Carbon Medicine in Ancient China

Hongyan Yang,Zengxiang Fu,Xingli Huang,Binrui Ma 한국탄소학회 2005 Carbon Letters Vol.6 No.4

In traditional Chinese medicine, some herbs are used after toasting or roasting. The process is called "Zhi Tan" in Chinese, which means charring, and the herbs after the treatment is called carbon medicine. Carbon medicine is widely used to arrest bleeding in traditional Chinese medicine. The paper introduces the records, development and applications of carbon medicine in ancient China. The earliest record found about carbon medicine was in the remains of Han dynasty (BC206-A.D.8). The paper also introduces the process of charring herbs and mechanism of carbon medicine in arresting bleeding. Calcium iron and tan released during the charring are believed as main factors for arresting bleeding, helped with porous surface structure of active carbon.

Carbon Medicine in Ancient China

Yang, Hongyan,Fu, Zengxiang,Huang, Xingli,Ma, Binrui Korean Carbon Society 2005 Carbon Letters Vol.6 No.4

In traditional Chinese medicine, some herbs are used after toasting or roasting. The process is called "Zhi Tan" in Chinese, which means charring, and the herbs after the treatment is called carbon medicine. Carbon medicine is widely used to arrest bleeding in traditional Chinese medicine. The paper introduces the records, development and applications of carbon medicine in ancient China. The earliest record found about carbon medicine was in the remains of Han dynasty (BC206-A.D.8). The paper also introduces the process of charring herbs and mechanism of carbon medicine in arresting bleeding. Calcium iron and tan released during the charring are believed as main factors for arresting bleeding, helped with porous surface structure of active carbon.

Effects of Lactobacillus curvatus and Leuconostoc mesenteroides on Suan Cai Fermentation in Northeast China^s

( Hongyan Yang ),( Hao Wu ),( Lijuan Gao ),( Hongbai Jia ),( Yuan Zhang ),( Zongjun Cui ),( Yuhua Li ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.12

To investigate the effects of Lactobacillus curvatus and Leuconostoc mesenteroides on suan cai (pickled Chinese cabbage) fermentation, L. curvatus and/or Ln. mesenteroides were inoculated into suan cai. Physicochemical indexes were measured, and the microbial dynamics during the fermentation were analyzed by Illumina MiSeq sequencing and quantitative polymerase chain reaction (qPCR). The results showed that inoculation with lactic acid bacteria (LAB) lowered the pH of the fermentation system more rapidly. The decrease in water-soluble carbohydrates in the inoculated treatments occurred more rapidly than in the control. The LAB counts in the control were lower than in other inoculated treatments during the first 12 days of fermentation. According to the Illumina MiSeq sequencing analyses, Firmicutes, Proteobacteria, Bacteroidetes, Actinobacteria, Cyanobacteria, Fusobacteria, and Verrucomicrobia were present in the fermentations, along with other unclassified bacteria. Generally, Firmicutes was predominant during the fermentation in all treatments. At the genus level, 16 genera were detected. The relative abundance of Lactobacillus in all inoculated treatments was higher than in the control. The relative abundance of Lactobacillus in the treatments containing L. curvatus was higher than in the Ln. mesenteroides-only treatment. The relative abundance of Leuconostoc in the Ln. mesenteroides-containing treatments increased continuously throughout the fermentation. Leuconostoc was highest in the Ln. mesenteroides-only treatment. According to the qPCR results, L. curvatus and/or Ln. mesenteroides inoculations could effectively inhabit the fermentation system. L. curvatus dominated the fermentation in the inoculated treatments.

A novel approach for the preparation of thermally stable cellulose nanocrystals via a sustainable FeCl3-catalyzed deep eutectic solvent treatment

Xianghao Yang,Hongxiang Xie,Zhufan Zou,Yang Zou,Wei Liu,Hongyan Lan,Xinxing Zhang,Youngsoo Bae,Chuanling Si 강원대학교 산림과학연구소 2018 강원대학교 산림과학연구소 학술대회 Vol.2018 No.09

