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Pentacyclic Triterpenoids and Their Cytotoxicity from the Stem Bark of Styrax japonica S. et Z.
Mi-Ran Kim,Hyang-Hee Lee,Kyung-Soo Hahm,Young-Hee Moon,Eun-Rhan Woo 대한약학회 2004 Archives of Pharmacal Research Vol.27 No.3
The methylene chloride soluble fraction of MeOH extract from the stem bark of Styrax japonica S. et Z. (Styracaceae) showed significant cytotoxicity by SRB method against five human tumor cell lines. Four known pentacyclic triterpenoids, oleanolic aldehyde acetate (1), erythrodiol- 3-acetate (2), euphorginol (3), and anhydrosophoradiol-3-acetate (4) were isolated by activity-guided fractionation. Their structures were determined by chemical and spectral analysis. Compounds 1-4 were isolated from S. japonica for the first time
Pentacyclic Triterpenoids and Their Cytotoxicity from the Stem Bark of Styrax japonica S. et Z.
Kim, Mi-Ran,Lee, Hyang-Hee,Hahm, Kyung-Soo,Moon, Young-Hee,Woo, Eun-Rhan The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.3
The methylene chloride soluble fraction of MeOH extract from the stem bark of Styrax japonica S. et Z. (Styracaceae) showed significant cytotoxicity by SRB method against five human tumor cell lines. Four known pentacyclic triterpenoids, oleanolic aldehyde acetate (1), erythrodiol-3-acetate (2), euphorginol (3), and anhydrosophoradiol -3-acetate (4) were isolated by activity-guided fractionation. Their structures were determined by chemical and spectral analysis. Compounds 1-4 were isolated from S. japonica for the first time.
Min, Kyueng-Whan,Park, Moon Hyang,Hong, Sung Ran,Lee, Heejung,Kwon, Sun Young,Hong, Sook Hee,Joo, Hee Jae,Park, In Ae,An, Hee Jung,Suh, Kwang Sun,Oh, Hoon Kyu,Yoo, Chong Woo,Kim, Mi Jin,Chang, Hee Kyu Raven Press 2013 International journal of gynecological pathology Vol.32 No.1
<P>Accurate diagnosis of ovarian clear cell carcinoma (CCC) is important because of its poor prognosis with chemoresistance and a high recurrent rate. The clinicopathologic characteristics and prognostic significance of the cell cycle regulator [early mitotic inhibitor-1 (Emi1)] and galactoside-binding protein (Galectin-3) were evaluated. Among 155 CCCs from 18 hospitals in Korea between 1995 and 2006, 129 pure CCCs were selected with consensus using immunohistochemical stains for hepatocyte nuclear factor-1β, Wilms' tumor protein, and estrogen receptor. The expressions of Emi1, Galectin-3, p53, and Ki-67 labeling index were analyzed with clinicopathologic parameters and the patient's survival. The mean age of the patients was 49.6 yr; the tumors were bilateral in 10.9%, and the average size was 12 cm. Adenofibromatous component was found in 7%, and endometriosis in 48.1% of the cases. Psammoma body was seen in 16.3%. Disease-free survival and overall survival rates were 78.3% and 79.1%, respectively. The International Federation of Obstetrics and Gynecology (FIGO) stage was the most important prognostic indicator. Emi1 expression (>5%) was seen in 23.3% of CCCs, and associated with high FIGO grades and poor overall survival (P<0.05). High Galectin-3 (80%) expression was seen in 59.7% of CCCs, and associated with FIGO stages III and IV, and high Ki-67 labeling index. High Ki-67 labeling index (50%) and p53 expression (50%) were seen in 27.1% and 18.6% of CCCs, respectively, but there was no clinicopathologic and prognostic significance. On the basis of the fact that the expression of Emi1 in CCC was correlated with a high histologic grade and worse overall survival, target therapy using inhibitors of Emi1 may be tried in the management of CCC patients with Emi1 expression.</P>
LIM, Suk-Kyung,MOON, Dong-Chan,CHAE, Myung Hwa,KIM, Hae Ji,NAM, Hyang-Mi,KIM, Su-Ran,JANG, Gum-Chan,LEE, Kichan,JUNG, Suk-Chan,LEE, Hee-Soo The Japanese Society of Veterinary Science 2016 The Journal of veterinary medical science Vol.78 No.12
