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고가의약품 사용경향 분석에 따른 정책대응 방안연구 : 약국 처방전명세서를 중심으로 Focusing on EDI Bills of Pharmacies
김진수,이용갑,김한성 대한보건협회 2001 대한보건연구 Vol.27 No.3
The purpose of this study is to examine the use of expensive drugs. For this study, EDI bills of pharmacies were used Here, the study indicates that the use of expensive drugs is very common and obstacles in the development of the pharmaceutical market is expected to grow. Moreover, in addition to the common use of expensive drugs, the study indicates that drug prescription is highly concentrated to a certain kind of pharmaceutical product. Based on the results of this study, a prompt introduction of the reference price system and an incentive system for the use of less expensive drugs must be considered.
이온화방사선에 의한 느타리버섯(Rleurotus ostreatus)의 ITS2 염기서열 변화
이영근,장화형,한갑진,고동규,이기성 한국환경생물학회 1998 환경생물 : 환경생물학회지 Vol.16 No.4
rDNA의 ITS2(internal transcribed spacer 2)부위에 대한 이온화방사선(gamma-ray)의 영향을 알아보기 위해서 감마선을 조사한 느타리버섯(Pleurotus ostreatus)의 5종의 변이중에서 ITS2의 염기서열을 결정하였다. ITS2의 염기서열은 1 kGy 조사군(PO-5, PO-6, PO-15와 PO-16)에서 변화되지 않았으나, 2kGy 조사군(PO-14)에서는 1개의 염기가 치환되었다. RAPD(ramdomly amplified polymorphic DNA) 양상에 의한 유전유사도의 변화가 다양하였고 섬유소성 고체검정 배지에서도 다양한 생장특성을 나타내었다. 본 연구결과는 ITS염기서열이 이온화 방사선에 의해 선량의존적으로 변화될 수 있음을 시사해 주었다.
( Sang Jin Lee ),( Jong Kyu Park ),( Hyun Il Seo ),( Koon Hee Han ),( Young Don Kim ),( Woo Jin Jeong ),( Gab Jin Cheon ),( Jae Seok Song ) 대한장연구학회 2013 Intestinal Research Vol.11 No.2
Background/Aims: Gastrointestinal stromal tumors (GIST) in the small intestine are rare and can cause bleeding. The study investigated the clinical characteristics of GIST in the small intestine and to determine the factors related to gastrointestinal bleeding. Methods: We retrospectively evaluated the clinical outcomes of 22 patients with small bowel GIST who were pathologically diagnosed at Gangneung Asan Hospital between March 1997 and August 2012. Results: The median age was 63.5 (38-82) years. Nine patients (40.9%) had gastrointestinal bleeding, five patients (22.7%) had abdominal pain, two patients (9%) had palpable mass. The site of tumor was the duodenum in nine cases (40.9%), jejunum in 7 cases (31.8%), and ileum in six cases (27.3%). Most patients underwent small bowel resection or wedge resection but three patients underwent pancreaticoduodenectomy. Tumor size ranged from 1.6 to 19 cm (median 6.5 cm). The median mitotic rate was 2 (0-50)/50 high power fields (HPF). The median mitotic rate was 2 (0-50)/50 HPF. Five patients (25%) showed recurrence. Gender, aspirin or warfarin use, size and mitotic index of tumor, hospital stay, recurrence and survival were not significantly different between bleeding and non-bleeding group. Bleeding group showed older age, proximal location in small intestine and mucosal ulceration significantly. Conclusions: Small bowel GISTs with bleeding were marked by older age, mucosal ulceration and location of proximal small bowel (duodenum and jejunum) rather than distal small bowel (ileum). (Intest Res 2013;11:113-119)
Effect of Chlorella vulgaris on Immune-enhancement and Cytokine Production in vivo and in vitro
Hyo-Jin An,Hong-Kun Rim,Jong-Hyun Lee,Min-Jun Seo,Jin-Woo Hong,Na-Hyung Kim,Noh-Yil Myung,Phil-Dong Moon,In-Young Choi,Ho-Jeong Na,Su-Jin Kim,Hyun-Ja Jeong,Hyeung-Suk Park,Jae-Gab Han,Jae-Young Um,Seu 한국식품과학회 2008 Food Science and Biotechnology Vol.17 No.5
The object of this study was to investigate the immune-enhancing effects of Chlorella vulgaris (CV) on a deteriorated immune function by a protein-energy malnutrition (PEM) diet. Unicellular algae, CV were used as a biological response modifier. Male C57BL/6J mice were fed for 15 days with standard diet or a PEM diet, which is associated with decreased host immune defense. After 8 days, mice in the PEM diet group were orally administered by 0.05, 0.1, and 0.15 g/kg body weight of CV or distilled water. Nutritional parameters, and interferon (IFN)-γ levels were significantly increased in the blood serum of the CV (0.15 g/kg)-treated group (29.6±2.8 pg/mL) compared to the non-treated PEM group (4.1±0.4 pg/mL, p<0.05). In addition, cell proliferation and production of cytokines were investigated via a CV (0.01, 0.1, and 1 mg/mL) treatment using a human T cell line MOLT-4 cell. The CV treatment (1 mg/mL) significantly increased the production of both IFN-γ and interleukin (IL)-2 (51.3±3.4 and 285.9±18.8 pg/mL, respectively) compared to the control (51.3±3.4 and 442.6±14.3 pg/mL, respectively), but did not affect the production of IL-4. These results suggest that CV may be useful in improving the immune function.
