니세틸 정(아세틸 - 엘 - 카르니틴 500mg)에 대한 뉴로세틸 정의 생물학적 동등성

조혜영,오인준,이용복,임동구,문재동,심영순,김은아,정현철 한국약제학회 2001 Journal of Pharmaceutical Investigation Vol.31 No.1

Acetyl-L-carnitine (ALC), an endogenous component of the L-carnitine family, is naturally occurring molecule synthesized from L-carnitine (LC) by carnitine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioequivalence of two ALC tablets, Nicetile^(TM) (Dong-A pharmaceutical Co., Ltd.) and Neurocetil^(TM) (Kyung-Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration. Twenty six normal male volunteers, 22.80±2.76 year in age and 63.07±7.98 ㎏ in body weight, were divided into two groups and a randomized 2 × 2 cross-over study was employed. After one tablet containing 500 ㎎ of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. Pharmacokinetic parameters such as AUC_t, C_(max) and T_(max) were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_(max) and T_(max) between two tablets were 2.72%, -0.65% and -8.42%, respectively, when calculated against the Nicetile^(TM) tablet. The powers (1-β) for AUC_t and C_(max) were 94.87% and 87.17%, respectively. Minimum detectable differences (△) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 15.58% and 19.16% AUC_t and C_(max), respectively). The 90% confidence intervals were within ±20% (e.g., -11.84∼6.41 and -10.57∼11.88 for AUC_t and C_(max), respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Neurocetil^(TM) tablet is bioequivalent to Nicetile^(TM) tablet.

니세틸 정(아세틸-엘-카르니틴 500 mg)에 대한 뉴로세틸 정의 생물학적 동등성

조혜영,김은아,정현철,심영순,임동구,오인준,문재동,이용복 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-

Acetyl-L-carnitine (ALC), an endogenous component of the L-carnitine family, is naturally occurring molecule synthesized from L-carnitine (LC) by carnitine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioequivalence of two ALC tablets, Nicetiler^TM (Dong-A pharmaceutical Co., Ltd.) and Neurocetil^TM (Kyung-Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration. Twenty six normal male volunteers, 22.80±2.76 year in age and 63.07 7.98㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 500㎎ of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. Pharmacokinetic parameters such as AUC_t, C_max and T_max were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_max and T_max between two tablets were 2.72%, -0.65% and -8.42%, respectively, when calculated against the Nicetile^TM tablet. The powers (1-β) for AUC_t and C_max were 94.87% and 87.17%, respectively. Minimum detectable differences (Δ) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 15.58% and 19.16% AUC_t and C_max, respectively). The 90% confidence intervals were within ±20% (e.g., -11.84∼6.41 and -10.57∼11.88 for AUC_t and C_max, respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Neurocetil^TM tablet is bioequivalent to Nicetile^TM tablet.

복강경담낭절제술에서 수술전 간담도신티그라피와 경구담낭조영술의 의의

문대혁(Dae Hyuk Moon),양승오(Seoung Oh Yang),이희경(Hee Kyung Lee),원경숙(Kyoung Sook Won),류진숙(Jin Sook Ryu),한동복(Dong Bok Han),박철민(Cheol Min Park),이문규(Moon Gyu Lee),박광민(Kwang Min Park),이승규(Sung Gyu Lee) 대한핵의학회 1997 핵의학 분자영상 Vol.31 No.1

N/A 131I-6β-iodomethyl-19-norcholesterol(NP-59) has an advantage to assess adrenal dysfunction caused by adrenal cortical disorders. The aim of this study is to evaluate the clinical usefulness of NP-59 scintigraphy in each adrenral disease. Ten patients who did eleven NP-59 adrenal scintigraphies at Dong-A University Hospital from March 1990 to December 1996 were selected as the subject. Among the subject there were 5 cases of Cushing's syndrome, 2 cases of incidentaloma, 1 case of metastatic adrenal tumor, liver cirrhosis with hirsutism and hypertension respectively. Among 5 case of Cushing's syndrome, there were 2 cases of Cushing's disease, 2 cases of adrenal adenoma and 1 case of adrenal carcinoma. There are no disagreement between clinical diagnosis and scan finding in Cushing's syndrome. In 2 incidentaloma cases, even though one is interpretated as a functioning tumor, both of 2 cases could avoid unnecessary biopsy according to scintigraphy result. One case of hirsutism, clinically adrenal originated, revealed the normal scintigraphic hirsutism was extra-adrenal origin. One case of hypertension took the study to exclude the possibility of primary aldosteronism. Normal suppression scan finding revealed that primary aldosteronism did not exist in this case. In conclusion, NP-59 scintigraphy was very useful in diagnosis and differential diagnosis of Cushing's syndrome and it could avoid unnecessary biopsy in the incidental adrenal tumor.

