콜롬비아 소가모스에서 미세먼지 감축 시나리오 분석

박일수(Park, Il-Soo),장유운(Jang, Yu-Woon),하상섭(Ha, Sang-Sub),장수환(Jang, Su-Hwan),정경원(Chung, Kyung-Won),김혜원(Kim, Hye-Won),김희선(Kim, Hee-Sun) 한국외국어대학교 중남미연구소 2016 중남미연구 Vol.35 No.2

콜롬비아 소가모스 지역에서 미세먼지 감축 시나리오를 TAPM 모델을 활용하여 도출하고 평가하였다. 시나리오 1의 제철소 및 금속 등 중공업 오염원을 대상으로 미세먼지 방지 기술을 이용하여 배출량을 80% 감축하는 방안에서는 도시 중심 평균 농도는 6.5 μg m-3로 1.5 % 감소하였고, 모델영역에서 최고 평균농도는 387 μg m-3 로 변동 없었다. 시나리오 2의 벽돌 및 석회공장 등을 대상으로 연료를 석탄에서 코크스로 교체하여 90 % 감축하는 방안에서는 도시 중심 평균 농도는 4.5 μg m-3로 31.8%, 모델영역에서 최고 평균농도는 111 μg m-3 로 71.6 % 감소하였다. 시나리오 1과 시나리오 2를 결합한 시나리오 3에서는 도시 중심에서 평균 농도는 4.3 μg m-3로 34.8 %, 모델영역에서 최고 평균농도는 110 μg m-3 로 71.7 % 감소하였다. 소가모스 지역에서 대기환경을 개선하는 로드맵 수립에는 수공업에서 주로 사용되는 석탄 연료를 청정연료인 코크스로 교체하는 방안이 최우선으로 고려되어야 하겠다. 이후 미세먼지 방지 시설을 굴뚝에 설치하는 방안도 차선책으로 고려하여 환경과 경제가 선 순환하는 녹색성장관점에서 장기적인 미세먼지 개선 마스터 플랜이 수립되어야 하겠다. Reduction scenarios for PM10 concentration in Sogamoso, Colombia were analyzed using the TAPM( The Air Pollution Model). The average concentration of PM10 in the downtown area was 6.5 μg m-3, a reduction of 1.5 %. The maximum average concentration in the model domain was 387 μg m-3 without any reduction in scenarios 1 which the PM10 emissions from heavy industries such as iron and metal was reduced by 80 % using the prevention technology. In scenario 2 which the PM10 emissions from the brick and lime industries was reduced by 90 % substituting coke (a cleaner fuel) for coal, the average concentration of PM10 in the downtown area was 4.5 μg m-3, a reduction of 31.8 % , the maximum average concentration in the model domain was 111 μg m-3 , a reduction of 71.6 %. In scenario 3 which the scenarios 1 and 2 were combined, the average concentration of PM10 in the downtown area was 4.3 μg m-3, a reduction of 34.8 % and the maximum average concentration was 110 μg m-3, a reduction of 71.7 %. To put forward a road map for the reduction of PM10 in the Sogamos region, substituting coke for coal in manual industries should have priority over reduction policies. Also, it is highly recommended that a longterm master plan for reducing PM10 concentrations should be established with a focus on environmentally-friendly development and future green growth policy with a win-win relationship between economy and environment.

플라즈마 정보인자를 활용한 SiO₂ 식각 깊이 가상 계측 모델의 특성 인자 역할 분석

장윤창,박설혜,정상민,유상원,김곤호,Jang, Yun Chang,Park, Seol Hye,Jeong, Sang Min,Ryu, Sang Won,Kim, Gon Ho 한국반도체디스플레이기술학회 2019 반도체디스플레이기술학회지 Vol.18 No.4

We analyzed how the features in plasma information based virtual metrology (PI-VM) for SiO2 etching depth with variation of 5% contribute to the prediction accuracy, which is previously developed by Jang. As a single feature, the explanatory power to the process results is in the order of plasma information about electron energy distribution function (PIEEDF), equipment, and optical emission spectroscopy (OES) features. In the procedure of stepwise variable selection (SVS), OES features are selected after PIEEDF. Informative vector for developed PI-VM also shows relatively high correlation between OES features and etching depth. This is because the reaction rate of each chemical species that governs the etching depth can be sensitively monitored when OES features are used with PIEEDF. Securing PIEEDF is important for the development of virtual metrology (VM) for prediction of process results. The role of PIEEDF as an independent feature and the ability to monitor variation of plasma thermal state can make other features in the procedure of SVS more sensitive to the process results. It is expected that fault detection and classification (FDC) can be effectively developed by using the PI-VM.

