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Kang, H.M.,Lee, E.K.,Song, B.M.,Heo, G.B.,Jung, J.,Jang, I.,Bae, Y.C.,Jung, S.C.,Lee, Y.J. Elsevier Scientific Pub. Co 2017 Veterinary microbiology Vol.198 No.-
<P>A highly pathogenic avian influenza (HPAI) H5N8 virus was first detected in poultry and wild birds in South Korea in January 2014. Here, we determined the pathogenicity and transmissibility of three different clades of 1-15 viruses in mandarin ducks to examine the potential for wild bird infection. H5N8 (Glade 2.3.4.4) replicated more efficiently in the upper and lower respiratory tract of mandarin ducks than two previously identified H5N1 virus clades (clades 2.2 and 2.3.2.1). However, none of the mandarin ducks infected with H5N8 and H5N1 viruses showed severe clinical signs or mortality, and gross lesions were only observed in a few tissues. Viral replication and shedding were greater in H5N8-infected ducks than in H5N1-infected ducks. Recovery of all viruses from control duck in contact with infected ducks indicated that the highly pathogenic H5 viruses spread horizontally through contact. Taken together, these results suggest that H5N8 viruses spread efficiently in mandarin ducks. Further studies of pathogenicity in wild birds are required to examine possible long-distance dissemination via migration routes. (C) 2016 Elsevier B.V. All rights reserved.</P>
H. pylori 제균 실패율과 clarithromycin 내성률의 일치성
허재형 ( J. H. Heo ),남승우 ( S. W. Nam ),노임환 ( I. H. Roe ),양미라 ( M. R. Yang ),김정택 ( J. T. Kim ),송일환 ( I. H. Song ),임창영 ( C. Y. Lim ),김정원 ( J. W. Kim ),신지현 ( J. H. Shin ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<목적> H. pylori 제균 치료성적을 좌우하는 요소에는 약제와 대상 환자군의 선정, 균검사방법의 차이, 항생제 저항성 등이 중요시되고 있다. 이 중에서도 항생제 저항성은 나라간의 H. pylori 제균 성적을 다르게 하는 대표적인 원인이다. 우리나라는 제균률이 외국보다 저조하여 85%내외로 보고되고 있다. 본 연구의 목적은 H. pylori 제균 실패율과 clarithromycin 내성률을 조사하여 제균 실패 원인으로서의 clarithromycin
대학생의 인터넷중독 및 스마트폰 중독 정도와 미술 치료 인식에 대한 조사 연구
박혜원,송승윤,윤하영,이경현,이소영,이지원,진예은,최시온,허은서,황다빈,신주현,이인영 이화여자대학교 간호학회 2018 이화간호학회지 Vol.- No.52
Purpose: Investigate the level of Internet and smart phone addiction of college students and difference of their perception on the art therapy. Method: Data was collected using 4 categories of questionnaires. Participants of this study were 383 college students who are currently attending universities located in seoul, Kyung-Ki and Incheon. The Chi-square test, One-way Analysis of Variance, Scheffé test were performed using IBM SPSS Statistics 23.0 Result: First, the study has established that the status of attending universities, grade, people who living with, age affected the level of Internet addiction of college students. In terms of the level of smart phone addiction of college students, the status of attending universities, gender, age were the affective factors. Second, there was a significant difference on the perception of the advantages of the art therapy and the level of acknowledging it, depending on the level of Internet addiction. Finally, depending on the level of smartphone addiction, there was a significant difference in the level of perception of the art therapy, expectation toward the art therapy and the helpfulness of art therapy. The more the participants are close to the addicted level, the more they want to experience the art therapy. Conclusion: These results suggest. First, it is necessary to use bigger group of participants. Second, it is necessary to improve the research methods for college students. Third, nurse should offer holistic care toward the patients regarding their general characteristics by adapting this study. Finally, it is necessary to improve the art therapy programs for the college students who are addicted to the Internet and smartphone and to develop researches proving the effectiveness of these programs.
