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웹 서비스 기반의 지방자치단체 민원서비스 통합방안에 관한 연구
강임철,김용일 호남대학교 2004 호남대학교 학술논문집 Vol.25 No.2
As information technology is prevailing, the integration of business processes has been expanded from private to public sector. Korean government introduced e-government and began to provide civil services electronically. However, current system is neither efficient nor convenient enough because the system is not supporting one-stop portal service. We suggest a model of the integrated electronic civil service using web service technology that can offer service integration under the distributed environment, also implement a prototype system for managing application to display placards.
( So Ri Kim ),( Yong Chul Lee ),( Dong Im Kim ),( Yang Keun Rhee ),( Heung Bum Lee ),( Seoung Ju Park ),( Chi Ryang Chung ),( Seung Yong Park ),( Mi Ran Kang ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
Oxidative stress is well known to be implicated in the development of asthma. The mitochondrial respiratory chain is a major site of intracellular reactive oxygen species (ROS) generation and, at the same time, an important target for the damaging effects of ROS. Mito-Tempo is a specific mitochondrial ROS inhibitor and it is known to be associated with opening of mi-tochondrial permeability transition pore and inhibition of cell necroptosis or apoptosis. However, there is little information on the protective effects of Mito-Tempo on the inflammatory airway disorders including bronchial asthma and its acute exacerbation. We investigate the effects of Mito-tempo on the allergic airway inflammation and hyperresponsiveness using the mice sensitized with OVA and LPS and then challenged with OVA (OVALPS-OVA mice). The OVALPS-OVA mice showed the typical features of neutrophilic asthma; increased airway inflammatory cells, the pathologic changes, the increased levels of Th2 cytokines in lungs of OVALPS-OVA mice, increased mitochondrial ROS generation, and increased bronchial hyperresponsiveness. Interestingly, we found that in OVALPS-OVA mice, Mito-Tempo, a novel mitochondrial targeting agent significantly reduced the increases in inflammatory cytokines, mitochondrial ROS generation, airway inflammation, and bron-chial hyperresponsiveness. These findings indicate that mitochondrial dysfunction including oxidative damage may be im-plicated in the pathogenesis of bronchial asthma and provide the therapeutic potential of a mitochondrial targeting agent, Mito-Tempo, for bronchial asthma.
The Relationship between Mitochondrial ROS and ER Stress in Allergic Airway Diseases
( So Ri Kim ),( Yong Chul Lee ),( Dong Im Kim ),( Mi Ran Kang ),( Yang Keun Rhee ),( Heung Bum Lee ),( Seoung Ju Park ),( Chi Ryang Chung ),( Seung Yong Park ),( Hee Jung Kim ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
Mitochondria and the Nox family of NADPH oxidase are the two major sources of reactive oxygen species (ROS) that are induced by external stimuli, and the mitochondria respiratory chain is considered as an important site of ROS production within most cells. Recent evidence has demonstrated that various biological stimuli increase accumulation of unfolded or mis-folded proteins in ER lumen, which is referred to as "ER stress". Moreover, these various pathologic stimuli have been reported to provoke oxidative stress as well as ER stress. In this study, we used the mice sensitized with OVA and LPS and then challenged with OVA (OVALPS-OVA mice) for elucidation of the relationship between mitochondrial ROS and ER stress in bronchial asthma. The OVALPS-OVA mice showed that the expression of ER stress markers and the protein levels of un-folded-protein response (UPR)-related marker in lung tissues were significantly increased after OVA challenge. In addition, we visualized the localization of mitochondrial ROS in BAL cells isolated from OVALPS-OVA mice using confocal microscopy; the significant increase in mitochondrial ROS in BAL cells was observed after OVA challenge. Our results also showed that Necrox-5 or 4-PBA significantly reduced the increases in ER stress, mitochondrial ROS, inflammatory cytokines, airway in-flammation, and bronchial hyperresponsiveness. These findings suggest that mitochondrial ROS and ER stress plays an im-portant role in the induction and maintaining allergic airway diseases synergistically.
Synthesis and Cytotoxicity of New Aromatic Ceramide Analogs with Alkylsulfonamido Chains
Kang, Joo-Sung,Kim, Seung-Yong,Choi, Su-Hang,Lim, Se-Jin,Im, Chae-Uk,Yim, Chul-Bu,Kim, Kyoung-Won 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.5
A series of D-erythro ceramide analogues, N-(2S,3R,4E)-1 ,3-dihydroxy-5-phenyl pent4-en-2-yl alkyl sulfonamides, were synthesized and evaluated for their in vitro cytotoxic activities against five human tumor ceil lines. The aromatic sullen amido ceramide analogue (10f)showed more potent cytotoxic activity than that of the B13, indicating that a sulfonamide group appears to serve as a bioisostere of an amide in drug design. Variations in the alkyl sulfonyl chain length signifcantly influenced the cytotoxic activity of the sulfonamido ceramide analogues, but the introduction of a para halogen on the phenyl ring of aromatic ceramide analogues had no affect on the activity.
Kang, Min-Jung,Lee, Hye-Im,Shin, Sang-Mi,Yoo, Hye-Hyun,Kwon, Oh-Seung,Jin, Chang-Bae,Chung, Bong-Chul Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.10
The objective of this study was to validate performance characteristics of the Access 2 (Beckman coulter) system for hCG assays for use as a confirmation test for doping control. The Access 2 assay was linear up to 500 IU/L. The correlation coefficient was higher than 0.999, and the sensitivity of the linearity was 0.82. There were no false positive or false negative cases. LOD was 0.59 IU/L. The method was robust when performed by different people. Repeatability and reproducibility were below 7%. We compared reproducibility and recoveries of Access 2 and Elecsys 2010. Access 2 demonstrated higher reproducibility than Elecsys 2010. Recoveries (accuracy) of Access 2 were between 85 and 105%. Recoveries for Elecsys 2010 were between 91 and 104%.
