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      • 건강성인자원자에 있어서 Theophylline과 β_(2)-adrenergicagonists (Procaterol 및 Albuterol)의 약동학적 상호작용

        신현택,권현명,김호순 숙명여자대학교 약학연구소 1998 약학논문집-숙명여자대학교 Vol.14 No.-

        Theophylline and adrenergic β₂ -agonists are frequently used together in bronchial asthma and chronic obstructive pulmonary disease(COPD). Among the adrenergic β₂ -agonists, procaterol and albuterol are most frequently used with theophylline in Korean hospitals. The effect of procaterol and albuterol administration on pharmacokinetics of theophylline was studied in 11 normal healthy volunteers(6 males, 5 females). The theophylline clearances with and without /J-adrenergic agonist (procaterol) were 38.76 + 9.53 ml/kg/hr and 32.46 + 8.46 ml/kg/hr respectively, which were not statistically significant. Similar result was seen with albuterol. The values of AUC, T_(1/2), Ke and Vdss were not influenced by either procaterol or albuterol. Also, there was no significant change in cardiac output and heart rate. In conclusion, adrenergic β₂ -agonists (procaterol and albuterol) do not alter theophylline pharmacokinetics.

      • 경량기포 콘크리트의 고방수 특성에 관한 연구

        신현택 경상대학교 생산기술연구소 2000 生産技術硏究所論文集 Vol.16 No.-

        The result of the addition of silicone and polymer with high waterproofing properties on the autoclaved lightweight concrete were studied by varying the contents of the waterproofing agent. ALC specimens were autoclave cured at 180℃ for 6 hrs under saturated steam pressure. The major experimental results are as follows. 1. The water absorbtion of waterproofing ALC specimens with 1.5 % waterproofing agent was smaller than that of control ALC specimens by 42.46%. 2. The compressive strength after freezing and thawing for 16days of control ALC specimen was 40 Kg/㎠, but in case of waterproofing ALC specimen with 1.5% waterproofing agent was 43.2 Kg/㎠. Therefore the performance for freezing and thawing of waterproofing ALC specimen was increased to 108 %. 3. The final hydrate material are 11 Å tobermolite and unreacted quartz as result of X-ray diffraction and SEM examination.

      • 無定形 실리카(왕겨재 및 실리카 흄)를 添加한 슬래그 시멘트의 蒸氣 養生에 의한 機械的 性質

        申鉉澤,鄭喜天 慶尙大學校 1991 論文集 Vol.30 No.2

        슬래그 시멘트에 무정형 실리카로서 왕겨재 및 실리카홈을 혼화재로 첨가한 조합물을 양생온도 90℃, 120℃, 양생시간 6,9,12hrs.로 변화시켜 증기양생한 경화체의 압축강도 및 미세조직을 관찰한 실험 결과는 다음과 같다. 1. 슬래그 시멘트에 왕겨재 또는 실리카 홈 0,3,5,7we.% 양생 조건 120℃-6,9,12hrs. 일때 9시간 증기양생시 가장 높은 압축강도를 나타낸다. 2. 동일한 상기 조건에서 혼합재료로서 왕겨재가 실리카 홈보다 높은 압축강도를 나타낸다. 3. 왕겨재 5%첨가시 120℃-9hrs 양생조건 일때 최고 압축강도는 793kg/㎠을 나타내었다. 4. SEM 미세조직 관찰에서 최고 압축강도가 높은 왕겨재의 경우는 미세기공이 적고 조직이 치밀함을 보여주었다. The mechanical properties and SEM micrograph of portland slag cement-amorphous silica(rice husk ash and silia fume) systems were studied with various compositions. Samples were steam cured at 90 and 120℃ for 6, 9, and 12hrs., respectively. The highest compressive strength (793 kg/ ㎠) was abtained the composition in weight ratio of portland slag cement : rice husk ash = 95 : 5 at 120℃-9hr steam curing. SEM micregraphs of the specimens with 5 wt.% RHA steam curing at 120℃-9hrs were more dense than specimen with 5 wt.% SF.

