S-336 A Case report : Secondary hypertrophic osteoarthropathy with early stage lung cancer

( Kang Mo Gu ),( Joo Young Lee ),( Jae Chol Choi ),( Jong Wook Shin ),( Jae Yeol Kim ),( In Won Park ),( Byoung Whui Choi ),( Jae Woo Jung ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1

Introduction:?Hypertrophic osteoarthropathy (HOA) occurs 5-10% patients with advanced lung cancer. Typical HOA characterized by clubbing of digits, periosteal new-bone formation and synovial effusion. In early stage of lung cancer, severe joint pain may be the presenting symptom of HOA and may precede clubbing of digits. We report a rare case of HOA combined with early stage of lung cancer.?Case:?A 52-year-old man with severe both knee joint pain and edema presented with a 4-month history. In physical examination, ballotment of patella and severe tenderness of knee joints were detected. Bone scan showed bilateral symmetrically increased cortical uptake along femurs and tibias suggested HOA. Laboratory findings were negative for rheumatoid factor and anti-CCP antibody, but the antinuclear antibody titer was 1:80. Joint fluid analysis showed nonspecific arthritis pattern. He suffered from chronic cough at the time knee pain started. For evaluate causes of chronic cough and HOA, chest PA and chest CT scan were done. About 4.5cm sized spiculated mass lesion in the right upper lobe was detected. Percutaneous needle biopsy confirmed adenocarcinoma. The patient received right upper lobectomy by video-assisted thoracoscopic surgery. Pathologic stage was non-small cell lung cancer stage IB (T2aN0M0). One month later, his pain was subsided without medication and bone scan showed decreased cortical uptake of involved bones.

Poster Session : PS 1601 ; Lung Cancer : A Case of Advanced Non-Small Cell Lung Cancer with Neuroendocrine Differentiation

( Kang Mo Gu ),( Jong Wook Shin ),( Joo Young Lee ),( Jin Se Kim ),( Ju Young Jang ),( Jae Woo Jung ),( Jae Chol Choi ),( Jae Yeol Kim ),( In Won Park ),( Byung Whui Choi ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Introduction: Histologic type of lung cancer has important roles for determining treatment strategies and patients` prognosis. Immunohistochemistry may be used to verify neuroendocrine differentiation within tumor. Advanced non-small cell lung cancer with neuroendocrine differentiation is rare form of non-small cell lung cancer. In this report, we presents a case of advanced non-small cell lung cancer with neuroendocrine differentiation. Case: 64-year-old man was admitted to the hospital because of dyspepsia and weight loss (56kg->45.6kg) for one year. Physical examination showed non-specifi c fi ndings. In laboratory fi nding, tumor marker was elevated (CEA 7.05U/ml, PIVKA II 501 mAUg/ ml). The fi ndings on abdominal imaging(Enhanced abdomen & pelvic CT and abdominal ultrasonography) showed multiple variable sized peripheral enhanced, hypervascular liver masses suggesting metastatic liver malignancy. Esophagogastroduodenoscopy and colonoscopy showed no abnormal lesion in stomach, duodenum and colon. For fi nding primary origin, enhance chest CT was done and 46mm mass lesion was detected in left upper lung and mediastinal lymph node metastasis were also detected. PET-CT showed higher fi uorodeoxyglucose(FDG) uptake in left upper lung mass, liver masses and moderate uptake in left hilar lymph node, right ileum, right femur, left femur head. For pathologic confi rm, CT-guided lung biopsy was done, poorly differentiated adenocarcinoma with neuroendocrine differentiation with a few positive for thyroid transcription factor-1(TTF-1), positive for CD56, negative for p63 was confi rmed. Clinical staging was Stage IV(T2aN2M1b). The patient received palliative chemotherapy with gemcitabine with carboplatin(fi rst line) and gefi tinib with nimotuzumab(second line).r

Usefulness of Post-bronchoscopy Sputum Culture for the Diagnosis of Nontuberculous Mycobacterial Pulmonary Disease

( Kang Mo Gu ),( Jae-joon Yim ),( Hye-rin Kang ),( Jimyung Park ),( Nakwon Kwak ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-

