텐터 신장률이 다른 면/스판덱스 능직물의 반복세탁에 따른 역학적 특성 및 태 비교

정혜원,권진,김효정,석혜준,Chung, Hae-Won,Kwon, Jin,Kim, Hyo-Jeong,Seok, Hye-Joon 한국섬유공학회 2010 한국섬유공학회지 Vol.47 No.4

The effects of the tentering-extension rates and repeated washing on the mechanical properties and hand values of cotton/ spandex twill were examined. A 3% spandex containing cotton twill was treated by tenter extension at different rates of 0%, 5%, 10% and 15%. The processed fabric with a 0% extension rate was also dyed using a reactive dye. The KES-FB system was utilized to measure the mechanical properties of the twill, and the basic and total hand values were determined using a KN-201-MDY and KN-301-WINTER, respectively. The fabrics treated with greater tentering extension and dried in a clothes tumble dryer showed lower bending and shear properties, and became softer and smoother. The greatest change in the mechanical properties and hand values occurred after the first wash, but the differences in the washed and unwashed state decreased with increasing number of wash cycles. These results show that cotton/spandex twill should be extended 5% during tentering to yield less deterioration of the T.H.V., and be dried in a clothes tumble dryer to maintain a soft and smooth hand without affecting the shrinkage and elasticity.

$Ca^{2+}$ Inhibitor가 생쥐난자 성숙에 미치는 영향

정혜원,유한기,배인하,Chung, Hye-Won,Yoo, Han-Ki,Bae, In-Ha 대한생식의학회 1992 Clinical and Experimental Reproductive Medicine Vol.19 No.1

In the present study, it was aimed to find the role of calcium on the maturation of mouse follicular oocytes as well as for the role of calcium inhibitors, $Ni^{2+}$ and $La^{3+}$. Mouse follicular oocytes were cultivated in different media at $37^{\circ}C$, in 100% humidified $CO_2$ incubator for 3 and 17 hrs. The results were as follows; 1. There was no differences in GVBD between the control and experimental groups during the 3 hr culture. 2. Mouse oocytes were matured to higher rate in MHBS rather than HTF for 17 hr culture. 3. Maturation rate was significantly lower in $Ca^{2+}$-free and $Ca^{2+}$ 0.4 mM which were tested, compared to other calcium concentration used in the present study. 4. Calcium inhibitor, $Ni^{2+}$, it showed highest degeneration rate at all calcium concentrations and additionally in $Ni^{2+}$ $100{\mu}M$ treated group next. Maturation rate was significantly decrease as the $Ca^{2+}$ inhibitor concentration increased. 5. In all Lanthanum treated groups of calcium-free, degeneration were significantly high treated groups at 0.4 mM $Ca^{2+}$ concentrations degeneration rates of all group were significantly lower than that of the control but maturation rates were not significantly different in any group. In lanthanum $100{\mu}M$ treated group at 0.4 mM and 0.8 mM calcium concentration, its maturation rate was significantly higher than that of the control. Maturation rates of all groups of lanthanum treated at 1.71 mM calcium concentration were not significantly different among groups. 6. In the calcium treated group (0.4mM-1.7 mM), the presence of phosphate does not seem to be needed for oocyte maturation. However, the presence of phosphate at $Ca^{2+}$ 0.8 mM only seems to stimulated maturation.

전이성 임신성 융모막암종에 의한 신장 파열 선택적 신장동맥색전술 보고

정혜원 ( Hye Won Chung ),최준용 ( Jun Yong Choi ),신소진 ( So Jin Shin ),조치흠 ( Chi Heum Cho ),차순도 ( Soon Do Cha ),권상훈 ( Sang Hoon Kwon ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.11

Choriocarcinoma is a rapidly growing tumor that characteristically outgrows its blood supply. We report a rare case of metastatic choriocarcinoma presenting with acute right flank pain due to kidney rupture secondary to renal metastasis. The renal metastasis was embolised to stanch blood for control of hemorrhage. A brief review of the imaging features and therapeutic options for the ruptured renal metastases is discussed along with the case.

