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김그림 ( Geu Rim Kim ),박지혜 ( Ji Hye Park ),양예은 ( Ye Eun Yang ),이경아 ( Kyung A Lee ) 대구가톨릭대학교 자연과학연구소 2014 자연과학연구논문집 Vol.12 No.1
The purpose of this study was to investigate preference for salty taste of University foodservice customer in the Gyeongsangbuk-do area. Data were collected from subjects, including 94 male and 213 female University students. This survey was conducted using self-boarding Questionnaires. By the stage of salt-related dietary behaviors, the ``Pre-contemplation stage`` comprised 39.1%, ``Contemplation stage`` 29.1%, ``Preparation stage`` 14.9% and`` Action stage`` 16.9%. Exactly 38.5% of all students showed ``salty`` for self-assessed preference of saltness, and 56.4% showed ``salty`` for assessed saltness of university foodservice operation. Male had higher self-assessed preference for salty taste more than female, overweight students had higher the score, and ``Pre-contemplation stage`` group had higher the score than other group.
Jungeun Kim,Soo Jung Rim,Minkyung Jo,Min Geu Lee,Subin Park 대한신경정신의학회 2022 PSYCHIATRY INVESTIGATION Vol.19 No.1
Objective The objective of this study was to monitor the trend of psychiatric visits and medication prescriptions among people tested for SARS-CoV-2 during the initial phase of coronavirus disease 2019 (COVID-19) pandemic in South Korea. Methods We conducted a population-based cohort study using data from the National Health Insurance Service (NHIS) linked to the Korea Disease Control and Prevention Agency (KDCA) data. The overall trend of psychiatric visits during COVID-19 for each month was compared to the month prior to COVID-19. The number of psychiatric medication prescription records was monitored from January 2019 to May 2020. Results A total of 212,678 individuals were tested for SARS-CoV-2 between January 2020 and May 2020. Among these individuals, 72.1% (n=153,309) did not have pre-existing mental illness, and 27.9% (n=59,369) had pre-existing mental illness. We found that most psychiatric visits were made in March, and patients without pre-existing mental illness significantly increased in psychiatric outpatients during the COVID-19 pandemic (p trend<0.001). In addition, psychiatric medication prescriptions were the most prescribed between March and April 2020. Conclusion We identified a rising trend in psychiatric visits and medication prescriptions among people who were tested for SARSCoV- 2 during the initial phase of COVID-19 pandemic in South Korea.
Gyurin Kim,Soo Jung Rim,Minkyung Jo,Min Geu Lee,Se Jin Park,Subin Park 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.3
Objective: To investigate the cumulative effect of antipsychotics at different dosages on mortality in patients with schizophrenia. Methods: We analyzed data from the Korean National Health Insurance System−National Sample Cohort covering the 2002−2013 period. We used Cox regression analysis to calculate hazard ratios for mortality risks according to cumulative antipsychotic exposure levels (low, moderate, and high). Results: Our analyses revealed no significant association between antipsychotic exposure and mortality (either all-cause or cause-specific) in patients with schizophrenia. Conclusion: Our results imply that the excess mortality of patients with schizophrenia is attributable to factors other than antipsychotic usage.
쥐의 척수 손상정도에 따른 운동 유발전위의 잠복기 및 진폭의 변화
심대무,김상수,박병림,황규택,김영진 대한척추외과학회 1994 대한척추외과학회지 Vol.1 No.1
Motor evoked potentials(MEPs) and somatosensory evoked potentials(SSEPs) have been used to evaluate the integrity of ascending and descending pathways in the spinal cord, and assess pathways involved in spinal cord injury. The purpose of this study was to evaluate the changes of MEPs elicited by transcranial electrical stimu- lation following acute spinal cord injury in Sprague-Dawley rats. MEPs were evoked by electrical stimulation of the right somatic motor cortex through a stainless steel screw and recorded epidurally at T8 and L1 spinal cord levels using two pairs of teflon-coated stainless steel wire electodes with 1mm exposed tip. Thirty animals received a 12.5g/㎝(n=10), 25g/㎝(n=10). 75g/㎝(n=10) weight drop injury at T10 spinal cord level and other 5 animals severed as a ventral or dorsal cord transection. The nomal MEPs were composed of reproducible 4 waves, such as P1,P2,P3, and P4. The conduction velocities of P1,P2,P3,P4 were 60,45,37,25m/sec, respectively. The ventral cord section produced complete loss of MEPs, whereas the dorsal cord section showed minimal change of MEPs. The 75g/㎝ drop injury abol- ished all MEP waves distal to the lesion and the MEPs did not appear till 3 hours after injury. Decrement of amplitude and shift of latency of MEPs following 25g/㎝ drop injury were greater than those in MEPs following 12.5g/㎝ drop injury. The MEPs following 12.5g/㎝ drop injury recovered by 60 min, and duration of recovery in 25g/㎝ drop injury was longer than in 12.5g/㎝ drop injury. These results suggest that the ventral descending tracts may play a major role in the spinal conduction pathway of MEPs in rats and MEPs will be a useful method of the assessment of severity in spinal cord injury.
