Prediction of Pharmacokinetics and Penetration of Moxifloxacin in Human with Intra-Abdominal Infection Based on Extrapolated PBPK Model

Zhu, LiQin,Yang, JianWei,Zhang, Yuan,Wang, YongMing,Zhang, JianLei,Zhao, YuanYuan,Dong, WeiLin The Korean Society of Pharmacology 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.2

The aim of this study is to develop a physiologically based pharmacokinetic (PBPK) model in intra-abdominal infected rats, and extrapolate it to human to predict moxifloxacin pharmacokinetics profiles in various tissues in intra-abdominal infected human. 12 male rats with intra- abdominal infections, induced by Escherichia coli, received a single dose of 40 mg/kg body weight of moxifloxacin. Blood plasma was collected at 5, 10, 20, 30, 60, 120, 240, 480, 1440 min after drug injection. A PBPK model was developed in rats and extrapolated to human using GastroPlus software. The predictions were assessed by comparing predictions and observations. In the plasma concentration versus time profile of moxifloxcinin rats, $C_{max}$ was $11.151{\mu}g/mL$ at 5 min after the intravenous injection and $t_{1/2}$ was 2.936 h. Plasma concentration and kinetics in human were predicted and compared with observed datas. Moxifloxacin penetrated and accumulated with high concentrations in redmarrow, lung, skin, heart, liver, kidney, spleen, muscle tissues in human with intra-abdominal infection. The predicted tissue to plasma concentration ratios in abdominal viscera were between 1.1 and 2.2. When rat plasma concentrations were known, extrapolation of a PBPK model was a method to predict drug pharmacokinetics and penetration in human. Moxifloxacin has a good penetration into liver, kidney, spleen, as well as other tissues in intra-abdominal infected human. Close monitoring are necessary when using moxifloxacin due to its high concentration distribution. This pathological model extrapolation may provide reference to the PK/PD study of antibacterial agents.

The actuation equation of macro-fiber composite coupled plate and its active control over the vibration of plate and shell

Tu, Jianwei,Zhang, Jiarui,Zhu, Qianying,Liu, Fan,Luo, Wei Techno-Press 2018 Structural monitoring and maintenance Vol.5 No.2

Plate and shell structure is widely applied in engineering, i.e. building roofs, aircraft wings, ship platforms, and satellite solar arrays. Its vibration problem has become increasingly prominent due to the tendency of lightening, upsizing and flexibility. As a new smart material with great actuating force and toughness, macro-fiber composite (MFC) is composed of piezoelectric fiber and epoxy resin basal body, which can be directly pasted onto the surface of plate and shell and is suitable for vibration control. This paper deduces the actuation equation of MFC coupled plate in different boundary conditions, an equivalent finite element modeling method is proposed which uses MFC actuating force as the applied excitation, and on this basis the active control simulation and experiment of MFC over plate and shell structure vibration are accomplished. The results indicate that MFC is able to implement effective control over plate and shell structure vibration in multi-band range. The comparison between experiment and simulation proves that the actuation equation deduced herein, effective and practicable, can be applied into the simulation calculation of MFC vibration control over plate and shell structure.

Prediction of Pharmacokinetics and Penetration of Moxifloxacin in Human with Intra-Abdominal Infection Based on Extrapolated PBPK Model

LiQin Zhu,JianWei Yang,Yuan Zhang,YongMing Wang,JianLei Zhang,YuanYuan Zhao,WeiLin Dong 대한약리학회 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.2

The aim of this study is to develop a physiologically based pharmacokinetic (PBPK) model in intraabdominalinfected rats, and extrapolate it to human to predict moxifloxacin pharmacokinetics profilesin various tissues in intra-abdominal infected human. 12 male rats with intra- abdominal infections,induced by Escherichia coli, received a single dose of 40 mg/kg body weight of moxifloxacin. Bloodplasma was collected at 5, 10, 20, 30, 60, 120, 240, 480, 1440 min after drug injection. A PBPK modelwas developed in rats and extrapolated to human using GastroPlus software. The predictions wereassessed by comparing predictions and observations. In the plasma concentration versus time profileof moxifloxcinin rats, Cmax was 11.151 μg/mL at 5 min after the intravenous injection and t1/2 was2.936 h. Plasma concentration and kinetics in human were predicted and compared with observed datas. Moxifloxacin penetrated and accumulated with high concentrations in redmarrow, lung, skin, heart,liver, kidney, spleen, muscle tissues in human with intra-abdominal infection. The predicted tissue toplasma concentration ratios in abdominal viscera were between 1.1 and 2.2. When rat plasma concentrationswere known, extrapolation of a PBPK model was a method to predict drug pharmacokineticsand penetration in human. Moxifloxacin has a good penetration into liver, kidney, spleen, as well asother tissues in intra-abdominal infected human. Close monitoring are necessary when using moxifloxacindue to its high concentration distribution. This pathological model extrapolation may provide referenceto the PK/PD study of antibacterial agents.

