Aspirin 諸合性에 關한 再考

김정란,박숙자,유영자,박옥운,김정은,노수자,오경희,조연자 梨花女子大學校 藥學硏究所 1962 梨花藥學硏究 Vol.- No.3

자매에서 발생한 중증 마이코플라즈마 폐렴에서 스테로이드 치료

김도희,이경일,김명숙,윤유숙,황자영,임정우,강진한,이준성 대한감염학회 2009 감염과 화학요법 Vol.41 No.3

Numerous evidences support the pathogenesis that M. pneumonias pneumonia is associated with cell-mediat-ed immune reaction. We report 2 cases of severe M. pneumoniae pneumonia in previously healthy sisters, who were both admitted during an epidemic of M. pneumoniae pneumonia. The elder sister, who was 16 years old, was admitted with M. pneumoniae pneumonia. She showed no response to treatment with clarithroycin and levo-floxacin, and eventually progressed to severe ARDS, requiring mechanical ventilation. After treatment with hydrocortisone (200 mg/day), there were rapid improvements in clinical manifestations and chest radiographic findings. The younger sister, who was 14 years old, was admitted 10 days later, Presenting with fever but no pneumonic lesions on chest radiograph. Just like her sister, the infection showed no response to clarithromycin. Fever persisted and pneumonic consolidation with mild pleural effusion was noticed in the left lower lobe on the 5th hospital-day. After treatment with oral prednisolone (1 mg/kg), she showed rapid defervescence and on the 8th hospital day, no pneumonic lesions were detectable on chest radiograph. Given the fact that the pathogenesis of pneumonia and extrapulmonary manifestations in M. pneumoniae infection is immune-mediated, an immuno-suppressive therapy would be validated for selected patients with M. pneumoniae infections.

복수과 진료 환자의 중복 처방에 대한 분석 및 평가

이지은,장혜경,오지영,유윤경,김현지,임숙인,연숙희,강진숙,최귀령 한국병원약사회 2003 병원약사회지 Vol.20 No.1

In an aging society, there is an increasing possibility of the duplication of the drugs given to patients because they take many kinds of drugs. Among the prescriptions given to the patients who was treated at multiple ambulatory clinics in St. Mary's hospital for one month of September, 2002, in which drugs that has identical or similar effects are prescribed, we analysed and evaluated them by patients' characteristics, kinds of medication, severity of side effects on a case by case basis. More, we assessed the potential additional costs. As a result of this study, the duplication rate turned out to be 6.69% and it was shown that the proportion of the elderly patients over 60 was high. The gastro-intestinal medications took up a large part and most of the cases showed that the danger caused by double taking of medicine was slight, but there were some examples in which the serious side effects were predicted. Expected additional costs were the average 11.349 won and it ranges from the minimum of 56 won to the maximum of 135,720 won. In conclusion, the management of drug histories of the patients who need the plural treatments is very important and the necessity of the individual and professional guidance of taking medicines for the elderly patients is emerged, too.

Mycoplasma pneumoniae pneumonia in children

You-Sook Youn,이경일 대한소아청소년과학회 2012 Clinical and Experimental Pediatrics (CEP) Vol.55 No.2

Mycoplasma pneumoniae (MP), the smallest self-replicating biological system, is a common cause of upper and lower respiratory tract infections, leading to a wide range of pulmonary and extra-pulmonary manifestations. MP pneumonia has been reported in 10 to 40% of cases of community-acquired pneumonia and shows an even higher proportion during epidemics. MP infection is endemic in larger communities of the world with cyclic epidemics every 3 to 7 years. In Korea, 3 to 4-year cycles have been observed from the mid-1980s to present. Although a variety of serologic assays and polymerase chain reaction (PCR) techniques are available for the diagnosis of MP infections, early diagnosis of MP pneumonia is limited by the lack of immunoglobulin (Ig) M antibodies and variable PCR results in the early stages of the infection. Thus, short-term paired IgM serologic tests may be mandatory for an early and definitive diagnosis. MP infection is usually a mild and self-limiting disease without specific treatment,and if needed, macrolides are generally used as a first-choice drug for children. Recently, macrolide-resistant MP strains have been reported worldwide. However, there are few reports of apparent treatment failure, such as progression of pneumonia to acute respiratory distress syndrome despite macrolide treatment. The immunopathogenesis of MP pneumonia is believed to be a hyperimmune reaction of the host to the insults from MP infection, including cytokine overproduction and immune cell activation (T cells). In this context, immunomodulatory treatment (corticosteroids or/and intravenous Ig), in addition to antibiotic treatment, might be considered for patients with severe infection.