유기농 유당으로부터 유기농 Galactooligosaccharide 생산
신중철(Jung Cheul Shin),서형주(Hyung Joo Suh),장주현(Joo Hyun Jang),서그림(Geu Rim Seo),나경수(Kyung Soo Ra),김훈(Hoon Kim) 한국식품영양과학회 2017 한국식품영양과학회지 Vol.46 No.12
본 연구에서는 유기농 유당(organic lactose)을 원료로 Bacillus로부터 분리한 새로운 β-galactosidase의 당전이 반응(transgalactosylation)을 이용해 유기농 갈락토올리고당(galactooligosaccharide, GOS)을 생산하고, 이를 시판되는 타 효소제품을 이용해 조제된 GOS와 비교함으로써 새로운 GOS 제품의 활용 가능성을 검토하였다. Bacillus로부터 분리한 새로운 β-galactosidase를 비롯하여 시판되는 GOS 전환효소 3종(Lactozym, Maxilact 및 Pectinex)을 이용하여 유기농 유당이 GOS로 전환되는 비율을 검토한 결과, β-galactosidase는 유당을 가수분해하여 19.83%의 galactose와 glucose로 가수분해하였으며, transgalactosylation을 유도하여 glucose와 galactose의 β-1,6 결합 형태인 allolactose를 약 20.0% 가량 생성시키는 것으로 확인되었다. 또한, β-galactosidase는 시판되는 타 효소들에 비하여 유기농 유당으로부터 GOS로의 전환(총 GOS 전환율 60.50%)을 가장 효율적으로 유도하는 것으로 나타났다. 선별된 β-galactosidase와 Lactozym을 이용하여 효소의 첨 가량 및 반응시간이 유기농 GOS 생산에 미치는 영향을 비교한 결과, 두 종류의 효소에서 모두 효소-기질의 반응시간 및 효소의 첨가량은 GOS 생산량과의 뚜렷한 관련성을 찾아볼 수 없었으나, 유기농 유당으로부터 GOS의 전환수율은 Lactozym을 첨가한 군(39.5~50.6%)에 비해서 β-galactosidase가 첨가된 군(59.2~63.3%)에서 매우 높게 나타났다. 시판 GOS 제품들의 총 GOS 함량(54.03~60.27%)과 비교해본 결과, 최적조건으로 제조된 유기농 GOS의 총 GOS함량(60.50%)은 높은 수준인 것으로 확인되었다. 유당 함량분석을 통해 확인한 유기농 유당의 품질은 GOS 생산 원료로 매우 적합할 것으로 생각된다. 본 연구를 통해 개발된 유기농 GOS는 최초 유기농 GOS로, 시판 중인 GOS 제품들과의 당 조성 및 품질 비교에서도 떨어지지 않는 양질의 GOS 제품이 개발되었음을 확인할 수 있었다. 또한, GOS 전환율(생산수율), 효소의 가격경쟁력 및 효소 국내 수급사정 등을 고려했을 때 유기농 유당과 β-galactosidase를 이용한 유기농 GOS의 생산은 산업적인 활용 가능성이 매우 클 것으로 생각된다. In this study, we developed a novel organic galactooligosaccharide (GOS) by using β-galactosidase from organic lactose to perform transgalactosylation, and the quality of the novel organic GOS was compared to that of commercial GOS. A new β-galactosidase isolated from Bacillus species converted 80% of lactose composed of galactose and glucose into a transgalactosylation product containing a β-1,6 bond form of glucose and galactose. In addition, β-galactosidase was found to induce conversion of organic lactose to GOS (total GOS conversion of 60.50%) more efficiently than other commercially available enzymes (Lactozym, Maxilact, and Pectinex). The conversion yield of GOS from organic lactose was significantly higher in the β-galactosidase usage group (53.3∼63.3%) than in the Lactozym usage group (39.5∼50.6%). Compared with other commercial GOS products (54.03∼60.27%), total GOS content of organic GOS (60.50%) manufactured under optimal conditions was high. The result, which was confirmed by analysis of lactose contents, suggests that organic GOS in this study was shown to be a novel organic GOS with high quality and the quality of organic GOS is very suitable as a raw material for GOS production. Consequently, organic GOS prepared from the current study is likely to have potential as an industrial product containing high GOS content.