http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Systemic Lupus Erythematosus를 동반한 Multiple sclerosis
이지현,이기주,윤성호,부귀범,손현화,박유환,정춘해,김진호,정원영 조선대학교 부설 의학연구소 1998 The Medical Journal of Chosun University Vol.23 No.2
Multiple sclerosis and lupus erythematosus are chronic, potentially disabling diseases of unknown cause. It is a rare occasion that the finding of both diseases occurs in one patient. Because both diseases may affect the central nervous system, it may be difficult at times to differentiate symptoms of lupus erythematosus from those of multiple sclerosis. As far as we know, there was no case report of SLE in multilple sclerosis in Korea. We report a case of multiple sclerosis accompanied by SLE.
마이크로니들의 형태 및 적용방법이 약물의 피부 투과에 미치는 영향
임지호,이경록,이은주,조정원 충남대학교 약학대학 의약품개발연구소 2012 藥學論文集 Vol.27 No.-
The purpose of this study is to develop the microneedle using biodegradable and biocompatible polymer and to pioneer the new route of drug delivery through the research to apply the most desirable administration form of small molecules, peptides, proteins, genes, biological products including vaccines. Various biocompatible microneedles were manufactured. To apply drug to microneedle, drug formulation using ethylene vinyl acetate patch or polyacryl acid gel was developed. Drug permeation into rat skin based on the application method of patch or gel with microneedle was studied using Franz diffusion cell system. In vitro drug permeation results showed that the permeation by the application of hollow microneedle was not increased compared with solid microneedle. When G60 or G60*2 microneedle was used, the permeated amount of calcein was increased compared to when solid microneedle was used. The permeated amount of lidocaine HCl in 12 hr was increased when microneedle was used was increased. Skin irritation followed by microneedle showed there was little difference in the decrease of redness after microneedle application based on application time.
( Hyun Ji Lee ),( Eun Hye Lee ),( Seon Hwa Lee ),( Kyung Duck Park ),( Yong Hyun Jang ),( Weon Ju Lee ),( Seok-jong Lee ),( Jun Young Kim ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
Background: American Joint Committee on Cancer (AJCC) revised melanoma staging manual to 8th edition by key changes in Tumor, Nodes, Metastasis (TNM) classification and stage grouping. But it’s not advised to restage all previously staged melanomas. Objectives: To investigate the necessity of restaging in Korean melanoma patients staged by 7th edition of AJCC cancer staging manual (CSM). Methods: The 7th and 8th AJCC CSMs were meticulously compared. Pathological prognostic staging (PPS) of 276 melanomas from 2011 to 2018 were sorted by 7th and 8th AJCC CSMs, and their differences were analyzed. Results: Sixty-four cases (23.2%) differed in staging between 7th and 8th edition. PPS changed in 35 cases (12.7%), and 29 (10.5%) altered only TNM classification with same PPS. Main causes in changes of PPS include: 1) 7 changed from stage IB to IA by T1 redefinition or revision of stage IA to include T1bN0M0; 2) 27 in the stage III group, increased to the IIIB ~ IIID by revising T, N categories. None in our cases needed additional sentinel lymph node biopsy (SLNB) or systemic treatment. More counseling was needed for stage III groups, because melanoma-specific survival rate for stage III increased in 8th edition. Conclusion: Though careful attention should be needed for patients at changing points for additional SLNB, systemic treatment, and prognosis, restaging was not significantly needed in our patients.
