Four new compounds from the bulbs of Lycoris aurea with neuroprotective effects against CoCl2 and H2O2-induced SH-SY5Y cell injuries

An Jin,Xuelian Xiang,Yun-Yun Zhu,Heng-Yi Yu,Hui-Fang Pi,Peng Zhang,Han-Li Ruan 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3

Three new alkaloids, 2a-hydroxy-6-O-n-butyloduline,O-n-butyllycorenine, (-)-N-(chloromethyl)lycoramine(1–3), and a new phenolic compound, ((7S)-7-(4-hydroxyphenyl)-7-hydroxypropyl)-20-methylbenzene-30,60-diol (14), along with ten known alkaloids (4–13), wereisolated from the bulbs of Lycoris aurea collected fromHuaihua County of Hunan Province, China. Their structureswere elucidated by spectroscopic methods includingHRESIMS, UV, IR, and NMR. All the isolated compoundswere tested for their neuroprotective effects against CoCl2and H2O2-induced SH-SY5Y cell death. Compounds 1–7and 10 exhibited significant neuroprotective effects againstCoCl2-induced SH-SY5Y cell injury, while compounds1–5, 7, 10 and 12 showed obvious neuroprotective effectsagainst H2O2-induced SH-SY5Y cell death.

Effects of Cooling Rate on the Microstructure and Tensile Properties of Wire-Arc Additive Manufactured Ti–6Al–4V Alloy

Hui‑Jun Yi,Jin‑Woo Kim,Young‑Lak Kim,Sangyong Shin 대한금속·재료학회 2020 METALS AND MATERIALS International Vol.26 No.8

Wire-arc additive manufacturing has emerged as a technology that could replace the conventional manufacturing processof titanium alloys. However, it produces a coarse β grain, which can accumulate via several deposited materials, resulting isstrong texture and anisotropy. To investigate potential solutions, the effects of the cooling rate on the resulting microstructureand tensile properties were studied. The cooling rate of the deposited materials was adjusted by interpass temperaturecontrol. Under rapid cooling, fine α + α′ grain with a low aspect ratio were observed and tensile and hardness propertieswere also improved.

Effects of Quenching Methods and Aging Processes on the Crushing Properties and Microstructure of Al–Zn–Mg Alloy Thin-Walled Square Extrusions

Hui Guo,Jin Zhang,Cheng Wang,Yun‑lai Deng 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.8

In this study, the effects of different (online quenching and offline quenching) quenching methods and aging processes (T6and T73) on the crashworthiness and microstructural evolution of three Al–Zn–Mg alloys (G1–G3) were studied by conductingtensile test and axial compression tests at room temperature, combined with optical metallography, electron back scattereddiffraction, and transmission electron microscopy microstructural observations. The obtained results revealed that thecrushing properties of three different Al–Zn–Mg alloys subjected to different quenching methods and aging processes weresignificantly different. Their crushing energy absorption of are ranked as follows: G1 > G3 > G2. The highest total energyabsorption gap (between T6 and T73) is the G1 alloy, and the lowest one is the G3 alloy. The largest total energy absorptiongap between the two quenching methods is the G3 alloy, and the smallest one is the G1 alloy. The G2 alloy with the largesttotal amount of Zn + Mg has the highest number density of matrix precipitates, the largest precipitate gap (between T6 andT73) and the smallest precipitate gap between the two quenching methods. The G3 alloy with the largest Zn/Mg ratio hasthe smallest number density of matrix precipitates, the minimum precipitation gap (between T6 and T73) and the maximumprecipitation gap between the two quenching methods. The G1 alloy with the lowest Zn/Mg ratio has the smallest size ofgrain boundary precipitates and PFZ width, while their largest values are obtained for the G3 alloy with the maximum Zn/Mg ratio. As a crushing resistant structural material, the crushing properties is improved without reducing the strength. Theratio of Zn/Mg should be controlled within the range of 4.57–6.15, while the total amount of Zn + Mg should be controlledwithin the range of 6.18–7.01.

