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Association of the COMT Gene Polymorphism with the Risk of Endometriosis in Korean Women
이사라,이소현,이운정,허성은,이지영,문혜성,정혜원,Lee, Sa-Ra,Lee, So-Hyun,Lee, Woon-Jeong,Hur, Sung-Eun,Lee, Ji-Young,Moon, Hye-Sung,Chung, Hye-Won The Korean Society for Reproductive Medicine 2004 Clinical and Experimental Reproductive Medicine Vol.31 No.1
Objective: To investigate whether polymorphism of gene encoding COMT is associated with the risk of endometriosis in Korean women. Methods: We investigated 136 patients with histopathologically confirmed endometriosis rAFS stage III/IV and 251 control group women who were surgically proven to have no endometriosis. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) of PCR products were done to determine each participant's COMT genotype. Results: The distribution according to NIaIII genetic polymorphisms of COMT were as follows. $COMT^{HH}$, $COMT^{HL}$, and $COMT^{LL}$ genotypes were 56.6% (77 women), 34.6% (47 women) and 8.8% (12 women) in the study group and 50.6% (127 women), 39.4% (99 women) and 10.0% (25 women) in the control group. There was no significant difference between the study group and the control group. Conclusion: The results suggest that COMT genetic polymorphism may not be associated with the development of endometriosis in Korean women.
이사라 ( Sa Ra Lee ),( Young Jae Kim ),( Kwang Gi Kim ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Background: Uterine myoma is the most common benign gynecologic tumor in reproductive-aged women. During myomectomy for women who want to preserve fertility, it is advisable to detect and remove all myomas to decrease the risk of additional surgery. However, finding myomas during surgery is often challenging, especially for deep-seated myomas. Therefore, three-dimensional (3D) preoperative localization of myomas can be helpful for the surgical planning for myomectomy. However, the previously reported manual 3D segmenting method takes too much time and effort for clinical use. The objective of this study was to propose a new method of rapid 3D visualization of uterine myoma using a uterine template. Methods: Magnetic resonance images were listed according to the slide spacing on each plane of the multiplanar reconstruction, and images that were determined to be myomas were selected by simply scrolling the mouse down. By using the selected images, a 3D grid with a slide spacing interval was constructed and filled on its plane and finally registered to a uterine template. Results: The location of multiple myomas in the uterus was visualized in 3D and this proposed method is over 95% faster than the existing manual-segmentation method. Not only the size and location of the myomas, but also the shortest distance between the uterine surface and the myomas, can be calculated. This technique also enables the surgeon to know the number of total, removed, and remaining myomas on the 3D image. Conclusion: This proposed 3D reconstruction method with a uterine template enables faster 3D visualization of myomas.
이사라 ( Sa Ra Lee ),강은진 ( Eun Jin Kang ),김탁용 ( Tak Yong Kim ),김관우 ( Kwan Oo Kim ),박정호 ( Jung Ho Park ),배수찬 ( Soo Chan Bae ),이지현 ( Ji Hyun Lee ),곽은주 ( Eun Joo Kwak ),배상철 ( Sang Cheol Bae ) 대한류마티스학회 2004 대한류마티스학회지 Vol.11 No.2
Objective: Fibromylagia (FM) is a rheumatic disorder characterized by widespread bodily pain, tenderness, and fatigue. It has a major impact on the quality of life including the quality of marital life. The objectives of this study were to assess the quality of marital life in patients with FM in Korea and to identify the correlation of the quality of marital life with disease severity. Methods: Subjects were the patient group, composed of 50 married patients with FM, and a comparison group composed of 50 healthy married adults with similar demographic characteristics. The quality of marital life was measured using the Korean-Marital Satisfaction Inventory (K-MSI). The K-MSI consists of two valid scales, one global affective scale, and eleven additional scales measuring specific dimensions of relationship distress. The clinical parameters were assessed by Korean Fibromyalgia Impact Questionnaire (KFIQ) and tender point, respectively from 50 patients with FM. Results: Of the 50 subjects, 48 (96%) were women with mean (±SD) age of 52.6(±8.8) years. The mean (±SD) duration of disease was 25.7 (±19.8) months. The mean (±SD) scores of KFIQ and tender point count were 52.9 (±14.9) and 13.1 (±1.6), respectively. The T-score of most scales of K-MSI of FM patients were higher than that of healthy controls (p<0.01). The scores of KFIQ were positively correlated with the eight scales of K-MSI and negatively correlated with one scale (Role orientation) of K-MSI. The tender point count was positively correlated with only one of scale (Conflict with in-law) of K-MSI. Conclusion: The results suggest that the quality of marital life in Korean patients of FM is lower than healthy subjects. In a simple correlation analysis, KFIQ was a meaningful variable correlated with the quality of marital life.