H. pylori성 위염에서 위축진행과 Myeloperoxidase(MPO) 유전자 다형성(genetic polymorphism)의 관련성
이만용 ( M. Y. Lee ),노임환 ( I. H. Roe ),양미라 ( M. R. Yang ),남승우 ( S. W. Nam ),허재형 ( J. H. Heo ),임창영 ( C. Y. Lim ),송일한 ( I. H. Song ),김정원 ( J. W. Kim ),신지현 ( J. H. Shin ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<목적> H. pylori는 위 점막에서 많은 중성구들의 침윤이 특징적으로 관찰되는 활동성 위염을 일으키며 중성구들에서 나오는 많은 산소라디칼 등은 상피세포의 손상과 apoptosis을 유도하고 위축성 변화로 진전하는데 주도적인 역할을 한다. 특히 중성구의 myeloperioxidase(MPO)는 산소라디칼의 공격적인 산화적 잠재력을 중폭시키고 monochloramine을 생성하여 위세포의 손상과 위축성 변화를 야기한다고 이해되고 있다. 그러나 위축성위
고관영,허주환,문정효,장재석,김동윤,정민섭,김주찬,박기용,이강연,조명우,이권진,조영호,이효걸,김주호,이경희 울산과학대학 2000 연구논문집 Vol.27 No.1
본 논문에서는 기존의 Motion-JPEG 기반 감시시스템에서 낮은 동영상 압축성능 문제를 해결하기 위한 새로운 동영상 압축기법을 제안하였다. 제안된 방법에서는 현재 프레임의 JPEG 데이터 중 변화된 압축 데이터만이 실시간으로 추출하고 저장된다. 제안된 방법에 의해 저장된 데이터는 기존의 JPEG과는 다른 고유의 포맷을 가지기 때문에, 동영상 데이터는 더욱 안전하게 유지될 수 있다. 실험을 통해, 제안된 동영상 압축기법의 압축률이 기존의 Motion-JPEG 기반 감시시스템에 비해 3배정도 높다는 것을 확인할 수 있었다.
포스터 발표 : 위 ; Helicobacter pylori에 대한 포도주(wine)의 항세균 효과
김도형 ( D. H. Kim ),노임환 ( I. H. Roe ),허재형 ( J. H. Heo ),박상현 ( S. H. Park ),남승우 ( S. W. Nam ),임창영 ( C. Y. Lim ),송일한 ( I. H. Song ),김정원 ( J. W. Kim ),명나혜 ( N. H. Myung ),신지현 ( J. H. Shin ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
〈목적〉 위장질환을 일으키는 H. pylori를 억제시키는 항생제가 아닌 물질들은 새로운 대체요법으로 최근 들어와서 여러 가지 식용물질들에 대해 탐색되고 있다. 본 연구에서는 포도주의 항세균 효과를 생체내,외 실험으로 연구하였다. 〈방법〉 포도주는 적포도주(프랑스산, pH 3.9, 알코올농도 12%)와 백포도주(마주앙, pH 3.22, 알콜농도 11%)를 이용하였으며 같은 pH와 같은 알코올농도의 소주(참이슬, pH 7.87, 알코올농도 22%)로 비교
김고은,김유은,김희진,조유진,안주영,허다연,홍서우,차지영,박송이 이화여자대학교 간호학회 2018 이화간호학회지 Vol.- No.52
Purpose: The purpose of this study was to understand and explain the experiences of college life among junior nursing students who live apart from their families. Methods: 14 junior nursing students living apart from their families for at least one semester were recruited through snowballing and convenience sampling. Participants were interviewed individually using open ended questions. Data were collected from July to October in 2017 until data saturation. Interviews were transcribed verbatim and analyzed by using hermeneutic phenomenological method proposed by van Manen. Results: Five essential theme clusters emerged: (1) faced with diverse problems while living apart from family, (2) depend on family when stressed, (3) adapt to college life by being independent and forming self-initiative lifestyle, (4) confront with difficulties once again when adapting to academic curriculum restructured by practicum, (5) pave the way to nursing career and feel proud of overcoming the difficulties independently. Conclusion: Although most participants faced diverse problems in college life, they tried to adapt independently by forming self-initiative lifestyle and overturn the difficulties to positive experiences. In conclusion, the process of living apart from families transformed participants into proactive individuals. Adopting counseling programs could support starting their junior years successfully.