Background Bronchoscopy is recommended for suspected non-tuberculous mycobacteria pulmonary disease (NTM-PD) if sputum culture Results are consistently negative or adequate sputum samples cannot be obtained. The aim of this study is to assess the role of post-bronchoscopy sputum in improving diagnostic accuracy for patients with suspected NTM-PD who underwent bronchoscopy. Methods Patients with suspected NTM-PD who underwent bronchoscopy for diagnosis from January 1st, 2017 to June 30th, 2020 at Seoul National University Hospital were included for analysis. Patients were classified into the sputum culture negative group or the scanty sputum group. Results of mycobacterial culture from bronchial washing specimen and post-bronchoscopy sputum were compared between two groups. Results 141 patients were included in the analysis. 39 patients were classified into the sputum culture negative group and 102 patients into the scanty sputum group. NTM was cultured from bronchial washing specimen in 38.3% (54/141) of all patients; 30.7% (12/39) of patients in sputum culture negative group and 41.2% (42/102) of patients in scanty sputum group (P=0.345). NTM was exclusively cultured from post-bronchoscopy sputum in 3.5% (5/141) patients; 7.7% (3/39) patients in sputum culture negative group and 2.0% (2/102) of patients in scanty sputum group (P = 0.255). Conclusions In patients with suspected NTM-PD who have negative Results from sputum NTM culture or scanty sputum, post-bronchoscopy sputum could play a minor role in improving diagnostic accuracy in NTM-PD.

A Case of Antiphospholipid Syndrome Refractory to Secondary Anticoagulating Prophylaxis after Deep Vein Thrombosis-Pulmonary Embolism

Gu, Kang Mo,Shin, Jong Wook,Park, In Won The Korean Academy of Tuberculosis and Respiratory 2014 Tuberculosis and Respiratory Diseases Vol.77 No.6

Antiphospholipid syndrome (APS) is an acquired systemic autoimmune disorder characterized by a combination of clinical criteria, including vascular thrombosis or pregnancy morbidity and elevated antiphospholipid antibody titers. It is one of the causes of deep vein thrombosis and pulmonary embolism that can be critical due to the mortality risk. Overall recurrence of thromboembolism is very low with adequate anticoagulation prophylaxis. The most effective treatment to prevent recurrent thrombosis is long-term anticoagulation. We report on a 17-year-old male with APS, who manifested blue toe syndrome, deep vein thrombosis, pulmonary thromboembolism, and cerebral infarction despite adequate long-term anticoagulation therapy.

CASE REPORT : A Case of Antiphospholipid Syndrome Refractory to Secondary Anticoagulating Prophylaxis after Deep Vein Thrombosis-Pulmonary Embolism

( Kang Mo Gu ),( Jong Wook Shin ),( In Won Park ) 대한결핵 및 호흡기학회 2014 Tuberculosis and Respiratory Diseases Vol.77 No.6

Antiphospholipid syndrome (APS) is an acquired systemic autoimmune disorder characterized by a combination of clinical criteria, including vascular thrombosis or pregnancy morbidity and elevated antiphospholipid antibody titers. It is one of the causes of deep vein thrombosis and pulmonary embolism that can be critical due to the mortality risk. Overall recurrence of thromboembolism is very low with adequate anticoagulation prophylaxis. The most effective treatment to prevent recurrent thrombosis is long-term anticoagulation. We report on a 17-year-old male with APS, who manifested blue toe syndrome, deep vein thrombosis, pulmonary thromboembolism, and cerebral infarction despite adequate longterm anticoagulation therapy.

Usefulness of Post-bronchoscopy Sputum Culture for Diagnosis of Nontuberculous Mycobacterial Pulmonary Disease

Gu Kang-Mo,Kang Hye-Rin,Park Jimyung,Kwak Nakwon,Yim Jae-Joon 대한의학회 2021 Journal of Korean medical science Vol.36 No.31

Background: Bronchoscopy is recommended for patients with suspected nontuberculous mycobacterial pulmonary disease (NTM-PD) whose sputum culture results are consistently negative or from whom adequate sputum samples cannot be obtained. Post-bronchoscopy sputum (PBS) collection is recommended for patients with suspected tuberculosis who undergo bronchoscopy. However, it remains unclear whether PBS collection can increase the diagnostic yield of NTM-PD. Methods: Patients with suspected NTM-PD who underwent diagnostic bronchoscopy from January 1, 2017 to June 30, 2020 at the Seoul National University Hospital were included in the study. They were divided into the sputum culture-negative and scanty sputum groups. The results of mycobacterial cultures from bronchial washing specimens and PBS were compared between these groups. Results: In total, 141 patients were included in the study; there were 39 and 102 patients in the sputum culture-negative and scanty sputum groups, respectively. Nontuberculous mycobacteria were cultured from bronchial washing specimens collected from 38.3% (54/141) of all patients (30.7% [12/39] patients in the sputum culture-negative group and 41.2% [42/102] patients in the scanty sputum group; P = 0.345). Nontuberculous mycobacteria were exclusively cultured from PBS collected from 3.5% (5/141) of all patients (7.7% [3/39] patients in the sputum culture-negative group and 2.0% [2/102] patients in the scanty sputum group; P = 0.255). Conclusions: Additional PBS collection improved diagnostic yield marginally in patients with suspected NTM-PD who undergo bronchoscopy

Fabrication of conductive polymer-based nanofiber scaffolds for tissue engineering applications.