우리나라 노인여성의 골다공증성 척추골절로 인한 경제적 부담 추계

강혜영,강대룡,장영화,박성은,최원정,문성환,양규현,Kang, Hye-Young,Kang, Dae-Ryong,Jang, Young-Hwa,Park, Sung-Eun,Choi, Won-Jung,Moon, Seong-Hwan,Yang, Kyu-Hyun 대한예방의학회 2008 예방의학회지 Vol.41 No.5

Objectives : To estimate the economic burden of osteoporotic vertebral fracture (VF) from a societal perspective. Methods : From 2002 to 2004, we identified all National Health Insurance claims records for women ${\geq}50$ years old with a diagnosis of VF. The first 6-months was defined as a "clearance period," such that patients were considered as incident cases if their first claim of fracture was recorded after June 30, 2002. We only included patients with ${\geq}$ one claim of a diagnosis of, or prescription for, osteoporosis over 3 years. For each patient, we cumulated the claims amount for the first visit and for the follow-up treatments for 1 year. The hospital charge data from 4 hospitals were investigated to measure the proportion of the non-covered services. Face-to-face interviews were conducted with 106 patients from the 4 study sites to measure the out-of-pocket spending outside of hospitals. Results : During 2.5 years, 131,453 VF patients were identified. The patients had an average of 3.38 visits, 0.40 admissions and 6.36 inpatient days. The per capita cost was 1,909,690 Won: 71.5% for direct medical costs, 20.6% for direct non-medical costs and 7.9% for indirect costs. The per capita cost increased with increasing age: 1,848,078 Won for those aged 50-64, 2,084,846 Won for 65-74, 2,129,530 Won for 75-84and 2,121,492 Won for those above 84. Conclusions : Exploring the economic burden of osteoporotic VF is expected to motivate to adopt effective treatment options for osteoporosis in order to prevent the incidence of fracture and the consequent costs.

Sequence Control of Small-scaled ITER Power Supply for Reactive Power Compensation

Hye-Seong Heo(허혜성),Ki-Won Park(박기원),Hyun-Sik Ahn(안현식),Gye-Yong Jang(장계용),Hyun-Seok Shin(신현석),Jung-Wan Choi(최정완),Jong-Seok Oh(오종석) 대한전기학회 2009 대한전기학회 학술대회 논문집 Vol.2009 No.7

A technology based on thyristors will be used to manufacture the super-conducting coil AC/DC converters because of the low ratio of cost over installed power compared to a design based on GTO or similar technology. But phase-controlled converter suffers from fundamental disadvantage. They inject current harmonics into the input ac mains due to their nonlinear characteristics, thereby distort the supply voltage waveform, and demand reactive power from the associated ac power system at retarded angles. To overcome this disadvantage, in the case of two series converters at the DC side, connected to the same step-down transformer, apply for the sequence control. It is the most simple and efficient way to reduce the reactive power consumption at low cost. Analytical sequence control algorithm is suggested, the validity of the proposed scheme has been verified by experimental results with the small-scaled International Thermonuclear Experimental Reactor (ITER) Power Supply to minimize reactive power consumption.

Effects of Silicon on the Endogenous Gibberellic and Jasmonic acid Levels in Rice

Jang Soo-Won,Seo Hye-Song,Kim Jung-Tae,Lee In-Jung 한국작물학회 2003 한국작물학회 학술발표대회 논문집 Vol.2003 No.-

Ectopic pregnancy arising at a distal, fimbriated end of the fallopian tube, which was developed adjacent to the undescended ectopic ovary in unicornuate uterus : a case report

( Hye Ji Jeon ),( Yong Soo Jang ),( Seon Gyeong Kim ),( Hui Gyeong Seo ),( Deok Gyeong Kim ),( Ji Won Min ),( Yun Sook Kim ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-

