Modulation of senoinflammation by calorie restriction based on biochemical and Omics big data analysis

( Eunjin Bang ),( Bonggi Lee ),( Sang-gyun Noh ),( Dae Hyun Kim ),( Hee Jin Jung ),( Sugyeong Ha ),( Byung Pal Yu ),( Hae Young Chung ) 생화학분자생물학회(구 한국생화학분자생물학회) 2019 BMB Reports Vol.52 No.1

Aging is a complex and progressive process characterized by physiological and functional decline with time that increases susceptibility to diseases. Aged-related functional change is accompanied by a low-grade, unresolved chronic inflammation as a major underlying mechanism. In order to explain aging in the context of chronic inflammation, a new integrative concept on age-related chronic inflammation is necessary that encompasses much broader and wider characteristics of cells, tissues, organs, systems, and interactions between immune and non-immune cells, metabolic and non-metabolic organs. We have previously proposed a novel concept of senescent (seno)-inflammation and provided its frameworks. This review summarizes senoinflammation concept and additionally elaborates modulation of senoinflammation by calorie restriction (CR). Based on aging and CR studies and systems-biological analysis of Omics big data, we observed that senescence associated secretory phenotype (SASP) primarily composed of cytokines and chemokines was notably upregulated during aging whereas CR suppressed them. This result further strengthens the novel concept of senoinflammation in aging process. Collectively, such evidence of senoinflammation and modulatory role of CR provide insights into aging mechanism and potential interventions, thereby promoting healthy longevity. [BMB Reports 2019; 52(1): 56-63]

팬데믹 상황에서 음압병실 근무 간호사의 COVID-19 환자 간호 경험

노은영(Noh, Eun-Young),채영준(Chai, Young Jun),김현정(Kim, Hyun Jeong),김은진(Kim, Eunjin),박연환(Park, Yeon-Hwan) 한국간호과학회 2021 Journal of Korean Academy of Nursing Vol.51 No.5

Differential expression of nitric oxide synthase in human stomach cancer

Koh, Eunjin,Noh, Sung Hoon,Lee, Young Don,Lee, Hoi Young,Han, Jeung-Whan,Lee, Hyang Woo,Hong, Sungyoul 성균관대학교 약학연구소 1999 成均藥硏論文集 Vol.11 No.-

The level of expression and cellular localization of isoenzymes of nitric oxide synthase (NOS) was detected in human stomach tumor tissues. Tumor tissues showed 70% higher activity of NOS than that of normal tissues (P<0.01). Poorly differentiated adenocarcinoma tend to have higher activity (P<0.05) than well differentiated and moderately differentiated tumor tissues. Aminoguanidine (AG), 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine (AMT), N^G-monomethyl-L-arginine (L-NMMA), and N^ω-nitro-L-arginine (L-NNA) inhibited NOS activity in tumor tissues by 18,14,11 and 13%, respectively. The TNF-α mRNA expression was correlated with the inducible NOS(iNOS) level, which was high in adenocarcinomas and low in normal tissues. Tumor tissues showed higher expression of iNOS in gland epithelial cells but the level of eNOS was significantly decreased with an exception of concentrated localization in the proliferation capillary endothelium. These results revealed that isoforms of NOS might contribute differentially to growth and progression of human stomach tumor. ⓒ 1999 Elsevier Science Ireland Ltd. All rights reserved.

