Atlanto-occipital assimilation: embryological basis and its clinical significance

Hari Hara Hanusun N(Hari Hara Hanusun N ),Akanksha Singh(Akanksha Singh ),Pooja Poddar(Pooja Poddar ),Jessy J P(Jessy J P ),Neerja Rani(Neerja Rani ),Hitesh Gurjar(Hitesh Gurjar ),Seema Singh(Seema Si 대한해부학회 2024 Anatomy & Cell Biology Vol.57 No.1

Atlanto-occipital assimilation is an osseous embryological anomaly of the craniovertebral junction in which the atlas (C1) is fused to the occiput of skull. Embryologically, this assimilation may happen due to failure of the segmentation and separation of the caudal occipital and the cranial cervical sclerotome. The segmentation clock is maintained by NOTCH and WNT signalling pathways along with Hox genes and retinoic acid. This condition is likely to be a consequence of mutation in above mentioned genes. The knowledge of this assimilation may be crucial for the clinicians as it may lead to various neurovascular symptoms. The present case report involves the analysis of atlanto-occipital assimilation with its clinical significance and embryological basis.

Rhizobium etli USDA9032 Engineered To Produce a Phenazine Antibiotic Inhibits the Growth of Fungal Pathogens but Is Impaired in Symbiotic Performance

Krishnan, Hari B.,Kang, Beom Ryong,Hari Krishnan, Ammulu,Kim, Kil Yong,Kim, Young Cheol American Society for Microbiology 2007 Applied and environmental microbiology Vol.73 No.1

<B>ABSTRACT</B><P>Phenazine production was engineered in <I>Rhizobium etli</I> USDA9032 by the introduction of the <I>phz</I> locus of <I>Pseudomonas chlororaphis</I> O6. Phenazine-producing <I>R. etli</I> was able to inhibit the growth of <I>Botrytis cinerea</I> and <I>Fusarium oxysporum</I> in vitro. Black bean inoculated with phenazine-producing <I>R. etli</I> produced brownish Fix<SUP>−</SUP> nodules.</P>

A novel volumetric criterion for optimal shape matching of surfaces for protein-protein docking

Hari K. Voruganti,Bhaskar Dasgupta 한국CDE학회 2018 Journal of computational design and engineering Vol.5 No.2

The problem of molecular docking is to predict whether two given molecules bind together to interact. A shape-based algorithm is proposed for predictive docking by noting that shape complementarity between their outer surfaces is necessary for two molecules to bind. A methodology with five stages has been devel-oped to find the pose in which the shape complementarity is maximum. It involves surface generation, seg-mentation, parameterization, shape matching, and filtering and scoring. The most significant contribution of this paper is the novel scoring function called ‘Normalized Volume Mismatch’ which evaluates the matching between a pair of surface patches efficiently by measuring the gap or solid volume entrapped between two patches of a pair of proteins when they are placed one against the other at a contact point. After the evaluation, it is found that, with local shape complementarity as the only criterion, the algorithm is able to predict a conformation close to the exact one, in case of known docking conformations, and also rank the same among the top 40 solutions. This is remarkable considering the fact that many existing dock-ing methods fail to rank a near-native conformation among top 50 solutions. The shape-based approaches are used for the initial stage of docking to identify a small set of candidate solutions to be investigated fur-ther with exhaustive energy studies etc. The ability of capturing the correct conformation as highly ranked among top few candidate solutions is the most valuable facet of this new predictive docking algorithm

A New Excitation Control for Multimachine Power Systems Ⅰ : Decentralized Nonlinear Adaptive Control Design and Stability Analysis

Haris E. Psillakis,Antonio T. Alexandridis 대한전기학회 2005 International Journal of Control, Automation, and Vol.3 No.2

In this paper a new excitation control scheme that improves the transient stability of multimachine power systems is proposed. To this end the backstepping technique is used to transform the system to a suitable partially linear form. On this system, a combination of both feedback linearization and adaptive control techniques are used to confront the nonlinearities. As shown in the paper, the resulting nonlinear control law ensures the uniform boundedness of all the state and estimated variables. Furthermore, it is proven that all the error variables are uniformly ultimately bounded (VUE) i.e. they converge to arbitrarily selected small regions around zero in finite-time. Simulation tests on a two generator infinite bus power system demonstrate the effectiveness of the proposed control.