임신성 종양 및 화농성 육아종에 대한 임상 및 병리조직학적 연구

李建馥,咸日成,金東民 단국대학교 치의학연구소 1991 논문집 Vol.3 No.-

Pregnancy tumor is frequent disease entity in pregnant women and also pyogenic granuloma is very frequent disease entity in oral cavity, but at presnet day, the etiology and behavior of these disease is not clear. Therefore authors studied pregnancy tumor and pyogenic granuloma which have been experienced in Department of Periodontics of Dental Infirmary of Dankook University, and present preganacy tumor 8 cases and pyogenic granuloma 12 cases. Authors elicit the following results. 1. Pyogenic granuloma has a prediction for age, second decades to fifth decades of life and frequently occurs as twice as in female. 2. Pregnancy tumor more frequently occurs at the mixilla than mandibule and more frequently occurs at the anterior teeth area. On the contrary pyogenic granuloma has a prediction for mandible and molar area. Clinical sign and symptom shows swelling and hemorrhage on mild stimulation in both disease. 3. Pregnancy tumor and pyogenic granuloma may be occurred by specific reaction about nonspecific inflammation from local irritation. 4. The cause of non-complete regression of pregnancy tumor and pyogenic granuloma after parturition and subside of inflammation may be considered fibromatous change of these lesion.

遼末女眞社會의 構成 (Ⅰ) : 黑水와 黑水靺鞨 Focused on River Hei-shui˘(黑水) and Hei-shui˘-mo-he (黑水靺鞨)

李東馥 淸州大學校 1984 論文集 Vol.17 No.1

The people who founded Chin (金) dynasty were Sheng-nuzhens (生女眞). The main part of Sheng-nuzhens were Hei-shui-mo-he-rens (黑水靺鞨人) who had been living on the lower part of River Song-hua(松花江) in the east side of I-lan (依蘭) ever since both the period of Sui (隋) and Tang (唐) dynasty. The reason why the people were called Hei-shui-mo-he was due to the fact they lived around River Hei-shul(黑水). River Hei-shui has customarily been recognized as River Hei-long(黑龍江) of today, but in fact it indicates the lower areas of River Song-hua in the east part of I-lan. In the early 10th century, when Bo-hdi(渤海) dynasty had been declined, Hei-shuimo-he-rens, who had lived in the lower areas of River Song-hua at that time, expanded their power and pushed into Manchuria(滿洲). Their expansion of influence was much active around the time when Bo-hai dynasty was to be declined. When the Hei-shui-mo-he-rens advanced into the whole areas of Manchuria in the late period of Liao dynasty, they became the essential and major part of the people who founded the Sheng-nuzhen society.

Garre씨 골수염의 증례보고

李建馥,咸日成,金東民 단국대학교 치의학연구소 1991 논문집 Vol.3 No.-

Authors experienced Garre's osteomyelitis that showed 24 years male patient who visited the Dental Hospital of College of Dentistry of Dankook University because of right facial asymmetry from recurred swelling in right mandibular angle area. Because we thought that this case was rare, we examined the clinical, radiological, histopathological features, and discussed the etiologic factors and the pathogenesis of Garre's osteomyelitis through a review of literature. The results were as followings. 1. In clinical features, 24 years male patient showed right facial asymmetry from recurred swelling in right mandibular angle area. 2. In radiographic features, slight periosteal bone formation in right mandibular angle area was found. 3. In histopathologic features, parallel trabecular orientation that occurred perpendicular to the cortex was associated with medullary trabecular in the back ground of hemorragic loose connective tissue with lymphocytes and plasma cells. Many lamellated trabecular lined by active osteoblast cells were found. In other area, empty lacunae in trabecular were observed. 4. We considered the etiologic focus to be a low grade infection from prolonged infection right 1st mandibular molar.