Gu, Bon Kang,Kim, Min Sup,Kang, Chang Mo,Kim, Jong-Ll,Park, Sang Jun,Kim, Chun-Ho American Scientific Publishers 2014 Journal of Nanoscience and Nanotechnology Vol.14 No.10

<P>Natural and synthetic polymers, in particular those that are conductive, are of great interest in the field of tissue engineering and the pursuit of biomimetic extracellular matrix (ECM) structures for adhesion, proliferation, and differentiation of cells. In the present study, natural chitin and conductive polyaniline (PANi) blended solutions were electrospun to produce biodegradable and conductive biomimetic nanostructured scaffolds. The chitin/PANi (Chi-PANi) nanofibrous materials were characterized using field emission scanning electron microscopy, Fourier transform-infrared spectroscopy, wettability analysis, mechanical testing, and electrical conductivity measurements using a 4-point probe method. The calculated electrical conductivities of the PANi-containing nanofiber scaffolds significantly increased as the amount of PANi increased, reaching 5.21 0.28 x 10(-3) S/cm for 0.3 wt% content of the conducting polymer. In addition, the viability of human mesenchymal stem cells (hMSCs) cultured on the Chi-PANi nanofiber scaffolds in vitro was found to be excellent. These results suggest that the Chi-PANi nanofiber scaffolds have great potential for use in tissue engineering applications that involve electrical stimulation.</P>

Thematic Poster : TP-61 ; A Case of Advanced Non-Small Cell Lung Cancer with Neuroendocrine Differentiation

( Kang Mo Gu ),( Jong Wook Shin ),( Joo Young Lee ),( Jin Se Kim ),( Ju Young Jang ),( Jae Woo Jung ),( Jae Chol Choi ),( Jae Yeol Kim ),( In Won Park ),( Byung Whui Choi ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-

Introduction: Histologic type of lung cancer has important roles for determining treatment strategies and patients’ prognosis. Immunohistochemistry may be used to verify neuroendocrine differentiation within tumor. Advanced non-small cell lung cancer with neuroendocrine differentiation is rare form of non-small cell lung cancer. In this report, we presents a case of advanced non-small cell lung cancer with neuroendocrine differentiation. Case: 64-year-old man was admitted to the hospital because of dyspepsia and weight loss (56kg->45.6kg) for one year. Physical examination showed non-specific findings. In laboratory finding, tumor marker was elevated (CEA 7.05U/ml, PIVKA II 501 mAUg/ml). The findings on abdominal imaging(Enhanced abdomen & pelvic CT and abdominal ultrasonography) showed multiple variable sized peripheral enhanced, hypervascular liver masses suggesting metastatic liver malignancy. Esophagogastroduodenoscopy and colonoscopy showed no abnormal lesion in stomach, duodenum and colon. For finding primary origin, enhance chest CT was done and 46mm mass lesion was detected in left upper lung and mediastinal lymph node metastasis were also detected. PET-CT showed higher fluorodeoxyglucose(FDG) uptake in left upper lung mass, liver masses and moderate uptake in left hilar lymph node, right ileum, right femur, left femur head. For pathologic confirm, CT-guided lung biopsy was done, poorly differentiated adenocarcinoma with neuroendocrine differentiation with a few positive for thyroid transcription factor-1(TTF-1), positive for CD56, negative for p63 was confirmed. Clinical staging was Stage IV(T2aN2M1b). The patient received palliative chemotherapy with gemcitabine with carboplatin(first line) and gefitinib with nimotuzumab(second line).

