http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Jeong Hyunjin,Hong Eun-Hye,Ahn Jae-Hee,Cho Jaewon,Jeong Jae-Hyeon,Kim Chae-Won,Yoon Byung-Il,Koo Ja Hyun,Park Yun-Yong,Yang Yoon Mee,Iwawaki Takao,Bruce A. Vallance,Chang Sun-Young,Ko Hyun-Jeong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Endoplasmic reticulum stress is closely associated with the onset and progression of inflammatory bowel disease. ERdj5 is an endoplasmic reticulum-resident protein disulfide reductase that mediates the cleavage and degradation of misfolded proteins. Although ERdj5 expression is significantly higher in the colonic tissues of patients with inflammatory bowel disease than in healthy controls, its role in inflammatory bowel disease has not yet been reported. In the current study, we used ERdj5-knockout mice to investigate the potential roles of ERdj5 in inflammatory bowel disease. ERdj5 deficiency causes severe inflammation in mouse colitis models and weakens gut barrier function by increasing NF-κB-mediated inflammation. ERdj5 may not be indispensable for goblet cell function under steady-state conditions, but its deficiency induces goblet cell apoptosis under inflammatory conditions. Treatment of ERdj5-knockout mice with the chemical chaperone ursodeoxycholic acid ameliorated severe colitis by reducing endoplasmic reticulum stress. These findings highlight the important role of ERdj5 in preserving goblet cell viability and function by resolving endoplasmic reticulum stress.
Jeong, Jaewon,Kim, Soojin,Lim, Da-Sol,Kim, Seo-Hea,Doh, Heeju,Kim, So-Dam,Song, Yun Seon The Korean Society for Brain and Neural Science 2017 Experimental Neurobiology Vol.26 No.4
<P>Postconditioning has been shown to protect the mouse brain from ischemic injury. However, the neuroprotective mechanisms of postconditioning remain elusive. We have found that toll-like receptor 5 (TLR5) plays an integral role in postconditioning-induced neuroprotection through Akt/nuclear factor kappa B (NF-κB) activation in cerebral ischemia. Compared to animals that received 30 min of transient middle cerebral artery occlusion (tMCAO) group, animals that also underwent postconditioning showed a significant reduction of up to 60.51% in infarct volume. Postconditioning increased phospho-Akt (p-Akt) levels and NF-κB translocation to the nucleus as early as 1 h after tMCAO and oxygen-glucose deprivation. Furthermore, inhibition of Akt by Akt inhibitor IV decreased NF-κB promoter activity after postconditioning. Immunoprecipitation showed that interactions between TLR5, MyD88, and p-Akt were increased from postconditioning both <I>in vivo</I> and <I>in vitro</I>. Similar to postconditioning, flagellin, an agonist of TLR5, increased NF-κB nuclear translocation and Akt phosphorylation. Our results suggest that postconditioning has neuroprotective effects by activating NF-κB and Akt survival pathways via TLR5 after cerebral ischemia. Additionally, the TLR5 agonist flagellin can simulate the neuroprotective mechanism of postconditioning in cerebral ischemia.</P>
혐오사회와 공존의 시민성 교육: 시민교육 수업사례를 중심으로
정재원(Jeong, Jaewon) 학습자중심교과교육학회 2019 학습자중심교과교육연구 Vol.19 No.11
이 논문은 혐오 정서가 확산되고 있는 한국사회에서 이에 대한 대안으로 제시되고 있는 시민성 교육의 의미와 방향을 모색해보고자 하였다. 한국사회에서 나타나고 있는 혐오양상은 그 자체에 대한 비판을 넘어서 공존 사회로의 전환을 위한 의식이 요구되며, 이를 위한 시민성 교육으로 나아갈 필요가 있다. 이를 위해 시민성 교육의 역사와 그 의미를 살펴보았다. 이와 함께 구체적인 교육의 현장에서 혐오라는 주제를 어떻게 시민성 교육의 맥락 속에서 적용할 수 있는지 살펴보았다. 특히 대학의 시민교육 수업에서 혐오의 문제를 어떻게 다룰 수 있는지 교육적 방법을 제시하였다. ‘혐오’라는 주제에 대해서 대학생들의 인식과 이에 대한 분석 그리고 논쟁 방법, 실천활동 방법을 제안하였다. 본 연구는 혐오표현이 사회적 문제로 확산되고 있는 상황에서 혐오를 예방할 시민교육의 사례를 분석하고 그 의미를 탐색하였다는데 그 의미가 있다. This paper sought to find out the meaning and direction of citizenship education, which is suggested as a countermeasure to the hatred trend which is spreading out in Korean society. The step towards the hatred trend in Korean society requires a sense of transition to a co-existence society beyond the criticism of itself and needs to move on to citizenship education. To this end, the history of citizenship education and its meaning were investigated. Furthermore, how the subject of hatred could be applied to the specific educational field in the line of citizenship education was discussed. In particular, the educational methods were put forward to how to deal with the problem of hatred in the citizenship education classes of universities. On the subject of hatred, university students awareness and analysis of it, how to argue, and how to act were proposed. This paper is meaningful in that it analyzed cases of citizenship education to prevent hatred whilst hatred expression is spreading to social problems and explored its meaning.