The Impact of Sample Sizes on Multiple Membership Multilevel Modeling Estimation

정혜원(Hye won Chung),김지선(Ji seon Kim),박령선(Ryoung sun Park),전현정(Hyeon jeong Jeon) 한국교육평가학회 2015 교육평가연구 Vol.28 No.1

다중소속 다층자료가 교육현장자료에서 증가하고 있으나, 표본크기가 다중소속다층모형에 미치는 영향에 관한 연구는 매우 미흡하다. 이 시뮬레이션 연구에서는 표본의 크기가 다중소속다층모형의 모수 추정과 신뢰구간에 미치는 영향을 살펴보고자 하였다. 본 연구의 목적을 수행하기 위해 계층 내 상관계수 (ICC; 0.15, 0.25), 2수준 표본크기 (20, 30, 50, 100), 1수준 표본크기 (20, 30, 50, 100, 200)의 조건들이 고려되었다. 모든 실험조건에서 고정효과와 1수준 변량의 추정에서는 상대편의가 나타나지 않았다. 그러나 2수준 표본크기 조건에서는(<=50), 2수준 변량의 과대 추정되는 상대편의가 나타났다. 모든 실험조건에서, 고정효과와 변량의 95%신뢰구간 포함 비율은 명목수준인 5%보다 미만으로 나타났다. 본 연구에서는 연구자들에게 다중소속다층모형의 추정을 위해서 최소 50 그룹 및 각 그룹 당 30명 이상 참여자가 속해 있는 크기의 자료를 사용할 것을 제안하였다. Multiple membership data structures are increasingly encountered in the educational field, but few studies have investigated the impact of sample sizes on multiple membership multilevel modeling. This simulation study examines the parameter estimates and non-coverage rates of 95% credible intervals in multiple membership multilevel modeling under a variety of manipulated conditions including: the intraclass correlation coefficient (ICC; 0.15 and 0.25), the number of schools (20, 30, 50 and 100), and the number of students (20, 30, 50, 100 and 200). Across all conditions, no substantial relative bias was found for fixed effect and student level variance component estimates. However, in some of the smaller number of schools (<=50), school level variance component estimates were substantially positively biased. Across all conditions, non-coverage rates of 95% credible interval for the fixed effect and random variance component estimates were less than the nominal non-coverage rate (i.e., 5%). It is suggested that applied researchers should analyze sufficiently large dataset (at least 50 groups with 30 participants) for multiple membership multilevel modeling estimation.

Reproductive Endocrinology : PCOS as a Lifetime Metabolic Disorder

정혜원 ( Hye Won Chung ) 대한산부인과학회 2009 서울심포지움 Vol.14 No.-

37 Farnesyltransferase inhibitor의 세포 주기 및 활성화 Ras 단백의 신호전달체계 변화 양상 규명을 통한 암 성장 억제 기전 고찰

정혜원 ( Hye Won Chung ),김주원 ( Ju Won Kim ),송시영 ( Si Young Song ),김한수 ( Han Soo Kim ),박승우 ( Seung Woo Park ),정재복 ( Jae Bock Chung ),강진경 ( Jin Kyung Kang ) 대한소화기학회 2002 대한소화기학회 추계학술대회 Vol.2002 No.-

급성 췌장염 이후 발생한 후복막강 농양에 속발된 위와 대장 누공의 1예

정혜원(Chung Hye Won),이용찬(Lee Yong Chan),이준규(Lee Joon Kyu),백용한(Pack Yong Han),박인서(Park In Suh),문영명(Moon Young Myoung),김명진(Kim Myeong Jin) 대한내과학회 2000 대한내과학회지 Vol.58 No.6

N/A According to several reports, the incidence of pancreatic and peripancreatic abscess after acute pancreatitits is quoted at about 5 percentage and this rare complication may cause fistulas with multiple intra-abdominal organs. Mortality rates are nearly 100 per cent, mostly due to sepsis and hemorrhage in the abscence of surgical intervention and even with surgical drainage and celiotomy, death rate of 30 to 50 percentage are noted due to recurrence. The pathogenesisi of these fistulas may be multifactorial ; activated pancreatic enzyme and the products of secondary infection penetrating visceral wall directly, and vascular thrombosis and shock causing ischemic necrosis of the gastrointestinal wall. The gastrointestinal fistulas after acute necrotizing pancreatitis have been reported rarely in Korea. The authors experienced a sixty three year old male patient case of gastric and colonic fistulas in communication with retroperitoneal pancreatic abscess after acute pancreatitis. The patient received broad-spectrum antibiotics and percutaneous catheter drainage without surgical intervention. After treatment, he recovered well complete. Conservative care with drainage procedure may be a suitable alternative for managing the gastrointestinal fistulas with the pancreatic and peripancreatic abscess after acute nectrotizing pancreatitis.(Korean J Med 58:675-680, 2000)