밀양주변의 자생 용담 분포와 식물체의 형태적 특성

강점순,조동,안종길,최영환,손병구,정용모 密陽産業大學校 農業技術開發硏究所 1998 農業技術開發硏究所報 Vol.2 No.1

용담을 절화, 분화 및 화단용으로 개발하기 위해 기초자료를 얻고자 밀양 근교에 자생하고 있는 용담의 분포, 자생지의 환경 및 자생지별 형태적 특성등을 조사하여 다음과 같은 결과를 얻었다. 밀양근교 지역에서 자생용담은 100-300m에서부터, 800m의 고산지에 이르기까지 고도에 관계없이 분포하였고, 토양 조건은 산성 토양이며 무기물 및 유기물의 함량이 높았다. 군락지의 입지 조건은 광투과와 배수가 잘 되는 남서 방향에 많이 분포되어 있었다. 자생지별 생육 특성은 토양조건, 고도, 주변의 식생 등에 영향을 받아 초장과 잎의 형태 등에 약간의 차이가 있었다. 꽃은 길이가 4-6cm 정도였고, 5개의 수술과 한 개의 암술이 있으며 암술의 주두는 종자 성숙시기가 되면 두 갈래로 갈라지는 특성이 있었다. 잎의 형태는 대부분이 비교적 폭이 좁은 피침형 이었으며, 난상피침형도 관찰되었다. 지방은 2 심피에 1개의 자실이 있었고, 심피에 여러개의 종자가 착생되어 있었다. 꼬투리는 삭과이며, 종자는 넓은 피침형으로 양 끝에 날개가 있었다. This study was carried out to get a general information on Yongdam, Gentiana scabra Bunge var. buergei Max. which can be used as cut-flower, ornamental and medicinal plant among the native plants. To fulfil the purpose, distribution and morphological characteristics of the native Yongdam and the environments of natural habitat were estimated during the studying period. The results were summarized as follows. Native Yongdam was widely distributed around Miryang regardless of altitude. and the range of altitude for the habitat was between 100 and 800m, Soil acidity of the natural habitat were lower. and the concentration of inorganic and organic material of the natural habitat were higher than average, respectively. Main habitat of the plants were mainly located in the south-western direction which was usually drained well and had enough sun light during the day time. According to the morphological characteristics innatural habitat, there were slight differences on leaf length and shapes influenced by soil conditions, altitude and vegetation at the surrounding area. Average length of flowers was approximately 4-6cm, and each flower had 5 stamen and a pistil. Stigma of each pistil was divided into two section during the seed maturing period. Shape of leaves was usually lanceolate type with narrowed width, sometimes ovatolanceolate type was also founded. Ovary comprised two carpels and a locule, and each carpel had several seeds in it. Pods were capsule. and seed shape was lanceolate type with wings at the tips.

김치 발효를 위한 Leuconostoc mesenteroides 균주의 개량과 starter로의 첨가효과

강상모,양완숙,김영찬,정은영,한용구 한국산업미생물학회 1995 한국미생물·생명공학회지 Vol.23 No.4

김치로부터 Leuconostoc mesenteroides 균주를 선별한 후, NTG로 변이처리를 하여 내산성이며, 낮은 pH에서도 증식하며, 높은 CO_2 생성 능력을 갖는 균주로 개량하였다. HCl로 pH를 조절한 MRS 배지에서 변이주 M-10균주는 30℃에서 pH 5.0∼3.5, 20℃에서는 pH 5.0∼3.8, 10℃에서 변이주 M-10균주가 야생주 K-1균주 보다 더 많은 CO_2를 생성하였다. 젖산으로 pH를 조절한 MRS배지에서 내산성 변이주 Leuconostoc mesenteroides M-10균주가 받는 증식저해 영향은 야생주 K-1균주에 대한 것보다 적었다. 내산성 변이주 Leuconostoc mesenteroides M-10균주를 김치에 starter로 첨가하였을 때 10℃에서 야생주 K-1균주에 비하여 당소비가 떨어지고 pH 변화량과, 총산도 증가폭도 감소하고, 상쾌미에 의한 기호도도 향상되는 것이 나타났다. The heterofermentative Leuconostoc mesenteroides, which is propagated form the initial to the intermediate stage of Kimchi fermentation, produces organic acids and carbon dioxide to impart refreshment, weak acid taste to Kimchi. But owing to lactic acid production by the homofermentative Lactobacillus plantarum, Kimchi finally reaches its acidified state. So, Leu. Mesenteroides was isolated from Kimchi and identified and was improved by mutation for carbon dioxide production at low pH, and for the high total acceptability. We tested with a wild-type strain K-1 and its improved mutant strain M-10 of Leu. Mesenteroides. The wild-type strain K-1 could grow in pH 4.2 at 30℃ or 20℃, and in pH 5.0 at 10℃. But the mutant strain M-10 could grow in pH 3.3 at 10℃. In the respect of total acceptability, mutant strain M-10 inoculated Kimchi was ever better than any others. Mutant M-10 inoculated Kimchi prolonged the optimum ripening period of Kimchi up to two times as compared with the control group.