주류전시박람회 서비스품질과 참관동기에 따른 중국인참관객의 참관수요 결정요인 분석

한은진 ( Eunjin Han ),노정희 ( Jeong Hee Noh ) 대한관광경영학회 2016 觀光硏究 Vol.31 No.1

본 연구에서는 설문방법과 종속변수의 형태에 따라 선택된 수요모형으로 인적척도에 의해 측정된 자료를 위해 설정될 수 있는 절단된 포아송(Truncated Poisson)모형을 설정하고 참관객의 참관수요에 영향을 어떠한 요인들이 영향을 끼치는 요인들을 도출하였다. 연구의 목적 수행을 위하여 상해국제주류박람회에 참관한 중국인참관객을 대상으로 전시박람회 서비스품질이 참관객의 참관선택에 미치는 직접적인 영향을 규명하였다. 연구결과는 다음과 같다. 첫째, 전시박람회 서비스품질 선택속성 요인의 경우 접근성 및 편의시설과 인적서비스 및 품질이 긍정적인 영향을 미치는 것으로 나타났으며 프로그램 다양성요인이 부정적인 영향을 미치는 것으로 나타났다. 둘째, 전시박람회 참관동기 요인의 경우 친목도모 및 정보추구에서 긍정적인 영향을 미치는 것으로 나타났으며, 위락적요인은 부정적인 영향을 미치는 것으로 나타났다. 본 연구의 결과를 이용한 이론적, 실무적 시사점이 제시되었다. This study aims to extract factors affecting the demand for the service quality of exhibitions and fairs by establishing Truncated Poisson model which can be set up for measured data through the demand model appropriately selected according to the types of dependent variables and questionnaire methods. In order to carry out the objectives of the study, Chinese participants and visitors who came to the Shanghai International Wine and Spirits Exhibition were employed to identify direct effects of the service quality of an exhibition or a fair on the participation selection of the participants. Below are research results. First, in case of factors of service quality selection attributes of an exhibition or a fair, it was found that accessibility, convenience facilities, human services and quality had positive effects but the factor of program diversity had negative effects. Second, in case of the factor of exhibition participation motives, it was found that promoting friendship and pursuing information had positive effects but the leisure factor had negative effects. Academic and practical implications were suggested based on the results.

Nurses’ experiences in caring for patients with infectious disease in a negative pressure room during the COVID-19 pandemic

Eun-Young Noh,Young Jun Chai,Hyun Jeong Kim,Eunjin Kim,Yeon-Hwan Park 한국간호과학회 2021 한국간호과학회 학술대회 Vol.2021 No.10

Aim(s): The purpose of this study was to explore the nurses’ experiences in caring for patients with COVID-19 in a negative pressure room during the pandemic. Method(s): This study was a qualitative research, and the focus group interviews were used to collect data. Three focus groups with a total of 19 nurses were interviewed from February 17 to 25, 2021. All interviews were recorded and transcribed verbatim with the consent of the participants. The verbatim transcripts were analyzed using thematic analysis. Result(s): From the analysis, two main themes: “Struggling in an isolated space”, “Limitations of infrastructure and system” emerged. The nurses caring for COVID-19 patients experienced anxiety and fear about the infection, physical exhaustion, emotional burnout, a sense of duty as nurse, and also lack of guidelines, increased task and burden, limitations of nursing care, and system. Conclusion(s): The results suggest that physiological and psychological interventions are needed for nurses, especially education and training for infection prevention because of the high risk of infection. This study also revealed that nurses have demands of establishing guidelines, strengthening nurse staffing, and, above all, improving the healthcare system to respond effectively during the pandemic. The government and medical institution should be aware of the experiences and needs of nurses, and make efforts to improve the quality of life of healthcare workers and create a safe healthcare environment.

슈퍼커패시터를 이용한 전동차량용 에너지저장시스템의 제어기 설계

노세진(Sejin Noh),이진목(Jinmok Lee),손경민(kyoung min son),최은진(EunJin Choi),최재호 (Jaeho Choi ) 대한전기학회 2008 대한전기학회 학술대회 논문집 Vol.2008 No.7

Myocardial Infarction, Stroke, and All-Cause Mortality according to Low-Density Lipoprotein Cholesterol Level in the Elderly, a Nationwide Study

이유빈,구민지,Noh Eunjin,황순영,김정아,노은,Hong So-hyeon,최경묵,백세현,조금준,류혜진 대한당뇨병학회 2022 Diabetes and Metabolism Journal Vol.46 No.5