불국사 석탑의 물성 및 지반특성 조사

최희수,서만철,오진용 공주대학교 문화재보존과학연구소 2003 문화재과학기술 Vol.2 No.1

경주 불국사의 다보탑과 석가탑은 751년에 축조된 국보급 문화재이나 오늘날은 석재의 풍화 및 지대석의 어긋남 현상들이 관찰된다. 이에 대한 정확한 이해는 두 석탑의 안정성 진단에 필수적이며 따라서 석탑의 지반환경과 석재 물성에 관한 비파괴 정밀 조사가 필요로 한다. 이 연구에서는 석재의 역학적 성질을 위해 초음파 속도 측정을 실시하였고 천부지질구조를 위해 탄성파, 전기비저항, 지하레이더 등의 비파괴 복합 지구물리탐사를 석탑 주변에서 수행하였다. 초음파 속도범위는 석가탑에서는 1217~4403 m/s이며, 다보탑에서는 584~5845 m/s이며 이로부터 추정한 일축강도 평균치는 각각 463 kg/cm^(2), 409 kg/cm^(2)이다. 대체로 두 석탑 주변의 북서쪽 구역에서 낮은 탄성파 속도와 비저항 값이 나타나, 이 부분을 비교적 연약한 지반으로 해석한다. 그리고, 탄성파 속도분포에서는 다보탑 지반이 더 큰 속도를 보여 상대적으로 석가탑 지반보다 견고함을 보여준다. 대체로 석탑지반의 전기비저항은 최대 2200 Ωm이며 200 Ωm내외의 외부지반보다 더 높은 값을 보인다. 복합 지구물리탐사 결과를 종합하면 다보탑지반의 형태는 8각형(한 변은 6 m)으로 그 깊이는 약 4 m 이나, 석가탑지반은 약 8x10 m의 직사각형 형태로 깊이는 약 3 m 이다. Two three-story stone pagodas, Seokgatap and Dabotap, built in 791 at Bulkuksa temple, are well-known national treasures. However, they have experienced weathering process and an offset of the stone alignment is observed at the base part of Dabotap. Understanding of these phenomena is essential for the structural safety diagnosis for them, and therefore the nondestructive geophysical methods was applied. Direct measurements of ultrasonic velocities was introduced for the mechanical properties of the stone. Multidisciplinary geophysical prospectings including seismic, resistivity, ground-penetrating radar(GPR) methods were carried out around two pagodas for their site characteristics. The velocity ranges of ultrasonic waves for Dabotap and Seokgatap are 1217~4403m/s and 584~5845m/s, respectively, and the estimated averages of the uniaxial compressive strength are 463 kg/cm^(2) and 409 kg/cm^(2), respectively. At the northeast of each pagodas, the lower seismic velocities and resistivities are shown, which is interpreted to be weaker subsurface section. On the basis of the higher velocity structure, the site of Seokgatap appears to have solider stability than the Seokgatap site. Near the pagodas, higher(up to 2200 Ωm) resistivity is present whereas their outskirts have as low as 200 Ωm. By the combined results of each geophyscial methods, the subsurface boundaries of each stone pagodas are revealed. The Dabotap site is in the form of an octagon having 6-m-long side with the depth of ~4 m, whereas the Seokgatap site is the 8x10 m rectangle with the depth of 3 m.

Sol-Gel법을 이용한 Silica Membrane의 제조 공정에 관한 조사 연구

이진휘 건국대학교 1991 論文集 Vol.32 No.1

The general informations of sol-gel process are reviewed. Successful applications are dependent on sufficient scientific understanding of the various stages and factors of the process. A number of factors governing the development of the structure and microstructure during gelation and subsequent drying and firing conditions are mentioned. Examples are described for applications in the areas of composites, porous solids and coatings. Opportunities for many new applications are presently available for exploitations.

DiffServ 환경에서 Mobile Xcast 지원에 관한 연구

배진호,김태수,이광휘 국립7개대학공동논문집간행위원회 2003 공업기술연구 Vol.3 No.-

In the third generation of mobile computing environment, the applications that are compatible with small members of group in which the applications join the multicast sessions such as Internet phone, video conference and networked games are more prevalent. However, since the traditional multicast mechanisms supporting the mobile computing are suitable for large members of group in the multicast session, we need to consider a new mechanism to complement them. Therefore, in this paper we suggest a new multicast model that adopted explicit multicast(xcast), which has more gradual deployment with legacy Internet backbone. This proposed model is cost-effective and more scalable and guarantees the QoS in mobile computing.

감초로부터 글리시리진의 추출 및 정제

이진휘,서성조,서동호 서울産業大學校 1999 논문집 Vol.49 No.2

시장에서 구입한 감초를 70∼80℃의 물에 하루 동안 담가두어 감초내의 혼합 성분들을 추출한 후, 글리시리진이외의 성분들(sugars, starches, flavonoids, saponoids, aminoacids, gums and essential oil 등)이 에탄올에 용해되는 성질을 이용하여 글리시리진만을 선택적으로 분리해내기 위하여 에탄올 및 에탄올/아세트산 혼합액(99:1)을 각각 사용하였다. 글리시리진의 정성 및 정량분석은 HPLC(Waters 600 controller)를 사용하였다. 사용된 column은 μbondapak C??, 이동상은 물/아세트산/아세트나이트릴을 61:1:38로 만들어 유속 1.5㎖/min.을 적용하였다. 글리시리진 표준물질은 일양약품에서 제공한 글리시리진 암모늄염을 사용하였다. 정제 효과를 알아보기 위해 감초에서 물로 추출한 경우, 에탄올로 처리한 경우, 그리고 에탄올/아세트산(99:1) 혼합액으로 처리한 경우의 각각에 대한 글리시리진 함량을 비교 분석한 결과 순서대로 22.4%, 25.0% 및 29.5%로 나타났다. Glycyrrhizin was extracted from Glycyrrhiza uralensis(Licorice) with water at 70~80℃ for 24hours. To remove another components(usually sugars, starches, flavonoids, saponoids, aminoacids, gums, and essential oil etc.), extracted glycyrrhizin was purified with ethanol or ethanol/acetic acid (99:1). HPLC was used to quantitative and qualitative analysis. The colume used was μ bondapak C??(Waters) and mobile phase was water/acetic acid/acetonitrile(61:1:38) with 1.5㎖/min. flow rate. The amounts of glycyrrhizin Prepared after extracted by water, ethanol and ethanol/acetic acid(99:1) were 22.4%, 25.0% and 29.5% individually.