치료반응이 좋은 증례 현저하게 좋은 치료반응을 보인 진행성 간세포암(stage IVa)

정혜원 ( Hye Won Chung ),정재연 ( Jae Youn Cheong ),송건훈 ( Kun Hoon Song ),한광협 ( Kwang Hyub Han ),문영명 ( Young Myoung Moon ),김병로 ( Byoung Ro Kim ),성진실 ( Jin Sil Seong ),김명진 ( Myoung Jin Kim ),이도연 ( Do Yun Lee 대한간암학회 2001 대한간암학회지 Vol.1 No.-

폐경 여성에서 갑상선 기능과 골밀도의 연관성

정혜원 ( Hye Won Chung ),강병문 ( Byung Moon Kang ),김미란 ( Mee Ran Kim ),윤병구 ( Byung Koo Yoon ),이병석 ( Byung Seok Lee ),최훈 ( Hoon Choi ),박형무 ( Hyoung Moo Park ),김정구 ( Jung Gu Kim ) 대한폐경학회 2012 대한폐경학회지 Vol.18 No.1

연구목적: 골다공증은 가장 흔한 대사성 질환 중의 하나로, 연령이 증가함에 따라 골량이 감소하고 골의 미세구조 변화로 인한 골의 강도가 약화되어 골절의 위험성이 증가되는 전신성 골격계 질환이다. 최근 갑상선 호르몬이 골밀도와 연관성에 대한 보고가 있는데, 갑상선 자극호르몬이 낮은 경우 골밀도가 낮으며 티록신이 높을수록 골밀도는 낮아진다는 보고도 있다. 따라서 한국 폐경 여성에서 갑상선 질환이나 갑상선 기능의 변화가 골밀도에 미치는 영향을 알아보고자 본 연구가 진행되었다. 연구재료 및 방법: 서울 소재 8개 대학병원의 건강검진 센터에서 검진을 한 2,279명의 폐경 후 여성의 의무기록과 신장, 체중, 골밀도와 갑상선 기능검사결과를 조사하였다. 모든 자료는 SPSS 로 분석하여 그 유의성을 검증하였다. 결과: 다기관에서 조사한 비교적 대규모 수의 폐경 여성을 대상으로 한 본 연구에서 갑상선 기능 검사 중 혈청트리요오드사이로닌과 티록신은 골밀도와 연관성이 있으며 갑상선 자극호르몬은 유의한 연관성이 없었다. 이러한 연관성은 연령을 보정한 후에는 유의하지 않아 혈청 트리요오드사이로닌과 티록신의 골밀도 연관성은 연령에 따른 변화에 의한 것으로 추정된다. 갑상선 질환의 유무에 따라 요추 골밀도와 대퇴골 및 total hip 골밀도의 평균값은 차이가 없었다. 갑상선 자극호르몬이 0.5mU/L 미만인 group에서 갑상선 자극호르몬이 정상이거나 증가된 그룹보다 골감소증이 유의하게 높았다. 결론: 한국 폐경 여성에서 갑상선 기능과 골밀도는 연관성이 있었다. Objectives: Osteoporosis, defined as decreased bone mass and structural deterioration of bone, increases the incidence of fractures. Recently, there have been reports suggesting that thyroid hormones are related to bone mineral density (BMD). It has been reported that low normal circulating thyrotropin (TSH) levels correlate with lower BMD and that thyroxine (T4) and bone density are negatively related. This research aims to examine the relationship between BMD and thyroid diseases and other functional changes in postmenopausal women. Methods: The medical records of 2,279 postmenopausal women who attended the health care clinic in eight university hospitals between March 2001 and December 2007 were reviewed retrospectively. We determined the baseline characteristics of the women, including age, height, weight, and body mass index (BMI). The BMD was measured by dual-energy X-ray absorptiometry (DEXA). The correlation between the thyroid status and BMD was analyzed using the SPSS 12.0 program. Results: This research used data from a relatively large number of postmenopausal women gathered in a multicenter approach. Of the thyroid functional tests, thyroid stimulating hormone (triiodothyronine or T3) and T4 correlated with BMD, while free T4 and TSH did not show a statistically signifi cant correlation. After adjusted age, thyroid function test did not correlate with BMD. Osteopenia was signifi cantly higher in the group with TSH below 0.5mU/L compared with groups that had normal or high TSH. There was no statistically significant difference in lumbar BMD and total hip BMD among patients with thyroid diseases and healthy patients. Conclusion: The level of T3 and T4 correlated well with BMD in Korean post-menopausal women.