다낭성난소증후군 환자의 체외수정시술에서 Rosiglitazone이 난소기질혈류와 난소반응 및 체외수정결과에 미치는 영향
이사라 ( Sa Ra Lee ),김정훈 ( Chung Hoon Kim ),강혁재 ( Hyuk Jae Kang ),김진희 ( Jin Hee Kim ),홍석호 ( Seok Ho Hong ),김성훈 ( Sung Hoon Kim ),채희동 ( Hee Dong Chae ),강병문 ( Byung Moon Kang ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.6
목적 : 다낭성난소증후군 환자에서 rosiglitazone이 난소기질혈류와 난소반응 및 체외수정결과에 미치는 영향을 연구하고자 한다. 연구방법: 다낭성난소증후군이면서 그 외의 불임인자로는 난관인자만 존재하는 24-36세의 불임여성 46명을 대상으로 하여 무작위적으로 rosiglitazone군 (23명)과 대조군 (23명)으로 나누었다. 실험군은 GnRH agonist 투여 전, 생리주기 제1일째부터 4㎎의 rosiglitazone을 하루 1회 투여하였고, 이름 hCG 투여날까지 지속하였다. 대조군에서는 위약을 같은 기간동안 투여하였으며 양 군은 각각 23주기의 체외수정시술을 시행받았다. 모든 환자는 난소기질혈류를 알기 위해 질식색초음파 분석 (resistance index (RI) and pulsatility index (PI)을 rosiglitazone이나 위약을 투여하기 시작한 날 (RI0, PI0), GnRH agonist 투여날 (RI1, PI1), 그리고 난소자극을 시작한 날 (RI2, PI2)에 각각 측정하였다. 결과: 환자의 연령, 체질량지수, 불임기간, 내분비적 호르몬 수치, 공복 및 75g 당부하 2시간 후 혈당수치와 난소기질동맥의 RI0, PI0 값은 양군간에 차이가 없었다. RI1과 PI1 값은 실험군에서 보다 높은 값을 보였으나 통계적으로 유의성은 없었다. RI2와 PI2 값은 실험군에서 대조군보다 유의하게 높았다 (0.60±0.04 versus 0.56±0.03; p<0.05, 0.99±0.14 versus 0.88±0.05) p<0.01). hCG 투여날, 10-14㎜ 크기의 난포수 및 14㎜ 이상의 난포수와 회수된 난자수는 실험군에서 유의하게 적었다 (p<0.05, P<0.05). 임상적 임신율은 실험군에서 높았으나 통계적 유의성에는 도달하지 못했다. 결론: 다낭성난소증후군 환자에서 Rosiglitazone 치료는 난소내 기질혈류를 감소시키고 배란유도에 대한 난소반응을 증가시켜 체외수정시술결과를 향상시킨다. Objective: We investigated to evaluate the effects of rosiglitazone on intraovarian stromal blood flow, ovarian response to stimulation, and in vitro fertilization-embryo transfer (IVF-ET) outcome in polycystic ovary syndrome (PCOS) patients. Methods: Forty-six infertile women, 24 to 36 years of age, with only tubal factor and PCOS, were randomized into either rosiglitazone (n=23) or placebo (n=23) treatment group. A rosiglitazone of 4 ㎎ once daily was started on day 1 of the cycle prior to gonadotropin releasing hormone (GnRH) agonist suppression, and continued to the day of human chorionic gonadotropin (hCG) injection in study group. For a control Group, placebo was administered during the same period. Each of the 2 groups consisted of 23 cycles of IVF-ET. Transvaginal color Doppler analyses (resistance index (RI) and pulsatility index (PI)) were performed to assess the intraovarian stromal blood flow in all participants on the starting days of rosiglitazone or placebo (RI0, PI0), GnRH agonist administration (RI1, PI1) and ovarian stimulation (RI2, PI2). Results: There were no significant differences in age, body mass index (BMI), infertiliy duration, endocrine profile, fasting and 2-hour glucose levels after a 75 gm glucose load, RI0 and PI0 values of ovarian stromal artery between two groups. RI1 and PI1 values were higher in study group, but the differences were not statistically significant. RI2 and PI2 values in study group were significantly higher than in control group (0.60±0.04 versus 0.56±0.03; P<0.05, 0.99±0.14 versus 0.88±0.05; P<0.05, respectively). The number of follicles both 10-14㎜ and ≥14㎜ in diameter on the day of hCG injection and the number of retrieved oocytes were significantly lower in study group. The number of retrieved oocytes was significantly higher in study group. The clinical pregnancy rate was higher in study group but it did not make statistical significance. Conclusions: Rosiglitazone therapy could reduce the intraovarian stromal blood flow and appeared to be beneficial in improving response to ovulation induction and IVF outcomes in PCOS patients.