감초로부터 Glycyrrhizin 추출

이진휘,장향동,최하영,서동호,이성미,김경하 서울産業大學校 1998 논문집 Vol.47 No.1

Glycyrrhiza uralensis계의 원감초 뿌리에서 추출도는 감초는 여러가지 질병의 약제로 널리 이용되어 왔다. 그 주성분인 gliycyrrhizin은 항염증 활성 및 anti-allergic activity를 갖고 있으며 이러한 생리활성은 aglycone β-gliycyrrhetinic acid 의 활성에 의한 것으로 알려져 있고, β-gliycyrrhetinic acid는 steroid 구조와 유사하며, 면역조절 특성을 갖는 것으로 인식되고 있다. 이러한 β-gliycyrrhetinic acid 의 면역조절 활성에 기여하는 인자와 그 경로에 대하여 조사된 바 있다 Glycyrrhizin은 감초뿌리의 주성분중 하나이며, 그외에도 surgars(14%), starches(30%), flavonoids, saponoids, amonoacids, gums 및 essential oil 등을 포함하고 있다. Licorice, the root extract of Glycyrrhiza uralensis, is used as a medicine for various diseases. Antiinflammatory as well as anti-allergic activities have been attributed to one of its main constituents, glycyrrhizin. These activities are mainly ascribed to the action of the aglycome β-glycyrrhetinic acid. βGlyeyrrhetinic acid has a steroid-like structure and is believed to have immunomodulatory properties, To determine whether interference with complement functions may contribute to the immunomdulatory activity of β-glycyrrbetinic acid. its effect on the classical and alternative activation pathways of human complement were investigated. The main constituent found in the root is glycyrrhizin. The plant also contains various sugars(14%), starches(30%), flavonoids, saponoids, aminoacids, gums, and essential oil etc.

소규모 재개발에 의한 노후불량주거지의 점진적 정비수법에 관한 연구 : 일본의 소규모 연쇄형 재개발사례를 중심으로

신중진,임희지,김태엽 대한건축학회 2005 대한건축학회논문집 Vol.21 No.1

The purpose of this study sis to suggest Improvement Ideas of urban squatter area through the Japan examples For this, we analyzed the six examples of Japan and extracted their Improvement methods and main principles The frame of analysis was made from the problems of urban squatter area Improvement in Korea and It's Items are social, economic, system, organization and space These Items were applied to six examples In Japan too The results of this study is as follows First, the problems of urban squatter area Improvement were summarized to the destroy of local society, the privatization of development benefit, the lack of publicity effect, the exception of residential participation and reckless development Second, they were inventing diverse Improvement methods under the local situation in japan and their main principles were durability, strategy, flexibility, cooperation and unification Third, dll examples were proceeded by the leading public role and the most important concept was not physical supply but living independence about local society The last, we were able to suggest four subjects ①the introduction of incremental small-scale development concept ②the invent of adaptable Improvement methods in local situation ③the strengthen of public support and coordinate function ④the specialization and partnership of resident, company and public

효과적인 다차원 분석을 지원하는 스트레드시트 방식의 OLAP 인터페이스 설계 및 구현

윤민희,김진호,문양세 강원대학교 정보통신연구소 2006 정보통신논문지 Vol.10 No.-

OLAP systems support effectively data analysis over a large volume of business data to make decisions for an enterprise. In order to process data analysis efficiently, OLAP systems pre-compute the summary of business data over various dimensions and store them into data warehouses. Several specialized tools have been developed to display and to browse the results of complex analytical queries on data warehouses. In this paper, we developed a spreadsheet-like tool to support OLAP operations and to browse the results of analytical queries. Spreadsheet is one of the most popular and user-friendly data analysis tool. It also has lots of advantages, which is interactive, easy to learn, etc. Thus this paper implemented an OLAP tool using spreadsheet-style interface to analyze large OLAP data on World-Wide Web. Through this tool, users can process OLAP activities easily and effectively by using the same ways as well-known shreadsheet tools like Microsoft Excel.