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Han Ying-Hao,Mao Ying-Ying,Yu Nan-Nan,Jin Mei-Hua,Jin Ying-Hua,Wang Ai-Guo,Zhang Yong-Qing,Shen Gui-Nan,Cui Yu-Dong,Yu Li-Yun,Lee Dong-Seok,Jo Yu-Jin,Sun Hu-Nan,Kwon Jeongwoo,권태호 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.3
In this study, we used RNA sequencing (RNA-seq) to analyze and compare bulk cell samples from wild-type (WT) dermal mesenchymal stem cells (DMSCs) (n = 3) and Prx II knockout DMSCs (n = 3). The purpose of the study was to elucidate the role of Prx II on allogeneic immune rejection of transplanted DMSCs. The results revealed differential expression of 472 genes (176 up-regulated and 296 down-regulated; p ≤ 0.05) between the PrxII+/+ (WT) and PrxII−/− sample groups. When highly regulated genes were categorized according to the Gene Ontology (GO) molecular function classification and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, the PrxII−/− samples showed a robust downward trend in allograft rejection. The study identified 43 all immunologically rejected differentially expressed genes, of which 41 showed lower expression in the PrxII−/− vs. PrxII+/+ (WT) samples. These findings suggest that Prx II gene knockout may down-regulate the allograft rejection that occurs during DMSCs transplantation and improve the survival rate of DMSCs in the host. This study provides a new perspective on the clinical treatment of stem cell transplantation.
Han Ying-Hao,Chen Dong-Qin,Jin Mei-Hua,Jin Ying-Hua,Li Jing,Shen Gui-Nan,Li Wei-Long,Gong Yi-Xi,Mao Ying-Ying,Xie Dan-Ping,Lee Dong-Seok,Yu Li-Yun,Kim Sun-Uk,김지수,권태호,Cui Yu-Dong,Sun Hu-Nan 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.3
Severe inflammatory reactions caused by macrophage activation can trigger a systemic immune response. In the present study, we observed the anti-inflammatory properties of hispidin on LPS induced RAW264.7 macrophage cells. Our results showed that hispidin treatment significantly reduced the production of cellular NO, IL-6 and reactive oxygen species (ROS) while has not inhibitory effect on TNF-α productions. Excitingly, hispidin treatment retains the phagocytosis ability of macrophages which enabling them to perform the function of removing foreign invaders. Signaling studies showed, hispidin treatment dramatic suppressed the LPS induced mitogen activated protein kinases (MAPK) and JAK/STAT activations. In conclusion, our findings suggest that hispidin may be a new therapeutic target for clinical treatment of macrophages-mediated inflammatory responses.
Hu Ying,Liu Rongbo,Gao Fabao 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.7
Objective: To investigate the age-dependent changes in regional cerebral blood flow (CBF) in healthy adults by fitting mathematical models to imaging data. Materials and Methods: In this prospective study, 90 healthy adults underwent pseudo-continuous arterial spin labeling imaging of the brain. Regional CBF values were extracted from the arterial spin labeling images of each subject. Multivariable regression with the Akaike information criterion, link test, and F test (Ramsey’s regression equation specification error test) was performed for 7 models in every brain region to determine the best mathematical model for fitting the relationship between CBF and age. Results: Of all 87 brain regions, 68 brain regions were best fitted by cubic models, 9 brain regions were best fitted by quadratic models, and 10 brain regions were best fitted by linear models. In most brain regions (global gray matter and the other 65 brain regions), CBF decreased nonlinearly with aging, and the rate of CBF reduction decreased with aging, gradually approaching 0 after approximately 60. CBF in some regions of the frontal, parietal, and occipital lobes increased nonlinearly with aging before age 30, approximately, and decreased nonlinearly with aging for the rest of life. Conclusion: In adults, the age-related perfusion patterns in most brain regions were best fitted by the cubic models, and age-dependent CBF changes were nonlinear.
