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MMP-2 and MMP-9 Inhibitory Effects of Different Solvent Fractions from Corydalis heterocarpa
Ga Hyun Yu(유가현),Fatih Karadeniz(카라데니즈 파티),Chang-Suk Kong(공창숙) 한국생명과학회 2021 생명과학회지 Vol.31 No.11
염주괴불주머니(Corydalis heterocarpa)는 두해살이 풀로 노란 꽃이 피고 염주처럼 잘록한 열매를 맺는 것이 특징이다. 또한 우리나라 갯벌에서 서식하는 염생식물로 내건성, 내염성과 같은 독특한 생리적 기전을 가지고 있으며 민간에서 진통 경련 완화 치료제로 사용하고 있다. 본 연구에서는 항산화, 항염증, 항노화 등의 효과가 있는 것으로 보고되어 있는 염주괴불주머니(Corydalis heterocarpa)을 이용하여 용매분획물(H₂O, n-BuOH, 85% aq. MeOH, n-hexane)을 제조하였으며 이를 이용하여 PMA로 유도된 인간 섬유육종세포 HT-1080 세포에서 MMP-2, MMP-9의 발현 조절에 미치는 영향을 확인하였다. 염주괴불주머니 분획물 처리시 TIMP-1 및 TIMP-2를 증가시키면서 MMP-2 및 MMP-9의 mRNA 및 단백질 발현을 감소시키는 것으로 나타났다. 또한 염주괴불주머니 용매분획물 처리시 MAPKs 신호 전달 경로인 p38, JNK, ERK의 인산화를 억제하여 MMPs 발현을 감소시키는 것을 확인할 수 있었다. 특히 염주괴불주머니의 85% aq. MeOH와 n-hexane 용매분획물에서 MMP-2 및 MMP-9 발현이 효과적으로 억제되어 MMP 억제활성이 높은 물질이 들어있을 것으로 사료되며, 이를 통해 염주괴불주머니의 암 전이 억제 소재 개발을 위한 기초자료로 활용될 수 있을 것으로 기대된다. Natural products have always been an attractive source in terms of novel anti-metastatic compounds which can hinder MMP expression and activity. Corydalis heterocarpa is a salt marsh plant found in the seashores throughout Korea. Its yellow flowers and spikes have been an ingredient in folk medicine to treat spasm and contractions. The present study assessed the potential of different solvent-based fractions from the crude extract of Corydalis heterocarpa (CHE), a halophyte with reported bioactivities, to suppress the PMA-induced MMP expression in human fibrosarcoma HT-1080 cells. The solvent fractions which were named after the solvent used for fractionation (n-hexane, 85% aqueous (aq.) methanol (MeOH), n-butanol (BuOH), and H₂O were shown to inhibit the both elevated mRNA and protein expression levels of MMP-2 and MMP-9 and simultaneously relieved the suppression on the expression of the endogenous MMP inhibitors TIMP-1 and TIMP-2. Results indicated that the CHE fractions might intervene with the PMA-induced activation of the MAPK signaling which is the upstream activator of MMP overexpression. Among tested samples, 85% aq. MeOH and n-hexane fractions of CHE was determined to be the most active and future studies to isolate the bioactive substances responsible for the regulation of the MMP expression are, therefore, urged. In conclusion, C. heterocarpa was shown to be a potential source of anti-metastatic compounds and n-Hexane and MeOH fractions might yield lead molecules to develop novel MMP inhibitors.
