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김태형,김병호,이정일,김효종,한요셉,장영운,이동근,동석호,김경진,장린 대한소화기내시경학회 2000 Clinical Endoscopy Vol.21 No.6
Lung cancer begins insidiously, metastasizes early, and is frequently nonresectable at the time of diagnosis. Gastrointestinal metastases are considered the most unusual. A 60 year-old man was admitted for the evaluation of dizziness. For two weeks prior to admission, he had mild blood-tinged sputum and melena. He had right cervical lymphadenopathy, measured by 2 X 2 cm. Laboratory studies demonstrated hemoglobin of 3.7 g/dL, Posteroanterior and lateral chest radiographs revealed mass-like lesion of right upper lobe. An umblicated mass was found in the sigmoid colon by colonoscopic examination and biopsy was done. He developed abdominal pain, tenderness and rebound tenderness at admission 10 days, Abdominal CT showed that focal thickened wall and suspicious perforated lesion at the ileum. Operation was done. In recent time, we experienced a case in which perforation of gastrointestinal metastases developed with malignant tumors of the lung.
Hyo Lim Lee,Jong Min Kim,Jong Hyun Moon,Min Ji Kim,Hye Rin Jeong,Min Ji Go,Tae Yoon Kim,Seung Gyum Joo,Ho Jin Heo 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
This study was conducted to assess the synbiotics interaction between the Corni fructus and Lactobacillus reuteri in a dextran sulfate sodium (DSS)-induced colitis and cognitive dysfunction in C57BL/6 mice. Mice were treated with Corni fructus (PRE; prebiotics), Lactobacillus reuteri (PRO; probiotics), and synbiotics (SYN; combination of Lactobacillus reuteri and Corni fructus) for 3 weeks. Consumption of PRE, PRO and SYN ameliorated body weight loss and colon-length shortening. Those treatments improved intestinal permeability by decreasing of in serum and increasing of tight junction protein expression in colonic tissue. Those also decreased the expression of inflammatory cytokine, and the myeloperoxidase activity. Especially, SYN significantly increased the content of short chain fatty acids in colitis mice fecal compared to PRE and PRO. Furthermore, PRE, PRO and SYN improved behavioral dysfunction by evaluating the Y-maze and passive avoidance tests. SYN significantly protected the antioxidant damages and cholinergic dysfunction, and regulated protein expression of acetylcholinesterase and choline acetyltransferase compared with PRE and PRO.
Kim, Byung-Ho,Han, Yo Seb,Choe, Bong-Keun,Cho, Hyeseong,Nam, Gi Deog,Lee, Jin Woo,Kim, Young Il,Park, Jai Kyung,Dong, Seok Ho,Kim, Hyo Jong,Chang, Young-Woon,Lee, Joung-Il,Rin Chang KYUNG HEE UNIVERSITY MEDICAL CENTER 2006 고황의학상 수상논문집 Vol.21-22 No.-
Conditionally immortalized hepatocytes (CIH) established with a gene for the temperature-sensitive mutant of the T antigen (tsT) have characteristics to stop proliferating and to differentiate at nonpermissive temperatures (37-39℃) due to inactivation of the T antigen. Therefore, they may be a good alternative to primary hepatocytes for experimental investigations or clinical applications. Deinduction of the T antigen results in a transient increase of p53 in these cells, leading to reexpression of normal senescence because of the telomere attrition occurring during the early stages of immortalization. To determine this T antigen dependency for the maintenance of immortality, a type of rat CIH was cultured continuously at 39℃. The frequency of occurrence of T-antigen-independent clones ranged from 0.053% to 0.093%. These clones maintained the temperature-sensitive property of the T antigen; nevertheless, they were able to progress to the S phase and proliferate without undergoing apoptosis at 39℃ as at 33℃, a permissive temperature. The temperature-sensitive point mutation of tsT was not affected in these clones and the T antigen was functioning properly. The integrity of the p53 pathway was also maintained from the point of Western blot analysis of p21. Although the telomerase continued to be expressed and the telomere length was maintained, marked chromosomal damage could not be avoided in these cells. It is a plausible explanation that this escape phenomenon from conditional immortalization may be related to the change of other genes involved in cell cycles, which have yet to be elucidated. In conclusion, CIH could lose their temperature-sensitive characteristics without the change of tsT, itself, and the T antigen is not always necessary to maintain their immortality. Therefore, the results obtained from experimental investigations using these cells should be interpreted carefully, and unpredictable phenotypic changes should also be taken into consideration when using them in clinical applications.
종양표지자 CA19- 9 의 현저한 상승을 보인 간내 담관낭선종 1 예
김병호,김효종,김윤화,장린,이정일,동석호,장영운,김희진,박철영,강선우,손상용 대한소화기학회 1999 대한소화기학회지 Vol.33 No.6
A 24-year-old woman who had one month history of right upper quadrant abdominal mass and pain was admitted to our hospital. Examination by abdomen ultrasonography and computerized tomo graphy indicated that it was a large cystic tumor in the liver with multiple internal septation. Thus she received a laparotomy. A 15×12×5 cm cystic mass from left medial segment of the liver wa noted and could be removed by cystectomy and partial segmentectomy. On cut section, yellowish serous fluid containing multilocular cyst surrounded by a smooth and glistening wall was seen Microscopic findings revealed that it is a case of intrahepatic biliary cystadenoma with mesenchyma stroma. This tumor was noted with strikingly elevated serum level of the tumor-associated antigen CA 19-9 (500 U/ml). Twenty days after the surgery, the serum CA 19-9 level returned to normal (29 U/ml). This may be a valuable finding in the differential diagnosis, so we report this case with review of the literatures.
김병호,이정일,김효종,김영관,장린,동석호,장영운,김금정 대한소화기내시경학회 1993 Clinical Endoscopy Vol.13 No.1
Crohn's disease of the duodenum is a rare disorder that should be considered in patients with distal Crohn's disease in whom significant upper gastrointestinal symytoms develop. A combination of diagnostic tools, including attentive history taking.and appropriate radiographic and endoscopic studies, should be applied to make the diagnosis, Although not always confirmatory, careful histologic study if adequate biopsy material may be helpful. Medical treatment should be the treatment of choice for all patients with nonobstructing Crohn's disease of the duodenum and is similar to that of Crohn's disease elsewhere in the gastrointestinal tract. If obstruction develops, bypass surgery is indicated. We experienced a case of Crohn's disease of the duodenum and reported with the review of the literature.
Surface Modification of Silk Fibroin Nanofibrous Mat with Dextran for Wound Dressing
Kim, Moo Kon,Kwak, Hyo Won,Kim, Hyung Hwan,Kwon, Tae Rin,Kim, So Young,Kim, Beom Joon,Park, Young Hwan,Lee, Ki Hoon THE KOREAN FIBER SOCIETY 2014 FIBERS AND POLYMERS Vol.15 No.6
In this study, we examined the effects of a dextran-modified silk fibroin nanofibrous mat (D-SFNM) on wound healing. To increase the hydrophilicity of silk fibroin (SF), the SF nanofibrous mat (SFNM) was modified with oxidized dextran. The D-SFNM absorbed water faster than the SFNM, and the swelling ratio was increased by approximately 80 % compared with the SFNM. An in vitro cell (NIH3T3) test revealed that fewer cells attached to the D-SFNM than the SFNM, but the proliferation of cells was not significantly affected by the presence of dextran. An in vivo wound healing test with mice indicated that the D-SFNM resulted in a good wound recovery effect similar to a commercial wound dressing material. The increased hydrophilicity of the D-SFNM might balance the moist environment at the wound site, which improves the wound healing compared with the SFNM.