분사처리 후 산부식 표면처리된 교정용 미니 임플랜트의 골유착능에 관한 연구

전미선,강윤구,모성서,이근혜,국윤아,김성훈 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.5

본 연구에서는 교정 치료 시 골내 고정원으로 사용되는 교정용 임플랜트의 표면처리 여부가 골유착능에 있어서 어떠한 효과를 보이는지 제거회전력의 측정을 통해 알아보고자 하였으며, 그에 따른 교정력 적용의 확장과 임상적 의의를 알아보고자 하였다. 실험군은 분사처리 후 산부식(Sand-blasted Large grit, and Acid etched, SLA) 표면 처리된 교정용 미니 임플랜트인 C-implant (Cimplant, Seoul, Korea)를 사용하였으며 대조군은 같은 디자인이지만 표면 처리를 하지 않은 평활면 C-implant를 사용하였다. 실험군과 대조군을 각각 2개씩 11마리의 가토 경골에 식립하였고 식립 후 6주에 가토를 희생시켜 제거회전력을 측정하여 t-test를 통하여 두 군의 제거회전력 차이의 통계적 유의성을 알아보았으며 조직표본을 만들어 조직소견을 관찰하였다. 실험결과 제거회전력은 SLA 처리한 C-implant 군이 평활면 C-implant 군보다 통계적으로 유의성 있게 높은 결과를 보였다 (p < 0.05). 평활면 C-implant 군의 평균 제거회전력 값은 4.614 Ncm이고, SLA C-implant 군의 평균 제거회전력 값은 6.286 Ncm로, SLA 군이 평활면 군보다 73% 더 높은 제거회전력에 대한 저항성을 나타내었다. 이상의 연구 결과에서 SLA 표면처리가 C-implant의 골유착능을 증가 시켰음을 알 수 있었다. 따라서 표면 처리된 교정용 미니 임플랜트는 기존의 임플랜트에 비해 좀 더 강한 힘에 저항할 수 있으며 탈락률을 낮출 수 있을 것으로 생각된다. Objective: The purpose of this study was to compare the torque resistance to removal of sandblasted large grit and acid etched (SLA) surface treated orthodontic mini-implants and smooth surface orthodontic mini-implants as well as performing histologic observations. Methods: Two groups of custom screw shaped orthodontic mini-implants (C-implant, 1.8 mm outer diameter × 9.5 mm length, Cimplant, Seoul, Korea) were designated. 22 SLA treated C-implants (SLA group) and 22 machined surface C-implants (machined group) were placed in the tibia metaphysis of 11 adult New Zealand white rabbits. Following a 6-week healing period, the rabbits were sacrificed. Subsequently, the C-implants were removed under reverse torque rotation with a digital torque measuring device and independent t-test was performed. Selected tissues were prepared for histologic observation. Results: The SLA group presented a higher mean removal torque value (6.286 Ncm) than the machined group (4.491 Ncm) which was statistically significant (p < 0.005). Histologic observation revealed a trend of more new bone formation in contact with the screw surface in the SLA group than the smooth group. Conclusions: The results of this study suggested that SLA surface treatment can enhance the osseintegration potential for C-orthodontic mini-implants.

신경망을 이용한 공정 오차 보정

전경아,유지용,오혜근 한양대학교 이학기술연구소 2002 이학기술연구지 Vol.5 No.-

패턴의 미세화에 따른 정확하고 신속한 결과 예측은 Iithography simulation tool 의 높은 공정 변수 의존을 요구한다. 이로 인해 simulation tool 은 공정 변수 사이의 보정이 더욱 복잡해져 광 근접 효과 등으로 나타나는 다양한 패턴들의 크기 결과를 예측하는데 많은 어려움을 겪게된다. 이에 본 논문에서는 simulation 결과 값과 실측값의 차이를 신경망 알고리즘에 적용하여 공정 변수를 최적함으로서 simulation tool의 예측 정확성을 향상시키는 방법을 제시하였다. It is required to make an accurate and quick prediction of critical dimension (CD)for higher integrated devices. Because simulation tools consist of many process parameters and models, it is difficult that process parameters are calibrated to match the CD results for various patterns. This paper presents a method of improving the accuracy of predicting CD results by applying △ (the difference between simulation and experimental data) value to neural network algorithm (NNA) in order to reduce the CD difference caused by optical proximity effects.