Diagnostic accuracy of PET/CT in early stage ovarian cancer: comparison between PET/CT and CT or MRI
( Yu Bin Lee ),( Hyun Jong Park ),( Ga Won Yim ),( Sung Hoon Kim ),( Sang Wun Kim ),( Young Tae Kim ),( Jae Wook Kim ),( Eun Ji Nam ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-
The purpose of this study was to compare the diagnostic accuracy of positron emission tomography/computed tomography (PET/CT), abdomino-pelvic computed tomography (CT), and pelvic magnetic resonance imaging (MRI) for detection of early stage ovarian cancer. Medical record of 140 women who underwent PET/CT scanning with suspected early stage ovarian cancer (stage 1-2) from July 2005 to February 2012 was retrospectively reviewed. Preoperative CT, MRI, and PET/CT findings were compared with histopathologic results obtained from the surgery. The accuracy of each modality in detection of malignancy was evaluated by computing the relevant areas under a receiver operating characteristics(ROC) curve and comparisons of the area under the curve (AUC) according to the modality (MedCalc® version 9.6.3.0, Broekstraat 52, 9030 Mariakerke, Belgium). Histopathology showed 7 cases of benign tumors, 23 cases of borderline tumors, and malignant tumors in 110 cases. In detecting malignant lesions in the ovaries and the adnexa, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of PET/CT were higher than the corresponding values of CT or MRI. In discriminating between cases of benign/borderline and malignant, the accuracy of PET/CT (0.760) trended higher than that of CT or MRI (0.585). PET/CT is more accurate than abdomino-pelvic CT or pelvic MRI in diagnosis of early stage ovarian cancer and in differentiating between cases of benign/borderline and malignant ovarian tumors.
Ga Young Park,Hyun Jin Yu,Jee Soo Son,Sang Joon Park,Hee‑Jae Cha,Kyoung Seob Song 한국유전학회 2020 Genes & Genomics Vol.42 No.4
Background Respiratory diseases in pigs are the main health concerns for swine producers. Similar to the diseases in human and other animals, respiratory diseases are primary related to morbidity and are the result of infection with bacteria, viruses, or both. B. bronchiseptica causes serious respiratory diseases in the swine airway track. However, the B. bronchisepticaspecific bacteriophage has diverse advantages such as decreasing antibiotic overuse and possible therapeutic potential against bacteria. Objective The objects of this study were to investigate the therapeutic effect of specific B. bronchiseptica bacteriophages and to identify genes related to bacteriophage signaling utilizing RNA microarrays in swine nasal turbinate cells. Methods Bor-BRP-1 phages were applied 24 h prior to B.bronchiseptica infection (1 × 107 cfu/ml) at several concentrations of bacterial infection. Cells were incubated to detect cytokines and 24 h to detect mucin production. And real-time quantitative PCR was performed to examine related genes expression. To determine the change of total gene expression based on B.bronchiseptica and Bor-BRP-1 treatment, we performed RNA sequencing experiments. Results The results showed that B. bronchiseptica induced increased expression of several inflammatory genes such as IL-1β, IL-6, and Muc1 in a dose-dependent manner. However, Bor-BRP-1 induced reduction of gene expression compared to the B. bronchiseptica induction group. In addition, microarrays detected Bor-BRP-1-altered inflammatory gene expression against B. bronchiseptica, reducing B. bronchiseptica-induced airway inflammation in swine epithelial cells. Conclusion These results suggest that the specific bacteriophage has a therapeutic potential to defend against B. bronchiseptica infection by altering inflammatory gene expression profiles.
( Ga Ram Ahn ),( Hyun Jung Kwon ),( Yu Jin Jang ),( Eun Ja Choi ),( Hee Su Kim ),( Kap Sok Li ),( Myeung Nam Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
Background: Cryolipolysis is a noninvasive method for the selective reduction of localized fat tissues. It has demonstrated efficacy in both clinical and preclinical trials; however, despite its popularity, its mechanisms of action and evaluation methods are not yet fully defined. Objectives: The purpose of this study was to improved methods for cryolipolysis using a porcine model. Methods: The abdomens of female Prestige World Genetics (PWG) micro-pigs were treated with a cooling device (CRYOLIPO II™), and we examined photography, three-dimensional photography, ultrasound, gross, and microscopic pathology, and serum lipid level analyses in order to determine the mechanism of action, efficacy, and safety of the device. Results: CRYOLIPO II™ reduced abdominal fat in porcine model. Gross and microscopic histological results confirmed the noninvasive cold-induced selective subcutaneous fat destruction, and showed increases in pre-adipocyte differentiation and in the activation of lipid catabolism. In particular, we found that the device may increase PPARδ (delta) levels in adipose tissue at 30.60 days post-treatment. Conclusion: Fat reduction by cryolipolysis was achieved in our porcine model. Thus, our findings indicate that CRYOLIPO II™ may be a promising fat reduction device for body contouring and fat reduction in humans, and that cryolipolysis exerts its effects, at least partly, by targeting the PPARδ signaling pathway.