Unicornuate uterus is caused by a failure of one Mullerian duct to develop.It is linked to an increase in obstetrical complications such as early miscarriages, ectopic pregnancy and preterm labor. Despite the association of ectopic ovaries and unicornuate uterus, ectopic ovaries are reported only sporadically. We introduce first case of ectopic pregnancy arising at a distal, fimbriated end of the fallopian tube, which was developed adjacent to the undescended ectopic ovary in unicornuate uterus. PI: A 32- year-old woman admitted emergency room of our clinic due to severe lower abdominal pain. Her last menstrual period was 9 weeks ago. Four weeks ago, she was performed dilatation and curettage at local clinic due to no G-sac in uterus and slowly increasing ß-human chorionic gonadotropin (ß-hCG). After dilatation and curettage, her ß-hCG was continuously increased from 2,400 mIU/mL to 2,800 mIU/mL. So, she was injected methotrexate (MTX) 50mg IM. One week after MTX injection, her ß-hCG was decreased to 1,700 mIU/mL. Her vital sign was stable. Her ß-hCG was 386 mIU/mL. Ultrasonogram: Fluid collection of anterior cul-de sac (CDS) was 70 X 50mm, posterior CDS was 30 X 26mm. The endometrial thickness was 5mm, and no G-sac. Laparoscopic Findings: Unicornuate uterus, about 500ml hemoperitoneum, left side salpinx and ovary was intact. Right side salpinx was seen, but no right side fimbriae and ovary. No ectopic mass in pelvic cavity. High up in the right abdomen, just below the liver, an ectopic mass could be visualized with a arising at a distal, fimbriated end of the fallopian tube, which was developed adjacent to the undescended right ectopic ovary. We removed ectopic mass. One day after operation, her ß-hCG decreased to 91 mIU/mL. She discharged. Hysterosalpingography: Unicornuate uterus, preserved patency of left salpinx and some right salpinx. MRI: Unicornuate uterus, Right ovary was seen at right inferior hepatic portion, bilateral normal kidney, double IVC.

Overexpression of OsMLD encoding MYB-like DNA binding domain increases tolerance to salt stress in rice (Oryza sativa L.)

Hye-Jung Lee,Sailila E Abdula,Moo-Geun Jee,Dae-Won Jang,Dal-A Yu,Sung-Han Park,Ung-Han Yoon,Tae-Ho Kim,Yong-Gu Cho 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07

MYB-like domain (MLD) gene is a transcription factor that plays a diverse role in plant development and in response to abiotic stresses. In this study, we isolated and developed CaMV35S::OsMLD rice lines and determined its expression pattern under abiotic stresses. It has Myb_CC_LHEQLE superfamily similar to most transcription factor genes but with a very unique binding domain of SHLQKYR in the C-terminal region. Overexpressing rice lines showed enhanced tolerance to salinity with elevated mRNA transcript. Additionally, mRNA transcripts were up-regulated by ABA, H2O2 and dehydration stresses. Further investigation in the enhanced tolerance to salinity showed an increased accumulation of proline and a decreased in malondialdehyde contents indicating that OsMLD gene may be involved in the regulation of proline and osmolytes during abiotic stresses. These results showed that OsMLD gene could be used in the development of rice intended for soil with salinity-related problem.

Clinicopathological Significance of Elevated PIK3CA Expression in Gastric Cancer

Jang, Si-Hyong,Kim, Kyung-Ju,Oh, Mee-Hye,Lee, Ji-Hye,Lee, Hyun Ju,Cho, Hyun Deuk,Han, Sun Wook,Son, Myoung Won,Lee, Moon Soo The Korean Gastric Cancer Association 2016 Journal of gastric cancer Vol.16 No.2

Purpose: PIK3CA is often mutated in a variety of malignancies, including colon, gastric, ovary, breast, and brain tumors. We investigated PIK3CA expression in gastric cancer and explored the relationships between the PIK3CA expression level and clinicopathological features as well as survival of the patients. Materials and Methods: We examined PIK3CA expression in a tissue microarray of 178 gastric adenocarcinomas by immunohistochemistry and reviewed patients' medical records. Results: In our study, 112 of the 178 gastric cancer patients displayed positive PIK3CA expression. Overexpression of PIK3CA was correlated with low grade differentiation (P=0.001), frequent lymphatic invasion (P=0.032), and high T stage (P=0.040). Patients with positive PIK3CA staining were more likely to display worse overall survival rate than those with negative PIK3CA staining, as determined by Kaplan-Meier survival analysis with log-rank test (P=0.047) and a univariate analysis using the Cox proportional hazard model (hazard ratio=1.832, P=0.051). Conclusions: Elevated PIK3CA expression was significantly correlated with tumor invasiveness, tumor phenotypes, and poor patient survival.