Micronucleus test를 이용한 수종 결합용레진과 상아질결합제의 돌연변이 유발에 관한 연구

이용근,전혜림,김철위,윤숙진 大韓齒科器材學會 1992 대한치과재료학회지 Vol.19 No.1

The purpose of this study was to evaluate the mutagenicity of the bonding resins of dental composites and the dentin bonding agents. Eight bonding resins, six dentin bonding agents and distilled water (negative control) were administered orally and cyclophosphamide (positive control) was administered intraperitoneally to the mice. The mice were killed by cervical dislocation at 24 hours after administration and the femurs were removed and dissected. The bone marrow cells were collected and smeared on glass slides and stained with haematoxylin-eosin staining method and were observed with light microscope(X450). The following results can be drawn: 1. The bonding resins of dental composites and the dentin bonding agents were tested in this study seemed to be non-mutagenic. 2. The numbers of micronucleated polychromatic erythrocytes were similar both in the bonding resins of dental composites and the dentin bonding agents. 3. In the case of some products(AP, SC' and AA), the number of micronucleated polychromatic erythrocs was high beyond other products.

회맹장 및 대장을 침범한 장 결핵에 있어서 바륨을 이용한 방사선 이중조영촬영 소견에 대한 연구

진용현,전혜정,이용근,강철호,조성범,김윤환,박철민,차상훈,김일영,이혜경 건국대학교 의과학연구소 2002 건국의과학학술지 Vol.12 No.-

To determine the characteristic double contrast barium enema findings of ileo-cecal and colonic tuberculosis and to make differential diagnosis from other bowel inflammatory disease. Sixty-seven patients confirmed as ileo-cecal and/or colonic-tuberculosis in six hospitals were evaluated retrospectively. The diagnosis was proven by endoscopic biopsy, surgery, and clinical follow up. Nine of 67 patients were excluded because radiologic findings were normal though endocopic biopsy examinations resulted in tuberculosis. Histopathological diagnosis were madein 58 cases as follows: endoscopic biopsy(n=29), operation(n=12), follow up examination(n=14), tissue culture(n=1), laparoscopic biopsy(n=2). There were 30 men and 28 females. The mean age were 36 yrs(range:16-67), 34 patients were in the second and third decade. The distribution of lesions, morphological characteristics, mucosal changes, ulcer shape and depth, associated with other tuberculous lesion, multiplicity were retrospectively analyzed in the findngs of double contrast barim enema. The commonest clinical symptoms were abdominal pain(n=35, 60%) and diarrhea(n=18, 31%). The chest radiography revealed association of pulmonary tuberculosis in 39 cases. Tuberculous lesions of other organs except chest were present in five cases. Double contrast barium enema findings showed a thickening and irregularity of intestinal mucosal fold(n=29, 50%), bowel contraction and/or shortening(n=26, 45%). There were small, nodular, superficial ulcers in the case of ulcer depth less than 2 mm in the depth. As many as 39 cases(67%) in this series had two or more lesions in the intestinal tuberculosis. The involved segment revealed symmetrical feature(n=21, 36%). Inflammatory pseudopolypoid lesions were noted in 30 cases(52%). The ileo-cecal region was involved in 38 cases(66%). The ascending colon(n=25, 43%) was the second commonest site with or without contiguous cecal involvement. Lesions in terminal ileum, ileo-cecal valve, transverse colon, descending colon and appendix were seen in 19, 18, 18, 12 and seven cases, respectively. Among 18 cases of ileo-cecal valve lesions, there were incompetency in nine cases(16%) and wide gapping in four cases(7%). In 14 cases, tuberculous enterocolitis was diagnosed by clinical follow-up and double contrast barium enema study. 12 out of 14 cases, the findings of double contrast barium enema of tuberculous enterocolitis were normalized after anti-tuberculous medication. However, two cases showed more aggravated state than before due to inappropriate treatment. Double contrast barium enema plays an important role in the diagnosis of tuberculous enterocolitis, determines the type, site and extent of the involvement and helps in treatment guide by using sequential studies.