절개반흔 자궁내막증의 치료에서 성선자극호르몬유리호르몬작용제의 역할

정혜원 ( Hye Won Chung ),박소연 ( So Yun Park ),이사라 ( Sa Ra Lee ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.12

목적 복벽절개 혹은 회음절개술 후 발생하는 절개반흔 자궁내막증 환자의 임상특징 및 가장 적합한 진단 및 치료법에 관해 알아보고자 하였다. 연구방법 1996년부터 2008년까지 본 병원에서 절개반흔 자궁내막증으로 종물절제술을 받은 30명의 환자를 대상으로 하여 의무기록을 바탕으로 후향적으로 분석하였다. 대상자의 연령, 분만력, 수술 과거력, 증상, 생리력, 종물의 특성, 수술 전 잠정진단명, 치료법과 재발에 대해 분석하였다. 결과 절개반흔 자궁내막증으로 확진된 환자 30명 중, 복벽절개반흔 자궁내막증 환자는 총 24명, 회음절개 반흔 자궁내막증 환자는 총 6명이었다. 증상은 대부분에서 주기적 통증을 동반하거나 동반하지 않는, 절개반흔 부위의 촉지되는 종물이었고, 마지막 수술 시점부터 증상발현까지의 기간은 평균 23.8개월이었다. 수술 전 영상검사를 시행한 경우는 14예였으나 절개반흔 자궁내막증으로 진단된 경우는 한 예도 없었다. 모든 경우에서 종물을 포함한 광범위한 절제를 시행받았고 성선자극호르몬유리호르몬작용제를 투여받은 경우는 13예였다. 재발은 4예(13.3%)에서 진단되었고 모든 경우가 수술 전 혹은 수술 후에 성선자극호르몬유리호르몬작용제를 투여받지 않은 경우에서였으나 통계적으로 유의한 차이는 없었다. 결론 본 연구결과에서 절개반흔 자궁내막증의 발생기전이 시술중의 자궁내막의 이식에 의한 것임을 뒷받침하고 있으며, 영상 검사가 진단에 크게 도움이 되지 않으며 병력 청취나 임상진찰에서 절개반흔 자궁내막증이 의심될 때 진단 및 치료를 위해 종물을 제거하는 것이 필요하다. 성선자극호르몬유리호르몬작용제를 수술 전후에 사용하는 것은 절개반흔 자궁내막증의 재발 억제에 도움이 될 가능성은 있겠으나 통계적으로 유의한 재발억제 효과는 없었다. Objective To investigate the characteristics and to define the most effective diagnosis and treatment option for the scar endometriosis resulting from abdominal incision or episiotomy. Methods Medical records of thirty women with scar endometriosis who underwent mass excision between 1996 and 2008 in our hospital were reviewed retrospectively. Data on the age, parity, surgical history, symptom, menstrual history, characteristics of the mass, preoperative diagnosis, treatment method and recurrence were analyzed. Results Scar endometriosis were developed after Cㅊesarean section in 24 patients and episiotomy in 6 patients. Nearly all patients presented with a palpable mass with or without cyclic pain and mean duration of symptom was 23.8 months. Preoperative imaging study was performed in 14 patients, however there was no one whose preoperative imaging result was endometriosis. All scar endometriosis was completely excised with surrounding tissue. Gonadotrophin releasing hormone (GnRH) agonist was administered in 13 patients pre- or postoperatively. Recurrence of scar endometriosis after wide mass excision was noted in 4 patients (13.3%) who did not receive GnRH agonist therapy pre- or postoperatively. Conclusion This study supports that scar endometriosis is a result of the transplantation of endometrial tissue during procedures. The contribution of the imaging studies seems to be limited, so surgeon could perform mass excision for diagnosis and treatment with clinical history and physical exam without performing imaging study especially in for small scar endometriosis. Surgical excision accompanied by pre-, or postoperative GnRH agonist therapy may be helpful option for the prevention of recurrence however, we could not find any statistical significance in the effectiveness of GnRH agonist treatment.