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A major role for microRNAs in glioblastoma cancer stem-like cells
Hong Wei Yang,Hongyan Xing,Mark D. Johnson 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.3
Studies have demonstrated that miRNAs contributeto the maintenance and phenotype of in several cancertypes. This review will focus on the roles of a few wellstudied miRNAs in cancer stem-like cells of glioblastoma.
Non-fragile Dynamic Output Feedback H_∞ Control for Discrete-Time Systems with FWL Consideration
Wei-Wei Che,Guang-Hong Yang 제어·로봇·시스템학회 2011 International Journal of Control, Automation, and Vol.9 No.5
The non-fragile dynamic output feedback H_∞ controller design problem is investigated. The controller to be designed is assumed to be with additive gain variations. A two-step procedure is proposed to develop sufficient conditions for the non-fragile H_∞ controller design by employing the structured vertex separator. A comparison between the proposed and the existing controller design methods is provided, and a numerical example is carried out to support the theoretical findings.
Yang, Hong-Wei(양홍위),Ock, Deok-Kyung(옥덕경),Song, Song-Mi(송송미),Lim, Choong-Hoon(임충훈) 한국체육과학회 2020 한국체육과학회지 Vol.29 No.6
The purpose of this study was to examine the influence of color modification on sport brand logo in the aspects of four attributes of color (i.e., identifiability, association, symbolism, and attractiveness). Also, we analyze the effect of color modification on sport brand logo as a function of the level of brand familiarity and gender. A total of 600 participant’s data was used in this study that adopted a repeated-measures experimental design in which subjects were randomly assigned to one of four experimental conditions. When representative color is modified to opposite color from the original brand color for the familiar sport brand, the attributes of color (i.e., identifiability, association, symbolism, attractiveness) and purchase intention were decreased. With regard to the low familiarity brand, color attributes and purchase intention had significantly increased under the color modified condition. In addition, a significant interaction effect between purchase intention and gender was found only in the high familiarity brand group. Compared to women’s purchase intentions, men’s purchase intentions decreased to a greater degree, when the level of familiarity is high. The findings of the current study add to the understanding of the effects of color marketing on consumers’ perceptions of a sport brand and on subsequent purchase intentions. Also, the results indicated that the effects of color marketing were dependent on brand familiarity and the effects varied according to gender.
Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora
Wei-Lie Xiao,Rui-Rui Wang,Wei Zhao,Ren-Rong Tian,Shan-Zhai Shang,Liu-Meng Yang,Jian-Hong Yang,Jian-Xin Pu,Yong-Tang Zheng,Han-Dong Sun 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.5
This study investigated the 70% aqueous acetone extract of the fruits of Schisandra rubriflora which led to the isolation of eight lignans, including a new isolate, rubrisandrin C (1), and seven known lignans (2-8) . The structure of 1 was established by extensive 1D and 2D NMR spectroscopy and its absolute stereochemistry was determined by CD spectrum. Compounds 1-5 and 7-8 were evaluated for their anti-HIV-1 activity that showed inhibitory activity on HIV-1IIIB induced syncytium formation with EC50 values in the range of 2.26~20.4 μg/mL. Compounds 1 and 7 exerted their obvious protection of HIV-1IIIB inducted MT-4 host cells lytic effects with a selectivity index of 15.4 and 24.6, respectively.
Hong-Qi Yang,Wen-Cong Zhao,Wei-Min Yang,Yong-Li Li,Zhi-Kun Sun,Shuai Chen,Wei Li,Jian-Jun Ma 대한신경과학회 2016 Journal of Clinical Neurology Vol.12 No.3
Background and PurposezzAcute disseminated encephalomyelitis (ADEM) is an infammatory demyelinating disorder that predominantly afects children. Previous studies have mostly involved children in Western developed countries. MethodszzTis study retrospectively reviewed the clinical profles of ADEM in adult Chinese patients. ResultszzADEM occurred during summer and autumn in about two-thirds of the 42 included patients. Prior infection was found in fve patients and no preimmunization was recorded. Te most frequent clinical presentations were alterations in consciousness (79%) and behavior changes (69%), followed by motor defcits (64%) and fever (50%). About one-quarter (26%) of the patients showed positive results for oligoclonal bands, and about half of them exhibited increases in the IgG index and 24-hour IgG synthesis rate. Magnetic resonance imaging showed white- and gray-matter lesions in 83% and 23% of the patients, respectively. Steroids were the main treatment, and full recovery occurred in 62% of the patients, with residual focal neurological defcits recorded in a few patients. Afer a mean follow-up period of 3.4 years, two patients exhibited recurrence and one patient exhibited a multiphasic course. One patient was diagnosed with multiple sclerosis (MS). ConclusionszzWith the exception of the seasonal distribution pattern and prior vaccine rate, the clinical profles of ADEM in adult Chinese patients are similar to those in pediatric populations. No specifc markers are available for distinguishing ADEM from MS at the initial presentation. Careful clinical evaluations, cerebrospinal fuid measurements, and neuroradiological examinations with long-term follow-up will aid the correct diagnosis of ADEM.
