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Hye-Yeon Han,Bong-Soo Bark,Hyung Joon Kim,Seung-Hwa Jeong,Jiyeon Kim,Sung-Hee Jeong,Gyoo Cheon Kim,Dae-Seok Hwang,Uk-Kyu Kim,Hyungwoo Kim,Mi Heon Ryu 대한구강악안면병리학회 2016 대한구강악안면병리학회지 Vol.40 No.6
The fruit of Kochia scoparia Scharder is traditionally used as a medicinal ingredient to treat allergic skin diseases and inflammatory diseases in China, Japan and Korea. Recently, several studies reported that K. scoparia had potential for the cytotoxicity of human cancer cells. To investigate the anti-cancer effect of K. scoparia on oral cancer and to determine the specific type of cell death induced by MEKS treatment. We investigated the anti-cancer effects of K. scoparia, methanol extract (MEKS) in HSC4 human oral cancer cells. We examined the effects of MEKS on the proliferation rate, cell cycle arrest, 7-AAD-ANNEXIN V double stain, reactive oxygen species (ROS) generation and activation of apoptosis and necroptosis-associated proteins in HSC4 cells. MTT assay results demonstrated that MEKS decreased the proliferation rates of HSC4 cells in a dose-dependent manner with an IC50 value of 45.3 μg/ml. MEKS at 50 μg/ml significantly increased the sub-G1 DNA contents of HSC4 cells to 84.8%, versus untreated cells. However, the activation of apoptosis-associated proteins such as cleaved caspase 3, cleaved caspase 8, cleaved caspase 9 and cleaved Poly (ADP-ribose) polymerase (PARP) did not detect. The level of Bax protein markedly increased in MEKS-treated HSC4 cells. In addition, the cell viability of the DPQ pre-treated HSC4 cells with MEKS treatment was significantly greater than that of MEKS treated-cells. These results suggest that MEKS inhibits cell proliferation and induces necroptosis in oral cancer cells and that MEKS may have potential chemotherapeutic value for the treatment of human oral cancer.
Lee, Yeon-Kyung,Kim, Keun-Sik,Kim, Jung-Seok,Baek, Jin-Ee,Park, Sang-Il,Jeong, Hwa-Yeon,Yoon, Sang-Soon,Jung, Kyeong-Cheon,Song, Hyung-Geun,Park, Yong-Serk Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.29 No.5
Targeted mRNA degradation by short interfering RNAs (siRNAs) offers a great potential to treat cancers. siRNA therapeutics for leukemias are, however, hindered by poor intracellular uptake, limited blood stability and nonspecific delivery. To solve these problems, we developed an anti-JL1 immunonanoplex (antibody-coupled nano-complex) for siRNA delivery using anti-JL1 minibody (leukemia cell-specific minibody) conjugated to oligo-9-Arg peptide (9R) for effective siRNA delivery to leukemic cells. The anti-JL1 immunonanoplexes were able to deliver siRNA specifically to leukemic cells (CEM and Jurkat), but not to control cancer cells (H9). According to FACS and confocal microscopic analysis, siRNAs delivered by immunonanoplex particles were rapidly taken up by the JL1- positive cancer cells in 2 h. Furthermore, we showed that the anti-JL1 immunonanoplexes were effectively targeted to JL1-positive cells (CEM) inoculated in the mouse bone marrow. These results suggest that the anti-JL1 immunonanoplex is a powerful siRNA delivery system for human leukemia therapies.