Cellulose nanocrystals (CNCs) as building blocks were widely used to produce renewable and sustainable nanomaterials. CNCs are mainly produced by inorganic acid hydrolysis such as sulfuric, hydrochloric, nitric, phosphoric acids, etc. However, there are some drawbacks for inorganic acid hydrolysis such as harsh corrosion of equipment, severe environmental pollution, large water usage and so on. Herein, we reported a green and sustainable method for the preparation of CNCs via a one-step treatment based on a deep system solvent (DES) system of FeCl3-catalyzed choline chloride and oxalic acid dihydrate (F-DES). Due to its low melting point, this F-DES can be easily obtained at a lower temperature. Results shows that CNC samples (F-CNC) could be successfully isolated from bleached eucalyptus Kraft pulp (BEKP) with a high yield (over 70%). Also the DES could be recovered from the reaction solution by a simple evaporation process with high recovery rate ( %). Thermogravimetric analyses revealed that the onset decomposition temperature for the obtained F-CNC was 321°C, which was much higher than that of the CNCs produced from the same raw BEKP by sulfuric acid hydrolysis. Therefore, the FeCl3-catalyzed deep eutectic solvent treatment could be a sustainable and economically feasible method for the production of CNCs with high thermal stability.

RNA m5C modification upregulates E2F1 expression in a manner dependent on YBX1 phase separation and promotes tumor progression in ovarian cancer

Liu Xiaoyi,Wei Qinglv,Yang Chenyue,Zhao Hongyan,Xu Jie,Mobet Youchaou,Luo Qingya,Yang Dan,Zuo Xinzhao,Chen Ningxuan,Yang Yu,Li Li,Wang Wei,Yu Jianhua,Xu Jing,Liu Tao,Yi Ping 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-

5-Methylcytosine (m5C) is a common RNA modification that modulates gene expression at the posttranscriptional level, but the crosstalk between m5C RNA modification and biomolecule condensation, as well as transcription factor-mediated transcriptional regulation, in ovarian cancer, is poorly understood. In this study, we revealed that the RNA methyltransferase NSUN2 facilitates mRNA m5C modification and forms a positive feedback regulatory loop with the transcription factor E2F1 in ovarian cancer. Specifically, NSUN2 promotes m5C modification of E2F1 mRNA and increases its stability, and E2F1 binds to the NSUN2 promoter, subsequently reciprocally activating NSUN2 transcription. The RNA binding protein YBX1 functions as the m5C reader and is involved in NSUN2-mediated E2F1 regulation. m5C modification promotes YBX1 phase separation, which upregulates E2F1 expression. In ovarian cancer, NSUN2 and YBX1 are amplified and upregulated, and higher expression of NSUN2 and YBX1 predicts a worse prognosis for ovarian cancer patients. Moreover, E2F1 transcriptionally regulates the expression of the oncogenes MYBL2 and RAD54L, driving ovarian cancer progression. Thus, our study delineates a NSUN2-E2F1-NSUN2 loop regulated by m5C modification in a manner dependent on YBX1 phase separation, and this previously unidentified pathway could be a promising target for ovarian cancer treatment.

Preparation and mechanism investigation of highly sensitive humidity sensor based on Ag/TiO2

Yang Chen,Zhang Hongyan,Gu Weiyuan,Chen Chu 한국물리학회 2022 Current Applied Physics Vol.43 No.-

In this paper, a high-performance silver-doped titanium dioxide (Ag/TiO2) humidity sensor was synthesized using a hydrothermal synthesis method for respiratory monitoring. The sensing mechanism was studied by the first principles of density functional theory (DFT). Calculations show that the doping of Ag+ ions increases the adsorption energy of TiO2 to water molecules. Furthermore, the Ti–O bond in TiO2 is broken due to the doping of Ag+ ions, which promotes the generation of Ti3+ defects. Experiments show that the doping of Ag+ ions can increase the hydroxide groups, Ti3+ defects and oxygen vacancies on the surface of TiO2, thus effectively improving the responsivity, linearity and hysteresis of the TiO2 humidity sensor. Compared to TiO2, the resistance of the Ag/TiO2 (0.5 mM) humidity sensor reaches 4.5 orders of magnitude with a high response of 39707.1, maximum hysteresis rate of 4.6%, response/recovery time of 31 s/15 s and the best linearity in a range of 11%– 95% RH. In addition, the Ag/TiO2 humidity sensor has been successfully used to detect different modes of respiration and determine the respiratory rate under different respiratory states. Significantly, this work demonstrates potential application value in human healthcare and activities monitoring.