Background: We assessed the myocardial infarction (MI), stroke, and all-cause death risks during follow-up according to the low-density lipoprotein cholesterol (LDL-C) levels among older adults.Methods: The Korean National Health Insurance Service datasets (2002 to 2020) were used for this population-based cohort study. The hazards of MI, stroke, and all-cause mortality during follow-up were analyzed according to LDL-C level in individuals aged ≥65 years without baseline cardiovascular diseases (<i>n</i>=1,391,616).Results: During a mean 7.55 years, 52,753 MIs developed; 84,224 strokes occurred over a mean 7.47 years. After a mean 8.50 years, 233,963 died. A decrease in LDL-C was associated with lower hazards of MI and stroke. The decreased hazard of stroke in lower LDL-C was more pronounced in statin users, and individuals with diabetes or obesity. The hazard of all-cause death during follow-up showed an inverted J-shaped pattern according to the LDL-C levels. However, the paradoxically increased hazard of mortality during follow-up in lower LDL-C was attenuated in statin users and individuals with diabetes, hypertension, or obesity. In statin users, lower LDL-C was associated with a decreased hazard of mortality during follow-up.Conclusion: Among the elderly, lower LDL-C was associated with decreased risks of MI and stroke. Lower LDL-C achieved by statins in the elderly was associated with a decreased risk of all-cause death during follow-up, suggesting that LDL-C paradox for the premature death risk in the elderly should not be applied to statin users. Intensive statin therapy should not be hesitated for older adults with cardiovascular risk factors including diabetes.

A Control Design of Energy Storage System for Electric Railway Vehicle Using Supercapacitor

노세진(Sejin Noh),이진목(Jinmok Lee),손경민(kyoung min son),최은진(EunJin Choi),최재호(Jaeho Choi) 대한전기학회 2008 대한전기학회 학술대회 논문집 Vol.2008 No.7(초록집)

Risk of Diabetes in Patients with Long-Standing Graves’ Disease: A Longitudinal Study

송의연,Min Ji Koo,Eunjin Noh,황순영,Min Jeong Park,김정아,Eun Roh,Kyung Mook Choi,Sei Hyun Baik,Geum Joon Cho,류혜진 대한내분비학회 2021 Endocrinology and metabolism Vol.36 No.6

Background: The detrimental effects of excessive thyroid hormone on glucose metabolism have been widely investigated. However, the risk of diabetes in patients with long-standing hyperthyroidism, especially according to treatment modality, remains uncertain, with few longitudinal studies. Methods: The risk of diabetes in patients with Graves’ disease treated with antithyroid drugs (ATDs) for longer than the conventional duration (≥2 years) was compared with that in age-and sex-matched controls. The risk was further compared according to subsequent treatment modalities after a 24-month course of ATD: continuation of ATD (ATD group) vs. radioactive iodine ablation (RIA) group. Results: A total of 4,593 patients were included. Diabetes was diagnosed in 751 (16.3%) patients over a follow-up of 7.3 years. The hazard ratio (HR) for diabetes, after adjusting for various known risk factors, was 1.18 (95% confidence interval [CI], 1.10 to 1.28) in patients with hyperthyroidism. Among the treatment modality groups, the RIA group (n=102) had a higher risk of diabetes than the ATD group (n=4,491) with HR of 1.56 (95% CI, 1.01 to 2.42). Further, the risk of diabetes increased with an increase in the ATD treatment duration (P for trend=0.019). Conclusion: The risk of diabetes was significantly higher in patients with long-standing Graves’ disease than in the general population, especially in patients who underwent RIA and prolonged ATD treatment. Special attention to hyperglycemia during follow-up along with effective control of hyperthyroidism may be necessary to reduce the risk of diabetes in these patients.