<P>Resistance to antimicrobials was measured in 73 isolates of <I>Campylobacter jejuni</I> (<I>C. jejuni</I>) and 121 isolates of <I>Campylobacter coli</I> (<I>C. coli</I>) from chicken and swine feces and carcasses in Korea. Both bacterial species showed the highest resistance to (fluoro) quinolones (ciprofloxacin and nalidixic acid) out of the nine antimicrobials tested. Erythromycin resistance was much higher in <I>C. coli</I> (19.0%, 23/121) than in <I>C. jejuni</I> (6.8%, 5/73). The mutation in the 23S rRNA gene was primarily responsible for macrolide resistance in <I>Campylobacter</I> isolates. Several amino acid substitutions in the L4 and L22 ribosomal proteins may play a role in the mechanism of resistance, but the role requires further evaluation. A total of eight virulence genes were detected in 28 erythromycin-resistant <I>Campylobacter</I> isolates. All <I>C. jejuni</I> isolates carried more than four such genes, while <I>C. coli</I> isolates carried fewer than three such genes. The high rate of resistance highlights the need to employ more prudent use of critically important antimicrobials, such as fluoroquinolones and macrolides, in swine and poultry production, and to more carefully monitor antimicrobial resistance in <I>Campylobacter</I> isolates in food animals.</P>
Tamang, Migma Dorji,Moon, Dong Chan,Kim, Su-Ran,Kang, Hee Young,Lee, Kichan,Nam, Hyang-Mi,Jang, Geum-Chan,Lee, Hee-Soo,Jung, Suk-Chan,Lim, Suk-Kyung Elsevier 2017 Veterinary microbiology Vol.201 No.-
<P><B>Abstract</B></P> <P>Altogether 7720 <I>Enterococcus faecalis</I> and 3939 <I>E</I>. <I>faecium</I> isolated from food animals and animal carcasses during 2003–2014 in Korea were investigated to determine if linezolid-resistant (LR) enterococci (≥8μg/ml) are present. Overall, 12 <I>E</I>. <I>faecalis</I> and 27 <I>E</I>. <I>faecium</I> recovered from chickens (<I>n</I> =32), pigs (<I>n</I> =6), and cattle (<I>n</I> =1) were resistant to linezolid and were further characterized using molecular methods Most LR isolates were also resistant to chloramphenicol (97.44%) and florfenicol (92.31%). Molecular analysis showed no mutations in the 23S ribosomal RNA and in the ribosomal protein L3. The <I>optrA</I> gene was found in 89.74% of the LR enterococci, including 12 <I>E</I>. <I>faecalis</I> and 23 <I>E</I>. <I>faecium</I> isolates. Among them, 30 <I>optrA</I>-positive isolates co-carried phenicol exporter gene <I>fexA</I>. Seven LR <I>E. faecium</I> isolates had Asn130Lys mutations in the ribosomal protein L4, of which six also carried <I>optrA</I> gene. None of the isolates carried the mutliresistance gene <I>cfr</I>. Transfer of <I>optrA</I> gene was observed in 16 of the 35 <I>optrA</I>-positive isolates by conjugation. Pulsed-field gel electrophoresis demonstrated that the vast majority of <I>Enterococcus</I> strains carrying <I>optrA</I> gene were genetically heterogeneous. Multi-locus sequence typing revealed eight novel Sequence types among <I>E</I>. <I>faecalis</I> and <I>E</I>. <I>faecium</I> strains. To our knowledge, this is the first report of <I>optrA</I> gene in isolates from cattle and animal carcasses. This is also the first report of <I>optrA</I> gene in Korea. Active surveillance of <I>optrA</I> in enterococci is urgently warranted.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Overall, 12 <I>Enterococcus faecalis</I> and 27 <I>E</I>. <I>faecium</I> were resistant to linezolid. </LI> <LI> The <I>optrA</I> gene was found in all 12 <I>E</I>. <I>faecalis</I> and 23 <I>E</I>. <I>faecium</I> isolates. </LI> <LI> Among them, 30 <I>optrA</I>-positive isolates co-carried phenicol exporter gene <I>fexA</I>. </LI> <LI> First report of <I>optrA</I> gene in isolates from cattle and animal carcasses. </LI> <LI> Fist report of <I>optrA</I> in Korea indicating the emergence of <I>optrA</I> in a new setting. </LI> </UL> </P>