Research on Constructing Application System of Exhibition Integrated Information Service Platform in Airport Economic Zone

Yang Changhui,Meng Hongyan 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.4

Information technology has been widely used in the daily management of enterprises. Through the use of it, construct the integrated information service system which is based on exhibition services and takes exhibition organizer, exhibitor and audience as the main service object. Implement digital exhibition service, integrated information service, scientific activity management and customer service network and meet the needs of exhibition service, information service, activity management and customer service. This paper analyzes the service object and domestic demand of exhibition integrated information service system, proposes the system structure of exhibition integrated information service system and analyzes communication platform, operation platform and application platform of the system. Application of exhibition integrated information service system is contribute to realize the interaction among the information flow, capital flow and logistics, implement the purpose of information resources sharing, efficient management and decision science, drive the comprehensive development of enterprise informatization, business electronization, logistics internationalization and supply chain informatization and promote regional economic prosperity and social progress.

A newly developed vacuum leak calibration system at NIM

Hongyan YU,Jinku WANG,Yuanchao YANG,Jin YUE,Chuxin GE 한국진공학회 2016 한국진공학회 학술발표회초록집 Vol.2016 No.8

Concurrence of ovarian cancer and dermatomyositis: a propensity score analysis

Hongyan Cheng,Lanqing Huo,Dan Wang,Yang Xiang 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.6

Objective: To analyze the clinical characteristics, prognosis and parallel clinical course ofovarian cancer (OC) and dermatomyositis (DM). Methods: The medical records of 23 consecutive patients who were diagnosed with OC andDM and were treated at Peking Union Medical College Hospital (PUMCH) between 2002and 2017 were reviewed. Propensity score matching method was used to match controlgroup (OC patients without DM) at a ratio of 1:5. The correlation between OC and DM wasmeasured using the Pearson correlation scatter plot and Pearson's r. Kaplan-Meier survivalanalysis and Cox proportional hazard regression analysis were performed to evaluate theprognostic factors. Results: After matching, 23 patients who have the concurrence of OC and DM (DM group)and 115 patients diagnosed with OC alone (No DM group) were included. The 5-year overallsurvival rates (71.6% vs. 51.8%, p=0.020) and 5-year progression-free survival (30.5% vs. 0%, p=0.018) were poorer in DM group. Correlation between serum cancer antigen 125 (CA125) and creatine kinase (CK) level was observed in 12 patients. The time between OC andDM diagnosis is significant through univariable analysis (p=0.021) but not in multivariableanalysis in patients who have the concurrence of OC and DM. Conclusion: The concurrence of OC and DM as a paraneoplastic syndrome is rare and has apoor prognosis. The risk for patients diagnosed with DM is highest within 3 years before orafter OC diagnosis. A correlation and a parallel clinical course exist between these 2 diseases.

Modeling and performance evaluation of a piezoelectric energy harvester with segmented electrodes

Hongyan Wang,Lihua Tang,Xiaobiao Shan,Tao Xie,Yaowen Yang 국제구조공학회 2014 Smart Structures and Systems, An International Jou Vol.14 No.2

Conventional cantilevered piezoelectric energy harvesters (PEHs) are usually fabricated with continuous electrode configuration (CEC), which suffers from the electrical cancellation at higher vibration modes. Though previous research pointed out that the segmented electrode configuration (SEC) can address this issue, a comprehensive evaluation of the PEH with SEC has yet been reported. With the consideration of delivering power to a common load, the AC outputs from all segmented electrode pairs should be rectified to DC outputs separately. In such case, theoretical formulation for power estimation becomes challenging. This paper proposes a method based on equivalent circuit model (ECM) and circuit simulation to evaluate the performance of the PEH with SEC. First, the parameters of the multi-mode ECM are identified from theoretical analysis. The ECM is then established in SPICE software and validated by the theoretical model and finite element method (FEM) with resistive loads. Subsequently, the optimal performances with SEC and CEC are compared considering the practical DC interface circuit. A comprehensive evaluation of the advantageous performance with SEC is provided for the first time. The results demonstrate the feasibility of using SEC as a simple and effective means to improve the performance of a cantilevered PEH at a higher mode.