Schedule-dependent synergistic effects of 5-fluorouracil and selumetinib in <i>KRAS</i> or <i>BRAF</i> mutant colon cancer models

Jang, Hye Yeon,Kim, Do Hyung,Lee, Haeng Jung,Kim, Won Dong,Kim, Seog-Young,Hwang, Jung Jin,Lee, Seung Jin,Moon, Dae Hyuk Elsevier 2019 Biochemical pharmacology Vol.160 No.-

<P><B>Abstract</B></P> <P>Combination of MEK inhibitor and 5-FU had showed limited efficacy in clinical trials. We previously reported that acquired resistance to 5-FU was related with continued activation of <I>salvage</I> pathway. Here we investigated whether combination of 5-FU and a MEK inhibitor had treatment sequence-dependent synergistic effects in <I>KRAS</I> or <I>BRAF</I> mutant colon cancer models. Treatment with 5-FU followed by selumetinib (FS) induced highest cell death and synergy compared with reverse (SF) and concomitant (cFS) treatment in six cell lines. SF or cFS combination induced synergy in 1 or 2 cell lines, respectively, in which the synergy was less than that by FS combination. FS enhanced apoptosis and decreased anchorage-independent growth. Induction of thymidine kinase 1, a rate-limiting enzyme in <I>salvage</I> pathway, by 5-FU was abrogated by subsequent treatment with selumetinib, and ERK reactivation after selumetinib was prohibited by pretreatment with 5-FU. FS altered mRNA expression in groups of genes distinct from SF. Administration of 5-FU (10 or 30 mg/kg/day) for 7 days, followed by selumetinib (10 or 25 mg/kg/day) for another 7 days, in colo205 and HCT8 xenograft models significantly decreased tumor growth compared with a single agent. However, co-administration in the reverse sequence did not show the difference in tumor size compared with the treatment of single agent. Decreased expression of Ki67 was observed in tumors from mice treated with FS. Our results suggest that sequential administration of 5-FU plus selumetinib would be a promising strategy for patients having <I>KRAS</I> or <I>BRAF</I> mutant colon cancers.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Pcp-2 Interacts Directly with Kinesin Superfamily KIF21A Protein

Hye-Young Park(박혜영),Sang-Jin Kim(김상진),Sung Su Ye(예성수),Won Hee Jang(장원희),Sang Kyeong Lee(이상경),Yeong-Hong Park(박영홍),Yong Wook Jung(정용욱),Il Soo Moon(문일수),Moo Seong Kim(김무성),Dae-Hyun Seog(석대현) 한국생명과학회 2008 생명과학회지 Vol.18 No.8

KIF21A는 kinesin superfamily에 속하는 분자 motor로서 미세소관을 따라서 분비소포를 운반한다. 최근의 연구결과 KIF21A 유전자 일부의 missense 돌연변이에 의하여 congenital fibrosis of the extraocular muscles (CFEOM)1의 유발됨이 밝혀졌다. CFEOM1은 KIF21A의 돌연변이로 인하여 분화 발생과정에 occulo-motor신경과 neuromuscular junction 형성에 필요한 단백질을 이동시키지 못함으로써 유발된다. 본 연구에서는 효모 two-hybrid system을 사용하여 KIF21A의 WD-40 repeat domain과 결합하는 분자량이 작은 Purkinje cell protein-1 (Pcp-2), 또는 L7으로도 알려진 단백질을 분리하였다. Pcp-2는 효모 two-hybrid assay에서 KIF21A와 KIF21B의 WD-40 영역과는 결합하지만 다른 종류의 KIFs와는 결합하지 않았다. 또한 단백질간의 특이적 결합을 pull-down assay로 확인 하였으며, 생쥐의 뇌 파쇄액에 Pcp-2 항체로 면역침강을 행하여 KIF21A를 확인한 결과 Pcp-2와 같이 침강하였다. 이러한 결과들은 KIF21A는 Pcp-2와 결합하며, 또한 Pcp-2는 KIF21A의 adaptor 단백질로서 세포 내 KIF21A의 수송에서 매개 단백질로 작용함을 시사한다. KIF21A is a member of the Kinesin superfamily proteins (KIFs), which are microtubule-dependent molecular motors, anterograde axonal transporters of cargoes. Recently, congenital fibrosis of the extraocular muscles 1 (CFEOM1) has been shown to result from a small number of recurrent heterozygous missense mutations of KIF21A. CFEOM1 results from the inability of mutated KIF21A to successfully deliver cargoes to the development of the occulo-motor neuron or neuromuscular junction. Here, we used an yeast two-hybrid system to identify a protein that interacts with the WD-40 repeat domain of KIF21A and found a specific interaction with Purkinje cell protein-2 (Pcp-2), a small protein also known as L7. Pcp-2 protein bound to the WD-40 domain of KIF21A and KIF21B but not to other KIFs in yeast two-hybrid assays. In addition, this specific interaction was also observed in the glutathione S-transferase pull-down assay. An antibody to Pcp-2 specifically co-immunoprecipitated KIF21A associated with Pcp-2 from mouse brain extracts. These results suggest that Pcp-2 may be involved in the KIF21A-mediated transport as a KIF21A adaptor protein.