Yang, Jin-Wei,Li, Cui,He, Xiao-Peng,Zhao, Hong,Gao, Li-Xin,Zhang, Wei,Shi, Xiao-Xin,Tang, Yun,Li, Jia,Chen, Guo-Rong Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.11
The incorporation of microwave irradiation with the prevalent "click chemistry" is currently of considerable synthetic interest. We describe here the introduction of such laboratorial shortcut into carbohydrate-based drug discovery, resulting in the rapid formation of a series of triazole-linked salicylic $\beta$-D-O-glycosides with biological activities. All "clicked" products were achieved in excellent yields ($\approx$ 90%) within only a quarter. In addition, based on the structural characteristics of the afforded glycomimetics, their inhibitory activities were evaluated toward protein tyrosine phosphatases 1B (PTP1B) and a panel of homologous protein tyrosine phosphatases (PTPs). Docking simulation was also conducted to plausibly propose binding modes of this glycosyl salicylate series with the enzymatic target.
Wei, Wei,Ye, Chen,Huang, Hui-Chuan,Yang, Min,Mei, Xin-Yue,Du, Fei,He, Xia-Hong,Zhu, Shu-Sheng,Liu, Yi-Xiang The Korean Society of Ginseng 2020 Journal of Ginseng Research Vol.44 No.4
Background: Cultivation of medicinal crops, which synthesize hundreds of substances for curative functions, was focused on the synthesis of secondary metabolites rather than biomass accumulation. Nutrition is an important restrict factor for plant growth and secondary metabolites, but little attention has been given to the plasticity of nutrient uptake and secondary metabolites synthesis response to soil nitrogen (N) change. Methods: Two year-field experiments of Sanqi (Panax notoginseng), which can synthesize a high level of saponin in cells, were conducted to study the effects of N application on the temporal dynamics of biomass, nutrient absorption, root architecture and the relationships between these parameters and saponin synthesis. Results: Increasing N fertilizer rates could improve the dry matter yields and nutrient absorption ability through increasing the maximum daily growth (or nutrient uptake) rate. Under suitable N level (225 kg/ha N), Sanqi restricted the root length and surface and enhanced the root diameter and N uptake rate per root length (NURI) to promote nutrient absorption, but the opposite status of Sanqi root architecture and NURI was found when soil N was deficient. Furthermore, increasing N rates could promote the accumulation of saponin in roots through improving the NURI, which showed a significant positive relationship with the content of saponin in the taproots. Conclusion: Appropriate N fertilizer rates could optimize both root architecture and nutrient uptake efficiency, then promote both the accumulation of dry matter and the synthesis of saponins.
Sparse Structured Non-fragile H∞ Controller Design for Linear Systems
Wei-Wei Che,Guang-Hong Yang,Xiao-Zheng Jin 제어·로봇·시스템학회 2013 International Journal of Control, Automation, and Vol.11 No.4
This paper presents a study on the problem of designing non-fragile H∞ controllers with sparse structures for linear continuous-time systems. A new algorithm is proposed to define and further design sparse structured controllers. Firstly, sparse structures are specified from a given fully parameterized H∞ controller. Then, a three-step design procedure for non-fragile dynamic output feedback H∞ controllers with the sparse structures is provided. The resulting designs guarantee that the closed-loop system is asymptotically stable and the H∞ performance from the disturbance to the regulated output is less than a prescribed level. A numerical example is given to illustrate the design methods.