$Mycoplasma$ $pneumoniae$ pneumonia in children

Youn, You-Sook,Lee, Kyung-Yil The Korean Pediatric Society 2012 Clinical and Experimental Pediatrics (CEP) Vol.55 No.2

$Mycoplasma$ $pneumoniae$ (MP), the smallest self-replicating biological system, is a common cause of upper and lower respiratory tract infections, leading to a wide range of pulmonary and extra-pulmonary manifestations. MP pneumonia has been reported in 10 to 40% of cases of community-acquired pneumonia and shows an even higher proportion during epidemics. MP infection is endemic in larger communities of the world with cyclic epidemics every 3 to 7 years. In Korea, 3 to 4-year cycles have been observed from the mid-1980s to present. Although a variety of serologic assays and polymerase chain reaction (PCR) techniques are available for the diagnosis of MP infections, early diagnosis of MP pneumonia is limited by the lack of immunoglobulin (Ig) M antibodies and variable PCR results in the early stages of the infection. Thus, short-term paired IgM serologic tests may be mandatory for an early and definitive diagnosis. MP infection is usually a mild and self-limiting disease without specific treatment, and if needed, macrolides are generally used as a first-choice drug for children. Recently, macrolide-resistant MP strains have been reported worldwide. However, there are few reports of apparent treatment failure, such as progression of pneumonia to acute respiratory distress syndrome despite macrolide treatment. The immunopathogenesis of MP pneumonia is believed to be a hyperimmune reaction of the host to the insults from MP infection, including cytokine overproduction and immune cell activation (T cells). In this context, immunomodulatory treatment (corticosteroids or/and intravenous Ig), in addition to antibiotic treatment, might be considered for patients with severe infection.

소아 마이코플라즈마 폐렴에서 진단 방법의 비교 및 IgG 아군의 변화

윤유숙 ( You Sook Youn ),이경일 ( Kyung Yil Lee ),황자영 ( Ja Young Hwang ),임정우 ( Jung Woo Yim ),강진한 ( Jin Han Kang ),이준성 ( Joon Sung Lee ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2009 소아알레르기 및 호흡기학회지 Vol.19 No.2

목적: 마이코플라즈마 폐렴에서 3가지 혈청학적 방법과 polymerase chain reaction (PCR)의 진단 양성률과 마이코플라즈마 감염 후 IgG 및 IgG 아군의 변화를 알아보고자 하였다. 방법: 마이코플라즈마 폐렴이 유행한 시기에 가톨릭대학교 대전성모병원 소아청소년과에 폐렴으로 입원한 50명의 환아들을 대상으로 하였다. 환아들의 입원 시와 퇴원 시의 혈청으로부터 미세입자 응집 반응법(Seradia-Myco II), 냉응집소 검사 및 효소면역 측정법으로 마이코플라즈마 항체와 IgG 및 IgG 아군(IgG1, IgG2, IgG3 & IgG4) 값을 측정하였다. 또한 입원 시에 마이코플라즈마 PCR법을 실시하였으며, 각각의 결과를 비교하였다. 결과: 입원 시기 검사만을 분석한 마이코플라즈마 폐렴 양성률은 미세입자 응집 반응법, 냉응집소 검사, 효소면역 측정법과 PCR에서 각각 52%, 38%, 30% 및 12%를 보였다. 2차례 측정 결과로 분석한 마이코플라즈마 폐렴 양성률은 미세입자응집 반응법, 냉응집소 검사와 효소면역 측정법에서 76%, 60% 및 56%로 미세입자 응집 반응법이 가장 높았다. IgG 값은 퇴원 시 통계적으로 유의하게 증가였으며, 38명의 마이코플라즈마 폐렴 환아에서 혈청 총 IgG 값은 30명에서 증가를, 8명에서 감소가 관찰되었다. 마이코플라즈마 환아들 27명의 IgG 아군 변화에서 유의하게 IgG1과 IgG3가 증가하였으며 IgG2, IgG4의 변화는 차이를 보이지 않았다. 결론: 마이코플라즈마의 진단에 있어서 혈청학적 방법으로 2차례의 검사가 확정 진단과 비교적 빠른 진단을 위해 필요하며, 이용한 혈청학적 방법에 따라 민감도에 차이를 보였다. 마이코플라즈마 감염 후 증가된 IgG 항체에서 IgG1과 IgG3가 유의하게 증가하였다. Purpose: This study aimed to investigate the positive rate of 3 serologic methods and polymerase chain reaction (PCR) and the changes of IgG and IgG subclasses in children with Mycoplasma pneumoniae pneumonia (MP). Methods: Fifty children with pneumonia admitted to Daejeon St. Mary`s Hospital, Korea, during MP outbreaks were evaluated for the diagnostic antibody status using 3 serologic methods: indirect micro-particle agglutinin assay (MAA, Serodia-Myco II, Fujirebio, Tokyo, Japan), cold agglutinins and enzyme-linked immunoassay (EIA, Platelia M. pneumoniae IgM & IgG BIO-RAD, Marnes-la-Coquette, France) and PCR. The levels of antibody for MP in each method were measured 2 times during hospitalization: at presentation and at discharge (mean interval, 6.5 days). The levels of IgG and IgG subclasses (IgG1, IgG2, IgG3 and IgG4) were also analyzed 2 times (at presentation and at discharge) using stored sera. Results: At presentation, the positive rates of the diagnostic methods were 52%, 38%, 30% and 12% for MAA, cold agglutinins, EIA and PCR assay, respectively. Following analysis of the repetitive measurement of the antibody, the positive rates of the diagnostic methods were 76%, 60% and 56% for MAA, cold agglutinins and EIA, respectively. The mean IgG level of MP patients increased during hospitalization (973±184 vs. 1,040±205 mg/dL; P=0.008). Among the IgG subclasses, the levels of IgG1 and IgG3 showed a significant increase during hospitalization (553±129 vs. 611±151 mg/dL, P=0.003 for IgG1; 43±27 vs. 47±30 mg/dL, P=0.005 for IgG3). Conclusion: For the accurate and relatively rapid diagnosis of MP, a paired sample examination is mandatory, especially within a short-time period. The sensitivity of serologic tests for the diagnosis of MP may differ among commercially available kits. IgG1 and IgG3 appear to be the main IgG subclasses that show an increase after MP infection. [Pediatr Allergy Respir Dis(Korea) 2009;19:137-145]