Neural Network-based Event-triggered Adaptive Asymptotic Tracking Control for Switched Nonlinear Systems

Chenglong Zhu,Baomin Li,Jianwei Xia,Na Zhang,Rui Liu 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.6

In this paper, an adaptive event-triggered asymptotic tracking control problem is addressed for switched nonlinear systems with unknown control directions. In existing control schemes, the proposed controller is not directly aimed at the original system, which affects the control performance. Different from the existing control schemes, based on the original system, an event-triggered control law is constructed in this paper. The proposed event-triggered controller guarantees that the tracking error ς1 asymptotically converges to the origin. Finally, the effectiveness of the proposed controller design scheme is proved by simulation examples.

Migration and Energy Aware Network Traffic Prediction Method Based on LSTM in NFV Environment

Ying Hu,Liang Zhu,Jianwei Zhang,Zengyu Cai,Jihui Han 한국인터넷정보학회 2023 KSII Transactions on Internet and Information Syst Vol.17 No.3

The network function virtualization (NFV) uses virtualization technology to separate software from hardware. One of the most important challenges of NFV is the resource management of virtual network functions (VNFs). According to the dynamic nature of NFV, the resource allocation of VNFs must be changed to adapt to the variations of incoming network traffic. However, the significant delay may be happened because of the reallocation of resources. In order to balance the performance between delay and quality of service, this paper firstly made a compromise between VNF migration and energy consumption. Then, the long short-term memory (LSTM) was utilized to forecast network traffic. Also, the asymmetric loss function for LSTM (LO-LSTM) was proposed to increase the predicted value to a certain extent. Finally, an experiment was conducted to evaluate the performance of LO-LSTM. The results demonstrated that the proposed LO-LSTM can not only reduce migration times, but also make the energy consumption increment within an acceptable range.

Dynamic scaling hysteresis behavior and field-induced domain transition of 0.16PIN-0.62PMN-0.22 PT single crystals

Deng Tingyu,Fang Bijun,Zhu Rongfeng,Chen Jianwei,Luo Haosu 한국물리학회 2021 Current Applied Physics Vol.21 No.-

Due to the good dielectric, piezoelectric and ferroelectric properties, the pseudo-ternary ferroelectric single crystals Pb(In1/2Nb1/2)O3-Pb(Mg1/3Nb2/3)O3-PbTiO3 (PIN-PMN-PT) have been widely concerned and studied. In this study we found that the dynamic hysteresis loop area <A> with electric field E0 and frequency f0 of the 0.16 Pb(In1/2Nb1/2)O3-0.62 Pb(Mg1/3Nb2/3)O3-0.22PbTiO3 (0.16PIN-0.62PMN-0.22 PT) single crystals satisfies the relational equation <A> ∝ E0β f0α . In the <A> ∝ E0β relationship, both linear stages are found correlated with the low electric field in the first stage E0<Ec and the high electric field in the third stage E0 > 3Ec. The hysteresis loop area <A> with frequency f0 relationship satisfies the equation <A> ∝ f0α with roughly linear trend and the hysteresis loop area <A> decreases with increasing frequency f0. Such electric field dependent dynamic hysteresis scaling can be observed by polarized light microscopy.

Hexadecylamine Modified Copper Nanowire Coated Superhydrophobic Cotton Fabric for Antifouling, Oil-water Separation, and Infrared Reflection Applications

Jiaojiao Zheng,Hong Zhang,Tianyu Cao,Yuanyuan Zhu,Lizhong He,Jianwei Li,Xudong Chen,Yinhu Qu 한국섬유공학회 2022 Fibers and polymers Vol.23 No.10

Superhydrophobic surfaces by creating surface roughness followed by coating with low-surface-energyfluorinated materials have been intensively developed on cotton fabrics. However, exploring superhydrophobic surfaces withnon-fluorine components and further improving their attachment with cotton fabrics is still challenging. Herein, wedeveloped a superhydrophobic surface on cotton fabric by dip coating with hexadecylamine (HDA) modified coppernanowires (Cu NWs) based on the coordination between Cu atoms and amine groups. The HDA modified Cu NWs not onlycreated surface roughness, but also decreased the surface energy, leading to a superhydrophobic cotton fabric with watercontact angle of 164 °±2.0 °. Furthermore, ultrasonic washing and tape peeling tests exhibited the Cu NWs were adheredtightly to the surface of cotton fibers, owing to the strong hydrogen bond between amine groups on HDA molecules andhydroxyl groups on cotton fibers. In addition, the superhydrophobic cotton fabric showed excellent antifouling, oil-waterseparation and infrared reflection properties. It is believed that this facile method provide promising industrial applicationsfor fabricating superhydrophobic surfaces on other substrates.

