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Bayesian case influence analysis for GARCH models based on Kullback–Leibler divergence
Hong-Xia Hao,Jinguan Lin,Hong-Xia Wang,Xing-Fang Huang 한국통계학회 2016 Journal of the Korean Statistical Society Vol.45 No.4
Influence analysis has become an important tool for statistical analysis. This paper is concerned with Bayesian case influence analysis for generalized autoregressive conditional heteroscedasticity (GARCH) model. Case influence analysis is developed for both the joint and marginal posterior distributions based on the Kullback–Leibler divergence (K–L divergence). A simplified expression is presented for computing the K–L divergence between the full data posterior distribution and the case-deleted posterior distributions. The related computations can be done numerically by Markov Chain Monte Carlo samples from posterior distribution with full data. Some simulation studies are carried out to examine the performance of the proposed methods and show the relations between case-deletion model (CDM) and mean-shift outlier model (MSOM) for the GARCH models. Meanwhile, the methods are also illustrated by a real data.
Study on modulation of near infrared radiation based on plasma photonic crystal
Hao Jiong-Ju,Xie Xun,Gu Ke-Da,Liu Yu-Jie,Xia Lei,Yang Hong-Wei 한국물리학회 2020 Current Applied Physics Vol.20 No.8
In this paper, a plasma photonic crystal (PPC) for infrared radiation modulation which is composed of indium tin oxide (ITO) and plasma is proposed. The performance of plasma photonic crystal in near infrared radiation modulation is researched by transfer matrix method (TMM). The simulation results show that the near infrared radiation pass band can be adjusted by the changing of plasma frequency of plasma. The reflection to near infrared radiation by plasma photonic crystal increases with plasma frequency and that of absorption decreases. In addition, the modulation performance of the plasma photonic crystal at different incidence wave angles is also studied. The results show that the incident wave angles have little effect on the transmission of plasma photonic crystal in near infrared band. The reflection of the plasma photonic crystal to near infrared radiation decreases with increasing of the incident wave angle, but that of the absorption increases with the incident wave angle. Therefore, the proposed plasma photonic crystal has a potential application in tunable near infrared filter devices.
FBW7 Upregulation Enhances Cisplatin Cytotoxicity in Non-small Cell Lung Cancer Cells
Yu, Hao-Gang,Wei, Wei,Xia, Li-Hong,Han, Wei-Li,Zhao, Peng,Wu, Sheng-Jun,Li, Wei-Dong,Chen, Wei Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Introduction: Lung cancer is extremely harmful to human health and has one of the highest worldwide incidences of all malignant tumors. Approximately 80% of lung cancers are classified as non-small cell lung cancers (NSCLCs). Cisplatin-based multidrug chemotherapy regimen is standard for such lesions, but drug resistance is an increasing problem. F-box/WD repeat-containing protein 7 (FBW7) is a member of the F-box protein family that regulates cell cycle progression, and cell growth and differentiation. FBW7 also functions as a tumor suppressor. Methods: We used cell viability assays, Western blotting, and immunofluorescence combined with siRNA interference or plasmid transfection to investigate the underlying mechanism of cisplatin resistance in NSCLC cells. Results: We found that FBW7 upregulation significantly increased cisplatin chemosensitivity and that cells expressing low levels of FBW7, such as NCI-H1299 cells, have a mesenchymal phenotype. Furthermore, siRNA-mediated silencing or plasmid-mediated upregulation of FBW7 resulted in altered epithelial-mesenchymal transition (EMT) patterns in NSCLC cells. These data support a role for FBW7 in regulating the EMT in NSCLC cells. Conclusion: FBW7 is a potential drug target for combating drug resistance and regulating the EMT in NSCLC cells.
Qiu, Hao,Duan, Wei-Ming,Shu, Jie,Cheng, Hong-Xia,Wang, Wei-Ping,Huang, Xin-En,Chen, Hui-Li Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24
The epidermal growth factor receptor (EGFR) is an important surface receptor with N-glycans in its extracellular domain, whose glycosylation is essential for its function, especially in tumor cells. Here, we demonstrated that polylactosamine is markedly increased in H7721 hepatocellular carcinoma cells after treatment with EGF, while it apparently declined after exposure to all-trans retinoic acid (ATRA). In the study of the enzymatic mechanism of this phenomenon, we explored changes in the expression of poly-N-acetyllactosamine (PLN) branching glycosyltransferases using RT-PCR. Among the four glycosyltransferases with altered expression, GnT-V was most elevated by EGF, while GnT-V and B3GNT2 were most declined by ATRA. Next, we conducted co-immunoprecipitation experiments to test whether B3GNT2 and EGFR associate with each other. We observed that EGFR is a B3GNT2-targeting protein in H7721 cells. Taken together, these findings indicated that the altered expression of B3GNT2 will remodel the PLN stucture of EGFR in H7721 cells, which may modify downstream signal transduction.