Hu, Ying,Chen, Liyan,Jung, Hyeseung,Zeng, Yiying,Lee, Songyi,Swamy, Kunemadihalli Mathada Kotraiah,Zhou, Xin,Kim, Myung Hwa,Yoon, Juyoung American Chemical Society 2016 ACS APPLIED MATERIALS & INTERFACES Vol.8 No.34
<P>Three o-phenylendiamine (OPD) derivatives, containing 4-chloro-7-nitrobenzo [c] [1,2,5] oxadiazole (NBD-OPD), rhodamine (RB-OPD), and 1,8-naphthalimide (NAP-OPD) moieties, were prepared and tested as phosgene chemosensors. Unlike previously described methods to sense this toxic agent, which rely on chemical processes that transform alcohols and amines to respective phosphate esters and phosphoramides, the new sensors operate through a benzimidazolone-forming reaction between their OPD groups and phosgene. These processes promote either naked eye visible color changes and/or fluorescence intensity enhancements in conjunction with detection limits that range from 0.7 to 2.8 ppb. NBD-OPD and RB-OPD-embedded polymer fibers, prepared using the electrospinning technique, display distinct color and fluorescence changes upon exposure to phosgene. even in the solid state.</P>
Design and analysis of a 6-DOF mobile parallel robot with 3 limbs
Ying Hu,Jianwei Zhang,Zhong Wan,Jingchuan Lin 대한기계학회 2011 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.25 No.12
Mobile parallel robots (MPR), which structurally configured a moving platform and several parallel limbs with an actuating wheel at the end of each limb, exhibit advantages in high mobility, high load capability and high flexibility in complex task environments. In this paper, a 6-DOF MPR with 3-PPUU (Prismatic-Prismatic Universal-Universal) limbs is proposed. The structural scheme and inverse kinematics are first presented; the orientational workspace and the dexterity of the MPR are analyzed in detail. A parametric optimal design model is then developed; the optimal scheme of the MPR is obtained. The constant-posture control scheme and algorithm are also proposed in this paper. A prototype of the 3-PPUU MPR with omni-orientational wheels is developed and the precision for both translation and orientation of the prototype is measured by experiments, which verify the feasibility of the proposed MPR scheme.
Hu, Ying,Joung, Joonyoung F.,Jeong, Ji-Eun,Jeong, Yerin,Woo, Han Young,She, Yuanbin,Park, Sungnam,Yoon, Juyoung Elsevier 2019 Sensors and actuators. B Chemical Vol.280 No.-
<P><B>Abstract</B></P> <P>2-(Benzothiazol-2-yl)pyren-1-ol (<B>P3-NS</B>) was developed as a excited-state intramolecular proton transfer (ESIPT)- based sensor for nitroaromatic compounds (NACs). Results of studies of its photophysical and optical properties show that <B>P3-NS</B> exists in various, solvent dependent isomeric forms arising from rotation about the CC bond connecting the benzothiazole and pyren-1-ol rings and the location of the pyrene-OH proton. The results of density functional theory (DFT) calculations enabled identification of the major structures of <B>P3-NS</B> dissolved in different solvents. Upon electronic excitation in nonpolar or weakly polar solvents, <B>P3-NS</B> undergoes an ESIPT reaction to form a product that only weakly fluoresces. In contrast, <B>P3-NS</B> exists in a strongly fluorescent deprotonated form in highly polar solvents. The results of time-dependent DFT calculations indicate that fluorescence quenching of the product generated by ESIPT reaction of <B>P3-NS</B> is caused by intersystem crossing at a conical intersection between S<SUB>1</SUB> and T<SUB>2</SUB> states. The anionic form of <B>P3-NS</B>, present in highly polar solvents, was shown to be a fluorescence sensor for nitroaromatic compounds (NACs). Fluorescence quenching by NACs occurs by protonation of the anionic form of <B>P3-NS</B> (static quenching) and by photoinduced electron transfer from the anionic form to NACs (dynamic quenching).</P> <P><B>Highlights</B></P> <P> <UL> <LI> A new hydroxypyrene derivative <B>P3-NS</B> bearing benzothiazole is developed as a fluorescent sensor for nitroaromatic compounds. </LI> <LI> <B>P3-NS</B> undergoes excited-state intramolecular proton transfer reaction in nonpolar or weakly polar solvents. </LI> <LI> <B>P3-NS</B>, as a sensor, exhibits a selective strong response to picric acid over other nitroaromatic compounds. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Hu, Ying,Yin, Jun,Yoon, Juyoung Elsevier 2016 Sensors and actuators. B Chemical Vol.230 No.-
<P><B>Abstract</B></P> <P>A cyanine-based chemosensor containing dipicolylamine moieties is reported and its structure is well-defined. Investigation on the optical property shows it is pH-independent. Acidic medium can induce the color change from azure to dark blue while it presents the green in the alkaline condition (pH 10) in comparison to the neutral condition. More, owing to the introduction of dipicolylamine units, this chemosensor can be used as a colorimetric indicator for Zn(II) and Cu(II) ions along with color change from green to bright blue. Especially, its copper complex has a capability of determining the sulfide anion (S<SUP>2−</SUP>) with high selectivity, and as a consequence, the color of solution turns back to the green. This work provides a promising indicator for the analysis of multi species.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>