Are Serum Vitamin D Levels Associated With Dry Eye Disease? Results From the Study Group for Environmental Eye Disease

Jeon, Da-Hye,Yeom, Hyungseon,Yang, Jaewon,Song, Jong Suk,Lee, Hyung Keun,Kim, Hyeon Chang The Korean Society for Preventive Medicine 2017 예방의학회지 Vol.50 No.6

Objectives: Dry eye disease (DED) is an increasingly important public health problem in Korea. Previous studies conducted in Korea have reported inconsistent results regarding the protective effects of vitamin D on DED, and these discrepancies may be related to the relatively simple questionnaire that has been used. Thus, we evaluated the association of serum vitamin D levels with DED using the ocular surface disease index (OSDI). Methods: The present study evaluated data from participants in the Study Group for Environmental Eye Disease (2014-2015). This group included data from 752 participants, and data from 740 participants (253 men and 487 women) were analyzed in the present study. DED severity was evaluated using the OSDI. Results: Higher serum vitamin D levels were associated with a non-significantly reduced risk of DED in the crude analysis (odds ratio [OR], 0.991; 95% confidence interval [CI], 0.971 to 1.011) and in the adjusted analysis (OR, 0.988; 95% CI, 0.966 to 1.010). In the crude analysis of no/mild DED vs. moderate/severe DED, men exhibited a decreased risk with increasing serum vitamin D levels (OR, 0.999; 95% CI, 0.950 to 1.051), while women exhibited an increased risk (OR, 1.003; 95% CI, 0.979 to 1.027). In these analyses, we found no significant associations. Conclusions: The findings of the present study support previous reports that serum vitamin D levels are not associated with DED.

Genetic Variations in Korean Wild Ginsengs and Their Genetic Relationships

Hye Zin Hwang,Min Ji Yeon,Ji Yeon Seong,Ha Young Park,Su Ok Kim,Hyung Wook Jeon,Keun Chong Kim,Kang Jun Choi,Yong Jin Lee,Dong Sang Suh 한국유전학회 2006 Genes & Genomics Vol.28 No.2

Cross-Border Bankruptcy and Korea: on the Case of the Lehman Brothers

( Hye Jin Jeon ),( Nam Hee Kim ),( Jung Keun Yoon ) 고려대학교 법학연구원 2009 The Asian Business Lawyer Vol.4 No.-

T_H2 and T_H1 lung inflammation induced by airway allergen sensitization with low and high doses of double-stranded RNA

Jeon, Seong Gyu,Oh, Sun-Young,Park, Hye-Kyung,Kim, You-Sun,Shim, Eun-Jin,Lee, Hyun-Seung,Oh, Min-Hee,Bang, Boram,Chun, Eun-Young,Kim, Sang-Heon,Gho, Yong Song,Zhu, Zhou,Kim, You-Young,Kim, Yoon-Keun Elsevier 2007 The Journal of allergy and clinical immunology Vol.120 No.4