Effects of a chitosan nanoparticles encapsulation on the properties of litchi polyphenols

Xingan Cheng,Qiwen Zou,Hanhui Zhang,Jianwei Zhu,Murtaza Hasan,Fangyun Dong,Xin Liu,Junjie Li,Yuehua Wu,Xiaojing Lv,Keqiang Wang,Xiangling Deng,Zhanmei Liu,Xuhong Jiang 한국식품과학회 2023 Food Science and Biotechnology Vol.32 No.13

Litchi polyphenols have very specific biological activities. Nevertheless, the low and inconsistent oral bioavailability and instability hinder the further application of litchi polyphenols in food systems. This work prepared litchi polyphenols loaded chitosan nanoparticles (LP-CSNPs) by ionic gelation method to enhance the encapsulation on the properties of litchi polyphenols. The optimum conditions of formation via single factors and the Box–Behnken design were chitosan (CS) concentration 1.065 mg/mL, sodium tripolyphosphate (TPP) concentration 0.975 mg/mL, and the mass ratios of polyphenols and CS 1:1 with encapsulation efficiency (EE%) of 45.53%. LP-CSNPs presented the nanosized range of particle size (mean 170 nm), excellent polydispersity index (PDI) (0.156 ± 0.025), and zeta potential values (+ 35.44 ± 0.59). The in vitro release in simulated gastric fluid (pH 1.2) and intestinal fluid (pH 6.8) during 100 h was 58.34% and 81.68%, respectively. LP-CSNPs could effectively improve the storage stability and had great antibacterial activity compared with unencapsulated litchi polyphenols.

Texture Analysis of Three-Dimensional MRI Images May Differentiate Borderline and Malignant Epithelial Ovarian Tumors

Ye Rongping,Weng Shuping,Li Yueming,Yan Chuan,Chen Jianwei,Zhu Yuemin,Wen Liting 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.1

Objective: To explore the value of magnetic resonance imaging (MRI)-based whole tumor texture analysis in differentiating borderline epithelial ovarian tumors (BEOTs) from FIGO stage I/II malignant epithelial ovarian tumors (MEOTs). Materials and Methods: A total of 88 patients with histopathologically confirmed ovarian epithelial tumors after surgical resection, including 30 BEOT and 58 MEOT patients, were divided into a training group (n = 62) and a test group (n = 26). The clinical and conventional MRI features were retrospectively reviewed. The texture features of tumors, based on T2- weighted imaging, diffusion-weighted imaging, and contrast-enhanced T1-weighted imaging, were extracted using MaZda software and the three top weighted texture features were selected by using the Random Forest algorithm. A non-texture logistic regression model in the training group was built to include those clinical and conventional MRI variables with p value < 0.10. Subsequently, a combined model integrating non-texture information and texture features was built for the training group. The model, evaluated using patients in the training group, was then applied to patients in the test group. Finally, receiver operating characteristic (ROC) curves were used to assess the diagnostic performance of the models. Results: The combined model showed superior performance in categorizing BEOTs and MEOTs (sensitivity, 92.5%; specificity, 86.4%; accuracy, 90.3%; area under the ROC curve [AUC], 0.962) than the non-texture model (sensitivity, 78.3%; specificity, 84.6%; accuracy, 82.3%; AUC, 0.818). The AUCs were statistically different (p value = 0.038). In the test group, the AUCs, sensitivity, specificity, and accuracy were 0.840, 73.3%, 90.1%, and 80.8% when the non-texture model was used and 0.896, 75.0%, 94.0%, and 88.5% when the combined model was used. Conclusion: MRI-based texture features combined with clinical and conventional MRI features may assist in differentitating between BEOT and FIGO stage I/II MEOT patients.

Clinicopathological Significance of Expression of Tspan-1, Jab1 and p27 in Human Hepatocellular Carcinoma

Li Chen,Daiyue Yuan,Gui-lan Wang,You Wang,Yuan-Yuan Wu,Jianwei Zhu 대한의학회 2010 Journal of Korean medical science Vol.25 No.10

The aim of this study was to investigate the expression of Tspan-1, Jab1 and p27 in human hepatocellular carcinoma (HCC) and their clinicopathological significance. The expression of Tspan-1, Jab1 and p27 was detected in HCC tissues, the tissues around cancer (76 cases),and the normal tissues around the liver hemangiomas (10 cases). The overexpression of Tspan-1 and Jab1 was found in HCC tissues, positively correlated with clinical stage and negatively correlated with survival rate. The expression of p27 was found inversely linked to which of Tspan-1 and Jab1. In conclusion, the expression of Tspan-1, Jab1 and p27 is significantly associated with development of HCC. Overexpression of Tspan-1 and Jab1suggests poor prognosis but overexpression of p27 may expect good prognosis for patients with HCC.