TTAC-0001, a human monoclonal antibody targeting VEGFR-2/KDR, blocks tumor angiogenesis
Lee, Weon Sup,Pyun, Bo-Jeong,Kim, Sung-Woo,Shim, Sang Ryeol,Nam, Ju Ryoung,Yoo, Ji Young,Jin, Younggeon,Jin, Juyoun,Kwon, Young-Guen,Yun, Chae-Ok,Nam, Do-Hyun,Oh, Keunhee,Lee, Dong-Sup,Lee, Sang Hoon Taylor Francis 2015 mAbs Vol.7 No.5
Lee, Hae-Weon,Yoon, Kyung Joong,Son, Ji-Won,Lee, Jong-Ho,Kim, Byung-Kook,Je, Hae-June The Electrochemical Society 2013 ECS transactions Vol.57 No.1
<P>Solid oxide fuel cell is a composite of composites, and goes through a series of composite processing. SOFC always experience extensive constrained sintering in co-firing and post-firing due to shrinkage mismatches. Even though constraints are internal, external, or in combination, SOFCs suffer from critical flaws without optimization of constrained sintering. Thus it is necessary to understand the effects of internal and external constraints on sintering and microstructure development. In this study, we present examples and mechanistic explanation in which critical process flaws were suppressed by hierarchical functional control of the powder packing structure in the viewpoint of constrained sintering.</P>
Ji Young Lee,Ji Young Park,Na Mi Lee,Ki Wook Yun,Soo Ahn Chae,In Seok Lim,Eung Sang Choi,Sin Weon Yun 중앙대학교 의과대학 의과학연구소 2013 中央醫大誌 Vol.38 No.3
Positive-pressure ventilation can cause various life-threatening barotraumas in cases of extremely low birth weight (ELBW) prematurity with lung disease. Isolated tension pneumopericardium unaccompanied by other barotraumas is very rare and can rapidly deteriorate. Sudden unexplainable hemodynamic collapse in premature infants receiving mechanical ventilation always requires urgent investigation. Here, we describe a case of isolated tension pneumopericardium in an ELBW premature male infant. The gestational age of 23 weeks, and the birth weight was 636 g. The infant was diagnosed with severe respiratory distress syndrome. After application of surfactant and conventional ventilation, oxygenation and vital signs improved briefly. However, the hypoxia worsened, requiring a higher pressure setting to maintain oxygenation and ventilation. When the oxygen saturation did not improve despite the higher pressure, we switched to a high-frequency oscillatory ventilator. At this point, the infant's condition suddenly deteriorated. We took a chest radiograph, started resuscitation, and quickly recognized a large amount of air compressing the heart. Vigorous resuscitation, including pericardial decompression, was actively performed but ultimately unsuccessful. We wish to bring this case to the attention of clinicians, who should always be aware of this fatal but treatable disease. Prompt recognition and intervention could be the only way to save the lives of affected infants.
Intraventricular Antimicrobial Therapy for Intractable Ventriculitis: Two Case Reports
Lee, Ji Weon,Yoon, Yoonsun,Kim, Sang-Dae,Kim, Yun-Kyung The Korean Society of Pediatric Infectious Disease 2022 Pediatric Infection and Vaccine Vol.29 No.1
It is challenging to treat ventriculitis with parenteral treatment alone in some cases because of the difficulty involved in maintaining an appropriate level of antibiotics in cerebrospinal fluid (CSF). We report two cases of ventriculitis who did not respond to intravenous (IV) antibiotics but were successfully treated with intraventricular antibiotics using IV agents. The first case was a four-month-old male patient with X-linked hydrocephalus. He showed ventriculitis due to Klebsiella pneumoniae not producing extended-spectrum β-lactamase and susceptible to third-generation cephalosporins and gentamicin, following ventriculoperitoneal (VP) shunt. His condition did not improve during the 47 days of treatment with IV cefotaxime and meropenem. We achieved improvement in clinical presentation and CSF profile after three times of intraventricular gentamicin injection. The patient was discharged from the hospital with antiepileptic drugs. The second case was a six-month-old female patient with a history of neonatal meningitis complicated with hydrocephalus at one month of age, VP shunt at two months of age, followed by a methicillin-resistant coagulase-negative staphylococci (CoNS) shunt infection with ventriculitis after the shunt operation. CoNS ventriculitis recurred four weeks later. We failed to treat intractable methicillin-resistant CoNS ventriculitis with IV vancomycin for ten days, and thus intraventricular antimicrobial treatment was considered. Five times of intraventricular vancomycin administration led to improvement in clinical parameters. There were only neurological sequelae of delayed language development but no other major complications. Patients in these two cases responded well to intraventricular antibiotics, with negative CSF culture results, and were successfully treated for ventriculitis without serious complications.