Han, Hye-Yeon,Kim, Hyung Joon,Jeong, Seung-Hwa,Kim, Jiyeon,Jeong, Sung-Hee,Kim, Gyoo Cheon,Hwang, Dae-Seok,Kim, Uk-Kyu,Ryu, Mi Heon Hindawi 2018 Evidence-based Complementary and Alternative Medic Vol.2018 No.-
<P>Jaceosidin is a single compound from the Japanese mugwort<I> Artemisia princeps</I>, which is used as a food and a traditional medicinal herb.<I> A. princeps</I> extracts and flavonoid components have been shown to have antihyperglycaemic, antioxidant, and anti-inflammatory properties. Although the anticancer properties of these extracts were recently demonstrated, the related mechanisms have not been characterised. In this study, we investigated the effects of jaceosidin in oral squamous cell carcinoma (OSCC) cells and initially showed selective suppression of proliferation (IC<SUB>50</SUB> = 82.1 <I>μ</I>M in HSC-3 cells and 97.5 <I>μ</I>M in Ca9.22 cells) and accumulation of cells at the sub-G1 stage of the cell cycle. In addition, jaceosidin increased cleavage of caspase-9 and caspase-3 in OSCC cells, although caspase-8 was not detected. In further experiments, jaceosidin downregulated Akt phosphorylation and ectopic activation of Akt blocked the antiproliferative effects of jaceosidin. Finally, we showed that jaceosidin has no effects on HaCaT normal epithelial cell viability, indicating selective chemotherapeutic potential of jaceosidin and that tumour-specific downregulation of Akt increases apoptosis and inhibits growth in OSCC cells.</P>
이정화 ( Jeong Hwa Lee ),권기현 ( Ki Hyun Kwon ),하동천 ( Dong Cheon Ha ),김보경 ( Bo Kyoung Kim ),정승혜 ( Seung Hye Jung ),김연수 ( Yeon Soo Kim ),이동수 ( Dong Soo Lee ) 대한내과학회 2012 대한내과학회지 Vol.82 No.6
췌장의 가성낭종은 췌장염에 의하여 흔히 발생하는 합병 증으로 대개 췌장 내부나 췌장의 주위조직에 발생한다. 합병 증으로는 감염, 주위내장이나 복강 내로의 파열, 누공, 장관폐쇄, 출혈 등이 발생하며, 가성낭종에 의한 출혈은 상부위 장관 출혈의 드문 원인중의 하나이지만, 위험한 합병증이다. 저자들은 혈변을 주소로 내원한 만성 췌장염 환자에서 십이지장 점막하종양 출혈로 오인하였다가 췌장 가성낭종이 십이지장의 유두부를 침범하여 이로 인해 유발된 상부위장관 출혈로 진단하였으며, 보존적 치료로 호전된 1예를 경험하였기에 보고하고자 한다. Pancreatic pseudocysts occur following acute pancreatitis, chronic pancreatitis or secondary to pancreatic trauma. Most pancreatic pseudocysts are located in or around the pancreas, but they can be found in all the potential spaces around viscera in and outside of the abdominal cavity. The complications of pancreatic pseudocyst are infection, rupture, obstruction, fistula, or hemorrhage. Hemorrhage is a rare but frequently fatal complication of pancreatic pseudocysts. We report a case of pancreatic pseudocyst presented as bleeding of duodenum, which was misidentified for duodenal submucosal tumor bleeding.
정성수,So-Yeon Lee,Jisun Yoon,Hyun-Ju Cho,Young-Ho Kim,Dong In Suh,Song-I Yang,Ji-Won Kwon,Gwang Cheon Jang,Yong Han Sun,Sung-Il Woo,You-Sook Youn,Kang-Seo Park,Eun Lee,Hwa Jin Cho,Myung-Hee Kook,Hye Ryo 대한천식알레르기학회 2020 Allergy, Asthma & Immunology Research Vol.12 No.1
Purpose: Data are lacking on the association between the allergic rhinitis (AR) phenotype and sensitization to specific allergens or bronchial hyperresponsiveness (BHR) in children. We here investigated risk factors and comorbidities, including sensitization to specific allergens and BHR, for the AR phenotype by AR and its Impact on Asthma (ARIA) classification in a general population-based birth cohort study. Methods: We enrolled 606 children aged 7 years from the Panel Study of Korean Children. The AR phenotype was assigned in accordance with the ARIA classification in children. Skin prick tests and Provocholine provocation test were performed. Risk factors and comorbidities for AR phenotypes were then analyzed.Results: The prevalence of mild and moderate to severe AR in our study cohort was 37.2% and 8.8%, respectively. Recent use of analgesics or antipyretics and current cat ownership were associated with the risk of mild persistent AR. Sensitizations to Dermatophagoides Pteronyssinus (Der p), Japanese hop and cat were associated with moderate to severe persistent AR. Children with moderate to severe AR had a higher risk of current asthma and BHR compared to mild AR cases (adjusted odds ratio [aOR], 5.26; 95% confidence interval [CI], 1.77–15.62). Moderate to severe AR with allergic sensitization was associated with the highest risk of BHR (aOR, 11.77; 95% CI, 3.40–40.74). Conclusions: Moderate to severe-persistent AR is more closely related to respiratory comorbidities and sensitizations than mild AR. Stratifying the AR phenotype by ARIA classification may assist in disease management.
Cho, Hyun-Kyu,Lim, Hwa-Yeon,Cho, Cheon-Gyu American Chemical Society 2013 Organic letters Vol.15 No.22
<P>New synthetic routes to (±)-1-<I>epi</I>-pancratistatin and (±)-pancratistatin were devised using (<I>E</I>)-β-borylstyrene as a dienophile for the key Diels–Alder reaction with 3,5-dibromo-2-pyrone. The boronate in the cycloadduct was oxidized to provide the pivotal C1-hydroxyl group of the titled compounds.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/orlef7/2013/orlef7.2013.15.issue-22/ol4028623/production/images/medium/ol-2013-028623_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ol4028623'>ACS Electronic Supporting Info</A></P>