열처리에 따른 Zircaloy-4 Tube의 부식특성에 관한 연구

이동복,최송천 成均館大學校 科學技術硏究所 1994 論文集 Vol.45 No.1

열처리에 따른 Zircaloy-4 tube의 부식 특성을 조사하기 위하여 pilger된 시편, 수냉된 시편, 열처리된 시편에 대해, 500℃, 102 기압의 증기하에서의 부식 시험을 실시하였다. 주어진 시험조건하에서 수냉된 시편과 pilger된 시편은 좋은 nodular 부식 저항을 보였으나, 열처리된 시편은 나쁜 nodular 부식 저항을 가졌다. To investigate the effect of heat treatment on the corrosion behavior of water-quenched, heat -treated, and as-pilgered Zircaloy-4 tubes, corrosion testing was conducted at 500℃ in 102 atm of steam atmosphere. Under these given conditions, water-quenched and as-pilgered and the grains become bigger and equiaxed. Heat treated specimens exhibited improved resistance to nodular corroson, while heat- treated specimens had poor nodular corrosion resistance.

철강 제조업체 근로자에서 효소면역측정법을 통한 B형 간염 바이러스 표지자 조사

이종영,강승원,하명화,김중구,배삼덕,김두희,남복동 大韓産業醫學會 1996 대한직업환경의학회지 Vol.8 No.2

포항 지역 한 철강 제조업에서 1995년 1월부터 10월 사이에 실시한 정기 건강진단을 받은 남자 근로자 11,523명을 대상으로 HBsAg 및 Anti-HBs, HBeAg 및 Auti-HBe은 EIA법으로, SGOT 및 SGPT는 반응속도법(IU)으로 검사하였다. 그리고 이들 대상자에서 교육정보, 근무 형태, 음주 및 흡연습관과 간기능 이상 여부를 조사하여 다음과 같은 결과를 얻었다. 1. B형 간염 표지자의 분포를 보면 HBsAg(+)/Anti-HBs(-)는 8.1%, HBsAg(-)/Anti-HBs(+)는 60.5% 그리고 HBsAg(+)/Anti-HBs는 0.1%이었으며, HBsAg의 양성율은 8.2%, Anti-HBs 양성율은 60.6%이었다. 2. 연령에 따라 HBsAg(+)/Anti-HBs(-)와 HBsAg(-)-HBs(+)가 유의하게 증가한 반면(p<0.05), 교육정도와 근무형태에 있어서는 통계적으로 유의한 차이가 없었다. 3. 음주율은 HBsAg(+)/Anti-HBs(-)에서 HBsAg(-)/Anti-HBs(-)와 HBsAg(-)/Anti-HBs(+)의 84.6% 및 85.7%에 비해 낮지만 73.9%나 되었고, 흡연율은 HBsAg(-)/Anti-HBs(+), HBsAg(+)/Anti-HBs(-) 및 HBsAg(-)/Anti-HBs(-)에서 54.3%, 53.7% 및 53.0%의 순서로 나타났다. HBsAg(+)/Anti-HBs(-)에서 간기능 이상자가 40.1%이었으나 HBsAg(-)Anti-HBs(-)와 HBsAg(-)/Anti-HBs(+)에서도 각각 21.9% 및 18.4%를 차지하였다. 4. HBsAg(+)에서의 e항원에 대한 표지자의 분포를 보면 HBeAg(+)/Anti-HBe(-)는 31.3%, HBeAg(-)/AntiHBe(+)는 55.0% 그리고 HBeAg(+)/Anti-HBe(+)는 1.6%이었고 HBeAg(+)/Anti-HBe(-)는 연령에 따라 감소하고 HBeAg(-)/AntiHBs(-)와 HBeAG(-)/AntiHBe(+)는 증가하였다. HBsAg 양성자중 HBeAg의 총 양성율은 32.9%로 연령이 증가할수록 유의하게 감소하였다. 본 연구는 근로자의 B형 간염 표지자 조사에 있어 Anti-HBs의 검사에서는 EIA 방법으로 실시해야 하는 근거를 제시하는 것이며, 철강산업 근로자에서는 B형간염 이외의 간장질환에도 관심을 가져야 할 것으로 보이며 음주 문제에 대한 대책마련이 시급히 이루어 져야 할 것으로 생각된다. A study for seroprevalence of Hepatitis B virus markers (HBsAg, Anti-HBs, HBeAg and Anti-HBe) by EIA method and the Liver Function Test(SGOT and SGPT) using kinetic method was carried out from January to October 1995 among male workers of a major iron and steel manufacturing company located in Pohang. The results were as follows; 1. The distribution of hepatitis B virus markers showed that the proportions of HBsAg(+)/Anti-HBs(-), HBsAg(-)/Anti-HBs(+) and HBsAg(+)/Anti-HBs(+) were 8.1%, 60.5% and 0.1%, respectively. The positive rate of HBsAg in all subjects was 8.2%, whereas that of anti-HBs was 60.6%. 2. The proportions of HBsAg(+)/Anti-HBs(-) and HBsAg(-)/Anti-HBs(+) increased significantly with age. While the distribution of hepatitis B virus markers exhibited no significant differences among the groups classified by educational background or work type. 3. The proportion of drinkers in HBsAg(+)/Anti-HBs(-)(73.9%) was significantly lower than those of HBsAg(-)/Anti-HBs(-) and HBsAg(-)/Anti-HBs(+) (84.6% and 85.7%, respectively). The proportions of smoking for the three groups of HBsAg(-)/Anti-HBs(+), HBsAg(+)/Anti-HBs(-) and HBsAg(-)/Anti-HBs(-) were 54.3%, 53.7% and 53.0%, respectively(p<0.01). The proportion of the subjects with abnormal liver function test in HBsAg(+)/Anti-HBs(-) was 40.1%, whereas those in HBsAg(-)/Anti-HBs(-) and HBsAg(-)/Anti-HBs(+) were 21.9% and 18.4%, respectively. 4. The distribution of e Ag markers among HBsAg(+) subjects showed that the proportions of HBeAg(+)/Anti-HBe(-), HBeAg(-)/Anti-HBe(+) and HBeAg(+)/Anti-HBe(+) were 31.3%, 55.0% and 1.6%, respectively. The proportion of HBeAg(+)/Anti-HBe(-) decreased significantly with age and those of HBeAg(-)/Anti-HBe(-) and HBeAg(-)/Anti-HBe(+) increased with age. The positive rate of HBeAg among HBsAg(+) subjects was 32.9%. In conclusion, as a screening method, EIA is recommended to test hepatitis B virus markers, especially when examining Anti-HBs more sensitively. For the workers of the iron and steel manufacturing company studied, liver diseases caused by other than hepatitis B should be given a special care including an education avoiding alcohol drinking.