간호대생들의 임상실습 스트레스, 학업적 자기효능감 및 진로정체감에 대한 연구
최유빈,최민지,이은형,이연우,우소연,하희주,허예지,박수현,허미래,이가현 이화여자대학교 간호과학대학 2015 이화간호학회지 Vol.- No.49
Purpose: The purpose of this study was to investigate clinical practice stress, academic self-efficacy, and career identity among undergraduate students in nursing practicum. Method: This study was a descriptive correlational design using the survey method. The study included 267 undergraduate students attending to 5 college in Seoul. The data was gathered from August 2014 to October 2014 and the data were analyzed using IBM SPSS statistics version 22.0 Program with descriptive statistics, t-test, analysis of variance with Scheffe test, and Pearson’s correlation coefficient. Results: Situational characteristics of Clinical Practice Stress(CPP) was significantly different with regards to task difficulties and efficacy self-confidence of academic self-efficacy(ASE) (r= .179, p= .003; r= .166, p= .006). Statistically significant positive relationship was founded between Personal characteristics of CPP and self-confidence of ASE (r= .239, p< .01). External regulators of CPP was significantly different according to self-confidence and task difficulties (r= .175, p= .003; r= .132, p= .028). The self-confidence and efficacy for self-confidence of ASE were a significantly correlated with Career Identity; The Career identity also was a significantly correlated with all sub-categories of CSS scale(r= -0.208, p< 0.01; r= -0.369, p< 0.01; r= -0.153, p< .011) Conclusion: This study showed positive statistical relationships associated with clinical practice stress, academic self-efficacy, and career identity as a preliminary evidence-based study for guiding education in nursing curriculum. Further research should be need for students’ future as a professional nurse.
Radotinib induces high cytotoxicity in c-KIT positive acute myeloid leukemia cells
Heo, S.K.,Noh, E.K.,Kim, J.Y.,Jo, J.C.,Choi, Y.,Koh, S.,Baek, J.H.,Min, Y.J.,Kim, H. North-Holland 2017 European journal of pharmacology Vol.804 No.-
<P>Previously, we reported that radotinib, a BCR-ABL1 tyrosine kinase inhibitor, induced cytotoxicity in acute myeloid leukemia (AML) cells. However, the effects of radotinib in the subpopulation of c-KIT-positive AML cells were unclear. We observed that low-concentration radotinib had more potent cytotoxicity in c-KIT-positive cells than c-KIT-negative cells from AML patients. To address this issue, cell lines with high c-KIT expression, HEL92.1.7, and moderate c-KIT expression, H209, were selected. HEL92.1.7 cells were grouped into intermediate and high c-HIT expression populations. The cytotoxicity of radotinib against the HEL92.1.7 cell population with intermediate c-HIT expression was not different from that of the population with high c-KIT expression. When H209 cells were grouped into c-KIT expression-negative and c-HIT expression-positive populations, radotinib induced cytotoxicity in the c-KIT-positive population, but not the c-KIT-negative population. Thus, radotinib induces cytotoxicity in c-KIT-positive cells, regardless of the c-KIT expression intensity. Therefore, radotinib induces significant cytotoxicity in c-KIT-positive AML cells, suggesting that radotinib is a potential target agent for the treatment of c-KIT-positive malignancies including AML.</P>
Heo, Y.,Kim, E.H.,Kobatake, E.,Nah, J.W.,Ito, Y.,Son, T.I. Korean Society of Industrial and Engineering Chemi 2016 Journal of industrial and engineering chemistry Vol.36 No.-
<P>Gelatin derivative was prepared to coating titanium surface and photo-immobilize rhBMP-2 for improved osteoinduction and function. The conjugation was confirmed by P-31 and H-1 NMR. Photo immobilization of the azide-phosphonate-gelatin (Az-P-Gel) was evaluated by micropatterning. The rate of recombinant human bone morphogenetic protein (rhBMP-2) release was evaluated for performance of Az-P-Gel as a carrier. The water contact angle was determined to characterize Ti surface coated with Az-P-Gel. Ability to induce osteogenesis of Az-P-Gel was evaluated using alkaline phosphatase (ALP) activity assay, Alizarin Red S staining, and calcium colorimetric assay. Our results demonstrate that Ti modified with Az-P-Gel and rhBMP-2 facilitates bone regeneration. (C) 2016 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.</P>