( Kyu-hyun Han ),( Jong-min Park ),( Migyeong Jeong ),( Young-min Han ),( Eun-jin Go ),( Juyeon Park ),( Hocheol Kim ),( Jae Gab Han ),( Oran Kwon ),( Ki Baik Hahm ) 대한간학회 2017 Gut and Liver Vol.11 No.5
Background/Aims: In inflammatory bowel disease (IBD), repeated bouts of remission and relapse occur in patients and can impose a risk of colitis-associated cancer. We hy-pothesized that plant extracts of Atractylodes macrocephala (AM) or Taraxacum herba (TH) may be better than sulfasala-zine for treating this disease because these extracts can promote additional regeneration. Methods: Murine intestinal epithelial IEC-6 cells were pretreated with AM or TH before a lipopolysaccharide (LPS)-induced challenge. Acute colitis was induced with 7 days of dextran sulfate sodium (DSS) in male C57BL/6 mice, and extracts of AM and TH were admin-istered for 2 weeks before DSS administration. Results: In vitro studies demonstrated that AM or TH treatment reduced LPS-induced COX-2 and tumor necrosis factor-α mRNA levels but increased heme oxygenase-1 (HO-1). Oral preadministra-tion of AM and TH rescued mice from DSS-induced colitis by inhibiting inflammatory mediators via inactivated extracel-lular signal regulated kinase and repressed nuclear factor κB and signal transducer and activator of transcription 3, but the effect was weaker for sulfasalazine than that for the extracts. Anti-inflammatory activities occurred via the inhibi-tion of macrophage and T lymphocyte infiltrations. Unlike sul-fasalazine, which did not induce HO-1, TH extracts afforded significant HO-1 induction. Conclusions: Because the AM or TH extracts were far superior in preventing DSS-induced colitis than sulfasalazine, AM or TH extracts can be consid-ered natural agents that can prevent IBD relapse. (Gut Liver 2017;11:655-666)
연구논문 : 미국인의 김치와 김치이용음식에 대한 인식과 기호도 -Illinois주와 California주-
한재숙 ( Jae Sook Han ),한경필 ( Gyeong Phil Han ),이진식 ( Jin Shik Lee ),한갑조 ( Gab Jo Han ),김영진 ( Young Jin Kim ) 한국식생활문화학회 2010 韓國食生活文化學會誌 Vol.25 No.5
The purpose of this study was to investigate American`s perception and preference for Korean kimchi. A questionnaire was used to examine the perceptions of 126 males (40.4%) and 186 females (59.6%) residing in Illinois and California. Approximately 68% of the respondents had eaten Korean food. The perception of kimchi was the highest with a mean of 3.62. The respondents felt that the "Kimchi is a good side dish with cooked rice", "Kimchi (with garlic) prevents SARS", which was significantly different (M=3.06, p< .001), and "Kimchi prevents adult diseases" (M=3.24, p< .01). When evaluating the different kinds of kimchi, onion juice kimchi had the most preferred taste and also the highest overall acceptability (M=5.50, p< .05) of the second days. In the sensory evaluation by kimchi use, the best taste (p< .001) was in the order of kimchi pizza (M=6.58), kimchi dumplings (M=6.40), and kimchi chicken a`laking (M=6.33). The order for overall acceptability (p< .001) was kimchi dumplings (M=6.30), kimchi pizza (M=6.25), kimchi bacon roll, kimchi fried rice, and kimchi chicken a`laking (M=6.17).
Han, Seunghoon,Jeon, Sangil,Hong, Taegon,Lee, Jongtae,Bae, Soo Hyeon,Park, Wan-su,Park, Gab-jin,Youn, Sunil,Jang, Doo Yeon,Kim, Kyung-Soo,Yim, Dong-Seok Dove Medical Press 2015 Drug design, development and therapy Vol.9 No.-
<P>No wholly successful weight-control drugs have been developed to date, despite the tremendous demand. We present an exposure–response model of sibutramine mesylate that can be applied during clinical development of other weight-control drugs. Additionally, we provide a model-based evaluation of sibutramine efficacy. Data from a double-blind, randomized, placebo-controlled, multicenter study were used (N=120). Subjects in the treatment arm were initially given 8.37 mg sibutramine base daily, and those who lost <2 kg after 4 weeks’ treatment were escalated to 12.55 mg. The duration of treatment was 24 weeks. Drug concentration and body weight were measured predose and at 4 weeks, 8 weeks, and 24 weeks after treatment initiation. Exposure and response to sibutramine, including the placebo effect, were modeled using NONMEM 7.2. An asymptotic model approaching the final body weight was chosen to describe the time course of weight loss. Extent of weight loss was described successfully using a sigmoidal exposure–response relationship of the drug with a constant placebo effect in each individual. The placebo effect was influenced by subjects’ sex and baseline body mass index. Maximal weight loss was predicted to occur around 1 year after treatment initiation. The difference in mean weight loss between the sibutramine (daily 12.55 mg) and placebo groups was predicted to be 4.5% in a simulation of 1 year of treatment, with considerable overlap of prediction intervals. Our exposure–response model, which included the placebo effect, is the first example of a quantitative model that can be used to predict the efficacy of weight-control drugs. Similar approaches can help decision-making during clinical development of novel weight-loss drugs.</P>