LCD 제조 및 검사공정을 위한 자기부상 전송장치 개발

李斗馥,金東遠 홍익대학교 산업기술연구소 2003 産業技術 Vol.13 No.-

A magnetic levitation is suitable for moving materials in such a clean environment which must be kept free from even microscopic dust motes, for example, in a super clean room in LCD(Liquid Crystal Display) manufacturing plants and PDP(Plasma Display Panel) or biochemical plants, delicate medical machines, because friction can be disappeared or reduced. In addition to this, another advantage of levitation is that the manipulator can operate as a rigid body rather than using joints parts. In this work, the magnetic levitation is applied to transport a several liquid crystal display classes between LCD fabrication process modules in clean rooms because it can eliminate particles and oil contamination that normally exits in conventional transport systems due to contact motions of mechanical component. The transport system consists of a carrier, levitation track, and propelling system. Levitation is achieved by using antagonistic forces produced between electromagnet tracks and permanent magnets. Stabilization is achieved by using a simple feedback control. The continuous propelling force is obtained by sending specific current patterns to the propulsion coils.

가스상 오염물질 제거기술

이동섭,김복조 경운대학교 산업기술연구소 2002 産業技術硏究論文誌 Vol.4 No.2

Many European institutions and companies are developing ceramic filters which can substitute particulates and gas removal devices currently in use and which are believed to be the control devices of next generation. Because of their resistance to both chemical and thermal shocks, Ceramic filter system alone can remove particulates and gaseous air pollutants simultaneously without compulsory cooling systems, thus reducing installation and operating cost significantly. In this research, there is developed and tested, which is catalyst impregnated ceramic filters applicable to simultaneous removal of particulates and gaseous air pollutants. Emission standards of air pollutants are getting stringent and the market share of air pollutants control devices in Korea is projected up to 800 billion won by the year 2002 and low density ceramic filter system can substitute electrostatic precipitators and conventional bag filter systems significantly. catalyst doped ceramic filter were believed to be the most promising technology which can substitute particulates and gaseous pollutants removal devices in the near future.