<P><B>Background</B></P><P>Although respiratory viral infections in early childhood can enhance the development of airway allergen sensitization, the exact mechanisms of the effects of viral infections on the adaptive immune response to inhaled allergens are controversial.</P><P><B>Objective</B></P><P>We sought to evaluate the effects of double-stranded RNA (dsRNA) on airway sensitization to inhaled allergens.</P><P><B>Methods</B></P><P>Novel mouse models were created through simultaneous airway sensitization to an allergen and low or high doses of dsRNA. The mouse models were applied to Toll-like receptor 3–, IL-13–, IL-4–, signal transducer and activator of transcription (STAT) 6–, IFN-γ–, and T-box expressed in T cells (T-bet)–deficient mice to evaluate underlying pathophysiologic mechanisms in the development of allergic lung inflammation.</P><P><B>Results</B></P><P>We found that airway allergen sensitization with dsRNA induced lung inflammation that was not present in Toll-like receptor 3–deficient mice. Moreover, lung inflammation enhanced by low-dose dsRNA was impaired in IL-13–deficient mice, whereas lung inflammation by high-dose dsRNA was impaired in IFN-γ–deficient mice. The models also demonstrated that low-dose dsRNA enhanced IL-4 expression during allergen sensitization and that inflammation enhanced by low-dose dsRNA was not present in IL-4– or STAT6-deficient mice. In contrast, the present study showed that high-dose dsRNA enhanced IFN-γ expression during allergen sensitization and that the development of lung inflammation enhanced by high-dose dsRNA was impaired in T-bet–deficient mice.</P><P><B>Conclusion</B></P><P>These findings suggest that airway allergen exposure during respiratory viral infections might induce asthma induced by both T<SUB>H</SUB>1 and T<SUB>H</SUB>2 immune responses to inhaled allergens.</P><P><B>Clinical implications</B></P><P>Targeting both T<SUB>H</SUB>1 and T<SUB>H</SUB>2 lung inflammation might be important in the treatment of virus-associated asthma.</P>

Allergic reaction enhanced by LPS induces severe Lung Parenchymal inflammation and alveolar destruction which are inhibited by FGF2

Hye Kyung Park,Tae Bum Kim,Seong Gyu Jeon,Yoon Keun Kim,Sang Heon Cho,Kyung Up Min,Chun Geun Lee,Jack A. Elias,You Young Kim 대한내과학회 2004 대한내과학회 추계학술대회 Vol.2004 No.1

Dependence Potential of the Synthetic Cannabinoids JWH-073, JWH-081, and JWH-210: In Vivo and In Vitro Approaches

( Hye Jin Cha ),( Kwang Wook Lee ),( Min Ji Song ),( Yang Jin Hyeon ),( Ji Young Hwang ),( Choon Gon Jang ),( Joon Ik Ahn ),( Seol Hee Jeon ),( Hyun Uk Kim ),( Young Hoon Kim ),( Won Keun Seong ),( Ho 한국응용약물학회 2014 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.4

Synthetic cannabinoids (CBs) such as the JWH series have caused social problems concerning their abuse liability. Because the JWH series produces euphoric and hallucinogenic effects, they have been distributed illegally under street names such as “Spice” and “Smoke”. Many countries including Korea have started to schedule some of the JWH series compounds as controlled substances, but there are a number of JWH series chemicals that remain uncontrolled by law. In this study, three synthetic CBs with different binding affinities to the CB1 receptor (JWH-073, 081, and 210) and Δ9-tetrahydrocannabinol (Δ9-THC) were evaluated for their potential for psychological dependence. The conditioned place preference test (unbiased method) and self-administration test (fixed ratio of 1) using rodents were conducted. Kivalues of the three synthetic cannabinoids were calculated as supplementary data using a receptor binding assay and overexpressed CB1 protein membranes to compare dependence potential with CB1 receptor binding affinity. All mice administered JWH-073, 081, or 210 showed significantly increased time spent at unpreferred space in a dose-dependence manner in the conditioned place preference test. In contrast, all tested substances except Δ9-THC showed aversion phenomenon at high doses in the conditioned place preference test. The order of affinity to the CB1 receptor in the receptor binding assay was JWH-210 > JWH-081 >> JWH-073, which was in agreement with the results from the conditioned place preference test. However, no change in self-administration was observed. These fi ndings suggest the possibility to predict dependence potential of synthetic CBs through a receptor binding assay at the screening level.