위절제술 후 절제연 양성으로 진단된 진행성 위암 환자의 임상적 경과

양송이,이상호 고신대학교의과대학 2012 고신대학교 의과대학 학술지 Vol.27 No.1

Objectives: Many investigators have recommended adequate resection margin and lymphadenectomy for radical curative resection. The aim of this study is to evaluate clinical characteristics of positive resection margin (proximal or distal) of postgastrectomy in advanced gastric cancer. Methods: We studied 17 patients with gastric cancer who were diagnosed positive resection margin by intraoperative frozen biopsy or permanent biopsy report from January 2005 to December 2007, retrospectively. Surgical margin monitored by endoscopy. Results: Distal gastrectomy was performed in 13 patients and total gastrectomy in 4. Gastrectomy with combined resection including splenectomy was performed in 3, distal pancreatectomy in 2, transverse colon segmental resection in 1, and cholecystectomy in 2. Positive Proximal margin was found in 12, positive distal margin in 3, and both in 2. Palliative chemotherapy was performed in 8 patients. Postoperative follow up endoscopy was established in only 8 patients. Malignant results from endoscopic biopsy in gastroenteric or esophagoenteric anastomotic line were proven in 2 patients during follow up. 9 patients were not performed follow-up endoscopy. Among total 17 patients, 2 patients are alive. Fifteen patients died of aggravation of disease in 13 and postoperative complication in 2. Conclusions: Although positive surgical margin in far advanced gastric cancer were found, it can consider that does not further resection to obtain microscopic clear anastomotic margin.

Molecular Identification of the Vaccine Strain from the Inactivated Rabies Vaccine

Yang, Dong-Kun,Oh, Yoon-I,Cho, Soo-Dong,Kang, Hee-Kyung,Lee, Kyung-Woo,Kim, Yeon-Hee,Song, Jae-Young The Korean Society for Microbiology 2011 Journal of Bacteriology and Virology Vol.41 No.1

Since 1994, several different inactivated rabies vaccines have been used to immunize domestic animals such as dogs, cats, and cattle in South Korea. The Korean Veterinary Authority has conducted safety and efficacy testes of inactivated vaccines using laboratory animals. In this study, we applied a molecular method to investigate the genetic characterization of the rabies virus (RABV) genes in six commercial inactivated rabies vaccines, and determined the efficiency of two extraction reagents (i.e., sodium citrate or isopropyl myristate) to separate the vaccine antigens from the antigen/adjuvant complexes. Six partial nucleocapsid (N: 181 bp) and five partial glycoprotein (G: 306 bp) genes were successfully amplified with specific primer sets, which demonstrated that sodium citrate is more efficient in than isopropyl myristate in extracting viral RNA from inactivated gel vaccines. In addition, we identified the viral strain of the vaccine by analyzing the nucleotide sequences of the N and the G genes. The nucleotide similarity of the partial N and G genes ranged from 97.1 to 99.4% and from 91.8 to 100% among rabies vaccine strains, respectively, indicating that each manufacturer used different rabies virus strains to produce their vaccines. The molecular method used in this study could also be used to identify viral strains in other inactivated vaccines.

