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Negative neuromuscular and functional repercussion of forced swimming after axonotmesis
Júlia Araújo de Moura,Jaqueline de Morais,Samara Maria Neves Barbosa,Marcílio Coelho Ferreira,Ivo Vieira de Sousa Neto,Hércules Ribeiro Leite,Murilo Xavier Oliveira,Thaís Peixoto Gaiad,Ana Paula Santo 한국운동재활학회 2022 JER Vol.18 No.3
Tábata Longo da Silva Machado,Alysson Zanatta,Larissa Gonçalves Braz Santos,Rafaella Ferreira de Araújo Litvin,Lizandra Moura Paravidine Sasaki,Júlio Elito Júnior,Edward Araujo Júnior,Alberto Moreno Z 대한산부인과학회 2019 Obstetrics & Gynecology Science Vol.62 No.6
The objective of this study was to evaluate the feasibility of posterior colpotomy for the surgical treatment oftubal ectopic pregnancy in hemodynamically stable women. We performed a retrospective analysis of medicalrecords obtained over a period of 18 months. Twelve cases were identified, with the following characteristics: meangestational age, 7.7 weeks; mean serum β-human chorionic gonadotropin level, 7,786 mIU/mL; and greater diameterof the mass, 15–69 mm. Treatment was successful in all cases. Salpingectomy was performed in 10 patients (83.3%)and salpingostomy, in 1 patient. The remaining patient only received peritoneal lavage, as the evidence of ectopicabortion with only a slightly dilated uterine tube was found during surgery. The mean surgical time was 42.5 minutes. In the analyzed cases, posterior colpotomy was found to be a feasible alternative method for the surgical treatmentof tubal ectopic pregnancy in hemodynamically stable women.
Antinociceptive Action and Redox Properties of Citronellal, an Essential Oil Present in Lemongrass
Lucindo Quintans-Júnior,Ricardo Fagundes da Rocha,Fernanda Freitas Caregnato,José Claudio Fonseca Moreira,Francilene Amaral da Silva,Adriano Antunes de Souza Araújo,João Paulo Almeida dos Santos,Mônic 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.6
Citronellal (CT) is a monoterpenoid and the major constituent of the mixture of terpenoids that give the citronella oil its lemon scent. Citronella oil is widely used around the world for various purposes and is mainly obtained from plants of the Cymbopogon genus, which are known as “lemongrass.” Considering these plants have been used worldwide for various medicinal purposes, the interest of researchers to understand the biological activities of monoterpenoids related to the Cymbopogon genus has been increasing. In the present work, we investigated the antinociceptive action and the redox properties of CT. Our results indicate that intraperitoneal injection of CT was effective in reducing nociceptive face-rubbing behavior in both phases of the formalin test, which was also naloxone-sensitive. CT also evoked antinociceptive response in the capsaicin and glutamate tests. The total radical-trapping antioxidant parameter and total antioxidant reactivity assays indicate that CT at doses of 0.1 and 1 mg/mL exerts a significant antioxidant activity, which is probably related to its ability to scavenge superoxide and nitric oxide, but not H_2O_2 or hydroxyl radicals, as evaluated separately by specific in vitro tests. These results show for the first time the antinociceptive potential of CT and indicate that the antioxidant properties of this compound may rely on its mechanism of biological actions because CT-containing natural products are used to treat various diseases related to oxidative stress and reactive species.
Kuguacin: biological activities of triterpenoid from Momordica charantia—a scoping review
Pedro Henrique Sette-de-Souza,Brenda Alencar Araújo Souza,Moan Jéfter Fernandes Costa,Fábio Andrey da Costa Araújo 경희대학교 융합한의과학연구소 2023 Oriental Pharmacy and Experimental Medicine Vol.23 No.1
The Momordica charantia is a vegetable crop used worldwide due to its biological activities. Investigations into the pharmacological activities of the M. charantia revealed that it presented a wide range of properties, including antimicrobial, anti-cancer, anti-diabetic, and anti-obesity. Over the years, the M. charantia compounds have been identified and studied. In this study, we highlighted the Kuguacin, a triterpenoid isolated from any M. charantia parts. Thus, we aimed to synthesize the scientific knowledge about the Kuguacin biological activities and identify gaps in this area. We performed a scoping review using the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) to design the study’s protocol, with search in PUBMED, EMBASE, SCOPUS, Science Direct, and SciFinder databases. Most of the studies used in vitro methods, and the Kuguacin were isolated from leaves, vines, fruits, and roots. Studies reported the anti-diabetic, anti-cancer, anti-influenza, anti-HIV, and anti-tuberculosis activities of the Kuguacin.
