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Dong Dong Zhang,Yang Fang Wu,Wei Xia Chen,Yao Xu,Si Yan Liu,Huang Huang Luo,Guang Mei Jiang,Yue Wu,Peng Hu 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Renal osteodystrophy (ROD) occurs as early as chronic kidney disease (CKD) stage 2 and seems ubiquitous in almost all pediatric patients with CKD stage 5. Fibroblast growth factor (FGF)-23, a bone-derived endocrine regulator of phosphate homeostasis, is overexpressed in CKD and disturbs osteoblast differentiation and matrix mineralization. In contrast, C-type natriuretic peptide (CNP) acts as a potent positive regulator of bone growth. In the present study, we infused CNP into uremic rats and observed whether CNP could attenuate ROD through the inhibition of FGF-23 cascades. In uremic rats, CNP administration significantly alleviated renal dysfunction, calcium phosphate metabolic disorders, hypovitaminosis D, secondary hyperparathyroidism, the decrease in bone turnover markers and retarded bone pathological progression. More importantly, within FGF-23/mitogen-activated protein kinase (MAPK) signaling, the fibroblast growth factor receptor-1, Klotho and alternative (STAT-1/phospho-STAT-1) elements were upregulated by CNP, whereas FGF-23, RAF-1/phospho-RAF-1, and downstream (ERK/phospho-ERK and P38/phospho-P38) elements were paradoxically underexpressed in bone tissue. Therefore, CNP exerts a therapeutic effect on ROD through inhibition of FGF-23/MAPK signaling at the RAF-1 level.
Tsung-Hua Lu(Tsung-Hua Lu),Shih-Hsien Lin(Shih-Hsien Lin),Mei Hung Chi(Mei Hung Chi),Ching-Lin Chu(Ching-Lin Chu),Dong-Yu Yang(Dong-Yu Yang),Wei Hung Chang(Wei Hung Chang),Po See Chen(Po See Chen),Yen 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1
Objective: Hypoactivity in the reward system among patients with attention deficit hyperactivity disorder (ADHD) is a well-known phenomenon. Whether the activity in the reward pathway is related to harm avoidance, such as in sensitivity to punishment, is unclear. Evidence regarding the potential difference between ADHD patients and controls in terms of this association is scarce. Methods: Event-related functional magnetic resonance imaging was conducted on subjects performing the Iowa gambling test. Fourteen adults with ADHD and 14 controls were enrolled in the study. Results: Harm avoidance was found to be positively correlated with the activities of the bilateral orbitofrontal cortex and right insula in individuals with ADHD. A group difference was also confirmed. Conclusion: Understanding the roles of harm avoidance and brain activation during risk tasks is important.
Synthesis of 4H-pyrans catalyzed by thermol-regulated PEG1000-based ionic liquid/EM
Dong Fang,Jin-ming Yang,Hua-bin Zhang,Chang-mei Jiao 한국공업화학회 2011 Journal of Industrial and Engineering Chemistry Vol.17 No.3
A recyclable temperature-dependant phase-separation catalytic system comprised of PEG1000-based functional dicationic acidic ionic liquid and ethylene glycol monomethyl ether was used to prepare polyfunctionalized 4H-pyrans via one-pot three-component condensation with yields of 81–93%. The reaction was accomplished homogeneously at 90 8C, while the products was separated from the catalyst system by liquid/liquid phasic-separation at room-temperature, and the catalyst could be reused at least eight times without noticeably decreasing the catalytic activity.
A Novel Electrochemical Biosensor Based on Graphene and Cu Nanowires Hybrid Nanocomposites
Mei Chen,CHANGJUN HOU,DANQUN HUO,Liang Dong,Mei Yang,Huanbao Fa 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2016 NANO Vol.11 No.11
In this research, a new electrochemical sensor based on hybrid nanocomposite consisting of copper nanowires (CuNWs) and graphene (GR) were developed for the detection of organophosphorus pesticides (OPs). The surface morphology of the hybrid nanocomposite were studied by scanning electron microscope (SEM). The electrochemical behavior of the hybrid nanocomposites based sensor and its application for pesticides determination were evaluated by cyclic voltammetry (CV) and square wave voltammetry (SWV). Under optimized operational conditions, SWV was further employed for methyl parathion detection, which shows a wide dynamic range from 0.2 µM to 5 µM, a high sensitivity (69.2 · cm2 · µM-1) and the detection limit as low as 50 nM. It also had specific detection to the methyl parathion residues and had good reproducibility and stability. These results implicated the potential applicability of CuNWs/GNs-Chit hybrid nanocomposites in sensitive and selective detection of organophosphorus pesticides.