돈분 퇴비화 중 부숙도에 미치는 영향인자 구명

김태일,송준익,양창범,김민균 한국동물자원과학회 2004 한국축산학회지 Vol.46 No.2

This study was conducted to investigate indices affecting composts maturity for swine manure compost produced in a commercial composting facility with air-forced from the bottom. The composting was made of swine manure mixed with puffing rice hull(6:4) and turned by escalating agitator twice a day. Composting samples were collected periodically during a 45-d composting cycle at that system, showing that indices of Ammonium-N to Nitrate-N ratio were sensitive indicators of composting quality. Pile temperature maintained more than 62℃ and water contents decreased about 20% for 25days of composting. A great variety and high numbers of aerobic thermophilic heterotropic microbes playing critical roles in stability of composts have been examined in the final composts, showing that they were detected 10^(8) to 10^(10) CFUg^(-1) in mesophilic bacteria, 10³-10⁴ in fungi and 10^(6)-10^(8) in actinomycetes, respectively. The results of this study for determining a factor affecting compost stability evaluations based on composting steps were as follows; 1. Ammonium-N concentrations were highest at the beginning of composting, reaching approximately 421㎎/㎏. However Ammonium-N concentrations were lower during curing, reaching approximately 104㎎/㎏ just after 45 day. The ratio between NH₃-N was above 11 at the beginning of composting and less than 2 at the final step(45 day). 2. Seed germination Indes was dependent upon the compost phytotoxicity and is nutrition. The phytotocity caused the GI to low during the period of active composting(till 25 days of composting time) depending on the value of the undiluted. After 25 days of composting time, the GI was dependent upon compost nutrition. The Germination index of the final step was calculated at over 80 without regard to treatments. 3. E4:E6 ratio in humic acid of composts was correlatively decreased from 8.86 to 6.76 during the period of active composting. After 25 days of composting time, the E4:E6 was consistently decreased from 6.76 to 4.67(r² of total composting period was 0.95). 4. Water soluble carbon had a tendency to increase from 0.54% to 0.78% during the period of active composting. After 25 days of composting time, it was consistently decreased from 0.78% to 0.42%. Water soluble nitrogen increased from 0.22% after 15days of compostion. In consequence, the correlation coefficient(r²) between water soluble carbon and water soluble nitrogen was 0.12 during the period of active composting while was 0.50 after 25 days of composting time.

비육돈 사료의 고추냉이 첨가수준별 분뇨의 악취물질 농도 변화

이강훈,황옥화,박규현,양승학,송준익,전중환,이준엽,오상집,성하균,최동윤,조성백,Lee, K.H.,Hwang, O.H.,Park, K.H.,Yang, S.H.,Song, J.I.,Jeon, J.H.,Lee, J.Y.,Ohh, S.J.,Sung, H.G.,Choi, D.Y.,Cho, S.B. 한국축산환경학회 2012 축산시설환경학회지 Vol.18 No.suppl.

서양고추냉이를 비육돈에 급여하여 분뇨에서 발생되는 악취물질의 농도변화를 조사하였다. 1. 서양고추냉이 분말을 사료에 혼합하여 돼지에 급여한 후 분뇨의 단쇄지방산 농도를 측정한 결과, 사료에 고추냉이를 0.02% 혼합했을 때 아세트산, 프로피온산, 부티르산, 이소부티르산, 이소발레르산, SCFA 및 I-SCFA 농도가 가장 높았다(p<0.05). 2. 페놀과 p-크레졸을 합한 페놀류 농도는 고추냉이를 0.01~0.02% 첨가하였을 때 대조구보다 감소하였다(p<0.05). 인돌과 스카톨을 합한 인돌류 농도는 사료에 고추냉이를 0.03% 첨가하였을 때 가장 낮았다(p<0.05). 3. 따라서 분뇨의 페놀류 농도를 줄이기 위해서는 사료에 고추냉이를 0.02% 이하로 첨가하고, 인돌류 농도를 줄이기 위해서는 사료에 고추냉이를 0.03% 정도 첨가하여야 할 것으로 판단된다. This study was performed to test the effect of horseradish powder in fattening pig diet on odorous compound concentration from manure. Twenty fattening boars [Landrace ${\times}$ Yorkshire) ${\times}$ Duroc] weighing an average body weight of $68.4{\pm}4.95}$ kg were randomly assigned to one of 4 treatments (horseradish level in diets: 0, 0.01, 0.02, 0.03%) based on their body weight. This experiment was a randomized complete block (RCB) design using 5 pigs per treatment with 1 pig per metabolizable cage. Pigs were fed experimental diet (amount proportional to 3% of their body weight) twice a day (09:00 and 16:00) for 7 d after having 14 d adaptation period. Experimental diets were mixed with water by 1:2.5 v/v. Concentration of volatile fatty acids (VFAs) was highest (p<0.05) when pigs fed diet with 0.02% horseradish powder. Level of phenol compounds including phenol and p-cresol were decreased (p<0.05) in 0.01~0.02% horseradish treatment group compared with control group. Concentration of indoles including indole and skatole was lowest (p<0.05) in 0.03% horseradish treatment group compare to others. Therefore, results from our current study suggest that the optimal levels of horseradish powder in diet for reducing phenol and indole compounds in pig manure were 0.02 and 0.03%, respectively.