여성암 환자의 억압된 분노와 삶의 질과의 관계

태영숙(Tae Young Sook),윤수정(Youn Su Jung),우윤정(Woo Youn Jung),이혜진(Lee Hye Jin),최유진(Cna You Jin),최윤조(Cha Youn Jou) 고신대학교 전인간호과학연구소 2003 전인간호과학학술지 Vol.2 No.-

The purpose of this study is to provide the basic data to improve the QOL in patients suffering from female cancers. Subjects of this study were consisted 255 persons who admitted or visited three university hospitals. The instruments used for this study included the Quality Of Life Scale(QOL) developed by National Conference on Cancer Nursing and successively amended by K won (1990)’ Anger in developed by Spielberger(1988) and successively amended by Chon (1997). The collected data were analyzed using a SPSS 11.0 for PC. To find out significant factors of Anger in & QOL in patients with Female Cancer patients, Frequency, Percentage, t-test, ANOVA , Scheffe-test, Pearson s correlation coefficients were conducted. The main findings • Anger in score was a little low & QOL score was middle. Several characteristics of the subjects were identified to differentiate the Anger in and QOL . Age status(F=2.64,p=0.05), education status(F=2.73, p=0.04), Health insurance(t=2.27, p=0.00) and cancer insurance status(t=2.97, p=0.00) was significant factors of the Anger in . Education status(F=2.64 p=0.05), Occupation status(t=2.90, p=0.00), Monthly income (F=3.23 p=0.01), Stage of disease(F=9.23 p=0.00),Perceived health status(F=73.61 p=0.00), Perceived fatigue status(F= 11.26 p=0.00) was significant factors of the QOL In conclusion, Anger in score was a little low & QOL sore was moderate. The degree of Anger in and quality of life were significantly negative correlated. Therefore, It is needed strategies for intervention of Anger in to improve the QOL in female cancer patients. The significant characteristics of related to anger in & QOL should consider in sociopsychogical nursing intervention.

자가검진법을 이용한 건강검진 생활태도에 대한 고찰

유봉숙,윤미영,김진원,조주연 大韓家庭醫學會 1994 Korean Journal of Family Medicine Vol.15 No.2-3

자가검진법을 이용한 건강증진 생활태도에 대한 고찰

유봉숙,윤미영,김진원,조주연 대한가정의학회 1994 Korean Journal of Family Medicine Vol.15 No.2

Molecular Cloning and Biochemical Analysis of Dihydroflavonol 4-Reductase (DFR) from Brassica rapa ssp. Pekinesis (Chinese Cabbage) using a Heterologous System

( Won Sook Lee ),( Jung A You ),( Hee Chung ),( Youn Hyung Lee ),( Nam In Baek ),( Jong Su Yoo ),( Young Doo Park ) 한국식물학회 2008 Journal of Plant Biology Vol.51 No.1