Mei Yang,Hexuan Li,Dong-Joo Kim 한국무역연구원 2021 The International Academy of Global Business and T Vol.17 No.2
Purpose – The shadow banking business in China has expanded significantly in the past decade, especially in the real estate industry, which is closely related to the livelihood of many. The purpose of this paper is to investigate the relationship between the realized sale prices of real estates and the real estate investment trusts (REIT) of shadow banking in China. Design/Methodology/Approach – The analysis is performed with a VAR model based on Chinese data collected from Usetrust, CSMAR, the People’s Bank of China, and the National Bureau of Statistics of China during 2013 to 2020. It verifies the impact of the realized sale prices of real estate and relative macroeconomic indicators, on the REIT issuance of shadow banking by variance decomposition and impulse response analysis. Findings – The prices of real estate have the greatest impact on REIT, and there is a one-way Granger causality between them. The findings indicate that it would be beneficial to establish a real estate price prediction and warning mechanism for local governments and relevant institutions to avoid the potential risks to consumers, the finance market, and the real estate industry, which might be caused by price declines or shadow banking failures. Research Implications – In previous literature, it was found that the expansion of shadow banking affected the Chinese real estate market significantly, including an increase in real estate prices, risks of real estate bubbles, and a decrease in monetary policy. Most studies related to this topic collected data from official or commercial databases, respectively. Different from previous research to some extent, this paper is based on up-to-date data collected up the end of 2020. Additionally, it collects data from the two data sources from a broader aspect. The purpose of the research is to empirically explore the mutual influence of shadow banking and real estate prices, and facilitate the regulation of shadow banking for regulators and stakeholders.
Mei Hong Zhu,Sung Jin Park,Hyun Jin Kim,Dong Ki Yang,Suk Hyo Suh,Insuk So,Ki Whan Kim 대한생리학회-대한약리학회 2002 The Korean Journal of Physiology & Pharmacology Vol.6 No.2
<P> Effects of oxidized low-density lipoprotein (ox-LDL), l-α-stearoyl-lysophosphatidylcholine (LPC), on intracellular Ca<SUP>2</SUP> concentration were examined in mouse endothelial cells by measuring intracellular Ca<SUP>2</SUP> concentration ([Ca<SUP>2</SUP>]<SUB>i</SUB>) with fura 2-AM and reverse transcription-polymerase chain reaction (RT-PCR). LPC increased [Ca<SUP>2</SUP>]<SUB>i</SUB> under the condition of 1.5 mM [Ca<SUP>2</SUP>]<SUB>o</SUB> but did not show any effect under the nominally Ca<SUP>2</SUP>-free condition. Even after the store depletion with 30μM 2,5-di-tert- butylhydroquinone (BHQ) or 30μM ATP, LPC could still increase the [Ca<SUP>2</SUP>]<SUB>i</SUB> under the condition of 1.5 mM [Ca<SUP>2</SUP>]<SUB>o</SUB>. The time required to increase [Ca<SUP>2</SUP>]<SUB>i</SUB> (about 1 minute) was longer than that for ATP-induced [Ca<SUP>2</SUP>]<SUB>i</SUB> increase (10∼30 seconds). LPC-induced [Ca<SUP>2</SUP>]<SUB>i</SUB> increase was completely blocked by 1μM La<SUP>3</SUP>. Transient receptor potential channel(trpc) 4 mRNA was detected with RT-PCR. From these results, we suggest that LPC increased [Ca<SUP>2</SUP>]<SUB>i</SUB> via the increase of Ca<SUP>2</SUP> influx through the Ca<SUP>2</SUP> routes which exist in the plasma membrane.
Dynamic mechanism of HIV replication inhibitor peptide encapsulated into carbon nanotubes
Bao-Dong Chen,Chuan-Lu Yang,Jun-Sheng Yang,Mei-Shan Wang,Xiao-Guang Ma 한국물리학회 2013 Current Applied Physics Vol.13 No.6
Biomolecules encapsulated in carbon nanotubes (CNTs) have attracted much interest and facilitated exciting opportunities for biological and biomedical applications of CNTs. Understanding the fundamental interaction and change in biomolecules during encapsulation is indispensable but remains a challenge for both theoretical and experimental investigations. This paper focuses on the interaction between HIV replication inhibitor peptide (HRIP) and CNTs in a neutral solution with molecular dynamics simulation. We observed that HRIP spontaneously inserts into the CNTs and oscillates around the center of the tube, where the non-covalent interaction is minimum. The effects of the diameters of the CNTs on HRIP were investigated. The optimal diameter of the CNT that can provide the most effective encapsulation and causes minimum conformational change in HRIP was found. The present results provide valuable insights in the understanding of nanoscale drug delivery using CNT-based devices.
A reduced time-varying model for a long beam on elastic foundation under moving loads
Guiming Mei,Caijin Yang,Shulin Liang,Jiangwen Wang,Dong Zou,Weihua Zhang,Yunshi Zhao,Zhong Huang,Shuqi Song,Mengying Tan,Yao Cheng,Bingrong Miao 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.9
Dynamics of a long beam on the elastic foundation subjected to moving loads is studied in the present paper. The sliding window technique is used to dynamically truncate the long beam and a reduced time-varying beam system is obtained. The Hamilton’s principle is employed to establish the equations of motion of the reduced system. The variable separation method is adopted to solve dynamical responses of the reduced system. Examples of a long simply supported Timoshenko beam on the nonlinear foundation subjected to a single moving load and multiple loads are included. Numerical results of the reduced model compared with the ones obtained from the moving element model adapted in literature are carried out to show the validity and the good efficiency of the method proposed in the present paper.