      • 편도체 중심핵의 가역적 손상이 공포의 습득과 표현에 미치는 영향

        신선희,김기석,김현택 한국심리학회 한국심리학회지 생물 및 생리 Vol.4 No.1

        지난 수년간 여러 보고들은 편도체가 무조건공포 및 조건공포에 관여함을 시사해 왔는며 근래에 들어서는 이 구조물을 하부핵군으로 구분하여 기능적으로 특정화하려는 노력이 시도되고 있다. 편도체 중심핵은 이들 하부핵군들 중 여러 가지 공포반응을 지배하는 뇌간 영역들에 가장 광범위한 투사를 하기 때문에 공포의 표현에 관여할 것이라는 견해가 지배적이다. 그러나 공포의 습득에서 편도체 중심핵의 역할에 대해서는 상반된 주장들이 있다. 따라서 본 연구는 공포나 불안을 측정하는 여러 동물모형중에서 상승된 경악반응 절차를 사용하여, 편도체 중심핵의 가역적 손상이 공포의 습득과 표현에 어떠한 영향을 미치는지 살펴보고 이를 통해 공포학습에서 편도체 중심핵의 역할을 알아보고자 하였다. 공포의 습득장면과 표현장면을 분리하여 연구하기 위해 국소마취제 리도카인이 사용되었다. 실험집단으로는 리도카인의 미세 주입 시기를 훈련 직전과 검사 직전으로 구분한, 리도카인-식염수 집단, 식염수-리도카인집단, 식염수-식염수집단, 리도카인-리도카인집단이 사용되었다. 실험결과, 훈련전이나 혹은 검사전에 리도카인을 투여받은 피험동물들은 경악반응의 상승을 거의 보이지 않았다. 그러나 이같은 결과를 상황의존적 인출실패 때문이라고 볼 수 없다. 왜냐하면 리도카인-리도카인 집단 역시 상승된 경악반응을 보이지 않았기 때문이다. 따라서 본 연구의 결과는 편도체 중심핵이 공포의 표현뿐만아니라 공포의 습득에도 중대하게 관여함을 시사한다. For the past years there have been not a few reports that suggested the amygdala is responsible for conditioned fear as well as for unconditioned fear. In recent years the attempts have been made to divide the amygdala into several sub-structures and to specify each of them in view of its function. And it is generally accepted that among the sub-divisions the central amygdala takes part in the expression of fear because it projects its fibers most expensively to the brainstem areas which control a variety of fear responses. But with respect to the acquisition of fear, the role of the central amygdala is of much controversy. The present study is therefore to investigate what effects the reversible lesions of the central amygdaloid nucleus have on the acquisition and the expression of fear, using the fear-potentiated startle paradigm as an animal model for measuring fear or anxiety, and accordingly to identify the role of the centra amygdala in fear conditioning. To separate conditioning trial from test trial, the local anesthetic lidocaine was used, and so the experiment consisted of four groups on the basis of lidocaine micro-injected right before the conditioning trial or just before the test trial: lidocaine-saline group, saline-lidocaine group, saline-saline group, and lidocaine-lidocaine group. As a result, the animals which had been lidocaine-injected either before the conditioning trial or before the test trial, showed little increase in the startle responses. But the result cannot be due to the state dependent retrieval failure since the lidocaine-lidocaine group showed no fear-potentiated startle responses either. Thus, the result of the study strongly suggests that the central amygdala is involved not only in the expression of fear but also in the acquisition of fear.

      • 輕量콘크리트블록의 製造에 關한 硏究

        申鉉澤 慶尙大學校 1985 論文集 Vol.24 No.1

        Expanded polystyrene beads used as aggregate instead of natural gravel for the manufacture of light weight hollow concrete block. These granules are spherical, hydrophobic and have a closed cell structure. But they do not absorb water. Steam-cured lightweight plastic aggregate concrete block prepared from portland cement, natural sand and expanded polystyrene beads were investigated by means of test of compressive strength and measurement of specific gravity.

      • NADPH의 안정화 및 이온토포레시스를 이용한 피부투과

        신현택,이승연,오승열 숙명여자대학교 약학연구소 2005 약학논문집-숙명여자대학교 Vol.22 No.-

        Nicotinamide Adenine Dinucleotide Phosphate (NADPH) has antioxidant effect in the body and thus decreases the symptoms of senility. The development of a transdermal delivery formulation for NADPH is a very difficult task, due to its rapid decomposition by oxidation, low partition coefficient into stratum corneum, high molecular weight and electrical charge at neutral pH in aqueous solution. The purpose of this work is to test several anti-oxidants as the stabilizing agent for NADPH in the aqueous formulation, and to study the effect of these agents on the in-vitro iontophoretic transport through hairless mouse skin. The stability of NADPH in aqueous solution with/without various antioxidants such as butylated hydroxy toluene (BHT), resveratrol, a-tocopherol and Vitamine C was studied. BHT an a-tocopherol (0.01 % w/w) exhibited minimal stabilizing effect, however resveratrol and vitamine C showed significant stabilizing effect. Stabilizing effect of vitamine C was proportional to the concentration in aqueous solution. Although vitamine C increased the stability ofNADPH significantly, it decreased flux of NADPH in a concentration dependent fashion, therapeutic amount ofNADPH can be delivered through skin using iontophoresis and These results suggest that, in order to develope a efficient iontophoresis formulation, it is important to choose a stabilizing agents which are not only potent in stabilizing effect but also not competitive for the delivery of NADPH.

      • 경량 기포콘크리트의 특성에 관한 연구

        신현택,정희천 국립경상대학교 공과대학 부설 첨단소재연구소 1991 尖端素材 Vol.1 No.-

        The effects of the addition of fly ash and carbon fiber on the mechanical properties of aerated concrete were studied by varing the compositions and curing conditions. Samples were steam cured at atmospheric (90℃-5hrs.) and high pressure (175℃-5hrs.) respectively. The highest compressive and flexural strength (56, 31 ㎏/㎠) was obtained at autoclave curing condition, and optimum composition was in weight ratio of portland cement : fly ash = 55 : 45, which contained 0.4 vol.% carbon fiber. The specific gravity and thermal conductivity of cured cement in autoclave was smaller than that in atmospheric. In the case of autoclave curing (portland cement : fly ash = 55 : 45 ), hydration products were CSH and 11 Åtobermorite, which were considered to the increase of strength.

      • 高機能性을 갖는 ALC에 關한 硏究

        申鉉澤,申智容 慶尙大學校生産技術硏究所 1996 生産技術硏究所論文集 Vol.12 No.-

        The effects of the addition of silicone resin with water-repellent properties on the autoclaved lightweight concrete were studied by varing the compositions of silicone resin. ALC samples were cured at 180℃-7hrs under saturated steam pressures. The major experimental results are as follow. 1. The water absorption (7day) of water-repellent ALC specimen with 2.0% of alkyl polysiloxane was smaller than that of experimental standard ALC specimen by 93.1%. 2. The compressive strength after freezing and thawing for 16 days of control ALC specimen was 16.8 ??, but in case of water-repellent ALC specimen with 2.0% alkyi polysiloxane was 41.8 ??. Therefore the performance for freezing and thawing of water-repellent ALC specimen was increased to 149%. 3. The final hydrate materials are 11Å tobermorite, alkyi polysiloxane and unreacted Quartz as results of X-ray diffraction and SEM examination.

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