costello (1984) with the collaboration of NIMH. The author analyzed the data by discriminant analysis and discussed the results that revealed as follows; 1. The most powerful discriminant variable was loss of interest in all cases regardless to the differences of information source (DISC or DISP) and school age group (lower or higher grade). 2. As other depressive symptoms that have discriminate power between normal and depressive disorder, irritability, decreased attention, and social withdrawal in lower grade DISC group; psychomotor agitation, loss of energy, and worthlessness in higher grade-DISC group; psychomotor agitation, conduct problem, aggressive behavior, loss of energy, decreas-ed attention, loss of appetite, somatic symptom, no pleasure to reward in lower grade-DISP group; and finally change in school work, separation, suicide, social withdrawal, under-achievement, irritability, crying, and phobia in higher grade - DISP group, were identified.
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일 정신과 병실내의 공동사회 모임 : 3년간의 경험에 대한 분석 An Analysis of Three-Year Experience.
이만홍,신동범,이영주,강봉선 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.2
The community meeting is an essential program to practice, enculturate, and educate the egalitarianism of the milieu, so it is usually called the keystone of the therapeutic community. We organized and have been operating a community meeting for three years in a 30-bed psychiatric inpatient ward of a university hospital which is a modified therapeutic community with patients of mixed diagnostic entities. Based on the analysis of verbatim scripts of 143 sessions for last three years, we have illustrated a modified format as a model and reviewed it's vissisitudes and some problematic areas of our experience such as the therapist's role, topic distribution, resolution of crisis and conflict, and several specific dynamic features of the large group. We also discussed some issues occurring in our community meeting which are summarized as follows; 1. The format of a community meeting can be varied according to ward policy, patient population, goals, and especially leadership pattern. In this respect, our format is a structured one directed by patients and passively supported by nurses. 2. The community meeting has two therapeutic aspects according to the type of topic: system maintaining and large group psychodynamics. These two aspects should be disitrbuted in adequate proportion for successful session. 3. The most stressful therapeutic impact on the community meeting usually occurs through the revelation of conflict and crisis and their resolution. Continuous efforts to understand count ertransferential reactions and to gain introspect into the therapists' own feelings are of prime necessity. 4. The community meeting as large group the rapy has several important dynamics that can be neglected in small group therapy and we should understand them fully to utilize them: role functioning, the anxiety of being isolated and anonymous, the mechanism of splitting, and the feeling of pseudoegalitarianism.
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김윤신,이종대,강봉선 漢陽大學校 環境 및 産業醫學硏究所 1997 環境과 産業醫學 Vol.6 No.1
본 보고서는 일부 병원에서의 미생물성 물질의 오염 상태와 오존 Gas 및 오존수의 미생물에 대한 제거효율의 기초자료를 제시함으로서 병원감염의 원인이 되는 미생물의 분포를 정확히 파악하고, 그 원인 제거를 위한 공기 청정 방법의 하나로 대두되는 오존장치의 효율성을 검토하여 병원이라는 특수환경내에서의 오염 방지를 통하여 궁극적으로는 국민 건강 향상과 환경 기술의 개발에 이바지하는 기초 자료를 제공하고자 한다.
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이만홍,강봉선 大韓神經精神醫學會 1984 신경정신의학 Vol.23 No.4
The authors organized and has been operating a mixed therapeutic mileu in an university hospital since 1981, which is structurally modified one and is including heterogenous patient subgroups of various diagnostic entities. Based on this experience, the authors has been performing a series of treatment outcome study of this modified therapeutic community. This paper is a trial to identify the possible presence of contraindication of our MIXed therapeutic milieu. From out clinical experience, we suspected 3 patient subgroups as the possible contraindication; Organic Brain Syndromes(OBS), Posttraumatic neurosis(PTN) and Antisocial Personality Disorders(APD). 42 consecutive patients of these 3 subgroups admitted to out mixed milieu during 2 year period(Sept. 1, 1981 to Aug. 31, 1983) were evaluated for their outcome by measuring discharge rate of signing out against medical advice(AMA %), drop-out rate of follow-up treatment(Drop-out %), and the Psychiatric Inpatient Assessment Scale (PIAS) which was developed by the authors, and they were compared with the outcome of 131 patients of control group which was presented in our previous reports. We also examined their antitherapeutic effects to other patients or to the mixed therapeutic milieu per se. The results showed that: 1. Organic brain syndrome patients could be considered as one of the identified contraindication to our mixed therapeutic milieu in terms of significantly low outcome of their own. 2. Though the outcomes of post-traumatic neuroses and antisocial personality disorders were not significantly lower than that of the control group, they could be also considered as one of the contraindications to our therapeutic milieu in terms of their antitherapeutic nature to other patients and therapeutic community per se. 3. It was suggested by the authors that antisocial personality disorder patients may be much more beneficially indicated to HOMOGENOUS therapeutic community rather than mixed therapeutic milieu.
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