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김상효,조성범,정재익 연세대학교 산업기술연구소 1996 논문집 Vol.28 No.1
The steel-box girder decks are widely adopted for middle and long-span bridges due to many advantages, when comparing with other open-section girder types, such as higher torsional rigidity, better resistance against corrosion, etc. In current design practice, the design variables of steel-box girder are selected mainly on the basis of engineer's experience and direct observation. Then the assumed sections are checked for design limit states. Therefore, the resulted design sections are doubtful in the optimum viewpoint. To achieve more rational design, systematic design procedure is required, by which the design constraints on steel-box girders are satisfied and the design variables of minimum cost are obtained. Generally both bending moments by transverse loads and torsional moments by eccentric loadings are the most important load effects in curved steel-box girder bridges. Therefore, an optimization program is developed to consider the torsional moment in addition to other load effects. The efficiency of the developed program has been verified by redesigning some sections selected from existing bridge designs. The resulting optimum sections with discrete variables are found to be cost-saving and comparable with original sections. Based on the parametric studies performed for mainly radius of curvature on curved bridge and bridge width, some essential guidelines for rational design of curved steel-box girder bridges are suggested.
항정신병 약물이 Cyclooxygenase-2 유전자 발현과 Prostaglandin E_2 농도에 미치는 영향
김종우,조성욱,범재명,윤도준,장환일,송지영 대한생물치료정신의학회 2001 생물치료정신의학 Vol.7 No.2
Objectives : Cyclooxygenase(COX) is the central enzyme in the biosynthetic pathway to prostaglandins from arachidonic acids. The action mechanism of nonsteroidal anti-inflammatory drugs is through inhibition of COX activity and prostanoid biosynthesis including prostaglandin E_2(PGE_2). The antipsychotic drugs are known having an analgesic effects, however its mechanisms of actions of action to pain control was not still clearly proved. In the present study, the effects of antipsychotic drugs(chlorpromazie and clozapine) on the production of PGE_2 and the expression of COX-2mRNA and protein in P815 cell line were studied. Methods : For that purpose, the methods of RT-PCR, western blot and prostagalndin E_2 enzymeimmunoassay were applied. Results : The results showed tha tin P815 cells treated with chlorpromazine, the level of COX2 mRNA was significantly decreased compared to the control cells. And total cellular PGE_2 levels were significantly decreased after treatment with chlorpromazine and clozapine. Conclusion : These results suggest that antipsychotic drugs have revealed their analgesic effect through the inhibition of COX-2 activity and PGE_2 production. And also, these results partly supports the excess theory of prostaglangdins in the pathogenesis of schizophrenia.
전옥철,김윤준,류범영,최재곤,조병욱,홍진후 조선대학교 생산기술연구소 1999 生産技術硏究 Vol.21 No.1
A series of wholly aromatic polyesters with side chains were synthesized by solution polycondensation from 2,5-dialkoxyterephthaloyl chlorides with the corresponding diol. The polymers showed the schlieren textures which is indicative of a nematic phase above their melting temperature. The inherent viscosities (η_(inh)) measured at 35℃ in phenol/p-chlorophenol/1,1,2,2-tetrachloroethane were 0.56-0.98 dℓ/g. The glass transition temperature (T_(g)) and melting temperature (T_(m)) decreased with increasing the length of the alkoxy side chain. Initial decomposition temperatures in TGA occurred at 338 ~ 363℃ in N₂ gas and thermal stability of polymers decreased with increasing the length of the side chain.
Apoptotic Effects of Co-Treatment with a Chios Gum Mastic and Eugenol on G361 Human Melanoma Cells
Jae-Beom Jo,Sang-Hun Oh,In-Ryoung Kim,Gyoo-Cheon Kim,Hyun-Ho Kwak,Bong-Soo Park The Korean Academy of Oral Biology 2013 International Journal of Oral Biology Vol.38 No.3
We investigated the synergistic apoptotic effects of cotreatments with Chios gum mastic (CGM) and eugenol on G361 human melanoma cells. An MTT assay was conducted to investigate whether this co-treatment efficiently reduces the viability of G361 cells compared with each single treatment. The induction and augmentation of apoptosis were confirmed by DNA electrophoresis, Hoechst staining, and analyses of DNA hypoploidy. Western blot analysis and immunofluorescent staining were also performed to evaluate expression and translocation of apoptosisrelated proteins following CGM and eugenol co-treatment. Proteasome activity and mitochondrial membrane potential (MMP) changes were also assayed.The results indicated that the co-treatment of CGM and eugenol induces multiple pathways and processes associated with an apoptotic response in G361 cells. These include nuclear condensation, DNA fragmentation, a reduction in MMP and proteasome activity, an increase of Bax and decrease of Bcl-2, a decreased DNA content, cytochrome c release into the cytosol, the translocation of AIF and DFF40 (CAD) into the nucleus, and the activation of caspase-9, caspase-7, caspase-3, PARP and DFF45 (ICAD). In contrast, separate treatments of 40 μ g/ml CGM or 300 μM eugenol for 24 hours did not induce apoptosis. Our present data thus suggest that a combination therapy of CGM and eugenol is a potential treatment strategy for human melanoma.