Zhang, Yumiao,Hong, Hao,Sun, Boyang,Carter, Kevin,Qin, Yiru,Wei,Wang, Depeng,Jeon, Mansik,Geng, Jumin,Nickles, Robert J.,Chen, Guanying,Prasad, Paras N.,Kim, Chulhong,Xia, Jun,Cai, Weibo,Lovell, Jonat The Royal Society of Chemistry 2017 Nanoscale Vol.9 No.10
<P>Surfactant-stripped, nanoformulated naphthalocyanines (nanonaps) can be formed with Pluronic F127 and low temperature membrane processing, resulting in dispersed frozen micelles with extreme contrast in the near infrared region. Here, we demonstrate that nanonaps can be used for multifunctional cancer theranostics. This includes lymphatic mapping and whole tumor photoacoustic imaging following intradermal or intravenous injection in rodents. Without further modification, pre-formed nanonaps were used for positron emission tomography and passively accumulated in subcutaneous murine tumors. Because the nanonaps used absorb light beyond the visible range, a topical upconversion skin cream was developed for anti-tumor photothermal therapy with laser placement that can be guided by the naked eye.</P>
Li, Jun,Hao, Hong,Xia, Yong,Zhu, Hong-Ping Techno-Press 2015 Structural Engineering and Mechanics, An Int'l Jou Vol.54 No.2
Shear connectors are generally used to link the slab and girders together in slab-on-girder bridge structures. Damage of shear connectors in such structures will result in shear slippage between the slab and girders, which significantly reduces the load-carrying capacity of the bridge. Because shear connectors are buried inside the structure, routine visual inspection is not able to detect conditions of shear connectors. A few methods have been proposed in the literature to detect the condition of shear connectors based on vibration measurements. This paper proposes a different dynamic condition assessment approach to identify the damage of shear connectors in slab-on-girder bridge structures based on power spectral density transmissibility (PSDT). PSDT formulates the relationship between the auto-spectral densities of two responses in the frequency domain. It can be used to identify shear connector conditions with or without reference data of the undamaged structure (or the baseline). Measured impact force and acceleration responses from hammer tests are analyzed to obtain the frequency response functions at sensor locations by experimental modal analysis. PSDT from the slab response to the girder response is derived with the obtained frequency response functions. PSDT vectors in the undamaged and damaged states can be compared to identify the damage of shear connectors. When the baseline is not available, as in most practical cases, PSDT vectors from the measured response at a reference sensor to those of the slab and girder in the damaged state can be used to detect the damage of shear connectors. Numerical and experimental studies on a concrete slab supported by two steel girders are conducted to investigate the accuracy and efficiency of the proposed approach. Identification results demonstrate that damages of shear connectors are identified accurately and efficiently with and without the baseline. The proposed method is also used to evaluate the conditions of shear connectors in a real composite bridge with in-field testing data.
Jun Li,Hong Hao,Yong Xia,Hong-ping Zhu 국제구조공학회 2015 Structural Engineering and Mechanics, An Int'l Jou Vol.54 No.2
Shear connectors are generally used to link the slab and girders together in slab-on-girderbridge structures. Damage of shear connectors in such structures will result in shear slippage between theslab and girders, which significantly reduces the load-carrying capacity of the bridge. Because shearconnectors are buried inside the structure, routine visual inspection is not able to detect conditions of shearconnectors. A few methods have been proposed in the literature to detect the condition of shear connectorsbased on vibration measurements. This paper proposes a different dynamic condition assessment approachto identify the damage of shear connectors in slab-on-girder bridge structures based on power spectraldensity transmissibility (PSDT). PSDT formulates the relationship between the auto-spectral densities oftwo responses in the frequency domain. It can be used to identify shear connector conditions with or withoutreference data of the undamaged structure (or the baseline). Measured impact force and accelerationresponses from hammer tests are analyzed to obtain the frequency response functions at sensor locations byexperimental modal analysis. PSDT from the slab response to the girder response is derived with theobtained frequency response functions. PSDT vectors in the undamaged and damaged states can becompared to identify the damage of shear connectors. When the baseline is not available, as in most practicalcases, PSDT vectors from the measured response at a reference sensor to those of the slab and girder in thedamaged state can be used to detect the damage of shear connectors. Numerical and experimental studies ona concrete slab supported by two steel girders are conducted to investigate the accuracy and efficiency of theproposed approach. Identification results demonstrate that damages of shear connectors are identifiedaccurately and efficiently with and without the baseline. The proposed method is also used to evaluate theconditions of shear connectors in a real composite bridge with in-field testing data.