Accuracy of administrative claim data for gastric adenoma after endoscopic resection
Ga-Yeong Shin,Hyun Ho Choi,박재명,Sang Yoon Kim,Jun Young Park,Donghoon Kang,Yu Kyung Cho,Sung Soo Kim,Myung-Gyu Choi 대한소화기내시경학회 2023 Clinical Endoscopy Vol.56 No.3
Background/Aims: Administrative databases provide valuable information for large-cohort studies. This study aimed to evaluate the diagnostic accuracy of an administrative database for resected gastric adenomas. Methods: Data of patients who underwent endoscopic resection for benign gastric lesions were collected from three hospitals. Gastric adenoma cases were identified in the hospital database using International Classification of Diseases (ICD) 10-codes. The non-adenoma group included patients without gastric adenoma codes. The diagnostic accuracy for gastric adenoma was analyzed based on the pathological reports of the resected specimen. Results: Among 5,095 endoscopic resections with codes for benign gastric lesions, 3,909 patients were included in the analysis. Among them, 2,831 and 1,078 patients were allocated to the adenoma and non-adenoma groups, respectively. Regarding the overall diagnosis of gastric adenoma with ICD-10 codes, the sensitivity, specificity, positive predictive value, and negative predictive value were 98.7%, 88.5%, 95.2%, and 96.8%, respectively. There were no significant differences in these parameters between the tertiary and secondary centers. Conclusions: Administrative codes of gastric adenoma, according to ICD-10 codes, showed good accuracy and can serve as a useful tool to study prognosis of these patients in real-world data studies in the future.
Echocardiographic and ABPM parameters between 4 groups of hypertensive patients
( Ga In Yu ),( In Kyoung Shim ),( Jung Ho Heo ),( Kyoung Im Cho ),( Hyun Su Kim ),( Jae Woo Lee ),( Tae Joon Cha ) 대한내과학회 2013 대한내과학회 추계학술발표논문집 Vol.2013 No.1
Background: The utility of ambulatory blood pressure monitoring (ABPM) has been recognized, and the practice has been adopted widely. We investigated the clinical characteristics and ABPM profiles between patients with normotension, white coat hypertension, masked hypertension, and sustained hypertension by clinic BP and ABPM. Methods: This study is a retrospective analysis of patients with ABPM from January 2008 to May 2013. After measurement of clinic BP and ABPM, 4 groups of patients were identified namely: (i) NT: normotensive patients (BPs are normal both clinically and by ABPM) (ii) WCHT: white coat hypertensive patients (clinical BP were above limits, but ABPM were normal); (iii) MHT: masked hypertensive patients (clinical BP were normal, but ABPM were high); (iv) SHT: sustained hypertensive patients (both office and ABPM were high). Results: In total 75 patients with NT (mean age 46.5±13.7 years, female 32%), 34 patients with WCHT (mean age 51.6±13.9 years, female 50%), 201 patients with MHT (mean age 48.2±12.9 years, female 44.8%), and 83 patients with SHT (mean age 49.5±13.9 years, female 44.6%) were included. In echocardiographic findings, relative wall thickness and left ventricular mass were higher in MHT than NT (p=0.047, p=0.007) and WCHT (p=0.002, p=0.047). Subjects with NT and WCHT had similar 24 hours BP variability, and the variability among those with MHT was close to that in those with SHT. Conclusion: The short-term variability of BP is similar in MHT and SHT and higher than NT and WCHT. Left ventricular mass were higher in MHT than NT and WCHT. This results showed ABPM was more predictive of target organ damage than clinic BP and BP variability in patients with MHT may contribute to the elevated cardiovascular risk.