Prenatal particulate matter affects new asthma via airway hyperresponsiveness in schoolchildren

Yang, Song‐,I,Lee, So‐,Yeon,Kim, Hyo‐,Bin,Kim, Hwan‐,Cheol,Leem, Jong‐,Han,Yang, Hyeon‐,Jong,Kwon, Hyeok,Seo, Ju‐,Hee,Cho, Hyun‐,Ju,Yoon, Jisun,Lee, Eun Wiley (Blackwell Publishing) 2019 Allergy Vol.74 No.4

Particulate matter and childhood allergic diseases

Yang, Song-I The Korean Pediatric Society 2019 Clinical and Experimental Pediatrics (CEP) Vol.62 No.1

Particulate matter (PM) is a ubiquitous air pollutant that is a growing public health concern. Previous studies have suggested that PM is associated with asthma development and exacerbation of asthma symptoms. Although several studies have suggested increased risks of atopic dermatitis, allergic rhinitis, and allergic sensitization in relation to PM exposure, the evidence remains inconsistent. The plausible mechanisms underlying these effects are related to oxidative stress, enhancement of sensitization to allergens, inflammatory and immunological responses, and epigenetics. This review discusses the effect of PM on childhood allergic diseases, along with plausible mechanisms. Further studies are required to understand the role of PM exposure on childhood allergic diseases, to reduce these diseases in children.

KAAACI Allergic Rhinitis Guidelines: Part 1. Update in Pharmacotherapy

Yang Song-I,Lee Il Hwan,Kim Minji,Ryu Gwanghui,강성윤,Kim Mi-Ae,이상민,Kim Hyun-Jung,Park Do-Yang,Lee Yong Ju,Kim Dong-Kyu,Kim Soo Whan,Kim Do Hyun,Jun Young Joon,박상철,Kim Bong-Seong,Chung Soo Jie,Lee Hyun J 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.1

The prevalence of allergic rhinitis (AR) and the socioeconomic burden associated with the medical cost and quality of life (QOL) of AR have progressively increased. Therefore, practical guidelines for the appropriate management of AR need to be developed based on scientific evidence while considering the real-world environment, values, and preferences of patients and physicians. The Korean Academy of Asthma, Allergy and Clinical Immunology revised clinical guidelines of AR to address key clinical questions of the management of AR. Part 1 of the revised guideline covers the pharmacological management of patients with AR in Korea. Through a meta-analysis and systematic review, we made 4 recommendations for AR pharmacotherapy, including intranasal corticosteroid (INCS)/intranasal antihistamine (INAH) combination therapy, oral antihistamine/INCS combination therapy, leukotriene receptor antagonist treatment in AR patients with asthma, and prophylactic treatment for patients with pollen-induced AR. However, all recommendations are conditional because of the low or very low evidence of certainty. Well-designed and strictly executed randomized controlled trials are needed to measure and report appropriate outcomes.

Particulate matter and childhood allergic diseases

Song-I Yang 대한소아청소년과학회 2019 Clinical and Experimental Pediatrics (CEP) Vol.62 No.1

Particulate matter (PM) is a ubiquitous air pollutant that is a growing public health concern. Previous studies have suggested that PM is associated with asthma development and exacerbation of asthma symptoms. Although several studies have suggested increased risks of atopic dermatitis, allergic rhinitis, and allergic sensitization in relation to PM exposure, the evidence remains inconsistent. The plausible mechanisms underlying these effects are related to oxidative stress, enhancement of sensitization to allergens, inflammatory and immunological responses, and epigenetics. This review discusses the effect of PM on childhood allergic diseases, along with plausible mechanisms. Further studies are required to understand the role of PM exposure on childhood allergic diseases, to reduce these diseases in children.