서비스디자인 과정을 적용한 자살예방을 위한 공동주택 주거환경 디자인 연구

이승지(Lee, Seungji),노태린(Noh, Taerin),이은진(Lee, Eunjin),전수연(Jeon, Suyeon),김현수(Kim, Hyunsoo),윤선영(Yoon, Sunyoung) 인제대학교 디자인연구소 2021 Journal of Integrated Design Research (JIDR) Vol.20 No.3

연구배경 우리나라는 자살예방을 국정과제로 추진하고 있음에도 불구하고 자살률 감소에 큰 효과를 보지 못하고 있으므로, 자살의 복합성을 감안하여 범사회적 노력을 기울여야 한다. 이 연구는 사회문제해결 디자인 측면에서 자살에 대하여 디자인적 접근법을 모색함으로써 자살예방의 차원을 공공디자인 영역으로까지 확대하고자 한다. 연구의 목적은 다양한 이해관계자에 초점을 맞춘 서비스디자인 과정을 통하여 공동주택 주거환경에서의 자살영향 요인을 도출하고 이에 기반한 디자인적 개선안을 제시하는 데 있다. 연구방법 자살시도자, 사회복지사, 주거복지사, 주거환경관리자, 지역 거주민 등 다양한 이해관계자와의 인터뷰와 워크숍 등을 통하여 심층적이고 사실적인 수요자의 요구에 초점을 맞춘 서비스디자인 연구를 진행하였다. Discover-Define-Develop-Deliver의 서비스디자인 모델에 따라 주거환경 내 자살예방이라는 서비스를 구성하는 유무형의 요소들을 분석하고 개선안을 모색한다. 연구결과 서비스디자인 과정을 통하여 자살예방을 위한 공동주택 주거환경 디자인의 목표를 사람 간의 단절을 개선하기 위한 연결, 임대주택에 거주한다는 소외된 마음을 개선하기 위한 아파트 환경 특화 그리고 제한된 활동의 확대 3가지를 도출하였다. 이러한 목표를 실현하기 위한 빛, 정리정돈, 컬러, 이웃의자, 우리집 골목길, 자연쉼터, 운동쉼터, 테마사랑방, 역사형성, 행복지도 10가지의 디자인 키워드별 솔루션을 제시하였다. 실행주체별 차이를 고려하여 이를 내 집 – 내 집앞 – 내 아파트 – 내 동네의 공간별로 체계화하여 제시하고 현장검증을 통하여 그 실효성을 검증하였다. 결론 자살의 복합성을 감안하여 정신건강 영역에 집중된 자살예방 정책과 노력을 범사회적으로 확대할 필요가 있다. 이 연구에서는 사회문제해결 디자인의 측면에서 자살에 대하여 주거환경의 디자인적 접근법을 모색함으로써 자살예방의 차원을 확대하고자 하였다. Background Although Korea is promoting suicide prevention as a major government project, it has not seen a significant effect on reducing the suicide rate. Now, it is necessary to make overall social efforts. This study intends to expand the dimension of suicide prevention to the public design. The purpose of this study is to derive the factors influence suicide in the residential environment of multi-family housings through the service design process focusing on various stakeholders, and to propose design improvement plans based on this. Methods Service design research was conducted focusing on in-depth and realistic needs of consumers through interviews and workshops with various stakeholders such as suicide attempters, social workers, housing welfare workers, residential environment managers, and local residents. Based on the service design model of Discover-Define-Develop-Deliver, we analyze the tangible and intangible elements of residential environment that make up the service of suicide prevention and seek improvements. Result Through the servide design process, three goals of designing a residential environment for a multi-family housing for suicide prevention were set: connection to improve the disconnection between people, specialization of the residential environment to improve the alienation of living in pubic housing, and expansion of limited activities. To realize these goals, we presented solutions for each of ten design keywords-light, organizing, color, neighbor chair, alleyway of my house, nature shelter, exercise shelter, themed room, history formation, and happiness map. Considering the difference between the executioners, it is systematized by space in my house, in front of my house, in my apartment, and in my neighborhood, and verified its effectiveness through on-site verification. Conclusion Considering the complexity of suicide, suicide prevention policies and efforts focused on mental health need to be expanded to the whole society. This study tried to expand the dimension of suicide prevention by seeking a design approach of the residential environment in terms of social problem-solving design.