Gleidson Benevides de Oliveira,Helio Noberto de Araújo Júnior,Carlos Eduardo Bezerra de Moura,Phelipe Oliveira Favaron,Alexsandra Fernandes Pereira,Moacir Franco de Oliveira 대한수의학회 2023 Journal of Veterinary Science Vol.24 No.5
Background: Hystricomorpha rodents display a similar placentation model to humans. The present study was carried out considering the scarcity of information concerning the placental development in agouti. Objective: Describe the microscopy of the placenta, subplacenta and yolk sac of agoutis in early pregnancy and report on the inversion of the yolk sac. Methods: Fifteen females between the 14th–32nd day of gestation were used following euthanasia. Gestational buttons were collected, fixed, processed, stained to optical microscopy or immunohistochemistry. Results: Chorioallantoic placenta (CP) ranged from conical to a half-sphere, as follows: from the 14th to 17th day, the CP displays an inverted “V” shape, predominantly formed by cytotrophoblasts; from 20 to 22 days, formed almost entirely by cytotrophoblasts; at 28 days, a half sphere, with distinct lobes and interlobular area, numerous maternal gaps delimited by syncytiotrophoblasts and trophoblast giant cells; at 32 days, globose and undergoing the maturation process. Subplacenta, located between decidua and CP, initially presents septa consisting of simple columnar epithelium and after 17 days, comprising stratified epithelium. Visceral yolk sac (VYS) is attached to two CP projections between 14 and 17 days, formed by a simple cubic epithelium and inverted. Between 20 and 22 days, the epithelium displays apical villous projections with cytoplasmic vacuoles and a vascularized mesoderm. After the 24th day, the VYS near the placenta is pleated, very vascularized and villous, with decreased villi sizes further away from the placenta. Conclusion: The agouti CP displays similar characteristics to other hystricomorpha, including placenta lobulation, a subplacenta and an inverted vitelline placenta.
A Novel Feeder-Free Culture System for Expansion of Mouse Spermatogonial Stem Cells
최나영,박요셉,유재성,이혜정,Marcos J. Araúzo-Bravo,고기성,한동욱,Hans R. Schöler,고기남 한국분자세포생물학회 2014 Molecules and cells Vol.37 No.6
Spermatogonial stem cells (SSCs, also called germline stem cells) are self-renewing unipotent stem cells that produce differentiating germ cells in the testis. SSCs can be isolated from the testis and cultured in vitro for long-term periods in the presence of feeder cells (often mouse embryonic fibroblasts). However, the maintenance of SSC feeder culture systems is tedious because preparation of feeder cells is needed at each subculture. In this study, we developed a Matrigel-based feeder-free culture system for long-term propagation of SSCs. Although several in vitro SSC culture systems without feeder cells have been previously described, our Matrigel-based feeder-free culture system is time- and cost- effective, and preserves self-renewability of SSCs. In addition, the growth rate of SSCs cultured using our newly developed system is equivalent to that in feeder cultures. We confirmed that the feeder-free cultured SSCs expressed germ cell markers both at the mRNA and protein levels. Furthermore, the functionality of feeder-free cultured SSCs was confirmed by their transplantation into germ cell-depleted mice. These results suggest that our newly developed feeder-free culture system provides a simple approach to maintaining SSCs in vitro and studying the basic biology of SSCs, including determination of their fate.
Martins-Filho Paulo Ricardo,de Souza Araújo Adriano Antunes,Quintans-Júnior Lucindo José,Soares Bárbara dos Santos,Barboza Waneska de Souza,Cavalcante Taise Ferreira,Santos Victor Santana 한국역학회 2022 Epidemiology and Health Vol.44 No.-
This study investigated the dynamics of hospitalizations and in-hospital deaths from coronavirus disease 2019 (COVID-19) throughout the pandemic in northeast Brazil, the Brazilian region with the worst socioeconomic indicators. In total, 141,445 cases, 8,213 hospital admissions, and 1,644 in-hospital deaths from COVID-19 were registered from March 14, 2020 to February 5, 2022. The overall rates of hospitalization and in-hospital deaths were 5.8% and 20.0%, respectively. The hospitalization and death rates significantly decreased over time, which may have been related to progress in vaccination. During the spread of the Gamma variant (January to June 2021), most hospitalized individuals were young adults, and approximately 40% of deaths occurred in this age group. During the predominance of Delta (July to December 2021), over 75% of deaths occurred among the elderly and unvaccinated or partially vaccinated individuals. This rate decreased to 42.3% during the transmission of the Omicron variant (January to February 2022), during which 34.6% of deaths were recorded among fully vaccinated individuals (2 doses) and 23.1% among those who received full vaccination and a booster. The Omicron-driven third wave was associated with a rise in the proportion of deaths among vaccinated individuals, especially among those who had not received a booster dose.
Martins-Filho Paulo Ricardo,Pereira de Andrade Ana Luiza,Pereira de Andrade Ana Júlia,Moura da Silva Maria Daniella,de Souza Araújo Adriano Antunes,Nunes Paula Santos,Santos Victor Santana,Ferreira Li 대한신경과학회 2021 Journal of Clinical Neurology Vol.17 No.4
Background and Purpose Miller Fisher syndrome (MFS) is a subtype of Guillain-Barré syndrome characterized by the triad of ophthalmoparesis, areflexia, and ataxia. Although cases of MFS have been associated with severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2) infection, no studies have synthesized the clinical characteristics of patients with this condition. Methods In this rapid systematic review, we searched the PubMed database to identify studies on MFS associated with SARS-CoV-2 infection. Results This review identified 11 cases, of whom 3 were hospitalized with motor and/or sensory polyneuropathy as the first sign of SARS-CoV-2 infection. SARS-CoV-2 RNA was not detected in analyses of cerebrospinal fluid, suggesting a mechanism of immune-mediated injury rather than direct viral neurotropism. However, antiganglioside antibodies were found in only two of the nine patients tested. It is possible that target antigens other than gangliosides are involved in MFS associated with SARS-CoV-2 infection. Conclusions The present patients exhibited clinical improvement after being treated with intravenous immunoglobulin. Although rare, patients with SARS-CoV-2 infection may present neurological symptoms suggestive of MFS. Early recognition of the MFS clinical triad is essential for the timely initiation of treatment.