Kang, Jung Hoon,Im, Soo-Bin,Yang, Sang-Mi,Chung, Moonyoung,Jeong, Je Hoon,Kim, Bum-Tae,Hwang, Sun-Chul,Shin, Dong-Seong,Park, Jong-Hyun The Korean Neurosurgical Society 2019 Journal of Korean neurosurgical society Vol.62 No.6
Objective : We introduce innovative method of cervical column reconstruction and performed the reconstruction with a flanged titanium mesh cage (TMC) instead of a plate after anterior corpectomy for cervical spondylotic myelopathy (CSM) and an ossified posterior longitudinal ligament (OPLL). Methods : Fifty patients with CSM or OPLL who underwent anterior cervical reconstruction with a flanged TMC were investigated retrospectively. Odom's criteria were used to assess the clinical outcomes. The radiographic evaluation included TMC subsidence, fusion status, and interbody height. Thirty-eight patients underwent single-level and 12 patients underwent two-level corpectomy with a mean follow-up period of 16.8 months. Results : In all, 19 patients (38%) had excellent outcomes and 25 patients (50%) had good outcomes. Two patients (4%) in whom C5 palsy occurred were categorized as poor. The fusion rate at the last follow-up was 98%, and the severe subsidence rate was 34%. No differences in subsidence were observed among Odom's criteria or between the single-level and two-level corpectomy groups. Conclusion : The satisfactory outcomes in this study indicate that the flanged TMC is an effective graft for cervical reconstruction.
임종철,홍석우,강연익 釜山大學校生産技術硏究所 1998 生産技術硏究所論文集 Vol.55 No.-
최근 산업발달에 의한 교통량의 증가로 도로건설이 활발하게 진행되고 있는 실정이며, 도로건설은 지반조건이 불리한 연약지반상에서의 건설도 필수적이 되었다. 그러나, 연약지반에서의 성토공사시 시공상황을 적절히 고려하여 성토사면의 안정문제를 판단할 수 있는 전반적인 유지관리체계가 확립되어 있지않기 때문에 역약지반의 거동을 해석하기 위한 모델 및 시공시의 안정관리를 위한 연구가 활발히 진행되고 있다. 본 연구에서는, 설계 및 시공시 공정계획에 따른 성토사면의 안정성을 판단할 수 있도록 하기 위하여 정규압밀상태인 연약점토지반상의 점증성토와 방치기간을 고려할 수 있고, 압밀경과시간과 점토지반의 깊이에 따른 강도증가율을 고려할 수 있는 안정해석 프로그램(RSI-SLOPE)을 개발하였다. 이 프로그램을 이용하여 임의의 해석단면에 대하여 성토설계를 실시하였고 성토설계시 압밀계수(c)와 배수거리(H)의 영향을 비교·분석하였다. Recently, roads are being constructed actively due to traffic increase by industrial development. So, it is essential for the road to be constructed on the soft ground. But, it is not established to calculate stability of embankment with respect to the construction condition on soft ground. In this study, stability analysis program(RSI-SLOPE) is developed. By using this program, it is possible to consider the rate of strength increase according to consolidation period and the depth of clay ground as well as resting duration and gradually increasing embankment on the soft clay in normally consolidated state in order to be able to judge stability of embankment with time schedule in design or construction. In addition, this study contains analysis and comparison about influence of coefficient of consolidation(c) and drainage distance(H) in embankment design.
地盤 掘鑿時의 地盤앵커에 의한 近接 構造物의 沈下 抑制 效果
강낙안,공영주,주인곤,임종철 釜山大學校生産技術硏究所 1996 生産技術硏究所論文集 Vol.50 No.-
지하구조물의 건설을 위한 깊은 굴착으로 인해 근접구조물에 많은 피해가 발생하고 있다. 피해를 일으키는 주된 원인은 흙막이 벽체의 수평변위에 의한 지반침하와 지하수위 저하나 진동등에 의한 압밀, 다짐 발생에 따른 지반침하 등이다. 지금까지 대부분의 연구는 현장계측을 이용하였으므로, 벽체의 변위와 지반침하에 영향을 미치는 많은 인자들 각각의 영향을 밝히기는 대단히 어려웠다. 본 연구에서는 실내 모형실험을 통하여 최종 굴착시의 주동파괴면 안쪽에 놓여있는 구조물의 침하를 최소화할 수 있는 지반앵커(1단, 2단)의 위치 및 간격을 결정하였다. 실험결과, 앵커 1단 설치, 앵커 2단 설치의 경우가 모두 앵커 깊이 비=0.4∼0.5일 때, 근접구조물의 침하가 최소가 되었다. 또, 지반 굴착시의 지반변형을 관찰하여 위의 사실을 확인하고, 지반 파괴면의 위치 및 형상을 구하였다. The structure is often deformed and damaged by deep excavation. This deformation and damage are mainly made by ground settlement(consolidation, compaction) owing to groundwater drop or vibration etc. and lateral movement of retaining wall. Then, most studies about deformation of ground have done by using results of site measurement, so it was very difficult to find each effect of many factors separately. The purpose of this study is to decide the location and interval of ground anchor( lst, 2nd ground anchor) to be able to minimize the settlement of adjacent structure located inside the active failure surface by model test at laboratory. As results of this model test, it was known that the depth ration of anchor to minimize the settlement of near-by structure was 0.4∼0.5, and by the observation of ground deformation during excavation, the direction and magnitude of displacement and the failure line could be known.