Meta Case Study of Public Services Based Sub-District Organization Models: Context of Indonesia

( Haris Faozan ) 한국정책학회 2011 International Journal of Policy Studies Vol.2 No.1

Sub-district is one of the organization peripheral area that has a crucial role in public services. Law number 32, year 2001, states that in addition from having attributive duties, sub-district is also devolved in delegated authorities. However, both main tasks can not be performed optimally. The policies concerned with sub-district organization indicates complicated issues, and the public services of the sub-district remain low-performed. This paper presents models of sub-district organization that anticipate the needs and priorities of public services. This research is a meta applied case study. This study used research data about sub-district organizations in Indonesia. The analytical methodology was in-depth qualitative analysis based on the findings of the previous case studies. This study resulted in important findings. The design of sub-district organizations remained to have low performance based on the dimensions of its organizational structure. This internal drawback led to poor public service delivery. Based on these findings, this study recommends three sub-district organization models. One of these models can be selected by local government to redesign its sub-district organization, in accordance with organizational capacity and public service demands and priorities.

Comparison of Plant Growth Promoting Methylobacterium spp. and Exogenous Indole-3-Acetic Acid Application on Red Pepper and Tomato Seedling Development

Hari P. Deka Boruah,Puneet S. Chauhan,Woo-Jong Yim(임우종),Gwang-Hyun Han(한광현),Tong-Min Sa(사동민) 한국토양비료학회 2010 한국토양비료학회지 Vol.43 No.1

무균 및 온실조건에서 indole-3-acetic acid (IAA)의 처리와 1-aminocyclopropane-1-carboxylate deaminase (ACCD) 및 IAA 활성을 갖는 Methylobacterium 균주 접종 시 토마토와 고추의 생장을 비교 평가하였다. 무균조건에서 1.0 ㎍ mL?¹의 IAA는 고추와 토마토의 뿌리생장을 촉진시키는데 비해 10.0 ㎍ mL?¹ 이상의 높은 농도에서는 뿌리생장이 억제되었다. 그러나 높은 ACCD 활성을 갖고, IAA 활성은 낮거나 가지고 있지 않은 Methylobacterium 균주들을 접종하였을 때에는 고추와 토마토 모두 IAA 처리구 보다 뿌리생장이 증진되는 것을 확인하였다. 마찬가지로 온실조건에서 Methylobacterium 균주들을 접종했을 때, 마디길이와 잎의 크기 그리고 단위 면적당 잎의 무게(SLW)에서 유의성 있는 증진효과를 보였다. 전반적인 식물 생장에서 저농도의 IAA 처리 효과는 Methylobacterium의 효과와 비슷한 경향을 나타냈다. 유묘의 지상부 길이는 ACCD 활성과 IAA 생산능을 갖는 Methylobacterium 균주 처리구에서 유의성 있는 증가를 확인할 수 있었으며, 전체 건물중 또한 Methylobacterium 처리 시 유의성 있는 증진 효과를 확인 할 수 있었다. 하지만 고농도의 IAA는 고추와 토마토의 생물량을 억제시켰다. 이러한 결과는 접종 균주의 IAA와 ACCD가 고추와 토마토 유묘의 생장 증진에 영향을 끼친다는 것을 증명한다. A comparative study was performed in gnotobiotic and greenhouse conditions to evaluate the effect of exogenous application of indole-3-acetic acid (IAA) and inoculation of Methylobacterium spp. possessing 1-aminocyclopropane-1-carboxylate deaminase (ACCD) and IAA activity on red pepper and tomato seedling growth and development. Application of 1.0 ㎍ mL?¹ IAA positively influenced root growth while high concentrations (>10.0 ㎍ mL?¹) suppressed root growth of red pepper and tomato under gnotobiotic condition. On the other hand, inoculation of Methylobacterium strains with ACCD activity and IAA or without IAA enhanced root growth in both plants. Similarly, under greenhouse condition the inoculation of Methylobacterium sp. with ACCD activity and IAA enhanced plant fitness recorded as average nodal length and specific leaf weight (SLW) but the effect is comparable with the application of low concentrations of IAA. Seedling length was significantly increased by Methylobacterium strains while total biomass was enhanced by Methylobacterium spp. and exogenous applications of < 10.0 ㎍ mL?¹ IAA. High concentrations of IAA retard biomass accumulation in red pepper and tomato. These results confirm that bacterial strains with plant growth promoting characters such as IAA and ACCD have characteristic effects on different aspects of growth of red pepper and tomato seedlings which is comparable or better than exogenous applications of synthetic IAA.