상부위장관출혈의 원인별 임상상과 예후인자

송인성(I S Song),최규완(K W Choi),김정룡(C Y Kim),정현채(H C Jung),윤용범(Y B Yoon),양석균(S K Yang),임용철(Y C Lim),윤병철(Byung Cheol Kim),노임환(I H Roe),유권(K Yoo) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.4

N/A A total of 486 cases of upper gastrointestinal bleeding admitted to Seoul National University Hospital via emergency room from Jan. 1986 to Jun. 1988 were clinically reviewed and the following results were obtained: 1) The male to female ratio was 4.7:1 and peak incidence was in the 6th and 5th decades. The sex and age had no prognostic value. 2) The causes of bleeding were esophageal varix (35.2%), gastric ulcer (17.7%), duodenal ulcer (13.4%), stomach cancer (6.6%), gastritis (5.15), Mallory-Weiss syndrome (2.7gp), miscellaneous causes (l.0%), and unknown causes (18.3%). Variceal bleeders had the highest mortality rate. 3) There was no past history of bleeding in 61.5% overall, and it had no prognostic value. But variceal bleeders had past history of bleeding in, 50.3% and the first episode of bleeding offered higher mortality rate. 4) Three types of bleeding hefore admission were hematemesis in 27.85, melena in 25.7% and both of them in 46.5%, which had no prognostic value if variceal and nonvariceal bleeders were considered respectively. 5) Systolic blood pressure and pulse rate had some prognostic value, that is, high pulse rate on admission carried higher morthalty rate in variceal bleeders and low systolic blood pressure did in nonvariceal bleeders. 6) The three patterns of bleeding after admission were single bleeding in 63.0%, repeated bleeding in 21.0% and continuous bleeding in 16.0%. The mortality rate of repeated and continuous bleeding was higher than that of single bleeding. 7) The patients who received transfusion were 86.8% and the amount of blood transfused was more than 10 pints in 24.1%. The mortality rate increased as the amount of blood transfused increased. 8) Esophageal varix ivas the cause of the first bleeding in 76.4% of patients with chronic liver disease with esophageal varix. If the cause of the first bleeding was the esophageal varix in patients with chronic liver disease with esophageal varix, the cause of the second bleeding was also esophageal varix in 93.5%.

2009-2011년 신종 인플루엔자 A (H1N1)와 계절 인플루엔자 감염으로 입원한 소아 환자들의 임상 양상과 경과 비교

양송이 ( Song I Yang ),노정희 ( Jung Hee Rho ),선용한 ( Yong Han Sun ),조강호 ( Kang Ho Cho ),심소연 ( So Yeon Shim ),은병욱 ( Byung Wook Eun ),김지은 ( Jee Eun Kim ),손동우 ( Dong Woo Son ),차한 ( Hann Tchah ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2012 소아알레르기 및 호흡기학회지 Vol.22 No.3

Purpose: Pandemic influenza viruses have caused significant morbidity and mortality. Pandemic influenza A (H1N1) was detected in April 2009 and caused worldwide outbreak. We investigated the differences in clinical characteristics and courses between pandemic and seasonal influenzas. Methods: We reviewed the medical records of pediatric patients, (≤18 years) with influenza hospitalized to Gachon University Gil Medical Center from the 1 April 2009 to the 31 August 2011. Results: Two hundred twenty-six patients with pandemic influenza and 118 patients with seasonal influenza were included. Age, sex, and proportion of underlying diseases were similar between the two groups. Hypoxemia, shortness of breath, and tachypnea were more common in pandemic influenza.(P <0.05) Oxygen supplementation and radiologically confirmed pneumonia were more common in pandemic influenza.(P <0.005) However, there were no significant differences in the mean duration of hospitalization, proportion of patients admitted to the intensive care unit, need for mechanical ventilation, and death. Conclusion: Pandemic influenza caused more frequently lower respiratory tract infection and pneumonia. However, the courses of pandemic influenza were not different from those of seasonal influenza; probably, due to the effects of several factors, including antiviral therapy.