Leonhard Euler (1707-1783) and the computational aspects of some zeta-function series

Hari Mohan Srivastava 대한수학회 2007 대한수학회지 Vol.44 No.5

The effect of electrolyte wettability on reforming catalyst in direct ethanol MCFC

Hary Devianto,Zhenlan Li,윤성필,한종희,남석우,임태훈,이호인 한국물리학회 2010 Current Applied Physics Vol.10 No.2

To overcome the poisoning of reforming catalyst contacted with the electrolyte without degradations of performance and long-term stability, we proposed on the development of support which has low wettability to electrolyte, but still keeps high activity on steam reforming of bio-ethanol. To perform the wettability measurement, a couple of supports (MgO and PbO) were pressed to form disc-shaped specimen with relatively low porosity, and subjected to an on-line optical contact angle measurement device at MCFC operating condition. The results of wettability of the supports indicated that PbO showed low wettability to the carbonates melts giving high contact angle. The microstructure of unreacted PbO layer might be contributed to its low wettability. The highest activity was achieved with Ni/MgO, while the lowest wettability was attained with PbO as a support. Ni/1MgO·1PbO seemed to be the most promising candidate for avoiding the reforming catalyst from poisoning.

Risk Ranking of New-Emerging Virus Regarding Food Safety: A Systemic Review of Potential Viral Risks Associated with Food and Food-Related Environments

Hary Yu,Sun Min Park,Min Suk Rhee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

After the occurrence of the COVID-19 pandemic, there is a growing concern on potential risks of new-emerging pathogens and their link to food safety. This study tried to suggest the virus candidates which could infect humans via foods/food-related environments. A prioritization process was established for the candidates, of which the information was investigated by reviewing websites or reports of international microbiological authorities and academic researches. Prioritization was based on (1) whether the authorities were providing the hazard information, (2) whether it could cause respiratory diseases (respiratory virus) or zoonosis (zoonotic virus), and (3) whether its transmission via foods/environments has been reported. A total of 85 viruses were initially obtained and 48 relevant viruses, including 12 respiratory and 41 zoonotic viruses, were sorted out. Among 48 viruses, pathogens that provoked food (e.g. MERS-CoV, Hepatitis E, Lassa virus, Nipah virus) or animal/environment-mediated infections (e.g. SARS-CoV, Influenza A virus) were nominated as a high priority. This study proposes a blueprint for future microbiological management strategies regarding viral food safety.

Recent Global Strategies and Research and Development Projects on Viral Food Safety: Consideration on Future Research Themes

Hary Yu,Sun Min Park,Min Suk Rhee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

This study aimed to propose themes for future viral research, with increasing considerations and demands on viral food safety. National strategies and research and development (R&D) projects, completed or in progress within 10 years, were investigated in food safety agency websites/reports of five countries (United States, United Kingdom, Germany, Canada, and Australia/New Zealand). The research themes were extracted, listed, and further categorized into 10 major subdivisions ("detection methods", "genetic analysis", "surveillance", etc.) based on the opinions of food safety experts. Research projects regarding "basic characterization", such as survival or resistance analysis, took the highest proportion, followed by projects on "epidemiology" or "disinfection". Moreover, foodborne (norovirus, rotavirus, hepatitis A/E virus) and zoonotic viruses (influenza A virus, avian influenza virus, coronavirus including SARS-CoV-2) focused in predominant numbers of the global research projects were identified. The results of this study support the importance and urgency of future national research projects which could ensure virus issues in aspects of food safety.